{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:11:36Z","timestamp":1790964696144,"version":"4.1.0"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.intimp.2022.109614","type":"journal-article","created":{"date-parts":[[2023,3,4]],"date-time":"2023-03-04T05:15:54Z","timestamp":1677906954000},"page":"109614","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Mitochondrial calcium uptake 3 mitigates cerebral amyloid angiopathy-related neuronal death and glial inflammation by reducing mitochondrial dysfunction"],"prefix":"10.1016","volume":"117","author":[{"given":"Guijuan","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghua","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijian","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2022.109614_b0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3988\/jcn.2011.7.1.1","article-title":"Cerebral amyloid angiopathy: a systematic review","volume":"7","author":"Biffi","year":"2011","journal-title":"Journal of Clinical Neurology"},{"issue":"6","key":"10.1016\/j.intimp.2022.109614_b0010","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1002\/ana.22516","article-title":"Cerebral amyloid angiopathy in the elderly","volume":"70","author":"Viswanathan","year":"2011","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.intimp.2022.109614_b0015","doi-asserted-by":"crossref","first-page":"17","DOI":"10.5853\/jos.2015.17.1.17","article-title":"Cerebral amyloid angiopathy: emerging concepts","volume":"17","author":"Yamada","year":"2015","journal-title":"Journal of stroke"},{"key":"10.1016\/j.intimp.2022.109614_b0020","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nature15369","article-title":"Evidence for human transmission of amyloid-\u03b2 pathology and cerebral amyloid angiopathy","volume":"525","author":"Jaunmuktane","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2022.109614_b0025","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1089\/ars.2011.3895","article-title":"Amyloid beta induces oxidative stress-mediated blood\u2013brain barrier changes in capillary amyloid angiopathy","volume":"15","author":"Carrano","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.intimp.2022.109614_b0030","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.brainresrev.2003.08.001","article-title":"Pathogenesis of cerebral amyloid angiopathy","volume":"43","author":"Rensink","year":"2003","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.intimp.2022.109614_b0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1742-2094-7-18","article-title":"Steroid responsive encephalopathy in cerebral amyloid angiopathy: a case report and review of evidence for immunosuppressive treatment","volume":"7","author":"Kloppenborg","year":"2010","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.intimp.2022.109614_b0040","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S1474-4422(14)70003-1","article-title":"Outcome markers for clinical trials in cerebral amyloid angiopathy","volume":"13","author":"Greenberg","year":"2014","journal-title":"The Lancet Neurology"},{"key":"10.1016\/j.intimp.2022.109614_b0045","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1080\/14737175.2018.1480938","article-title":"Cerebral amyloid angiopathy: diagnosis and potential therapies","volume":"18","author":"Weber","year":"2018","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.intimp.2022.109614_b0050","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.1172\/JCI120842","article-title":"The role of mitochondria in aging","volume":"128","author":"Jang","year":"2018","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.intimp.2022.109614_b0055","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.neulet.2005.08.049","article-title":"Enhanced ROS production and antioxidant defenses in cybrids harbouring mutations in mtDNA","volume":"391","author":"Vives-Bauza","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.intimp.2022.109614_b0060","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.3390\/ijms20102374","article-title":"Role of mitochondrial DNA damage in ROS-mediated pathogenesis of age-related macular degeneration (AMD)","volume":"20","author":"Kaarniranta","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2022.109614_b0065","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s41583-018-0091-3","article-title":"Mitochondria as central regulators of neural stem cell fate and cognitive function","volume":"20","author":"Khacho","year":"2019","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.intimp.2022.109614_b0070","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.molmed.2007.12.002","article-title":"Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease","volume":"14","author":"Reddy","year":"2008","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.intimp.2022.109614_b0075","doi-asserted-by":"crossref","first-page":"8624","DOI":"10.1523\/JNEUROSCI.1957-08.2008","article-title":"Reverse