{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:40:29Z","timestamp":1787964029598,"version":"build-2784847793"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.intimp.2022.109538","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T11:48:03Z","timestamp":1670500083000},"page":"109538","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["A blend of formic acid, benzoic acid, and tributyrin alleviates ETEC K88-induced intestinal barrier dysfunction by regulating intestinal inflammation and gut microbiota in a murine model"],"prefix":"10.1016","volume":"114","author":[{"given":"Jun","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youjun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinming","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiande","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2022.109538_b0005","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3390\/toxins11010024","article-title":"Heat-stable enterotoxins of enterotoxigenic Escherichia coli and their impact on host immunity","volume":"11","author":"Wang","year":"2019","journal-title":"Toxins"},{"issue":"5","key":"10.1016\/j.intimp.2022.109538_b0010","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.it.2008.02.006","article-title":"Tissue distribution of lymphocytes and plasma cells and the role of the gut","volume":"29","author":"Pabst","year":"2008","journal-title":"Trends. Immunol."},{"key":"10.1016\/j.intimp.2022.109538_b0015","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.intimp.2018.03.014","article-title":"Blend of organic acids and medium chain fatty acids prevents the inflammatory response and intestinal barrier dysfunction in mice challenged with enterohemorrhagic Escherichia coli O157:H7","volume":"58","author":"Wang","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2022.109538_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108229","article-title":"Dietary emulsifiers directly impact adherent-invasive E. coli gene expression to drive chronic intestinal inflammation","volume":"33","author":"Viennois","year":"2020","journal-title":"Cell. Rep."},{"key":"10.1016\/j.intimp.2022.109538_b0025","first-page":"685","article-title":"Intestinal microbiota-derived GABA mediates interleukin-17 expression during enterotoxigenic Escherichia coli infection","volume":"7","author":"Ren","year":"2016","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2022.109538_b0030","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1096\/fj.201901717R","article-title":"Therapeutic administration of the recombinant antimicrobial peptide microcin J25 effectively enhances host defenses against gut inflammation and epithelial barrier injury induced by enterotoxigenic Escherichia coli infection","volume":"34","author":"Yu","year":"2020","journal-title":"FASEB. J."},{"key":"10.1016\/j.intimp.2022.109538_b0035","doi-asserted-by":"crossref","first-page":"skaa113","DOI":"10.1093\/jas\/skaa113","article-title":"Effects of an F18 enterotoxigenic Escherichia coli challenge on growth performance, immunological status, and gastrointestinal structure of weaned pigs and the potential protective effect of direct-fed microbial blends","volume":"98","author":"Becker","year":"2020","journal-title":"J. Anim. Sci."},{"issue":"3","key":"10.1016\/j.intimp.2022.109538_b0040","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.aninu.2020.11.018","article-title":"Mixed organic acids as an alternative to antibiotics improve serum biochemical parameters and intestinal health of weaned piglets","volume":"7","author":"Ma","year":"2021","journal-title":"Anim. Nutr."},{"key":"10.1016\/j.intimp.2022.109538_b0045","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.anifeedsci.2017.06.015","article-title":"Long-term administration of formic acid to weaners: Influence on intestinal microbiota, immunity parameters and growth performance","volume":"232","author":"Luise","year":"2017","journal-title":"Anim. Feed Sci. Technol."},{"key":"10.1016\/j.intimp.2022.109538_b0050","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.3382\/ps\/pex106","article-title":"Effects of commercial organic acid blends on male broilers challenged with E. coli K88: Performance, microbiology, intestinal morphology, and immune response","volume":"96","author":"Emami","year":"2017","journal-title":"Poult. Sci."},{"issue":"4","key":"10.1016\/j.intimp.2022.109538_b0055","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.aninu.2016.08.003","article-title":"Studying the effect of formic acid and potassium diformate on performance, immunity and gut health of broiler chickens","volume":"2","author":"Ragaa","year":"2016","journal-title":"Anim. Nutr."