{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T05:31:54Z","timestamp":1789882314144,"version":"4.0.1"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002862","name":"China University of Petroleum, Beijing","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013644","name":"Indian Council for Cultural Relations","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013644","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.intimp.2022.109382","type":"journal-article","created":{"date-parts":[[2022,10,29]],"date-time":"2022-10-29T17:00:51Z","timestamp":1667062851000},"page":"109382","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"special_numbering":"PA","title":["Monkeypox infection: The past, present, and future"],"prefix":"10.1016","volume":"113","author":[{"given":"Shubham","family":"Upadhayay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richmond","family":"Arthur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Soni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poonam","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"UmaShanker","family":"Navik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randhir","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thakur","family":"Gurjeet Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7978-1043","authenticated-orcid":false,"given":"Puneet","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.intimp.2022.109382_b0005","doi-asserted-by":"crossref","first-page":"980","DOI":"10.3201\/eid2505.190076","article-title":"Diagnosis of imported monkeypox, Israel, 2018","volume":"25","author":"Erez","year":"2019","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.intimp.2022.109382_b0010","series-title":"Seminars in Pediatric Infectious Diseases","article-title":"Monkeypox: a review of the history and emergence in the Western hemisphere","author":"Ligon","year":"2004"},{"key":"10.1016\/j.intimp.2022.109382_b0015","doi-asserted-by":"crossref","DOI":"10.1016\/S1473-3099(22)00228-6","article-title":"Clinical features and management of human monkeypox: a retrospective observational study in the UK","author":"Adler","year":"2022","journal-title":"Lancet. Infect. Dis"},{"key":"10.1016\/j.intimp.2022.109382_b0020","unstructured":"WHO, Monkeypox\/Vaccine\/Prevention. 2022, https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/monkeypox."},{"issue":"4","key":"10.1016\/j.intimp.2022.109382_b0025","first-page":"1027","article-title":"Human monkeypox: epidemiologic and clinical characteristics, diagnosis, and prevention","volume":"33","author":"Petersen","year":"2019","journal-title":"Infect. Dis. Clinics"},{"issue":"2","key":"10.1016\/j.intimp.2022.109382_b0030","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/infdis\/156.2.293","article-title":"Human monkeypox: clinical features of 282 patients","volume":"156","author":"Je\u017eek","year":"1987","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.intimp.2022.109382_b0035","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3389\/fpubh.2018.00241","article-title":"Emergence of monkeypox as the most important orthopoxvirus infection in humans","volume":"6","author":"Sklenovska","year":"2018","journal-title":"Front. Public Health"},{"key":"10.1016\/j.intimp.2022.109382_b0040","unstructured":"WHO, Multi-country monkeypox outbreak in non-endemic countries. 2022. https:\/\/www.who.int\/emergencies\/disease-outbreak-news\/item\/2022-DON385."},{"key":"10.1016\/j.intimp.2022.109382_b0045","doi-asserted-by":"crossref","unstructured":"D. Makkar, The Latest News for May 2022 All You Need to Know on Mon-keypox. 2022. https:\/\/doi.org\/10.20944\/preprints202206.0036.v1.","DOI":"10.14293\/S2199-1006.1.SOR-.PPCOS0D.v1"},{"issue":"11","key":"10.1016\/j.intimp.2022.109382_b0050","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.3390\/v12111257","article-title":"Monkeypox virus in Nigeria: infection biology, epidemiology, and evolution","volume":"12","author":"Alakunle","year":"2020","journal-title":"Viruses"},{"issue":"8","key":"10.1016\/j.intimp.2022.109382_b0055","doi-asserted-by":"crossref","first-page":"e6592","DOI":"10.1371\/journal.pone.0006592","article-title":"Comparison of monkeypox viruses pathogenesis in mice by in vivo imaging","volume":"4","author":"Osorio","year":"2009","journal-title":"PLoS ONE"},{"issue":"12","key":"10.1016\/j.intimp.2022.109382_b0060","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1038\/labinvest.3780373","article-title":"The pathology of experimental aerosolized monkeypox virus infection in cynomolgus monkeys (Macaca fascicularis)","volume":"81","author":"Zaucha","year":"2001","journal-title":"Lab. Invest."