{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T19:17:30Z","timestamp":1793647050662,"version":"4.5.1"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.intimp.2022.109611","type":"journal-article","created":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T23:51:25Z","timestamp":1671580285000},"page":"109611","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Icariin alleviates atherosclerosis by regulating the miR-205-5p\/ERBB4\/AKT signaling pathway"],"prefix":"10.1016","volume":"114","author":[{"given":"Peng","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengjun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahua","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dexian","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqun","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.intimp.2022.109611_b0005","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.medcli.2020.04.024","article-title":"Atherosclerosis and inflammation. New therapeutic approaches. Arteriosclerosis e inflamaci\u00f3n, Nuevos enfoques terap\u00e9uticos","volume":"155","author":"Pedro-Botet","year":"2020","journal-title":"Med. Clin. (Barc.)"},{"issue":"7855","key":"10.1016\/j.intimp.2022.109611_b0010","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/s41586-021-03392-8","article-title":"The changing landscape of atherosclerosis","volume":"592","author":"Libby","year":"2021","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.intimp.2022.109611_b0015","doi-asserted-by":"crossref","first-page":"C7","DOI":"10.1016\/j.jacc.2005.09.068","article-title":"Pathogenesis of atherosclerosis","volume":"47","author":"Falk","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"issue":"4","key":"10.1016\/j.intimp.2022.109611_b0020","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1161\/CIRCRESAHA.115.306361","article-title":"Vascular Smooth Muscle Cells in Atherosclerosis","volume":"118","author":"Bennett","year":"2016","journal-title":"Circ. Res."},{"issue":"12","key":"10.1016\/j.intimp.2022.109611_b0025","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/s41569-019-0227-9","article-title":"Vascular smooth muscle cells in atherosclerosis","volume":"16","author":"Basatemur","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.intimp.2022.109611_b0030","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s11883-017-0678-6","article-title":"Oxidative Stress in Atherosclerosis","volume":"19","author":"Kattoor","year":"2017","journal-title":"Curr. Atheroscler. Rep."},{"issue":"4","key":"10.1016\/j.intimp.2022.109611_b0035","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1615\/CritRevImmunol.2018026483","article-title":"How Oxidized Low-Density Lipoprotein Activates Inflammatory Responses","volume":"38","author":"Rhoads","year":"2018","journal-title":"Crit. Rev. Immunol."},{"issue":"22","key":"10.1016\/j.intimp.2022.109611_b0040","doi-asserted-by":"crossref","first-page":"3898","DOI":"10.1111\/bph.13818","article-title":"Targeting inflammation to reduce cardiovascular disease risk: a realistic clinical prospect?","volume":"174","author":"Welsh","year":"2017","journal-title":"Br. J. Pharmacol."},{"issue":"11","key":"10.1016\/j.intimp.2022.109611_b0045","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1038\/nm.2538","article-title":"Atherosclerosis: current pathogenesis and therapeutic options","volume":"17","author":"Weber","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.intimp.2022.109611_b0050","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3389\/fphar.2016.00469","article-title":"Chinese Herbal Medicine on Cardiovascular Diseases and the Mechanisms of Action","volume":"7","author":"Liu","year":"2016","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2022.109611_b0055","first-page":"3585","article-title":"Effects and mechanisms of icariin on atherosclerosis","volume":"8","author":"Hu","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"issue":"6","key":"10.1016\/j.intimp.2022.109611_b0060","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1139\/cjpp-2016-0367","article-title":"Icariin improves eNOS\/NO pathway to prohibit the atherogenesis of apolipoprotein E-null mice","volume":"95","author":"Xiao","year":"2017","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.intimp.2022.109611_b0065","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.omtn.2020.11.021","article-title":"Icariin attenuates endothelial-mesenchymal transition via H19\/miR-148b-3p\/ELF5 in ox-LDL-stimulated HUVECs","volume":"23","author":"Liu","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.intimp.2022.109611_b0070","doi-asserted-by":"crossref","first-page":"e159","DOI":"10.1161\/ATVBAHA.118.310227","article-title":"Impact of miRNA in Atherosclerosis","volume":"38","author":"Lu","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.intimp.2022.109611_b0075","doi-asserted-by":"crossref","first-page":"153858","DOI":"10.1016\/j.prp.2022.153858","article-title":"MiRNA-205-5p regulates the ERBB4\/AKT signaling pathway to inhibit the proliferation and migration of HAVSMCs induced by ox-LDL","volume":"233","author":"Huang","year":"2022","journal-title":"Pathol. Res. Pract."