{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:23:04Z","timestamp":1786990984042,"version":"build-2736575974"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012476","name":"Fundamental Research Funds for Central Universities of the Central South University","doi-asserted-by":"publisher","award":["2022ZZTS0827"],"award-info":[{"award-number":["2022ZZTS0827"]}],"id":[{"id":"10.13039\/501100012476","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903223"],"award-info":[{"award-number":["81903223"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102284"],"award-info":[{"award-number":["82102284"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173427"],"award-info":[{"award-number":["82173427"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.intimp.2022.109530","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T12:55:58Z","timestamp":1670590558000},"page":"109530","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Clinical features and prognostic factors of severe cutaneous adverse drug reactions: A single-center retrospective study of 209 cases in China"],"prefix":"10.1016","volume":"114","author":[{"given":"Min","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwen","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guishao","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiqi","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanshan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyun","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10106","key":"10.1016\/j.intimp.2022.109530_b0005","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1016\/S0140-6736(16)30378-6","article-title":"Severe cutaneous adverse reactions to drugs","volume":"390","author":"Duong","year":"2017","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.intimp.2022.109530_b0010","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.alit.2019.03.006","article-title":"Drug-induced hypersensitivity syndrome (DiHS)\/drug reaction with eosinophilia and systemic symptoms (DRESS): An update in 2019","volume":"68","author":"Shiohara","year":"2019","journal-title":"Allergol. Int."},{"issue":"6","key":"10.1016\/j.intimp.2022.109530_b0015","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s40257-015-0158-0","article-title":"Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: An Update","volume":"16","author":"Dodiuk-Gad","year":"2015","journal-title":"Am. J. Clin. Dermatol."},{"issue":"5","key":"10.1016\/j.intimp.2022.109530_b0020","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.jaad.2015.07.017","article-title":"Acute generalized exanthematous pustulosis (AGEP): A review and update","volume":"73","author":"Szatkowski","year":"2015","journal-title":"J. Am. Acad. Dermatol."},{"issue":"4","key":"10.1016\/j.intimp.2022.109530_b0025","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.mcna.2021.04.001","article-title":"Recognition and Management of Severe Cutaneous Adverse Drug Reactions (Including Drug Reaction with Eosinophilia and Systemic Symptoms, Stevens-Johnson Syndrome, and Toxic Epidermal Necrolysis)","volume":"105","author":"Owen","year":"2021","journal-title":"Med. Clin. North Am."},{"key":"10.1016\/j.intimp.2022.109530_b0030","doi-asserted-by":"crossref","unstructured":"D.Y. Kang, J. Yun, S.-Y. Lee, Y.-I. Koh, D.W. Sim, S. Kim, Y.H. Nam, J.-W. Park, S.H. Kim, Y.-M. Ye, H.-K. Park, M.-H. Kim, Y.-K. Jee, J.-W. Jung, M.-S. Yang, S.-H. Kim, J.K. Lee, C.-W. Kim, G.Y. Hur, M.-Y. Kim, S.J. Park, Y.E. Kwon, J.-H. Choi, J.-H. Kim, S.H. Kim, H.O. La, M.-G. Kang, C.S. Park, S.M. Lee, Y.Y. Jeong, H.-K. Kim, H.J. Jin, J.-W. Jeong, J. Lee, Y.W. Lee, S.E. Lee, M.S. Kim, H.-R. Kang, A Nationwide Study of Severe Cutaneous Adverse Reactions Based on the Multicenter Registry in Korea, J Allergy Clin Immunol Pract 9(2) (2021). https:\/\/doi.org\/10.1016\/j.jaip.2020.09.011.","DOI":"10.1016\/j.jaip.2020.09.011"},{"issue":"1","key":"10.1016\/j.intimp.2022.109530_b0035","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1001\/archderm.1993.01680220104023","article-title":"Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme","volume":"129","author":"Bastuji-Garin","year":"1993","journal-title":"Arch. Dermatol."},{"issue":"5","key":"10.1016\/j.intimp.2022.109530_b0040","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1111\/bjd.12501","article-title":"Drug reaction with eosinophilia and systemic symptoms (DRESS): an original multisystem adverse drug reaction. Results from the prospective RegiSCAR study","volume":"169","author":"Kardaun","year":"2013","journal-title":"Br. J. Dermatol."