},{"issue":"8","key":"10.1016\/j.intimp.2022.109382_b0065","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/S1473-3099(19)30294-4","article-title":"Outbreak of human monkeypox in Nigeria in 2017\u201318: a clinical and epidemiological report","volume":"19","author":"Yinka-Ogunleye","year":"2019","journal-title":"Lancet. Infect. Dis"},{"issue":"11","key":"10.1016\/j.intimp.2022.109382_b0070","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3390\/v9110331","article-title":"Poxvirus host range genes and virus\u2013host spectrum: a critical review","volume":"9","author":"Oliveira","year":"2017","journal-title":"Viruses"},{"issue":"5","key":"10.1016\/j.intimp.2022.109382_b0075","doi-asserted-by":"crossref","first-page":"688","DOI":"10.3390\/v4050688","article-title":"Poxvirus cell entry: how many proteins does it take?","volume":"4","author":"Moss","year":"2012","journal-title":"Viruses"},{"issue":"2","key":"10.1016\/j.intimp.2022.109382_b0080","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/imm.12143","article-title":"Toll-like receptor 3 in viral pathogenesis: friend or foe?","volume":"140","author":"Perales-Linares","year":"2013","journal-title":"Immunology"},{"issue":"3","key":"10.1016\/j.intimp.2022.109382_b0085","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nrmicro1099","article-title":"Poxvirus tropism","volume":"3","author":"McFadden","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.intimp.2022.109382_b0090","series-title":"The Enzymes","first-page":"1","article-title":"Structure and function of the poxvirus transcription machinery","author":"Fischer","year":"2021"},{"key":"10.1016\/j.intimp.2022.109382_b0095","series-title":"Characterization of Endogenous Major Histocompatibility Complex Class II Antigen Processing Pathways for Modified Vaccinia Virus Ankara Infection","author":"Yi","year":"2014"},{"key":"10.1016\/j.intimp.2022.109382_b0100","unstructured":"N.B. Marzook, Lights, Camera, Actin: Divergent roles of beta-and gamma-cytoplasmic actin in vaccinia virus infection, 2017."},{"issue":"1","key":"10.1016\/j.intimp.2022.109382_b0105","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3390\/pathogens10010006","article-title":"Poxviral strategies to overcome host cell apoptosis","volume":"10","author":"Suraweera","year":"2020","journal-title":"Pathogens"},{"issue":"3","key":"10.1016\/j.intimp.2022.109382_b0110","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S1473-3099(18)30043-4","article-title":"Genomic characterisation of human monkeypox virus in Nigeria","volume":"18","author":"Faye","year":"2018","journal-title":"Lancet. Infect. Dis"},{"key":"10.1016\/j.intimp.2022.109382_b0115","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a010199","article-title":"Poxvirus DNA replication","volume":"5","author":"Moss","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.intimp.2022.109382_b0120","doi-asserted-by":"crossref","unstructured":"R. Grant, L.-B.-L. Nguyen, R. Breban, Modelling human-to-human transmission of monkeypox. 98(9) (2020) 638.","DOI":"10.2471\/BLT.19.242347"},{"key":"10.1016\/j.intimp.2022.109382_b0125","doi-asserted-by":"crossref","unstructured":"A. Antinori et al., Epidemiological, clinical and virological characteristics of four cases of monkeypox support transmission through sexual contact, Italy, May 2022. 2022. 27(22): p. 2200421.","DOI":"10.2807\/1560-7917.ES.2022.27.22.2200421"},{"key":"10.1016\/j.intimp.2022.109382_b0130","unstructured":"CDC, Transmission | Monkeypox | Poxvirus. 2022, CDC. https:\/\/www.cdc.gov\/poxvirus\/monkeypox\/clinicians\/clinical-recognition.html."},{"key":"10.1016\/j.intimp.2022.109382_b0135","series-title":"Monkeypox transmission among international travellers\u2014serious monkey business?","first-page":"taz002.","author":"Angelo","year":"2019"},{"key":"10.1016\/j.intimp.2022.109382_b0140","doi-asserted-by":"crossref","unstructured":"J. Heskin et al., Transmission of monkeypox virus through sexual contact\u2013A novel route of infection. 