{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T13:13:40Z","timestamp":1792502020339,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32160209"],"award-info":[{"award-number":["32160209"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071361"],"award-info":[{"award-number":["82071361"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160357"],"award-info":[{"award-number":["82160357"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017691","name":"Guangxi Key Research and Development Program","doi-asserted-by":"publisher","award":["AB18050008"],"award-info":[{"award-number":["AB18050008"]}],"id":[{"id":"10.13039\/501100017691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.intimp.2022.109225","type":"journal-article","created":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T18:28:51Z","timestamp":1662748131000},"page":"109225","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Salinomycin alleviates osteoarthritis progression via inhibiting Wnt\/\u03b2-catenin signaling"],"prefix":"10.1016","volume":"112","author":[{"given":"Jian","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijun","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanchuan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialiang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinshao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengliang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kegong","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10182","key":"10.1016\/j.intimp.2022.109225_b0005","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/S0140-6736(19)30417-9","article-title":"Osteoarthritis","volume":"393","author":"Hunter","year":"2019","journal-title":"The Lancet"},{"key":"10.1016\/j.intimp.2022.109225_b0010","doi-asserted-by":"crossref","first-page":"16072","DOI":"10.1038\/nrdp.2016.72","article-title":"Osteoarthritis","volume":"2","author":"Martel-Pelletier","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"6","key":"10.1016\/j.intimp.2022.109225_b0015","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1001\/jama.2020.22171","article-title":"Diagnosis and Treatment of Hip and Knee Osteoarthritis: A Review","volume":"325","author":"Katz","year":"2021","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.intimp.2022.109225_b0020","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.joca.2019.12.003","article-title":"Osteoarthritis year in review 2019: mechanics","volume":"28","author":"Hunt","year":"2020","journal-title":"Osteoarthritis and cartilage"},{"issue":"6","key":"10.1016\/j.intimp.2022.109225_b0025","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1002\/art.34453","article-title":"Osteoarthritis: a disease of the joint as an organ","volume":"64","author":"Loeser","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.intimp.2022.109225_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2020.101249","article-title":"The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis","volume":"66","author":"Zheng","year":"2021","journal-title":"Ageing research reviews"},{"key":"10.1016\/j.intimp.2022.109225_b0035","article-title":"Cell Interplay in Osteoarthritis","volume":"9","author":"Li","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"9","key":"10.1016\/j.intimp.2022.109225_b0040","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1002\/1529-0131(200009)43:9<1916::AID-ANR2>3.0.CO;2-I","article-title":"The role of the chondrocyte in osteoarthritis","volume":"43","author":"Goldring","year":"2000","journal-title":"Arthritis Rheum."},{"issue":"9","key":"10.1016\/j.intimp.2022.109225_b0045","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s11926-017-0679-z","article-title":"Wnt\/beta-catenin Signaling in Osteoarthritis and in Other Forms of Arthritis","volume":"19","author":"Zhou","year":"2017","journal-title":"Curr. Rheumatol. Rep."},{"issue":"2","key":"10.1016\/j.intimp.2022.109225_b0050","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/art.24247","article-title":"Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: prominent role of Wnt-induced signaling protein 1","volume":"60","author":"Blom","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.intimp.2022.109225_b0055","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/j.1749-6632.2009.05212.x","article-title":"Beta-catenin, cartilage, and osteoarthritis","volume":"1192","author":"Wu","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.intimp.2022.109225_b0060","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/164_2021_525","article-title":"WNT Signalling in Osteoarthritis and Its Pharmacological Targeting","volume":"269","author":"De Palma","year":"2021","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.intimp.2022.109225_b0065","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.670960","article-title":"LRP5 and LRP6 in Wnt Signaling: Similarity and Divergence","volume":"9","author":"Ren","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.intimp.2022.109225_b0070","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.devcel.2009.06.016","article-title":"Wnt\/beta-catenin signaling: components, mechanisms, and