},{"issue":"1","key":"10.1016\/j.intimp.2022.109611_b0080","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s10753-015-0242-x","article-title":"Icariin Attenuates High-cholesterol Diet Induced Atherosclerosis in Rats by Inhibition of Inflammatory Response and p38 MAPK Signaling Pathway","volume":"39","author":"Hu","year":"2016","journal-title":"Inflammation"},{"key":"10.1016\/j.intimp.2022.109611_b0085","doi-asserted-by":"crossref","unstructured":"Y. Zhang, R. Xu, X. Li, Q. Tan, P. Huang, Y. Zhang, M. Qin, L. Ren, Effects of icariin on long noncoding RNA and mRNA expression profile in the aortas of apoE-deficient mice. Bioscience reports 39(7) (2019) BSR20190855.","DOI":"10.1042\/BSR20190855"},{"issue":"1","key":"10.1016\/j.intimp.2022.109611_b0090","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41572-019-0106-z","volume":"5","author":"Libby","year":"2019","journal-title":"Atherosclerosis. Nat Rev Dis Primers"},{"key":"10.1016\/j.intimp.2022.109611_b0095","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1001\/jama.2020.5685","article-title":"Lipids and Lipoproteins in 2020","volume":"324","author":"Ference","year":"2020","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.intimp.2022.109611_b0100","first-page":"3525","article-title":"miR-205-5p downregulation decreases gemcitabine sensitivity of breast cancer cells via ERp29 upregulation","volume":"18","author":"Ma","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.intimp.2022.109611_b0105","first-page":"1715","article-title":"miR-205-5p inhibits cell migration and invasion in prostatic carcinoma by targeting ZEB1","volume":"16","author":"Li","year":"2018","journal-title":"Oncol. Lett."},{"issue":"2","key":"10.1016\/j.intimp.2022.109611_b0110","doi-asserted-by":"crossref","first-page":"112579","DOI":"10.1016\/j.yexcr.2021.112579","article-title":"MiR-205-5p suppresses angiogenesis in gastric cancer by downregulating the expression of VEGFA and FGF1","volume":"404","author":"Zhang","year":"2021","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.intimp.2022.109611_b0115","doi-asserted-by":"crossref","first-page":"108585","DOI":"10.1016\/j.exer.2021.108585","article-title":"Knockdown of Malat1 alleviates high-glucose-induced angiogenesis through regulating miR-205-5p\/VEGF-A axis","volume":"207","author":"Tan","year":"2021","journal-title":"Exp. Eye Res."},{"issue":"3","key":"10.1016\/j.intimp.2022.109611_b0120","doi-asserted-by":"crossref","first-page":"4559","DOI":"10.1096\/fj.201801690R","article-title":"Overexpression of ERBB4 rejuvenates aged mesenchymal stem cells and enhances angiogenesis via PI3K\/AKT and MAPK\/ERK pathways","volume":"33","author":"Liang","year":"2019","journal-title":"FASEB J."},{"issue":"3","key":"10.1016\/j.intimp.2022.109611_b0125","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s13402-020-00499-4","article-title":"The role of ErbB4 in cancer","volume":"43","author":"Segers","year":"2020","journal-title":"Cell. Oncol. (Dordr.)"},{"key":"10.1016\/j.intimp.2022.109611_b0130","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.3390\/ijms20112703","article-title":"Akt Signaling in Macrophage Polarization, Survival, and Atherosclerosis","volume":"20","author":"Linton","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2022.109611_b0135","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/cvr\/cvy010","article-title":"Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness","volume":"114","author":"Durham","year":"2018","journal-title":"Cardiovasc. Res."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922010967?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922010967?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:44:38Z","timestamp":1761587078000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576922010967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":27,"alternative-id":["S1567576922010967"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2022.109611","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Icariin alleviates atherosclerosis by regulating the miR-205-5p\/ERBB4\/AKT signaling pathway","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2022.109611","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109611"}}