2022.","DOI":"10.1016\/j.jinf.2022.05.028"},{"key":"10.1016\/j.intimp.2022.109382_b0145","doi-asserted-by":"crossref","unstructured":"C.L. Hutson et al., Transmissibility of the monkeypox virus clades via respiratory transmission: investigation using the prairie dog-monkeypox virus challenge system. 2013. 8(2): p. e55488.","DOI":"10.1371\/journal.pone.0055488"},{"key":"10.1016\/j.intimp.2022.109382_b0150","doi-asserted-by":"crossref","unstructured":"E.M. Beer, V.B. Rao, A systematic review of the epidemiology of human monkeypox outbreaks and implications for outbreak strategy. 2019. 13(10): p. e0007791.","DOI":"10.1371\/journal.pntd.0007791"},{"key":"10.1016\/j.intimp.2022.109382_b0155","doi-asserted-by":"crossref","unstructured":"R. Vivancos et al., Community transmission of monkeypox in the United Kingdom, April to May 2022. 2022. 27(22): p. 2200422.","DOI":"10.2807\/1560-7917.ES.2022.27.22.2200422"},{"key":"10.1016\/j.intimp.2022.109382_b0160","unstructured":"CDC, Poxvirus\/Monkeypox\/Prevention. 2022. https:\/\/www.cdc.gov\/poxvirus\/monkeypox\/prevention.html."},{"issue":"6","key":"10.1016\/j.intimp.2022.109382_b0165","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1089\/vbz.2022.0022","article-title":"A Review of Zoonotic Disease Threats to Pet Owners: A Compendium of Measures to Prevent Zoonotic Diseases Associated with Non-Traditional Pets: Rodents and Other Small Mammals, Reptiles, Amphibians, Backyard Poultry, and Other Selected Animals","volume":"22","author":"Varela","year":"2022","journal-title":"Vector-Borne and Zoonotic Diseases"},{"key":"10.1016\/j.intimp.2022.109382_b0170","unstructured":"C. Clinic, Monkeypox. 2022. https:\/\/my.clevelandclinic.org\/health\/diseases\/22371-monkeypox."},{"key":"10.1016\/j.intimp.2022.109382_b0175","unstructured":"CDC, Monkeypox\/infection-control. 2022. https:\/\/www.cdc.gov\/poxvirus\/monkeypox\/clinicians\/infection-control-healthcare.html."},{"key":"10.1016\/j.intimp.2022.109382_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinf.2022.05.027","article-title":"Monkeypox: A new threat at our doorstep!","author":"Awan","year":"2022","journal-title":"J. Infect."},{"issue":"17","key":"10.1016\/j.intimp.2022.109382_b0185","doi-asserted-by":"crossref","first-page":"9176","DOI":"10.1128\/JVI.02173-10","article-title":"Effective antiviral treatment of systemic orthopoxvirus disease: ST-246 treatment of prairie dogs infected with monkeypox virus","volume":"85","author":"Smith","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.intimp.2022.109382_b0190","doi-asserted-by":"crossref","unstructured":"R.O. Baker, M. Bray, J.W. Huggins, Potential antiviral therapeutics for smallpox, monkeypox and other orthopoxvirus infections. 2003. 57(1-2): p. 13-23.","DOI":"10.1016\/S0166-3542(02)00196-1"},{"key":"10.1016\/j.intimp.2022.109382_b0195","doi-asserted-by":"crossref","unstructured":"E. De Clercq, Cidofovir in the treatment of poxvirus infections. 2002. 55(1): p. 1-13.","DOI":"10.1016\/S0166-3542(02)00008-6"},{"key":"10.1016\/j.intimp.2022.109382_b0200","doi-asserted-by":"crossref","unstructured":"D.F. Smee et al., Characterization of wild-type and cidofovir-resistant strains of camelpox, cowpox, monkeypox, and vaccinia viruses. 2002. 46(5): p. 1329-1335.","DOI":"10.1128\/AAC.46.5.1329-1335.2002"},{"key":"10.1016\/j.intimp.2022.109382_b0205","doi-asserted-by":"crossref","unstructured":"K.J. Stittelaar et al., Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection. 2006. 439(7077): p. 745-748.","DOI":"10.1038\/nature04295"},{"key":"10.1016\/j.intimp.2022.109382_b0210","doi-asserted-by":"crossref","unstructured":"S. Parker et al., Co-administration of the broad-spectrum antiviral, brincidofovir (CMX001), with smallpox vaccine does not compromise vaccine protection in mice challenged with ectromelia virus. 2014. 111: p. 42-52.","DOI":"10.1016\/j.antiviral.2014.08.003"},{"key":"10.1016\/j.intimp.2022.109382_b0215","doi-asserted-by":"crossref","unstructured":"C.L. Hutson et al., Pharmacokinetics and efficacy of a potential smallpox therapeutic, brincidofovir, in a lethal monkeypox virus animal model. 2021. 