{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:05:25Z","timestamp":1769731525088,"version":"3.49.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.intimp.2023.109724","type":"journal-article","created":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T04:07:05Z","timestamp":1674446825000},"page":"109724","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Posttreatment with dexmedetomidine aggravates LPS-induced myocardial dysfunction partly via activating cardiac endothelial \u03b12A-AR in mice"],"prefix":"10.1016","volume":"116","author":[{"given":"Xiangxu","family":"Tang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chanjuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomeng","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Xing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duomeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongmei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuxiu","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2108-4560","authenticated-orcid":false,"given":"Huadong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.intimp.2023.109724_b0005","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"issue":"10219","key":"10.1016\/j.intimp.2023.109724_b0010","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990\u20132017: analysis for the Global Burden of Disease Study","volume":"395","author":"Rudd","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.intimp.2023.109724_b0015","first-page":"30","article-title":"Pathophysiology of sepsis-induced myocardial dysfunction","volume":"3","author":"Lv","year":"2016","journal-title":"Mil. Med. Res."},{"issue":"6","key":"10.1016\/j.intimp.2023.109724_b0020","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41569-020-00492-2","article-title":"Pathophysiology of sepsis-induced cardiomyopathy","volume":"18","author":"Hollenberg","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"issue":"5","key":"10.1016\/j.intimp.2023.109724_b0025","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s11886-020-01277-2","article-title":"Sepsis-induced cardiomyopathy: a comprehensive review","volume":"22","author":"L'Heureux","year":"2020","journal-title":"Curr. Cardiol. Rep."},{"key":"10.1016\/j.intimp.2023.109724_b0030","doi-asserted-by":"crossref","first-page":"7927353","DOI":"10.1155\/2020\/7927353","article-title":"Prognostic role of left ventricular systolic function measured by speckle tracking echocardiography in septic shock","volume":"2020","author":"Hai","year":"2020","journal-title":"Biomed. Res. Int."},{"issue":"6","key":"10.1016\/j.intimp.2023.109724_b0035","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1016\/j.chest.2020.12.016","article-title":"Impact of right ventricular dysfunction on short-term and long-term mortality in sepsis: A Meta-analysis of 1,373 Patients","volume":"159","author":"Vallabhajosyula","year":"2021","journal-title":"Chest"},{"issue":"6","key":"10.1016\/j.intimp.2023.109724_b0040","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1111\/bph.15363","article-title":"Emerging benefits and drawbacks of \u03b12 -adrenoceptor agonists in the management of sepsis and critical illness","volume":"178","author":"Lankadeva","year":"2021","journal-title":"Br. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.intimp.2023.109724_b0045","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1097\/01.CCM.0000128579.84228.2A","article-title":"Effects of dexmedetomidine on mortality rate and inflammatory responses to endotoxin-induced shock in rats","volume":"32","author":"Taniguchi","year":"2004","journal-title":"Crit. Care Med."},{"issue":"3","key":"10.1016\/j.intimp.2023.109724_b0050","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00540-008-0611-9","article-title":"Dose- and time-related effects of dexmedetomidine on mortality and inflammatory responses to endotoxin-induced shock in rats","volume":"22","author":"Taniguchi","year":"2008","journal-title":"J. Anesth."},{"key":"10.1016\/j.intimp.2023.109724_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.05.030","article-title":"Dexmedetomidine effects in different experimental sepsis in vivo models","volume":"856","author":"Dardalas","year":"2019","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2023.109724_b0060","doi-asserted-by":"crossref","first-page":"R11","DOI":"10.1186\/cc7709","article-title":"Central sympatholytics prolong survival in experimental sepsis","volume":"13","author":"Hofer","year":"2009","journal-title":"Crit. Care"},{"issue":"5","key":"10.1016\/j.intimp.2023.109724_b0065","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1007\/s10753-014-9906-1","article-title":"Dexmedetomidine controls systemic cytokine levels through the cholinergic anti-inflammatory pathway","volume":"37","author":"Xiang","year":"2014","journal-title":"Inflammation"},{"issue":"11","key":"10.1016\/j.intimp.2023.109724_b0070","first-page":"5040","article-title":"Dexmedetomidine alleviates LPS-induced septic cardiomyopathy via the cholinergic anti-inflammatory pathway in mice","volume":"9","author":"Kong","year":"2017","journal-title":"Am. J. Transl. Res."