{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T02:17:27Z","timestamp":1775701047874,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2017MH022"],"award-info":[{"award-number":["ZR2017MH022"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2022QH326"],"award-info":[{"award-number":["ZR2022QH326"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770893"],"award-info":[{"award-number":["81770893"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201155"],"award-info":[{"award-number":["82201155"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.intimp.2022.109279","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T13:37:30Z","timestamp":1666186650000},"page":"109279","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"PA","title":["MCPIP1 alleviates inflammatory response through inducing autophagy in Aspergillus fumigatus keratitis"],"prefix":"10.1016","volume":"113","author":[{"given":"Fang","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanlin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.intimp.2022.109279_b0005","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1111\/myc.12822","article-title":"Fungal keratitis: an overview of clinical and laboratory aspects","volume":"61","author":"Mahmoudi","year":"2018","journal-title":"Mycoses"},{"key":"10.1016\/j.intimp.2022.109279_b0010","doi-asserted-by":"crossref","unstructured":"K. Ahmadikia, S. Aghaei Gharehbolagh, B. Fallah, M. Naeimi Eshkaleti, P. Malekifar, S. Rahsepar, M.I. Getso, S. Sharma, S. Mahmoudi, Distribution, prevalence, and causative agents of fungal keratitis: a systematic review and meta-analysis (1990 to 2020), Front. Cell Infect. Microbiol. 11 (2021) 698780.","DOI":"10.3389\/fcimb.2021.698780"},{"key":"10.1016\/j.intimp.2022.109279_b0015","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jtos.2021.12.001","article-title":"Fungal keratitis: a review of clinical presentations, treatment strategies and outcomes","volume":"24","author":"Sharma","year":"2022","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.intimp.2022.109279_b0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2015.07.001","article-title":"Corneal structure and transparency","volume":"49","author":"Meek","year":"2015","journal-title":"Prog. Retin. Eye Res."},{"issue":"4","key":"10.1016\/j.intimp.2022.109279_b0025","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/imcb.12010","article-title":"Osteopontin contributes to effective neutrophil recruitment, IL-1beta production and apoptosis in Aspergillus fumigatus keratitis","volume":"96","author":"Zhao","year":"2018","journal-title":"Immunol. Cell Biol."},{"issue":"9","key":"10.1016\/j.intimp.2022.109279_b0030","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.4049\/jimmunol.1701195","article-title":"Neutrophil caspase-11 is required for cleavage of caspase-1 and secretion of IL-1beta in Aspergillus fumigatus infection","volume":"201","author":"Sun","year":"2018","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2022.109279_b0035","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/ni.2797","article-title":"Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORgammat and dectin-2","volume":"15","author":"Taylor","year":"2014","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.intimp.2022.109279_b0040","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.727861","article-title":"Monocyte chemotactic protein-induced protein 1 (MCPIP-1): a key player of host defense and immune regulation","volume":"12","author":"Jin","year":"2021","journal-title":"Front. Immunol."},{"issue":"24","key":"10.1016\/j.intimp.2022.109279_b0045","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.1038\/emboj.2013.247","article-title":"USP10 inhibits genotoxic NF-kappaB activation by MCPIP1-facilitated deubiquitination of NEMO","volume":"32","author":"Niu","year":"2013","journal-title":"EMBO J."},{"issue":"13","key":"10.1016\/j.intimp.2022.109279_b0050","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1084\/jem.20092641","article-title":"MCP-induced protein 1 deubiquitinates TRAF proteins and negatively regulates JNK and NF-kappaB signaling","volume":"207","author":"Liang","year":"2010","journal-title":"J. Exp. Med."},{"issue":"7242","key":"10.1016\/j.intimp.2022.109279_b0055","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1038\/nature07924","article-title":"Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay","volume":"458","author":"Matsushita","year":"2009","journal-title":"Nature"},{"issue":"24","key":"10.1016\/j.intimp.2022.109279_b0060","doi-asserted-by":"crossref","first-page":"7386","DOI":"10.1111\/j.1742-4658.2009.07452.x","article-title":"Interleukin-1-inducible MCPIP protein has structural and functional properties of RNase and participates in degradation of IL-1beta mRNA","volume":"276","author":"Mizgalska","year":"2009","journal-title":"FEBS J."