{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:25:45Z","timestamp":1789518345869,"version":"build-2803163510"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.intimp.2023.109701","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T09:40:36Z","timestamp":1673257236000},"page":"109701","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Acute respiratory distress syndrome enhances tumor metastasis into lungs: Role of BRD4 in the tumor microenvironment"],"prefix":"10.1016","volume":"115","author":[{"given":"Venkatesh","family":"Pooladanda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sowjanya","family":"Thatikonda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai","family":"Priya Muvvala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandraiah","family":"Godugu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2023.109701_b0005","series-title":"STaTPEaRls [InTeRnEt]. TREasuRE IslaNd","article-title":"Acute Respiratory Distress Syndrome (ARDS)","author":"Diamond","year":"2020"},{"key":"10.1016\/j.intimp.2023.109701_b0010","unstructured":"Coronavirus Update (Live): 661,913,292 Cases and 6,686,635 Deaths from COVID-19 Virus Pandemic - Worldometer [Internet]. [cited 2022 Dec 26]. Available from: https:\/\/www.worldometers.info\/coronavirus\/."},{"issue":"6","key":"10.1016\/j.intimp.2023.109701_b0015","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.jinf.2020.03.037","article-title":"The pathogenesis and treatment of the \u2018Cytokine Storm\u2019 in COVID-19","volume":"80","author":"Ye","year":"2020","journal-title":"J. Infect."},{"key":"10.1016\/j.intimp.2023.109701_b0020","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2017.00547","article-title":"Baicalin alleviates Lipopolysaccharide-induced liver inflammation in chicken by suppressing TLR4-mediated NF-\u03baB pathway","volume":"8","author":"Cheng","year":"2017","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.intimp.2023.109701_b0025","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.4049\/jimmunol.1601515","article-title":"Akt signaling pathway in macrophage activation and M1\/M2 Polarization","volume":"198","author":"Vergadi","year":"2017","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2023.109701_b0030","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/j.1365-2249.2006.03291.x","article-title":"Activated signal transducer and activator of transcription-3 (STAT3) is a poor regulator of tumour necrosis factor-\u03b1 production by human monocytes","volume":"147","author":"Pr\u00eale","year":"2007","journal-title":"Clin. Exp. Immunol."},{"issue":"711","key":"10.1016\/j.intimp.2023.109701_b0035","article-title":"Sigma-1 receptor activation ameliorates LPS-induced NO production and ROS formation through the Nrf2\/HO-1 signaling pathway in cultured astrocytes","volume":"15","author":"Wang","year":"2019","journal-title":"Neurosci. Lett."},{"issue":"6917","key":"10.1016\/j.intimp.2023.109701_b0040","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature01322","article-title":"Inflammation and cancer","volume":"420","author":"Coussens","year":"2002","journal-title":"Nature"},{"issue":"7490","key":"10.1016\/j.intimp.2023.109701_b0045","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nature13062","article-title":"Inflammation lights the way to metastasis","volume":"507","author":"Coffelt","year":"2014","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.intimp.2023.109701_b0050","first-page":"61","article-title":"Causes of death in cancer patients","volume":"6","author":"Ambrus","year":"1975","journal-title":"J. Med."},{"issue":"1","key":"10.1016\/j.intimp.2023.109701_b0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00595-011-0058-8","article-title":"Role of tumor-associated macrophages in the progression of hepatocellular carcinoma","volume":"42","author":"Shirabe","year":"2012","journal-title":"Surg. Today."