},{"issue":"1","key":"10.1016\/j.intimp.2023.109724_b0075","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3892\/mmr.2020.11114","article-title":"Dexmedetomidine alleviated sepsis-induced myocardial ferroptosis and septic heart injury","volume":"22","author":"Wang","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.intimp.2023.109724_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109231","article-title":"Dexmedetomidine prevents septic myocardial dysfunction in rats via activation of \u03b17nAChR and PI3K\/Akt- mediated autophagy","volume":"120","author":"Yu","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"13","key":"10.1016\/j.intimp.2023.109724_b0085","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1001\/jama.2017.2088","article-title":"Dexmedetomidine for sepsis in intensive care unit randomized evaluation (DESIRE) trial investigators, effect of dexmedetomidine on mortality and ventilator-free days in patients requiring mechanical ventilation with sepsis: A randomized clinical trial","volume":"317","author":"Kawazoe","year":"2017","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.intimp.2023.109724_b0090","doi-asserted-by":"crossref","first-page":"e5504","DOI":"10.1371\/journal.pone.0005504","article-title":"Pivotal role of the alpha(2A)-adrenoceptor in producing inflammation and organ injury in a rat model of sepsis","volume":"4","author":"Miksa","year":"2009","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.intimp.2023.109724_b0095","doi-asserted-by":"crossref","first-page":"5478","DOI":"10.1038\/s41598-018-23304-7","article-title":"\u03b12A-adrenergic blockade attenuates septic cardiomyopathy by increasing cardiac norepinephrine concentration and inhibiting cardiac endothelial activation","volume":"8","author":"Yu","year":"2018","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.intimp.2023.109724_b0100","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1016\/j.resuscitation.2010.07.021","article-title":"Deterioration of myocardial injury due to dexmedetomidine administration after myocardial ischaemia","volume":"81","author":"Mimuro","year":"2010","journal-title":"Resuscitation"},{"issue":"6","key":"10.1016\/j.intimp.2023.109724_b0105","doi-asserted-by":"crossref","first-page":"4031","DOI":"10.4049\/jimmunol.0900105","article-title":"A pivotal role of endothelial-specific NF-kappaB signaling in the pathogenesis of septic shock and septic vascular dysfunction","volume":"183","author":"Ding","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2023.109724_b0110","doi-asserted-by":"crossref","first-page":"566","DOI":"10.3389\/fimmu.2020.00566","article-title":"Endothelial HSPA12B exerts protection against sepsis-induced severe cardiomyopathy via suppression of adhesion molecule expression by miR-126","volume":"11","author":"Zhang","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2023.109724_b0115","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.phrs.2015.11.004","article-title":"Dexmedetomidine protects the heart against ischemia-reperfusion injury by an endothelial eNOS\/NO dependent mechanism","volume":"103","author":"Riquelme","year":"2016","journal-title":"Pharmacol. Res."},{"issue":"4","key":"10.1016\/j.intimp.2023.109724_b0120","doi-asserted-by":"crossref","first-page":"e12675","DOI":"10.1111\/micc.12675","article-title":"Dexmedetomidine protects cardiac microvascular endothelial cells from the damage of ogd\/r through regulation of the ppar\u03b4-mediated autophagy","volume":"28","author":"Shao","year":"2021","journal-title":"Microcirculation"},{"issue":"1","key":"10.1016\/j.intimp.2023.109724_b0125","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nprot.2008.214","article-title":"Immunodesign of experimental sepsis by cecal ligation and puncture","volume":"4","author":"Rittirsch","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.intimp.2023.109724_b0130","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/359412","article-title":"Isolation, characterization, and transplantation of cardiac endothelial cells","volume":"2013","author":"Pratumvinit","year":"2013","journal-title":"Biomed. Res. Int."},{"issue":"1","key":"10.1016\/j.intimp.2023.109724_b0135","doi-asserted-by":"crossref","first-page":"C67","DOI":"10.1152\/ajpcell.2002.282.1.C67","article-title":"Conditional immortalization of growth factor-responsive cardiac endothelial cells from H-2K(b)-tsA58 mice","volume":"282","author":"Lidington","year":"2002","journal-title":"Am. J. Physiol. Cell. Physiol."},{"issue":"8","key":"10.1016\/j.intimp.2023.109724_b0140","doi-asserted-by":"crossref","first-page":"4616","DOI":"10.1074\/jbc.273.8.4616","article-title":"Role of activating protein-1 in the regulation of the vascular cell adhesion molecule-1 gene expression by tumor necrosis factor-alpha","volume":"273","author":"Ahmad","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"23","key":"10.1016\/j.intimp.2023.109724_b0145","doi-asserted-by":"crossref","first-page":"12749","DOI":"10.3390\/ijms222312749","article-title":"Dexmedetomidine promotes lipopolysaccharide-induced differentiation of cardiac fibroblasts and collagen I\/III synthesis through \u03b12A adrenoreceptor-mediated activation of the PKC-p38-Smad2\/3 signaling pathway in mice","volume":"22","author":"Liao","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.intimp.2023.109724_b0150","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/j.cellsig.2009.04.006","article-title":"Differential involvement of PKC-dependent MAPKs activation in lipopolysaccharide-induced AP-1 expression in human tracheal smooth muscle cells","volume":"21","author":"Lin","year":"2009","journal-title":"Cell Signal."