},{"issue":"3","key":"10.1016\/j.intimp.2022.109530_b0045","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1034\/j.1600-0560.2001.028003113.x","article-title":"Acute generalized exanthematous pustulosis (AGEP)\u2013a clinical reaction pattern","volume":"28","author":"Sidoroff","year":"2001","journal-title":"J. Cutan. Pathol."},{"issue":"2","key":"10.1016\/j.intimp.2022.109530_b0050","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/clpt.1981.154","article-title":"A method for estimating the probability of adverse drug reactions","volume":"30","author":"Naranjo","year":"1981","journal-title":"Clin. Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.intimp.2022.109530_b0055","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/clpt.2009.252","article-title":"ALDEN, an algorithm for assessment of drug causality in Stevens-Johnson Syndrome and toxic epidermal necrolysis: comparison with case-control analysis","volume":"88","author":"Sassolas","year":"2010","journal-title":"Clin. Pharmacol. Ther."},{"issue":"9","key":"10.1016\/j.intimp.2022.109530_b0060","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1001\/jamainternmed.2015.3536","article-title":"Allopurinol Use and Risk of Fatal Hypersensitivity Reactions: A Nationwide Population-Based Study in Taiwan","volume":"175","author":"Yang","year":"2015","journal-title":"JAMA Intern. Med."},{"issue":"11","key":"10.1016\/j.intimp.2022.109530_b0065","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1111\/ijd.12118","article-title":"Severe cutaneous adverse reactions in a local hospital setting: a 5-year retrospective study","volume":"53","author":"Su","year":"2014","journal-title":"Int. J. Dermatol."},{"issue":"5","key":"10.1016\/j.intimp.2022.109530_b0070","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/j.1365-2230.2006.02185.x","article-title":"Epidemiological study of severe cutaneous adverse drug reactions in a city district of China","volume":"31","author":"Li","year":"2006","journal-title":"Clin. Exp. Dermatol."},{"issue":"2","key":"10.1016\/j.intimp.2022.109530_b0075","doi-asserted-by":"crossref","first-page":"241","DOI":"10.4168\/aair.2019.11.2.241","article-title":"Severe Cutaneous Adverse Reactions in Korean Pediatric Patients: A Study From the Korea SCAR Registry","volume":"11","author":"Oh","year":"2019","journal-title":"Allergy, Asthma Immunol. Res."},{"issue":"3","key":"10.1016\/j.intimp.2022.109530_b0080","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.jaip.2017.02.013","article-title":"Severe Cutaneous Adverse Drug Reactions in Pediatric Patients: A Multicenter Study","volume":"5","author":"Dibek Misirlioglu","year":"2017","journal-title":"J. Allergy Clin. Immunol. Pract."},{"issue":"5","key":"10.1016\/j.intimp.2022.109530_b0085","doi-asserted-by":"crossref","first-page":"545","DOI":"10.5021\/ad.2019.31.5.545","article-title":"Severe Cutaneous Adverse Reactions: A Single-Center Retrospective Study of 173 Patients in China","volume":"31","author":"Xu","year":"2019","journal-title":"Ann. Dermatol."},{"issue":"4","key":"10.1016\/j.intimp.2022.109530_b0090","doi-asserted-by":"crossref","first-page":"e198","DOI":"10.1111\/ijd.13126","article-title":"Adverse cutaneous drug reactions in a single quaternary referral hospital","volume":"55","author":"Botelho","year":"2016","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.intimp.2022.109530_b0095","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1750-1172-6-52","article-title":"Genome-wide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe","volume":"6","author":"G\u00e9nin","year":"2011","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.intimp.2022.109530_b0100","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13601-017-0188-1","article-title":"Stevens-Johnson syndrome\/toxic epidermal necrolysis and erythema multiforme drug-related hospitalisations in a national administrative database","volume":"8","author":"Sousa-Pinto","year":"2018","journal-title":"Clin Transl Allergy"},{"issue":"1","key":"10.1016\/j.intimp.2022.109530_b0105","doi-asserted-by":"crossref","first-page":"62","DOI":"10.2340\/00015555-1169","article-title":"Profile and pattern of Stevens-Johnson syndrome and toxic epidermal necrolysis in a general hospital in Singapore: treatment outcomes","volume":"92","author":"Tan","year":"2012","journal-title":"Acta Derm. Venereol."},{"issue":"4","key":"10.1016\/j.intimp.2022.109530_b0110","doi-asserted-by":"crossref","first-page":"322","DOI":"10.18176\/jiaci.0497","article-title":"Severe Cutaneous Adverse Reactions to Drugs in Latin America: The RACGRAD Study","volume":"31","author":"Rojas Mej\u00eda","year":"2021","journal-title":"J. Investig. Allergol. Clin. Immunol."