},{"issue":"4","key":"10.1016\/j.intimp.2023.109701_b0060","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/nrm.2016.143","article-title":"Functions of bromodomain-containing proteins and their roles in homeostasis and cancer","volume":"18","author":"Fujisawa","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.intimp.2023.109701_b0065","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13072-020-00333-z","article-title":"Bromodomain and extra-terminal domain (BET) proteins regulate melanocyte differentiation","volume":"13","author":"Trivedi","year":"2020","journal-title":"Epigenetics Chromatin"},{"issue":"1","key":"10.1016\/j.intimp.2023.109701_b0070","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/s12943-018-0915-9","article-title":"BRD4 and Cancer: going beyond transcriptional regulation","volume":"17","author":"Donati","year":"2018","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.intimp.2023.109701_b0075","first-page":"18","article-title":"Tumoral BRD4 expression in lymph node-negative breast cancer: association with T-bet+ tumor-infiltrating lymphocytes and disease-free survival","volume":"20","author":"Lee","year":"2018","journal-title":"BMC Cancer [Internet]."},{"issue":"19","key":"10.1016\/j.intimp.2023.109701_b0080","doi-asserted-by":"crossref","first-page":"4869","DOI":"10.1158\/0008-5472.CAN-19-0442","article-title":"BRD4 Promotes Gastric Cancer Progression and Metastasis through Acetylation-Dependent Stabilization of Snail","volume":"79","author":"Qin","year":"2019","journal-title":"Cancer Res."},{"issue":"6","key":"10.1016\/j.intimp.2023.109701_b0085","doi-asserted-by":"crossref","first-page":"L1183","DOI":"10.1152\/ajplung.00224.2016","article-title":"BRD4 mediates NF-\u03baB-dependent epithelial-mesenchymal transition and pulmonary fibrosis via transcriptional elongation","volume":"311","author":"Tian","year":"2016","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"issue":"Suppl 17","key":"10.1016\/j.intimp.2023.109701_b0090","doi-asserted-by":"crossref","first-page":"S2155","DOI":"10.21037\/jtd.2019.10.54","article-title":"Chronic obstructive pulmonary disease (COPD) and lung cancer: common pathways for pathogenesis","volume":"11","author":"Parris","year":"2019","journal-title":"J. Thorac. Dis."},{"issue":"5","key":"10.1016\/j.intimp.2023.109701_b0095","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/sj.bjc.6604890","article-title":"Cancer risk in hospitalised asthma patients","volume":"100","author":"Ji","year":"2009","journal-title":"Br. J. Cancer."},{"issue":"1","key":"10.1016\/j.intimp.2023.109701_b0100","first-page":"21","article-title":"Reduced expression of TLR4 is associated with the metastatic status of human colorectal cancer","volume":"20","author":"Simiantonaki","year":"2007","journal-title":"Int. J. Mol. Med."},{"issue":"2","key":"10.1016\/j.intimp.2023.109701_b0105","first-page":"d12","article-title":"Cytokines in acute and chronic inflammation","volume":"1","author":"Feghali","year":"1997","journal-title":"Front Biosci."},{"issue":"25","key":"10.1016\/j.intimp.2023.109701_b0110","doi-asserted-by":"crossref","first-page":"9971","DOI":"10.1073\/pnas.1203543109","article-title":"Regulation of innate CD8+ T-cell activation mediated by cytokines","volume":"109","author":"Freeman","year":"2012","journal-title":"PNAS"},{"issue":"71","key":"10.1016\/j.intimp.2023.109701_b0115","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.intimp.2019.03.035","article-title":"Protective effects of ambroxol in psoriasis like skin inflammation: exploration of possible mechanisms","volume":"1","author":"Sunkari","year":"2019","journal-title":"Int. Immunopharmacol."},{"issue":"sup1","key":"10.1016\/j.intimp.2023.109701_b0120","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1080\/21691401.2018.1434661","article-title":"Nanoscale modification of chrysin for improved of therapeutic efficiency and cytotoxicity","volume":"46","author":"Sulaiman","year":"2018","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"issue":"2","key":"10.1016\/j.intimp.2023.109701_b0125","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41419-018-1247-9","article-title":"Nimbolide protects against endotoxin-induced acute respiratory distress syndrome by inhibiting TNF-\u03b1 mediated NF-\u03baB and HDAC-3 nuclear translocation","volume":"10","author":"Pooladanda","year":"2019","journal-title":"Cell Death Dis."