6(1): p. e00927-20.","DOI":"10.1128\/mSphere.00126-21"},{"key":"10.1016\/j.intimp.2022.109382_b0220","doi-asserted-by":"crossref","unstructured":"A.T. Russo et al., Co-administration of tecovirimat and ACAM2000\u2122 in non-human primates: Effect of tecovirimat treatment on ACAM2000 immunogenicity and efficacy versus lethal monkeypox virus challenge. 2020. 38(3): p. 644-654.","DOI":"10.1016\/j.vaccine.2019.10.049"},{"key":"10.1016\/j.intimp.2022.109382_b0225","doi-asserted-by":"crossref","unstructured":"R. Crump et al., Buccal viral DNA as a trigger for brincidofovir therapy in the mousepox model of smallpox. 2017. 139: p. 112-116.","DOI":"10.1016\/j.antiviral.2016.12.015"},{"issue":"7","key":"10.1016\/j.intimp.2022.109382_b0230","doi-asserted-by":"crossref","first-page":"4296","DOI":"10.1128\/AAC.00208-15","article-title":"Treatment with the smallpox antiviral tecovirimat (ST-246) alone or in combination with ACAM2000 vaccination is effective as a postsymptomatic therapy for monkeypox virus infection","volume":"59","author":"Berhanu","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.intimp.2022.109382_b0235","series-title":"Vaccinia Virus","first-page":"143","article-title":"Preliminary Screening and In Vitro Confirmation of Orthopoxvirus Antivirals","author":"Grosenbach","year":"2019"},{"key":"10.1016\/j.intimp.2022.109382_b0240","doi-asserted-by":"crossref","unstructured":"A.T. Russo et al., Effects of treatment delay on efficacy of tecovirimat following lethal aerosol monkeypox virus challenge in cynomolgus macaques. 2018. 218(9): p. 1490-1499.","DOI":"10.1093\/infdis\/jiy326"},{"key":"10.1016\/j.intimp.2022.109382_b0245","doi-asserted-by":"crossref","unstructured":"A.T. Russo et al., An overview of tecovirimat for smallpox treatment and expanded anti-orthopoxvirus applications. 2021. 19(3): p. 331-344.","DOI":"10.1080\/14787210.2020.1819791"},{"issue":"7077","key":"10.1016\/j.intimp.2022.109382_b0250","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/nature04295","article-title":"Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection","volume":"439","author":"Stittelaar","year":"2006","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.intimp.2022.109382_b0255","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3390\/v3010047","article-title":"Efficacy of CMX001 as a post exposure antiviral in New Zealand White rabbits infected with rabbitpox virus, a model for orthopoxvirus infections of humans","volume":"3","author":"Rice","year":"2011","journal-title":"Viruses"},{"issue":"4","key":"10.1016\/j.intimp.2022.109382_b0260","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.4049\/jimmunol.177.4.2552","article-title":"Subunit recombinant vaccine protects against monkeypox","volume":"177","author":"Heraud","year":"2006","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2022.109382_b0265","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1743-422X-6-188","article-title":"Inhibition of Monkeypox virus replication by RNA interference","volume":"6","author":"Alkhalil","year":"2009","journal-title":"Virol. J."},{"issue":"1","key":"10.1016\/j.intimp.2022.109382_b0270","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S1473-3099(03)00856-9","article-title":"Human monkeypox: an emerging zoonosis","volume":"4","author":"Di Giulio","year":"2004","journal-title":"Lancet. Infect. Dis"},{"issue":"6979","key":"10.1016\/j.intimp.2022.109382_b0275","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nature02331","article-title":"Immunogenicity of a highly attenuated MVA smallpox vaccine and protection against monkeypox","volume":"428","author":"Earl","year":"2004","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.intimp.2022.109382_b0280","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/nm1261","article-title":"Smallpox vaccine\u2013induced antibodies are necessary and sufficient for protection against monkeypox virus","volume":"11","author":"Edghill-Smith","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.intimp.2022.109382_b0285","unstructured":"CDC, Monkeypox\/Smallpox\/Vaccine. 2022. https:\/\/www.cdc.gov\/poxvirus\/monkeypox\/considerations-for-monkeypox vaccination.html."