},{"issue":"2","key":"10.1016\/j.intimp.2023.109724_b0155","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1093\/cvr\/cvv217","article-title":"Phosphoinositide 3-kinase gamma controls inflammation-induced myocardial depression via sequential cAMP and iNOS signalling","volume":"108","author":"Ndongson-Dongmo","year":"2015","journal-title":"Cardiovasc. Res."},{"issue":"5","key":"10.1016\/j.intimp.2023.109724_b0160","first-page":"832","article-title":"Presence of intrinsic myocardial systolic and diastolic dysfunction at an early stage of mild sepsis in rats","volume":"33","author":"Tang","year":"2017","journal-title":"Chinese Journal of Pathophysiology"},{"issue":"4","key":"10.1016\/j.intimp.2023.109724_b0165","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/cc12755","article-title":"Evaluation of left ventricular systolic function revisited in septic shock","volume":"17","author":"Repess\u00e9","year":"2013","journal-title":"Crit. Care"},{"key":"10.1016\/j.intimp.2023.109724_b0170","unstructured":"T. Yu, Q. Li, L. Liu, F. Guo, F. Longhini, Y. Yang, H. Qiu, Different effects of propofol and dexmedetomidine on preload dependency in endotoxemic shock with norepinephrine infusion, J."},{"issue":"4","key":"10.1016\/j.intimp.2023.109724_b0175","doi-asserted-by":"crossref","first-page":"R1019","DOI":"10.1152\/ajpregu.00132.2009","article-title":"Endotoxin depresses heart rate variability in mice: cytokine and steroid effects","volume":"297","author":"Fairchild","year":"2009","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"2","key":"10.1016\/j.intimp.2023.109724_b0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0004414","article-title":"Upregulation of phagocyte-derived catecholamines augments the acute inflammatory, response","volume":"4","author":"Flierl","year":"2009","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.intimp.2023.109724_b0185","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.4049\/jimmunol.145.5.1430","article-title":"Stimulation of alpha-adrenergic receptor augments the production of macrophage-derived tumor necrosis factor","volume":"145","author":"Spengler","year":"1990","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.intimp.2023.109724_b0190","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1084\/jem.20071393","article-title":"Divergent roles of endothelial NF-kappaB in multiple organ injury and bacterial clearance in mouse models of sepsis","volume":"205","author":"Ye","year":"2008","journal-title":"J Exp Med"},{"issue":"4","key":"10.1016\/j.intimp.2023.109724_b0195","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0008-6363(03)00509-1","article-title":"Inhibition of p38 MAPK decreases myocardial TNF-alpha expression and improves myocardial function and survival in endotoxemia","volume":"59","author":"Peng","year":"2003","journal-title":"Cardiovasc. Res."},{"issue":"2","key":"10.1016\/j.intimp.2023.109724_b0200","doi-asserted-by":"crossref","first-page":"R477","DOI":"10.1152\/ajpregu.00034.2002","article-title":"ICAM-1 and VCAM-1 mediate endotoxemic myocardial dysfunction independent of neutrophil accumulation","volume":"283","author":"Raeburn","year":"2002","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"15","key":"10.1016\/j.intimp.2023.109724_b0205","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1056\/NEJMoa2024922","article-title":"ENDS2 Study Investigators, Dexmedetomidine or propofol for sedation in mechanically ventilated adults with sepsis","volume":"384","author":"Hughes","year":"2021","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.intimp.2023.109724_b0210","first-page":"386","article-title":"Midazolam and dexmedetomidine sedation impair systolic heart function","volume":"122","author":"Omran","year":"2021","journal-title":"Bratisl. Lek. Listy"},{"issue":"2","key":"10.1016\/j.intimp.2023.109724_b0215","doi-asserted-by":"crossref","first-page":"137","DOI":"10.2174\/1574886315666200427120322","article-title":"Adverse drug reaction monitoring and reporting among physicians and pharmacists in Pakistan: A cross-sectional study","volume":"15","author":"Nisa","year":"2020","journal-title":"Curr. Drug. Saf."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923000474?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923000474?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T12:07:50Z","timestamp":1719230870000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576923000474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":43,"alternative-id":["S1567576923000474"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2023.109724","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Posttreatment with dexmedetomidine aggravates LPS-induced myocardial dysfunction partly via activating cardiac endothelial \u03b12A-AR in mice","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2023.109724","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109724"}}