},{"issue":"17","key":"10.1016\/j.intimp.2023.109701_b0130","doi-asserted-by":"crossref","first-page":"4706","DOI":"10.1158\/1078-0432.CCR-13-0011","article-title":"The ubiquitin-CXCR4 axis plays an important role in acute lung infection-enhanced lung tumor metastasis","volume":"19","author":"Yan","year":"2013","journal-title":"Clin. Cancer Res."},{"issue":"6","key":"10.1016\/j.intimp.2023.109701_b0135","doi-asserted-by":"crossref","first-page":"5270","DOI":"10.1002\/jcp.29413","article-title":"Repurposing an old drug for new use: niclosamide in psoriasis-like skin inflammation","volume":"235","author":"Thatikonda","year":"2020","journal-title":"J. Cell. Physiol."},{"issue":"1","key":"10.1016\/j.intimp.2023.109701_b0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-019-2212-y","article-title":"Piperlongumine regulates epigenetic modulation and alleviates psoriasis-like skin inflammation via inhibition of hyperproliferation and inflammation","volume":"11","author":"Thatikonda","year":"2020","journal-title":"Cell Death Dis."},{"issue":"14","key":"10.1016\/j.intimp.2023.109701_b0145","first-page":"2391","article-title":"IL-6 Activities in the Tumour Microenvironment. Part 1. Open Access Maced","volume":"7","author":"Chonov","year":"2019","journal-title":"J. Med. Sci."},{"issue":"8","key":"10.1016\/j.intimp.2023.109701_b0150","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1080\/21645515.2018.1461300","article-title":"Targeting interleukin-22 for cancer therapy","volume":"14","author":"Markota","year":"2018","journal-title":"Hum Vaccin. Immunother."},{"issue":"11","key":"10.1016\/j.intimp.2023.109701_b0155","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1111\/j.1745-7254.2008.00889.x","article-title":"Tumor necrosis factor and cancer, buddies or foes?","volume":"29","author":"Wang","year":"2008","journal-title":"Acta. Pharmacol. Sin."},{"key":"10.1016\/j.intimp.2023.109701_b0160","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18010064","article-title":"Current Concepts of ARDS: a Narrative Review","author":"Umbrello","year":"2016","journal-title":"Int. J. Mol. Sci. [Internet]."},{"key":"10.1016\/j.intimp.2023.109701_b0165","first-page":"1","article-title":"SARS-CoV-2 genomic variations associated with mortality rate of COVID-19","volume":"22","author":"Toyoshima","year":"2020","journal-title":"J. Hum. Genet."},{"issue":"254","key":"10.1016\/j.intimp.2023.109701_b0170","article-title":"The current understanding and potential therapeutic options to combat COVID-19","volume":"1","author":"Pooladanda","year":"2020","journal-title":"Life Sci."},{"issue":"9255","key":"10.1016\/j.intimp.2023.109701_b0175","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0140-6736(00)04046-0","article-title":"Inflammation and cancer: back to Virchow?","volume":"357","author":"Balkwill","year":"2001","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.intimp.2023.109701_b0180","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s13167-019-00194-x","article-title":"Chronic inflammation: key player and biomarker-set to predict and prevent cancer development and progression based on individualized patient profiles","volume":"10","author":"Qian","year":"2019","journal-title":"EPMA J."},{"key":"10.1016\/j.intimp.2023.109701_b0185","first-page":"557","article-title":"Acute respiratory distress syndrome in cancer patients","volume":"9","author":"Young","year":"2019","journal-title":"Oncologic Critical Care."},{"issue":"1","key":"10.1016\/j.intimp.2023.109701_b0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-1759(98)00128-8","article-title":"Chemokines and their role in tumor growth and metastasis","volume":"220","author":"Wang","year":"1998","journal-title":"J. Immunol. Methods"},{"issue":"83","key":"10.1016\/j.intimp.2023.109701_b0195","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.semcancer.2021.01.003","article-title":"Epigenetic underpinnings of inflammation: Connecting the dots between pulmonary diseases, lung cancer and COVID-19","volume":"1","author":"Ahmad","year":"2022","journal-title":"Semin. Cancer Biol."