of age-dependent memory impairment and mitochondrial DNA damage in microglia by an overexpression of human mitochondrial transcription factor a in mice","volume":"28","author":"Hayashi","year":"2008","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.intimp.2022.109614_b0080","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.3233\/JAD-190357","article-title":"Endothelial mitochondrial dysfunction in cerebral amyloid angiopathy and Alzheimer\u2019s disease","volume":"72","author":"Parodi-Rull\u00e1n","year":"2019","journal-title":"J. Alzheimers Dis."},{"issue":"2","key":"10.1016\/j.intimp.2022.109614_b0085","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.expneurol.2009.03.042","article-title":"Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer's disease","volume":"218","author":"Reddy","year":"2009","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.intimp.2022.109614_b0090","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.nbd.2011.12.022","article-title":"The abolishment of anesthesia-induced cognitive impairment by timely protection of mitochondria in the developing rat brain: the importance of free oxygen radicals and mitochondrial integrity","volume":"45","author":"Boscolo","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.intimp.2022.109614_b0095","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.bbadis.2009.08.010","article-title":"Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases","volume":"1802","author":"Gibson","year":"2010","journal-title":"Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease"},{"key":"10.1016\/j.intimp.2022.109614_b0100","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jnutbio.2018.01.009","article-title":"Supplementation of lycopene attenuates lipopolysaccharide-induced amyloidogenesis and cognitive impairments via mediating neuroinflammation and oxidative stress","volume":"56","author":"Wang","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.intimp.2022.109614_b0105","doi-asserted-by":"crossref","unstructured":"Williams GSB, Boyman L, Chikando AC, et al. Mitochondrial calcium uptake, Proceedings of the National Academy of Sciences, 2013, 110: 10479-10486.","DOI":"10.1073\/pnas.1300410110"},{"key":"10.1016\/j.intimp.2022.109614_b0110","first-page":"19","article-title":"Regulation of mitochondrial ATP synthase in cardiac pathophysiology","volume":"5","author":"Long","year":"2015","journal-title":"American journal of cardiovascular disease"},{"key":"10.1016\/j.intimp.2022.109614_b0115","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.2174\/0929867033457278","article-title":"The adenine nucleotide translocase: a central component of the mitochondrial permeability transition pore and key player in cell death","volume":"10","author":"Halestrap","year":"2003","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.intimp.2022.109614_b0120","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nature17656","article-title":"Architecture of the mitochondrial calcium uniporter","volume":"533","author":"Oxenoid","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2022.109614_b0125","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.cell.2012.10.011","article-title":"MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca2+ uptake that regulates cell survival","volume":"151","author":"Mallilankaraman","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2022.109614_b0130","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.cmet.2013.04.020","article-title":"MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca2+ uniporter","volume":"17","author":"Csord\u00e1s","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.intimp.2022.109614_b0135","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/embr.201337946","article-title":"MICU 1 and MICU 2 play nonredundant roles in the regulation of the mitochondrial calcium uniporter","volume":"15","author":"Kamer","year":"2014","journal-title":"EMBO Rep."},{"key":"10.1016\/j.intimp.2022.109614_b0140","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/s41418-018-0113-8","article-title":"MICU3 is a tissue-specific enhancer of mitochondrial calcium uptake","volume":"26","author":"Patron","year":"2019","journal-title":"Cell Death Differ."