},{"issue":"3","key":"10.1016\/j.intimp.2022.109279_b0065","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.molcel.2011.09.012","article-title":"MCPIP1 ribonuclease antagonizes dicer and terminates microRNA biogenesis through precursor microRNA degradation","volume":"44","author":"Suzuki","year":"2011","journal-title":"Mol. Cell"},{"issue":"8","key":"10.1016\/j.intimp.2022.109279_b0070","doi-asserted-by":"crossref","first-page":"4456","DOI":"10.1093\/nar\/gkab215","article-title":"Monocyte chemoattractant protein-induced protein 1 directly degrades viral miRNAs with a specific motif and inhibits KSHV infection","volume":"49","author":"Kook","year":"2021","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.intimp.2022.109279_b0075","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1159\/000339826","article-title":"Differential regulation by Toll-like receptor agonists reveals that MCPIP1 is the potent regulator of innate immunity in bacterial and viral infections","volume":"5","author":"Blazusiak","year":"2013","journal-title":"J. Innate Immun."},{"issue":"5","key":"10.1016\/j.intimp.2022.109279_b0080","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/cmi.2016.70","article-title":"Regnase-1, a rapid response ribonuclease regulating inflammation and stress responses","volume":"14","author":"Mao","year":"2017","journal-title":"Cell. Mol. Immunol."},{"issue":"45","key":"10.1016\/j.intimp.2022.109279_b0085","doi-asserted-by":"crossref","first-page":"11818","DOI":"10.1073\/pnas.1716173114","article-title":"Twenty-five years of mTOR: Uncovering the link from nutrients to growth","volume":"114","author":"Sabatini","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.intimp.2022.109279_b0090","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1172\/JCI73939","article-title":"mTOR: a pharmacologic target for autophagy regulation","volume":"125","author":"Kim","year":"2015","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.intimp.2022.109279_b0095","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/nyas.14305","article-title":"Molecular regulation of autophagy machinery by mTOR-dependent and -independent pathways","volume":"1467","author":"Al\u2010Bari","year":"2020","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"6","key":"10.1016\/j.intimp.2022.109279_b0100","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41580-018-0003-4","article-title":"Mechanism and medical implications of mammalian autophagy","volume":"19","author":"Dikic","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"10","key":"10.1016\/j.intimp.2022.109279_b0105","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/nri3532","article-title":"Autophagy in infection, inflammation and immunity","volume":"13","author":"Deretic","year":"2013","journal-title":"Nat. Rev. Immunol."},{"issue":"21","key":"10.1016\/j.intimp.2022.109279_b0110","doi-asserted-by":"crossref","first-page":"eaaz6717","DOI":"10.1126\/sciadv.aaz6717","article-title":"Gasdermin D in macrophages restrains colitis by controlling cGAS-mediated inflammation","volume":"6","author":"Ma","year":"2020","journal-title":"Sci. Adv."},{"issue":"43","key":"10.1016\/j.intimp.2022.109279_b0115","doi-asserted-by":"crossref","first-page":"11036","DOI":"10.1073\/pnas.1809575115","article-title":"Regnase-1 controls colon epithelial regeneration via regulation of mTOR and purine metabolism","volume":"115","author":"Nagahama","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.intimp.2022.109279_b0120","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/mc.23286","article-title":"MCPIP1 expression positively correlates with melanoma-specific survival of patients, and its overexpression affects vital intracellular pathways of human melanoma cells","volume":"60","author":"Nowak","year":"2021","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.intimp.2022.109279_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108366","article-title":"The cGAS-STING signaling pathway contributes to the inflammatory response and autophagy in Aspergillus fumigatus keratitis","volume":"202","author":"Han","year":"2021","journal-title":"Exp. Eye Res."},{"issue":"1","key":"10.1016\/j.intimp.2022.109279_b0130","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1167\/iovs.02-0446","article-title":"Experimental keratomycosis in a mouse model","volume":"44","author":"Wu","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"3","key":"10.1016\/j.intimp.2022.109279_b0135","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1016\/S1473-3099(20)30448-5","article-title":"The global incidence and diagnosis of fungal keratitis","volume":"21","author":"Brown","year":"2021","journal-title":"Lancet Infect. Dis."