},{"issue":"10","key":"10.1016\/j.intimp.2022.109530_b0115","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1001\/jamadermatol.2021.3154","article-title":"Assessment of Treatment Approaches and Outcomes in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Insights From a Pan-European Multicenter Study","volume":"157","author":"Kridin","year":"2021","journal-title":"JAMA Dermatol."},{"issue":"1","key":"10.1016\/j.intimp.2022.109530_b0120","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/sj.jid.5701033","article-title":"Stevens-Johnson syndrome and toxic epidermal necrolysis: assessment of medication risks with emphasis on recently marketed drugs. The EuroSCAR-study","volume":"128","author":"Mockenhaupt","year":"2008","journal-title":"J, Invest. Dermatol."},{"issue":"3","key":"10.1016\/j.intimp.2022.109530_b0125","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.jaip.2017.01.025","article-title":"Severe Delayed Cutaneous and Systemic Reactions to Drugs: A Global Perspective on the Science and Art of Current Practice","volume":"5","author":"Peter","year":"2017","journal-title":"J. Allergy Clin. Immunol. Pract."},{"issue":"11","key":"10.1016\/j.intimp.2022.109530_b0130","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1016\/j.jid.2018.04.027","article-title":"Stevens-Johnson Syndrome\/Toxic Epidermal Necrolysis: A Multicenter Retrospective Study of 377 Adult Patients from the United States","volume":"138","author":"Micheletti","year":"2018","journal-title":"J, Invest. Dermatol."},{"issue":"3","key":"10.1016\/j.intimp.2022.109530_b0135","doi-asserted-by":"crossref","first-page":"221","DOI":"10.4103\/0378-6323.132249","article-title":"Drug reaction with eosinophilia and systemic symptoms: observations from a tertiary care institution","volume":"80","author":"Sasidharanpillai","year":"2014","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"issue":"9","key":"10.1016\/j.intimp.2022.109530_b0140","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1111\/ijd.13667","article-title":"Clinical features of drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a study of 25 patients in Korea","volume":"56","author":"Lee","year":"2017","journal-title":"Int. J. Dermatol."},{"issue":"2","key":"10.1016\/j.intimp.2022.109530_b0145","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.jaad.2014.10.032","article-title":"Therapeutic management of DRESS: a retrospective study of 38 cases","volume":"72","author":"Funck-Brentano","year":"2015","journal-title":"J. Am. Acad. Dermatol."},{"issue":"3","key":"10.1016\/j.intimp.2022.109530_b0150","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/pde.13812","article-title":"Drug reaction with eosinophilia and systemic symptoms in a cohort of Asian children","volume":"36","author":"Han","year":"2019","journal-title":"Pediatr. Dermatol."},{"issue":"11","key":"10.1016\/j.intimp.2022.109530_b0155","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1111\/ijd.14493","article-title":"Stevens-Johnson syndrome and toxic epidermal necrolysis: a retrospective descriptive study","volume":"58","author":"Carrasquillo","year":"2019","journal-title":"Int. J. Dermatol."},{"issue":"4","key":"10.1016\/j.intimp.2022.109530_b0160","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.burns.2019.10.008","article-title":"Retrospective study of 213 cases of Stevens-Johnson syndrome and toxic epidermal necrolysis from China","volume":"46","author":"Yang","year":"2020","journal-title":"Burns"},{"issue":"1","key":"10.1016\/j.intimp.2022.109530_b0165","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/09546634.2018.1509047","article-title":"A retrospective analysis of infections and antibiotic treatment in patients with Stevens-Johnson syndrome and toxic epidermal necrolysis","volume":"31","author":"Diao","year":"2020","journal-title":"J. Dermatolog. Treat."},{"key":"10.1016\/j.intimp.2022.109530_b0170","first-page":"4320195","article-title":"The Epidemiology of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in China","volume":"2018","author":"Yang","year":"2018","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.intimp.2022.109530_b0175","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.2147\/DDDT.S71736","article-title":"Stevens-Johnson Syndrome and toxic epidermal necrolysis: a multi-aspect comparative 7-year study from the People's Republic of China","volume":"8","author":"Sun","year":"2014","journal-title":"Drug Des. Devel. Ther."},{"issue":"1","key":"10.1016\/j.intimp.2022.109530_b0180","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jaad.2007.08.036","article-title":"Allopurinol is the most common cause of Stevens-Johnson syndrome and toxic epidermal necrolysis in Europe and Israel","volume":"58","author":"Halevy","year":"2008","journal-title":"J. Am. Acad. Dermatol."