},{"issue":"678\u2013687","key":"10.1016\/j.intimp.2022.109614_b0145","first-page":"e5","article-title":"Molecular tuning of the axonal mitochondrial Ca2+ uniporter ensures metabolic flexibility of neurotransmission","volume":"105","author":"Ashrafi","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.intimp.2022.109614_b0150","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1161\/CIRCRESAHA.120.317177","article-title":"MICU3 Plays an Important Role in Cardiovascular Function","volume":"127","author":"Puente","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.intimp.2022.109614_b0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-021-04400-5","article-title":"MICU3 regulates mitochondrial Ca2+-dependent antioxidant response in skeletal muscle aging","volume":"12","author":"Yang","year":"2021","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.intimp.2022.109614_b0160","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.neuron.2019.11.020","article-title":"Molecular tuning of the axonal mitochondrial Ca2+ uniporter ensures metabolic flexibility of neurotransmission","volume":"105","author":"Ashrafi","year":"2020","journal-title":"Neuron"},{"issue":"11","key":"10.1016\/j.intimp.2022.109614_b0165","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.3390\/cells10112903","article-title":"Dissecting the crosstalk between endothelial mitochondrial damage, vascular inflammation, and neurodegeneration in cerebral amyloid angiopathy and Alzheimer\u2019s Disease","volume":"10","author":"Parodi-Rull\u00e1n","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.intimp.2022.109614_b0170","doi-asserted-by":"crossref","first-page":"4050796","DOI":"10.1155\/2019\/4050796","article-title":"The role of mitochondrial damage-associated molecular patterns in chronic neuroinflammation","volume":"2019","author":"Bajwa","year":"2019","journal-title":"Mediators Inflamm."},{"issue":"10","key":"10.1016\/j.intimp.2022.109614_b0175","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1038\/s41593-019-0486-0","article-title":"Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration","volume":"22","author":"Joshi","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.intimp.2022.109614_b0180","doi-asserted-by":"crossref","DOI":"10.1161\/STROKEAHA.110.595272","article-title":"Enhanced capillary amyloid angiopathy-associated pathology in Tg-SwDI mice with deleted nitric oxide synthase 2","volume":"41","author":"Van Nostrand","year":"2010","journal-title":"Stroke"},{"key":"10.1016\/j.intimp.2022.109614_b0185","doi-asserted-by":"crossref","first-page":"20296","DOI":"10.1074\/jbc.M312946200","article-title":"Early-onset and robust cerebral microvascular accumulation of amyloid \u03b2-protein in transgenic mice expressing low levels of a vasculotropic Dutch\/Iowa mutant form of amyloid \u03b2-protein precursor","volume":"279","author":"Davis","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2022.109614_b0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-021-02227-7","article-title":"Cathepsin H deficiency decreases hypoxia-ischemia-induced hippocampal atrophy in neonatal mice through attenuated TLR3\/IFN-\u03b2 signaling","volume":"18","author":"Ni","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.intimp.2022.109614_b0195","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/glia.20599","article-title":"Transplanted astrocytes internalize deposited \u03b2-amyloid peptides in a transgenic mouse model of Alzheimer's disease","volume":"56","author":"Pihlaja","year":"2008","journal-title":"Glia"},{"key":"10.1016\/j.intimp.2022.109614_b0200","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1093\/brain\/awv313","article-title":"Passive immunotherapy targeting amyloid-\u03b2 reduces cerebral amyloid angiopathy and improves vascular reactivity","volume":"139","author":"Bales","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.intimp.2022.109614_b0205","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.3233\/JAD-160013","article-title":"Influence of Low-dose aspirin on cerebral amyloid angiopathy in mice","volume":"52","author":"Hattori","year":"2016","journal-title":"Journal of Alzheimer's Disease"},{"key":"10.1016\/j.intimp.2022.109614_b0210","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/RCT.0b013e3181f31917","article-title":"Posterior reversible encephalopathy syndrome (PRES) with immune system activation, VEGF up-regulation, and cerebral amyloid angiopathy","volume":"35","author":"Kofler","year":"2011","journal-title":"J. Comput. Assist. Tomogr."},{"issue":"1","key":"10.1016\/j.intimp.2022.109614_b0215","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1750-3639.2007.00098.x","article-title":"Maturation and localization of macrophages and microglia during infection with a neurotropic murine coronavirus","volume":"18","author":"Templeton","year":"2008","journal-title":"Brain Pathol."