},{"issue":"2","key":"10.1016\/j.intimp.2022.109382_b0290","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1128\/JVI.02089-12","article-title":"Humoral immunity to smallpox vaccines and monkeypox virus challenge: proteomic assessment and clinical correlations","volume":"87","author":"Townsend","year":"2013","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.intimp.2022.109382_b0295","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0014-5793(01)03144-1","article-title":"Human monkeypox and smallpox viruses: genomic comparison","volume":"509","author":"Shchelkunov","year":"2001","journal-title":"FEBS Lett."},{"key":"10.1016\/j.intimp.2022.109382_b0300","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1023\/A:1016016013042","article-title":"Multiple genetic differences between the monkeypox and variola viruses","volume":"384","author":"Shchelkunov","year":"2002","journal-title":"Dokl. Biochem. Biophys."},{"issue":"17","key":"10.1016\/j.intimp.2022.109382_b0305","doi-asserted-by":"crossref","first-page":"4569","DOI":"10.1080\/07391102.2018.1554510","article-title":"Design of inhibitors of thymidylate kinase from Variola virus as new selective drugs against smallpox: part II","volume":"37","author":"Rodrigues Garcia","year":"2019","journal-title":"J. Biomol. Struct. Dyn."},{"issue":"3","key":"10.1016\/j.intimp.2022.109382_b0310","doi-asserted-by":"crossref","DOI":"10.3390\/v10030111","article-title":"Loss of Actin-Based Motility Impairs Ectromelia Virus Release In Vitro but Is Not Critical to Spread In Vivo","volume":"10","author":"Duncan","year":"2018","journal-title":"Viruses"},{"key":"10.1016\/j.intimp.2022.109382_b0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2019.197772","article-title":"Use of live Variola virus to determine whether CAST\/EiJ mice are a suitable surrogate animal model for human smallpox","volume":"275","author":"Gallardo-Romero","year":"2020","journal-title":"Virus Res."},{"issue":"10","key":"10.1016\/j.intimp.2022.109382_b0320","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01613-18","article-title":"MC159 of Molluscum Contagiosum Virus Suppresses Autophagy by Recruiting Cellular SH3BP4 via an SH3 Domain-Mediated Interaction","volume":"93","author":"Schmotz","year":"2019","journal-title":"J. Virol."},{"issue":"9","key":"10.1016\/j.intimp.2022.109382_b0325","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1016\/j.celrep.2018.11.009","article-title":"Identifying and Tracking Low-Frequency Virus-Specific TCR Clonotypes Using High-Throughput Sequencing","volume":"25","author":"Wolf","year":"2018","journal-title":"Cell. Rep."},{"key":"10.1016\/j.intimp.2022.109382_b0330","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.antiviral.2018.02.006","article-title":"Phage display antibodies against ectromelia virus that neutralize variola virus: Selection and implementation for p35 neutralizing epitope mapping","volume":"152","author":"Khlusevich","year":"2018","journal-title":"Antiviral Res."},{"issue":"1","key":"10.1016\/j.intimp.2022.109382_b0335","doi-asserted-by":"crossref","first-page":"e0170070","DOI":"10.1371\/journal.pone.0170070","article-title":"Cutaneous Deficiency of Filaggrin and STAT3 Exacerbates Vaccinia Disease In Vivo","volume":"12","author":"He","year":"2017","journal-title":"PLoS ONE"},{"issue":"8","key":"10.1016\/j.intimp.2022.109382_b0340","doi-asserted-by":"crossref","first-page":"e0158016","DOI":"10.1371\/journal.pone.0158016","article-title":"The Integration of Epistasis Network and Functional Interactions in a GWAS Implicates RXR Pathway Genes in the Immune Response to Smallpox Vaccine","volume":"11","author":"McKinney","year":"2016","journal-title":"PLoS ONE"},{"issue":"9","key":"10.1016\/j.intimp.2022.109382_b0345","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1093\/infdis\/jit341","article-title":"Genetic variation in IL18R1 and IL18 genes and Inteferon \u03b3 ELISPOT response to smallpox vaccination: an unexpected relationship","volume":"208","author":"Ovsyannikova","year":"2013","journal-title":"J. Infect. Dis."