diseases","volume":"17","author":"MacDonald","year":"2009","journal-title":"Dev. Cell"},{"issue":"5663","key":"10.1016\/j.intimp.2022.109225_b0075","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1126\/science.1094291","article-title":"Convergence of Wnt, beta-catenin, and cadherin pathways","volume":"303","author":"Nelson","year":"2004","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.intimp.2022.109225_b0080","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nm.3074","article-title":"WNT signaling in bone homeostasis and disease: from human mutations to treatments","volume":"19","author":"Baron","year":"2013","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.intimp.2022.109225_b0085","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.bone.2008.12.006","article-title":"Wnt signaling and osteoarthritis","volume":"44","author":"Luyten","year":"2009","journal-title":"Bone"},{"issue":"10","key":"10.1016\/j.intimp.2022.109225_b0090","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/ncprheum0904","article-title":"Wnt-beta-catenin signaling in the pathogenesis of osteoarthritis","volume":"4","author":"Corr","year":"2008","journal-title":"Nat. Clin. Pract. Rheumatol."},{"key":"10.1016\/j.intimp.2022.109225_b0095","doi-asserted-by":"crossref","unstructured":"J. Dewangan, S. Srivastava, S.K. Rath, Salinomycin: A new paradigm in cancer therapy, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 39(3) (2017) 1010428317695035.","DOI":"10.1177\/1010428317695035"},{"issue":"2","key":"10.1016\/j.intimp.2022.109225_b0100","doi-asserted-by":"crossref","first-page":"352","DOI":"10.4103\/jcrt.jcrt_1096_21","article-title":"Synergistic effect of growth factor receptor-bound protein 2\/epidermal growth factor receptor dual-targeting peptide inhibitor and salinomycin on osteosarcoma","volume":"18","author":"Yu","year":"2022","journal-title":"J. Cancer Res. Ther."},{"issue":"38","key":"10.1016\/j.intimp.2022.109225_b0105","doi-asserted-by":"crossref","first-page":"19931","DOI":"10.1039\/D0NR04552G","article-title":"Salinomycin nanocrystals for colorectal cancer treatment through inhibition of Wnt\/beta-catenin signaling","volume":"12","author":"Wang","year":"2020","journal-title":"Nanoscale"},{"issue":"5","key":"10.1016\/j.intimp.2022.109225_b0110","first-page":"630","article-title":"Salinomycin Suppresses Tumorigenicity of Liver Cancer Stem Cells and Wnt\/Beta-catenin Signaling","volume":"16","author":"Liu","year":"2021","journal-title":"Curr. Stem Cell Res. Ther."},{"issue":"2","key":"10.1016\/j.intimp.2022.109225_b0115","first-page":"1247","article-title":"Epidermal growth factor receptor aptamer-conjugated polymer-lipid hybrid nanoparticles enhance salinomycin delivery to osteosarcoma and cancer stem cells","volume":"15","author":"Yu","year":"2018","journal-title":"Experimental and therapeutic medicine"},{"issue":"17","key":"10.1016\/j.intimp.2022.109225_b0120","doi-asserted-by":"crossref","first-page":"3390","DOI":"10.1111\/bph.14770","article-title":"Salinomycin exerts anti-colorectal cancer activity by targeting the beta-catenin\/T-cell factor complex","volume":"176","author":"Wang","year":"2019","journal-title":"Br. J. Pharmacol."},{"issue":"32","key":"10.1016\/j.intimp.2022.109225_b0125","doi-asserted-by":"crossref","first-page":"13253","DOI":"10.1073\/pnas.1110431108","article-title":"Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells","volume":"108","author":"Lu","year":"2011","journal-title":"PNAS"},{"issue":"9","key":"10.1016\/j.intimp.2022.109225_b0130","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.joca.2007.03.006","article-title":"The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129\/SvEv mouse","volume":"15","author":"Glasson","year":"2007","journal-title":"Osteoarthritis and cartilage"},{"key":"10.1016\/j.intimp.2022.109225_b0135","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.2147\/OTT.S246706","article-title":"Salinomycin and Sulforaphane Exerted Synergistic Antiproliferative and Proapoptotic Effects on Colorectal Cancer Cells by Inhibiting the PI3K\/Akt Signaling Pathway in vitro and in vivo","volume":"13","author":"Liu","year":"2020","journal-title":"OncoTargets and therapy"},{"issue":"1","key":"10.1016\/j.intimp.2022.109225_b0140","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/s12943-019-1068-1","article-title":"Salinomycin effectively eliminates cancer stem-like cells and obviates hepatic metastasis in uveal melanoma","volume":"18","author":"Zhou","year":"2019","journal-title":"Molecular cancer"},{"key":"10.1016\/j.intimp.2022.109225_b0145","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.cellsig.2018.10.005","article-title":"Interleukin-1beta signaling in osteoarthritis - chondrocytes in focus","volume":"53","author":"Jenei-Lanzl","year":"2019","journal-title":"Cell. Signal."},{"issue":"1","key":"10.1016\/j.intimp.2022.109225_b0150","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nrrheum.2010.198","article-title":"The role of the cartilage matrix in osteoarthritis","volume":"7","author":"Heinegard","year":"2011","journal-title":"Nat. Rev. Rheumatol."