},{"key":"10.1016\/j.intimp.2022.109614_b0220","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1111\/j.1471-4159.2009.06096.x","article-title":"Matrix metalloproteinase inhibition reduces oxidative stress associated with cerebral amyloid angiopathy in vivo in transgenic mice","volume":"109","author":"Garcia-Alloza","year":"2009","journal-title":"J. Neurochem."},{"issue":"3","key":"10.1016\/j.intimp.2022.109614_b0225","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1007\/s12035-016-9770-0","article-title":"Resveratrol protects SAMP8 brain under metabolic stress: focus on mitochondrial function and Wnt pathway","volume":"54","author":"Palomera-Avalos","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.intimp.2022.109614_b0230","doi-asserted-by":"crossref","first-page":"e2455","DOI":"10.1371\/journal.pone.0002455","article-title":"PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons","volume":"3","author":"Wood-Kaczmar","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2022.109614_b0235","doi-asserted-by":"crossref","unstructured":"Hawkes CA, McLaurin JA. Selective targeting of perivascular macrophages for clearance of \u03b2-amyloid in cerebral amyloid angiopathy, Proceedings of the National Academy of Sciences, 2009, 106: 1261-1266.","DOI":"10.1073\/pnas.0805453106"},{"key":"10.1016\/j.intimp.2022.109614_b0240","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/j.freeradbiomed.2007.09.007","article-title":"Insights into amyloid-\u03b2-induced mitochondrial dysfunction in Alzheimer disease","volume":"43","author":"Wang","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.intimp.2022.109614_b0245","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1096\/fj.09-139584","article-title":"Differential activation of mitochondrial apoptotic pathways by vasculotropic amyloid-\u03b2 variants in cells composing the cerebral vessel walls","volume":"24","author":"Fossati","year":"2010","journal-title":"FASEB J."},{"key":"10.1016\/j.intimp.2022.109614_b0250","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00221-011-2952-0","article-title":"Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and Presenilin","volume":"217","author":"Prox","year":"2012","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.intimp.2022.109614_b0255","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/jnc.13287","article-title":"ADAM10 and BACE1 are localized to synaptic vesicles","volume":"135","author":"Lundgren","year":"2015","journal-title":"J. Neurochem."},{"key":"10.1016\/j.intimp.2022.109614_b0260","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00401-006-0115-3","article-title":"RAGE, LRP-1, and amyloid-beta protein in Alzheimer\u2019s disease","volume":"112","author":"Donahue","year":"2006","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.intimp.2022.109614_b0265","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.expneurol.2011.11.001","article-title":"The effect of amyloid associated proteins on the expression of genes involved in amyloid-\u03b2 clearance by adult human astrocytes","volume":"233","author":"Mulder","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.intimp.2022.109614_b0270","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0002-9440(10)63822-9","article-title":"Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-\u03b54 allele","volume":"162","author":"Cook","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.intimp.2022.109614_b0275","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/S0896-6273(03)00787-6","article-title":"Enhanced proteolysis of \u03b2-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death","volume":"40","author":"Leissring","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.intimp.2022.109614_b0280","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2353\/ajpath.2007.070105","article-title":"Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy","volume":"171","author":"Farris","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.intimp.2022.109614_b0285","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0197-4580(03)00111-8","article-title":"Co-accumulation of vascular endothelial growth factor with \u03b2-amyloid in the brain of patients with Alzheimer\u2019s disease","volume":"25","author":"Yang","year":"2004","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.intimp.2022.109614_b0290","doi-asserted-by":"crossref","first-page":"e3933","DOI":"10.7717\/peerj.3933","article-title":"The neuroprotective effect of nicotine in Parkinson\u2019s disease models is associated with inhibiting PARP-1 and caspase-3 cleavage","volume":"5","author":"Lu","year":"2017","journal-title":"PeerJ"},{"issue":"11","key":"10.1016\/j.intimp.2022.109614_b0295","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1007\/s11064-020-03121-z","article-title":"Mechanisms of NLRP3 inflammasome activation: its role in the treatment of Alzheimer\u2019s disease","volume":"45","author":"Zhang","year":"2020","journal-title":"Neurochem. Res."