},{"issue":"4","key":"10.1016\/j.intimp.2023.109701_b0200","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1189\/jlb.2RI0616-250R","article-title":"Bromodomain 4: a cellular Swiss army knife","volume":"100","author":"Devaiah","year":"2016","journal-title":"J. Leukoc. Biol."},{"issue":"6","key":"10.1016\/j.intimp.2023.109701_b0205","first-page":"3405","article-title":"Accelerated inflammation and oxidative stress induced by LPS in acute lung injury: \u0399nhibition by ST1926","volume":"41","author":"Dong","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.intimp.2023.109701_b0210","doi-asserted-by":"crossref","DOI":"10.1155\/2009\/958658","article-title":"The Effects of Interleukin-1\u03b2 in Tumor Necrosis Factor-\u03b1-Induced Acute Pulmonary Inflammation in Mice [Internet]","author":"Saperstein","year":"2009","journal-title":"Mediators Inflamm."},{"issue":"1","key":"10.1016\/j.intimp.2023.109701_b0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/thoraxjnl-2016-209170","article-title":"What drives neutrophils to the alveoli in ARDS?","volume":"72","author":"Zemans","year":"2017","journal-title":"Thorax"},{"issue":"5","key":"10.1016\/j.intimp.2023.109701_b0220","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/path.5221","article-title":"Neutrophils in the initiation and resolution of acute pulmonary inflammation: understanding biological function and therapeutic potential","volume":"247","author":"Potey","year":"2019","journal-title":"J. Pathol."},{"issue":"3","key":"10.1016\/j.intimp.2023.109701_b0225","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1189\/jlb.0206099","article-title":"TLR4 gene dosage contributes to endotoxin-induced acute respiratory inflammation","volume":"80","author":"Togbe","year":"2006","journal-title":"J. Leukoc. Biol."},{"issue":"12","key":"10.1016\/j.intimp.2023.109701_b0230","doi-asserted-by":"crossref","first-page":"e1002401","DOI":"10.1371\/journal.pgen.1002401","article-title":"Mechanisms Establishing TLR4-responsive activation states of inflammatory response genes","volume":"7","author":"Escoubet-Lozach","year":"2011","journal-title":"PLoS Genet."},{"issue":"4","key":"10.1016\/j.intimp.2023.109701_b0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-020-2440-1","article-title":"Activation of STAT3 is a key event in TLR4 signaling-mediated melanoma progression","volume":"11","author":"Fu","year":"2020","journal-title":"Cell Death Dis."},{"issue":"12","key":"10.1016\/j.intimp.2023.109701_b0240","doi-asserted-by":"crossref","first-page":"640","DOI":"10.5483\/BMBRep.2017.50.12.194","article-title":"JQ1, a BET inhibitor, controls TLR4-induced IL-10 production in regulatory B cells by BRD4-NF-\u03baB axis","volume":"50","author":"Lee","year":"2017","journal-title":"BMB Rep."},{"issue":"6","key":"10.1016\/j.intimp.2023.109701_b0245","doi-asserted-by":"crossref","first-page":"4454","DOI":"10.3892\/mmr.2015.3258","article-title":"Lipopolysaccharide induces inflammation and facilitates lung metastasis in a breast cancer model via the prostaglandin E2-EP2 pathway","volume":"11","author":"Li","year":"2015","journal-title":"Mol. Med. Rep."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923000243?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923000243?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T14:10:50Z","timestamp":1736431850000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576923000243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":49,"alternative-id":["S1567576923000243"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2023.109701","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute respiratory distress syndrome enhances tumor metastasis into lungs: Role of BRD4 in the tumor microenvironment","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2023.109701","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109701"}}