},{"issue":"1","key":"10.1016\/j.intimp.2022.109538_b0060","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1080\/00071660500475574","article-title":"Effect of formic acid on performance, digestibility, intestinal histomorphology and plasma metabolite levels of broiler chickens","volume":"47","author":"Hern\u00e1ndez","year":"2006","journal-title":"Br. Poult. Sci."},{"issue":"4","key":"10.1016\/j.intimp.2022.109538_b0065","doi-asserted-by":"crossref","first-page":"555","DOI":"10.3382\/japr.2006-00116","article-title":"Effect of formic acid and plant extracts on growth, nutrient digestibility, intestine mucosa morphology, and meat yield of broilers","volume":"16","author":"Garc\u00eda","year":"2007","journal-title":"J. Appl. Poult. Res."},{"key":"10.1016\/j.intimp.2022.109538_b0070","doi-asserted-by":"crossref","first-page":"5721585","DOI":"10.1155\/2019\/5721585","article-title":"Benzoic acid used as food and feed additives can regulate gut functions","volume":"2019","author":"Mao","year":"2019","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.intimp.2022.109538_b0075","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.livsci.2014.05.029","article-title":"Effects of dietary supplementation with benzoic acid on intestinal morphological structure and microflora in weaned piglets","volume":"167","author":"Diao","year":"2014","journal-title":"Livest. Sci."},{"issue":"2","key":"10.1016\/j.intimp.2022.109538_b0080","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1080\/00071668.2016.1262000","article-title":"Encapsulated benzoic acid supplementation in broiler diets influences gut bacterial composition and activity","volume":"58","author":"Yousaf","year":"2017","journal-title":"Br. Poult. Sci."},{"issue":"2","key":"10.1016\/j.intimp.2022.109538_b0085","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.clnu.2015.03.002","article-title":"Supplementation of tributyrin improves the growth and intestinal digestive and barrier functions in intrauterine growth-restricted piglets","volume":"35","author":"Dong","year":"2016","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.intimp.2022.109538_b0090","first-page":"226","article-title":"Dietary supplementation with tributyrin prevented weaned pigs from growth retardation and lethal infection via modulation of inflammatory cytokines production, ileal expression, and intestinal acetate fermentation","volume":"95","author":"Gu","year":"2017","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.intimp.2022.109538_b0095","doi-asserted-by":"crossref","first-page":"726","DOI":"10.3390\/ani10040726","article-title":"Effects of tributyrin supplementation on growth performance, insulin, blood metabolites and gut microbiota in weaned piglets","volume":"10","author":"Sotira","year":"2020","journal-title":"Animals"},{"key":"10.1016\/j.intimp.2022.109538_b0100","doi-asserted-by":"crossref","first-page":"887","DOI":"10.3390\/ani10050887","article-title":"A review of the effect of formic acid and its salts on the gastrointestinal microbiota and performance of pigs","volume":"10","author":"Luise","year":"2020","journal-title":"Animals"},{"issue":"14","key":"10.1016\/j.intimp.2022.109538_b0105","doi-asserted-by":"crossref","first-page":"4155","DOI":"10.1021\/acs.jafc.0c01414","article-title":"A combination of formic acid and monolaurin attenuates enterotoxigenic Escherichia coli induced intestinal inflammation in piglets by inhibiting the NF-\u03baB\/MAPK pathways with modulation of gut microbiota","volume":"68","author":"Ren","year":"2020","journal-title":"J. Agric. Food. Chem."},{"key":"10.1016\/j.intimp.2022.109538_b0110","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2021.623899","article-title":"Bacteriophage as an alternative to antibiotics promotes growth performance by regulating intestinal inflammation, intestinal barrier function and gut microbiota in weaned piglets","volume":"8","author":"Zeng","year":"2021","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.intimp.2022.109538_b0115","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.intimp.2022.109538_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2021.104476","article-title":"Oral L-theanine administration promotes fat browning and prevents obesity in mice fed high-fat diet associated with the modulation of gut microbiota","volume":"81","author":"He","year":"2021","journal-title":"J. Funct. Foods."},{"issue":"11","key":"10.1016\/j.intimp.2022.109538_b0125","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.5713\/ajas.2014.14356","article-title":"Protected organic acid blends as an alternative to antibiotics in finishing pigs","volume":"27","author":"Upadhaya","year":"2014","journal-title":"Asian-Australas. J. Anim. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2022.109538_b0130","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.intimp.2015.04.038","article-title":"Effects of curcumin on growth performance, jejunal mucosal membrane integrity, morphology and immune status in weaned piglets challenged with enterotoxigenic Escherichia coli","volume":"27","author":"Xun","year":"2015","journal-title":"Int. Immunopharmacol."},{"issue":"8","key":"10.1016\/j.intimp.2022.109538_b0135","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1111\/asj.12215","article-title":"Effects of dietary supplementation of lipid-encapsulated zinc oxide on colibacillosis, growth and intestinal morphology in weaned piglets challenged with enterotoxigenic Escherichia coli","volume":"85","author":"Kwon","year":"2014","journal-title":"Anim. Sci. J."},{"issue":"12","key":"10.1016\/j.intimp.2022.109538_b0140","doi-asserted-by":"crossref","first-page":"6401","DOI":"10.1039\/C8FO01551A","article-title":"Alginate oligosaccharide alleviates enterotoxigenic Escherichia coli-induced intestinal mucosal disruption in weaned pigs","volume":"9","author":"Wan","year":"2018","journal-title":"Food. Funct."},{"key":"10.1016\/j.intimp.2022.109538_b0145","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.anifeedsci.2017.08.018","article-title":"Mixed organic acids as antibiotic substitutes improve performance, serum immunity, intestinal morphology and microbiota for weaned piglets","volume":"235","author":"Long","year":"2018","journal-title":"Anim. Feed Sci. Technol."},{"key":"10.1016\/j.intimp.2022.109538_b0150","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.3390\/ani11113020","article-title":"Supplementation of mixed organic acids improves growth performance, meat quality, gut morphology and volatile fatty acids of broiler chicken","volume":"11","author":"Ma","year":"2021","journal-title":"Animals"},{"issue":"2","key":"10.1016\/j.intimp.2022.109538_b0155","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1139\/cjas-2021-0080","article-title":"Effect of dietary organic acids supplementation on growth performance, nutrient digestibility, and gut morphology in weaned pigs","volume":"102","author":"Lee","year":"2022","journal-title":"Can. J. Anim. Sci."},{"key":"10.1016\/j.intimp.2022.109538_b0160","doi-asserted-by":"crossref","first-page":"418","DOI":"10.3389\/fvets.2020.00418","article-title":"Effect of the single and combined use of curcumin and piperine on growth performance, intestinal barrier function, and antioxidant capacity of weaned Wuzhishan piglets","volume":"7","author":"Shi","year":"2020","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.intimp.2022.109538_b0165","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1159\/000171432","article-title":"Diamine oxidase: an overview of historical, biochemical and functional aspects","volume":"12","author":"Wolvekamp","year":"1994","journal-title":"Dig. Dis."},{"issue":"1","key":"10.1016\/j.intimp.2022.109538_b0170","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0003-2697(80)90314-0","article-title":"Spectrophotometric assay for D-(-)-lactate in plasma","volume":"102","author":"Brandt","year":"1980","journal-title":"Anal. Biochem."},{"issue":"6","key":"10.1016\/j.intimp.2022.109538_b0175","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1152\/japplphysiol.00536.2015","article-title":"Intestinal epithelial barrier function and tight junction proteins with heat and exercise","volume":"120","author":"Dokladny","year":"2016","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.intimp.2022.109538_b0180","doi-asserted-by":"crossref","first-page":"501","DOI":"10.3945\/jn.115.224857","article-title":"L-glutamine enhances tight junction integrity by activating CaMK Kinase 2-AMP-activated protein kinase signaling in intestinal porcine epithelial cells","volume":"146","author":"Wang","year":"2016","journal-title":"J. Nutr."},{"key":"10.1016\/j.intimp.2022.109538_b0185","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3389\/fphar.2016.00253","article-title":"Propionate ameliorates dextran sodium sulfate-induced colitis by improving intestinal barrier function and reducing inflammation and oxidative stress","volume":"7","author":"Tong","year":"2016","journal-title":"Front. Pharmacol."},{"issue":"5","key":"10.1016\/j.intimp.2022.109538_b0190","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1016\/j.jcmgh.2022.02.014","article-title":"Single-cell transcriptomic architecture unraveling the complexity of tumor heterogeneity in distal cholangiocarcinoma","volume":"13","author":"Li","year":"2022","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.intimp.2022.109538_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2019.103521","article-title":"Proanthocyanidins and probiotics combination supplementation ameliorated intestinal injury in Enterotoxigenic Escherichia coli infected diarrhea mice","volume":"62","author":"Tang","year":"2019","journal-title":"J. Funct. Foods."