},{"issue":"7434","key":"10.1016\/j.intimp.2022.109614_b0300","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nature11729","article-title":"NLRP3 is activated in Alzheimer\u2019s disease and contributes to pathology in APP\/PS1 mice","volume":"493","author":"Heneka","year":"2013","journal-title":"Nature"},{"issue":"14","key":"10.1016\/j.intimp.2022.109614_b0305","doi-asserted-by":"crossref","first-page":"8078","DOI":"10.1111\/jcmm.15439","article-title":"New mechanism of nerve injury in Alzheimer\u2019s disease: \u03b2-amyloid-induced neuronal pyroptosis","volume":"24","author":"Han","year":"2020","journal-title":"J. Cell Mol. Med."},{"issue":"4","key":"10.1016\/j.intimp.2022.109614_b0310","doi-asserted-by":"crossref","first-page":"e02063","DOI":"10.1002\/brb3.2063","article-title":"Pyroptosis executive protein GSDMD as a biomarker for diagnosis and identification of Alzheimer\u2019s disease","volume":"11","author":"Shen","year":"2021","journal-title":"Brain and Behavior"},{"key":"10.1016\/j.intimp.2022.109614_b0315","doi-asserted-by":"crossref","first-page":"508","DOI":"10.2174\/1570159X15666170720095240","article-title":"Microglia and astrocytes in Alzheimer's disease: implications for therapy","volume":"16","author":"Fakhoury","year":"2018","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.intimp.2022.109614_b0320","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jocn.2018.10.034","article-title":"Influence of microglia and astrocyte activation in the neuroinflammatory pathogenesis of Alzheimer\u2019s disease: rational insights for the therapeutic approaches","volume":"59","author":"Ahmad","year":"2019","journal-title":"J. Clin. Neurosci."},{"key":"10.1016\/j.intimp.2022.109614_b0325","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1042\/BST20140171","article-title":"The contribution of astrocytes to Alzheimer's disease","volume":"42","author":"Birch","year":"2014","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.intimp.2022.109614_b0330","doi-asserted-by":"crossref","first-page":"311a","DOI":"10.1016\/j.bpj.2015.11.1672","article-title":"MICU1 Regulation of Mitochondrial Calcium Uptake is Crucial for Liver Regeneration","volume":"110","author":"Antony","year":"2016","journal-title":"Biophys. J ."},{"key":"10.1016\/j.intimp.2022.109614_b0335","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.3389\/fphar.2018.01257","article-title":"Black truffle aqueous extract attenuates oxidative stress and inflammation in STZ-induced hyperglycemic rats via Nrf2 and NF-\u03baB pathways","volume":"9","author":"Zhang","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2022.109614_b0340","doi-asserted-by":"crossref","first-page":"S116","DOI":"10.1016\/j.freeradbiomed.2020.10.292","article-title":"Studying Oxidative Stress in A\u03b2-burdened Neurons at Pre-plaque stages of Alzheimer\u2019s Disease","volume":"159","author":"Foret","year":"2020","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.intimp.2022.109614_b0345","doi-asserted-by":"crossref","first-page":"e0119179","DOI":"10.1371\/journal.pone.0119179","article-title":"NLRP3 mediates NF-\u03baB activation and cytokine induction in microbially induced and sterile inflammation","volume":"10","author":"Kinoshita","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2022.109614_b0350","doi-asserted-by":"crossref","first-page":"101068","DOI":"10.1016\/j.redox.2018.101068","article-title":"Adropin protects against liver injury in nonalcoholic steatohepatitis via the Nrf2 mediated antioxidant capacity","volume":"21","author":"Chen","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.intimp.2022.109614_b0355","doi-asserted-by":"crossref","first-page":"519","DOI":"10.3892\/br.2016.630","article-title":"Role of oxidative stress in Alzheimer's disease","volume":"4","author":"Huang","year":"2016","journal-title":"Biomedical reports"},{"key":"10.1016\/j.intimp.2022.109614_b0360","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1006\/bbrc.2000.2897","article-title":"Activation of NADPH oxidase in Alzheimer's disease brains","volume":"273","author":"Shimohama","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2022.109614_b0365","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2202-9-S2-S8","article-title":"NADPH oxidase as a therapeutic target in Alzheimer's disease","volume":"9","author":"Block","year":"2008","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.intimp.2022.109614_b0370","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.freeradbiomed.2014.07.046","article-title":"Nox family NADPH oxidases: molecular mechanisms of activation","volume":"76","author":"Brandes","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.intimp.2022.109614_b0375","doi-asserted-by":"crossref","first-page":"101645","DOI":"10.1016\/j.redox.2020.101645","article-title":"Nrf2 mitigates prolonged pm2. 