},{"issue":"1","key":"10.1016\/j.intimp.2022.109225_b0155","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nrrheum.2010.196","article-title":"Role of proinflammatory cytokines in the pathophysiology of osteoarthritis","volume":"7","author":"Kapoor","year":"2011","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.intimp.2022.109225_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116786","article-title":"The role of matrix metalloproteinases in osteoarthritis pathogenesis: An updated review","volume":"234","author":"Mehana","year":"2019","journal-title":"Life Sci."},{"issue":"7","key":"10.1016\/j.intimp.2022.109225_b0165","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nrrheum.2016.65","article-title":"Ageing and the pathogenesis of osteoarthritis","volume":"12","author":"Loeser","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"issue":"6","key":"10.1016\/j.intimp.2022.109225_b0170","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1136\/annrheumdis-2017-212658","article-title":"Tyrosine kinase Fyn promotes osteoarthritis by activating the beta-catenin pathway","volume":"77","author":"Li","year":"2018","journal-title":"Ann. Rheum. Dis."},{"issue":"4","key":"10.1016\/j.intimp.2022.109225_b0175","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1136\/annrheumdis-2018-214200","article-title":"Wnt16 attenuates osteoarthritis progression through a PCP\/JNK-mTORC1-PTHrP cascade","volume":"78","author":"Tong","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.intimp.2022.109225_b0180","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13075-015-0540-6","article-title":"Loss of sclerostin promotes osteoarthritis in mice via beta-catenin-dependent and -independent Wnt pathways","volume":"17","author":"Bouaziz","year":"2015","journal-title":"Arthritis research & therapy"},{"issue":"12","key":"10.1016\/j.intimp.2022.109225_b0185","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1136\/annrheumdis-2014-205779","article-title":"Progranulin protects against osteoarthritis through interacting with TNF-alpha and beta-Catenin signalling","volume":"74","author":"Zhao","year":"2015","journal-title":"Ann. Rheum. Dis."},{"issue":"3","key":"10.1016\/j.intimp.2022.109225_b0190","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/labinvest.3700747","article-title":"Wnt\/beta-catenin signaling stimulates matrix catabolic genes and activity in articular chondrocytes: its possible role in joint degeneration","volume":"88","author":"Yuasa","year":"2008","journal-title":"Laboratory investigation; a journal of technical methods and pathology"},{"issue":"1","key":"10.1016\/j.intimp.2022.109225_b0195","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1359\/jbmr.080901","article-title":"Activation of \u03b2-Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis-Like Phenotype in Adult \u03b2-Catenin Conditional Activation Mice","volume":"24","author":"Zhu","year":"2009","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.intimp.2022.109225_b0200","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.pan.2012.11.314","article-title":"Mechanism of action of salinomycin on growth and migration in pancreatic cancer cell lines","volume":"13","author":"He","year":"2013","journal-title":"Pancreatology : official journal of the International Association of Pancreatology"},{"key":"10.1016\/j.intimp.2022.109225_b0205","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.2147\/OTT.S126463","article-title":"Salinomycin repressed the epithelial-mesenchymal transition of epithelial ovarian cancer cells via downregulating Wnt\/beta-catenin pathway","volume":"10","author":"Li","year":"2017","journal-title":"OncoTargets and therapy"},{"issue":"1","key":"10.1016\/j.intimp.2022.109225_b0210","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/jcb.23350","article-title":"The Wnt\/beta-catenin signaling pathway: a potential therapeutic target in the treatment of triple negative breast cancer","volume":"113","author":"King","year":"2012","journal-title":"J. Cell. Biochem."},{"issue":"10","key":"10.1016\/j.intimp.2022.109225_b0215","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1002\/jcb.24850","article-title":"Salinomycin suppresses LRP6 expression and inhibits both Wnt\/beta-catenin and mTORC1 signaling in breast and prostate cancer cells","volume":"115","author":"Lu","year":"2014","journal-title":"J. Cell. Biochem."},{"issue":"2","key":"10.1016\/j.intimp.2022.109225_b0220","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jphs.2014.12.009","article-title":"Salinomycin causes dedifferentiation via the extracellular signal-regulated kinase (ERK) pathway in rabbit articular chondrocytes","volume":"127","author":"Yu","year":"2015","journal-title":"J. Pharmacol. Sci."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922007093?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922007093?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:45:50Z","timestamp":1761587150000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576922007093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":44,"alternative-id":["S1567576922007093"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2022.109225","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Salinomycin alleviates osteoarthritis progression via inhibiting Wnt\/\u03b2-catenin signaling","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2022.109225","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"109225"}}