},{"issue":"2","key":"10.1016\/j.intimp.2022.109382_b0350","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jviromet.2011.05.002","article-title":"Species-specific identification of variola, monkeypox, cowpox, and vaccinia viruses by multiplex real-time PCR assay","volume":"175","author":"Shchelkunov","year":"2011","journal-title":"J. Virol. Methods"},{"issue":"43","key":"10.1016\/j.intimp.2022.109382_b0355","doi-asserted-by":"crossref","first-page":"7081","DOI":"10.1016\/j.vaccine.2010.08.008","article-title":"Smallpox vaccine with integrated IL-15 demonstrates enhanced in vivo viral clearance in immunodeficient mice and confers long term protection against a lethal monkeypox challenge in cynomolgus monkeys","volume":"28","author":"Zielinski","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.intimp.2022.109382_b0360","unstructured":"Vaccinia virus infection after sexual contact with a military smallpox vaccinee -Washington, 2010. MMWR Morb Mortal Wkly Rep, 2010. 59(25): p. 773-5."},{"issue":"15","key":"10.1016\/j.intimp.2022.109382_b0365","doi-asserted-by":"crossref","first-page":"5995","DOI":"10.1073\/pnas.0510462103","article-title":"A chemokine-binding domain in the tumor necrosis factor receptor from variola (smallpox) virus","volume":"103","author":"Alejo","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.intimp.2022.109382_b0370","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1128\/JVI.79.4.2133-2140.2005","article-title":"Wiskott-Aldrich syndrome protein is needed for vaccinia virus pathogenesis","volume":"79","author":"Guerra","year":"2005","journal-title":"J. Virol."},{"issue":"5","key":"10.1016\/j.intimp.2022.109382_b0375","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1093\/hmg\/8.5.783","article-title":"A novel imprinted gene, encoding a RING zinc-finger protein, and overlapping antisense transcript in the Prader-Willi syndrome critical region","volume":"8","author":"Jong","year":"1999","journal-title":"Hum. Mol. Genet."},{"issue":"19","key":"10.1016\/j.intimp.2022.109382_b0380","first-page":"4955","article-title":"Modified vaccinia virus Ankara for delivery of human tyrosinase as melanoma-associated antigen: induction of tyrosinase- and melanoma-specific human leukocyte antigen A*0201-restricted cytotoxic T cells in vitro and in vivo","volume":"59","author":"Drexler","year":"1999","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.intimp.2022.109382_b0385","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3109\/1040841X.2013.879849","article-title":"Metal nanoparticles: The protective nanoshield against virus infection","volume":"42","author":"Rai","year":"2016","journal-title":"Crit. Rev. Microbiol."},{"issue":"5","key":"10.1016\/j.intimp.2022.109382_b0390","doi-asserted-by":"crossref","first-page":"e202101149","DOI":"10.1002\/asia.202101149","article-title":"The Emerging Roles of Silver Nanoparticles to Target Viral Life Cycle and Detect Viral Pathogens","volume":"17","author":"Ghosh","year":"2022","journal-title":"Chem. Asian J."},{"key":"10.1016\/j.intimp.2022.109382_b0395","doi-asserted-by":"crossref","unstructured":"S. Galdiero et al., Silver Nanoparticles as Potential Antiviral Agents. 2011. 16(10): p. 8894\u20138918.","DOI":"10.3390\/molecules16108894"},{"issue":"4","key":"10.1016\/j.intimp.2022.109382_b0400","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s11671-008-9128-2","article-title":"A preliminary assessment of silver nanoparticle inhibition of monkeypox virus plaque formation","volume":"3","author":"Rogers","year":"2008","journal-title":"Nanoscale Res. Lett."},{"issue":"1","key":"10.1016\/j.intimp.2022.109382_b0405","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1477-3155-3-6","article-title":"Interaction of silver nanoparticles with HIV-1","volume":"3","author":"Elechiguerra","year":"2005","journal-title":"J. Nanobiotechnol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922008669?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922008669?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:55:59Z","timestamp":1761587759000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576922008669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":81,"alternative-id":["S1567576922008669"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2022.109382","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Monkeypox infection: The past, present, and future","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2022.109382","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109382"}}