5 exposure-triggered liver inflammation by positively regulating sike activity: Protection by juglanin","volume":"36","author":"Ge","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.intimp.2022.109614_b0380","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1002\/ddr.21567","article-title":"Activation of Nrf2 signaling by sitagliptin and quercetin combination against \u03b2-amyloid induced Alzheimer's disease in rats","volume":"80","author":"Li","year":"2019","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.intimp.2022.109614_b0385","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.freeradbiomed.2020.06.028","article-title":"Transcription factor NRF2 as a promising therapeutic target for Alzheimer\u2019s disease","volume":"159","author":"Qu","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.intimp.2022.109614_b0390","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1016\/j.freeradbiomed.2015.07.138","article-title":"Xanthine oxidase regulates pesticides-induced oxidative stress in rat polymorphonuclear leukocytes via NOS-independent pathway","volume":"86","author":"Singh","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.intimp.2022.109614_b0395","doi-asserted-by":"crossref","first-page":"101511","DOI":"10.1016\/j.redox.2020.101511","article-title":"Mitochondria at the crossroads of ATM-mediated stress signaling and regulation of reactive oxygen species","volume":"32","author":"Lee","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.intimp.2022.109614_b0400","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.tem.2015.12.001","article-title":"Mitochondrial dynamics and metabolic regulation","volume":"27","author":"Wai","year":"2016","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.intimp.2022.109614_b0405","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s41580-019-0173-8","article-title":"Mitochondria as multifaceted regulators of cell death","volume":"21","author":"Bock","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.intimp.2022.109614_b0410","first-page":"29","article-title":"Mitochondrial dysfunction in Parkinson's disease","author":"Winklhofer","year":"1802","journal-title":"Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease"},{"key":"10.1016\/j.intimp.2022.109614_b0415","first-page":"217","article-title":"PINK1 import regulation at a crossroad of mitochondrial fate: the molecular mechanisms of PINK1 import","volume":"167","author":"Sekine","year":"2020","journal-title":"The Journal of Biochemistry"},{"key":"10.1016\/j.intimp.2022.109614_b0420","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.bbrc.2017.01.061","article-title":"PINK1 alleviates myocardial hypoxia-reoxygenation injury by ameliorating mitochondrial dysfunction","volume":"484","author":"Li","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2022.109614_b0425","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nature14893","article-title":"The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy","volume":"524","author":"Lazarou","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2022.109614_b0430","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/ncb2901","article-title":"Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson\u2019s disease","volume":"16","author":"Tufi","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.intimp.2022.109614_b0435","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1093\/brain\/awx258","article-title":"PINK1 signalling rescues amyloid pathology and mitochondrial dysfunction in Alzheimer\u2019s disease","volume":"140","author":"Du","year":"2017","journal-title":"Brain"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922010992?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922010992?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T18:07:11Z","timestamp":1761588431000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576922010992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":87,"alternative-id":["S1567576922010992"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2022.109614","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondrial calcium uptake 3 mitigates cerebral amyloid angiopathy-related neuronal death and glial inflammation by reducing mitochondrial dysfunction","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2022.109614","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"109614"}}