},{"issue":"2","key":"10.1016\/j.intimp.2022.109530_b0185","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/pds.3937","article-title":"Incidence, causative factors and mortality rates of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in northern Italy: data from the REACT registry","volume":"25","author":"Diphoorn","year":"2016","journal-title":"Pharmacoepidemiol. Drug Saf."},{"issue":"3 Suppl","key":"10.1016\/j.intimp.2022.109530_b0190","doi-asserted-by":"crossref","first-page":"S74","DOI":"10.1016\/j.jaci.2010.11.048","article-title":"Immune pathomechanism of drug hypersensitivity reactions","volume":"127","author":"Pichler","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2022.109530_b0195","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1001\/jamadermatol.2021.5390","article-title":"Clinical Characteristics, Disease Course, and Outcomes of Patients With Acute Generalized Exanthematous Pustulosis in the US","volume":"158","author":"Creadore","year":"2022","journal-title":"JAMA Dermatol."},{"issue":"6","key":"10.1016\/j.intimp.2022.109530_b0200","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/j.1365-4362.1993.tb02814.x","article-title":"Stevens-Johnson syndrome and toxic epidermal necrolysis in Thailand","volume":"32","author":"Leenutaphong","year":"1993","journal-title":"Int. J. Dermatol."},{"issue":"9","key":"10.1016\/j.intimp.2022.109530_b0205","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1007\/s00228-022-03353-8","article-title":"DRESS characteristics according to the causative medication","volume":"78","author":"Chaabane","year":"2022","journal-title":"Eur. J. Clin. Pharmacol."},{"issue":"3","key":"10.1016\/j.intimp.2022.109530_b0210","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/1346-8138.12770","article-title":"Sequelae in 145 patients with drug-induced hypersensitivity syndrome\/drug reaction with eosinophilia and systemic symptoms: survey conducted by the Asian Research Committee on Severe Cutaneous Adverse Reactions (ASCAR)","volume":"42","author":"Kano","year":"2015","journal-title":"J. Dermatol."},{"issue":"4","key":"10.1016\/j.intimp.2022.109530_b0215","doi-asserted-by":"crossref","first-page":"363","DOI":"10.2340\/00015555-0438","article-title":"Clinical manifestations and characteristics of patients with acute generalized exanthematous pustulosis in Asia","volume":"88","author":"Chang","year":"2008","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.intimp.2022.109530_b0220","doi-asserted-by":"crossref","first-page":"1503709","DOI":"10.1155\/2017\/1503709","article-title":"Treatments for Severe Cutaneous Adverse Reactions","volume":"2017","author":"Cho","year":"2017","journal-title":"J. Immunol. Res."},{"issue":"10","key":"10.1016\/j.intimp.2022.109530_b0225","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1111\/ijd.14174","article-title":"Prevalence, risk factors, and mortality outcome in the drug reaction with eosinophilia and systemic symptoms patients with cardiac involvement","volume":"57","author":"Intarasupht","year":"2018","journal-title":"Int. J. Dermatol."},{"issue":"9","key":"10.1016\/j.intimp.2022.109530_b0230","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1111\/jcpt.13667","article-title":"Clinical features, treatment outcomes and prognostic factors of allopurinol-induced DRESS in 52 patients","volume":"47","author":"Liu","year":"2022","journal-title":"J. Clin. Pharm. Ther."},{"issue":"2","key":"10.1016\/j.intimp.2022.109530_b0235","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1046\/j.1523-1747.2000.00061.x","article-title":"SCORTEN: a severity-of-illness score for toxic epidermal necrolysis","volume":"115","author":"Bastuji-Garin","year":"2000","journal-title":"J. Invest. Dermatol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922010153?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922010153?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:47:47Z","timestamp":1761587267000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576922010153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":47,"alternative-id":["S1567576922010153"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2022.109530","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical features and prognostic factors of severe cutaneous adverse drug reactions: A single-center retrospective study of 209 cases in China","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2022.109530","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109530"}}