},{"issue":"6","key":"10.1016\/j.intimp.2022.109538_b0200","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1111\/jpn.13540","article-title":"Seaweed polysaccharide mitigates intestinal barrier dysfunction induced by enterotoxigenic Escherichia coli through NF-\u03baB pathway suppression in porcine intestinal epithelial cells","volume":"105","author":"Guo","year":"2021","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"10.1016\/j.intimp.2022.109538_b0205","doi-asserted-by":"crossref","first-page":"6867962","DOI":"10.1155\/2021\/6867962","article-title":"Lactobacillus plantarum and Lactobacillus brevis alleviate intestinal inflammation and microbial disorder induced by ETEC in a murine model","volume":"2021","author":"Han","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"2","key":"10.1016\/j.intimp.2022.109538_b0210","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s10396-019-00929-3","article-title":"The relationship of spleen stiffness value measured by shear wave elastography with age, gender, and spleen size in healthy volunteers","volume":"46","author":"Albayrak","year":"2019","journal-title":"J. Med. Ultrason."},{"key":"10.1016\/j.intimp.2022.109538_b0215","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.jep.2016.08.044","article-title":"Protective effects of organic acid component from Taraxacum mongolicum Hand.-Mazz. against LPS-induced inflammation: Regulating the TLR4\/IKK\/NF-\u03baB signal pathway","volume":"194","author":"Yang","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2022.109538_b0220","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.intimp.2016.02.028","article-title":"Organic acid component from Taraxacum mongolicum Hand.-Mazz alleviates inflammatory injury in lipopolysaccharide-induced acute tracheobronchitis of ICR mice through TLR4\/NF-\u03baB signaling pathway","volume":"34","author":"Yang","year":"2016","journal-title":"Int. Immunopharmacol."},{"issue":"24","key":"10.1016\/j.intimp.2022.109538_b0225","doi-asserted-by":"crossref","first-page":"13482","DOI":"10.1039\/C8RA01943F","article-title":"Alginate oligosaccharide enhances intestinal integrity of weaned pigs through altering intestinal inflammatory responses and antioxidant status","volume":"8","author":"Wan","year":"2018","journal-title":"RSC. Adv."},{"key":"10.1016\/j.intimp.2022.109538_b0230","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.pharmthera.2015.12.005","article-title":"Toll-like receptors mediating vascular malfunction: Lessons from receptor subtypes","volume":"158","author":"Wang","year":"2016","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.intimp.2022.109538_b0235","doi-asserted-by":"crossref","first-page":"1157023","DOI":"10.1155\/2021\/1157023","article-title":"Toll-like receptors (TLRs): structure, functions, signaling, and role of their polymorphisms in colorectal cancer susceptibility","volume":"2021","author":"Sameer","year":"2021","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.intimp.2022.109538_b0240","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/s42269-019-0227-2","article-title":"Toll-like receptors activation, signaling, and targeting: an overview","volume":"43","author":"El-Zayat","year":"2019","journal-title":"Bull. Natl. Res. Cent."},{"key":"10.1016\/j.intimp.2022.109538_b0245","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3390\/microorganisms9010110","article-title":"Dietary organic acids modulate gut microbiota and improve growth performance of nursery pigs","volume":"9","author":"Wei","year":"2021","journal-title":"Microorganisms"},{"issue":"4","key":"10.1016\/j.intimp.2022.109538_b0250","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41575-019-0258-z","article-title":"Gut microbiota-derived metabolites as key actors in inflammatory bowel disease","volume":"17","author":"Lavelle","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922010232?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922010232?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:54:29Z","timestamp":1761587669000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576922010232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":50,"alternative-id":["S1567576922010232"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2022.109538","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A blend of formic acid, benzoic acid, and tributyrin alleviates ETEC K88-induced intestinal barrier dysfunction by regulating intestinal inflammation and gut microbiota in a murine model","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2022.109538","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109538"}}