},{"issue":"11","key":"10.1016\/j.intimp.2022.109279_b0140","first-page":"1676","article-title":"Review of clinical and basic approaches of fungal keratitis","volume":"9","author":"Wu","year":"2016","journal-title":"Int. J. Ophthalmol."},{"issue":"19","key":"10.1016\/j.intimp.2022.109279_b0145","doi-asserted-by":"crossref","first-page":"7183","DOI":"10.3390\/ijms21197183","article-title":"MCPIP1 RNase and its multifaceted role","volume":"21","author":"Musson","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2022.109279_b0150","doi-asserted-by":"crossref","first-page":"8812020","DOI":"10.1155\/2020\/8812020","article-title":"Monocyte chemotactic protein 1-induced protein 1 is highly expressed in inflammatory bowel disease and negatively regulates neutrophil activities","volume":"2020","author":"Lin","year":"2020","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.intimp.2022.109279_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2020.104705","article-title":"MCPIP1 inhibits Hepatitis B virus replication by destabilizing viral RNA and negatively regulates the virus-induced innate inflammatory responses","volume":"174","author":"Li","year":"2020","journal-title":"Antiviral Res."},{"issue":"1","key":"10.1016\/j.intimp.2022.109279_b0160","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00430-017-0523-0","article-title":"MCPIP1 inhibits coxsackievirus B3 replication by targeting viral RNA and negatively regulates virus-induced inflammation","volume":"207","author":"Li","year":"2018","journal-title":"Med. Microbiol. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2022.109279_b0165","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00502-21","article-title":"Subversion of lipopolysaccharide signaling in gingival keratinocytes via MCPIP-1 degradation as a novel pathogenic strategy of inflammophilic pathobionts","volume":"12","author":"Gasiorek","year":"2021","journal-title":"mBio"},{"issue":"50","key":"10.1016\/j.intimp.2022.109279_b0170","doi-asserted-by":"crossref","first-page":"6720","DOI":"10.1038\/s41388-021-02062-3","article-title":"MCPIP1 inhibits Wnt\/beta-catenin signaling pathway activity and modulates epithelial-mesenchymal transition during clear cell renal cell carcinoma progression by targeting miRNAs","volume":"40","author":"Gorka","year":"2021","journal-title":"Oncogene"},{"issue":"7","key":"10.1016\/j.intimp.2022.109279_b0175","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1002\/jcb.25832","article-title":"MCPIP1 exogenous overexpression inhibits pathways regulating MYCN oncoprotein stability in neuroblastoma","volume":"118","author":"Boratyn","year":"2017","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.intimp.2022.109279_b0180","first-page":"13","article-title":"The role of autophagy in microbial infection and immunity","volume":"4","author":"Desai","year":"2015","journal-title":"Immunotargets Ther."},{"key":"10.1016\/j.intimp.2022.109279_b0185","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.832750","article-title":"Autophagy-inflammation interplay during infection: balancing pathogen clearance and host inflammation","volume":"13","author":"Pang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2022.109279_b0190","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.semcdb.2019.07.014","article-title":"Autophagy in intracellular bacterial infection","volume":"101","author":"Hu","year":"2020","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.intimp.2022.109279_b0195","doi-asserted-by":"crossref","unstructured":"C. Qin, Y. Lu, L. Bai, K. Wang, The molecular regulation of autophagy in antimicrobial immunity, J. Mol. Cell Biol. 14 (4) (2022).","DOI":"10.1093\/jmcb\/mjac015"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922007639?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922007639?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:59:09Z","timestamp":1761587949000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576922007639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":39,"alternative-id":["S1567576922007639"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2022.109279","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MCPIP1 alleviates inflammatory response through inducing autophagy in Aspergillus fumigatus keratitis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2022.109279","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"109279"}}