{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T03:53:42Z","timestamp":1785556422236,"version":"3.56.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100021524","name":"School of Life Sciences and Biotechnology Division of Life Sciences, Korea University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021524","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872877"],"award-info":[{"award-number":["81872877"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104179"],"award-info":[{"award-number":["82104179"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271838"],"award-info":[{"award-number":["82271838"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008048","name":"Nanjing University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.intimp.2023.109810","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T20:15:08Z","timestamp":1676060108000},"page":"109810","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Purine metabolites promote ectopic new bone formation in ankylosing spondylitis"],"prefix":"10.1016","volume":"116","author":[{"given":"Shuqiong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhidan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijun","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiguo","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1425-0089","authenticated-orcid":false,"given":"Yang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenli","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9570","key":"10.1016\/j.intimp.2023.109810_b0005","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/S0140-6736(07)60635-7","article-title":"Ankylosing spondylitis","volume":"369","author":"Braun","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.intimp.2023.109810_b0010","first-page":"iii8-18","article-title":"Ankylosing spondylitis: an overview","volume":"61 Suppl 3","author":"Sieper","year":"2002","journal-title":"Ann. Rheum. Dis."},{"issue":"4","key":"10.1016\/j.intimp.2023.109810_b0015","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.semarthrit.2006.08.003","article-title":"Ankylosing spondylitis: a contemporary perspective on diagnosis and treatment","volume":"36","author":"Mansour","year":"2007","journal-title":"Semin. Arthritis Rheum."},{"issue":"13","key":"10.1016\/j.intimp.2023.109810_b0020","first-page":"1303","article-title":"Ankylosing Spondylitis and Axial Spondyloarthritis","volume":"375","author":"Taurog","year":"2016","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.intimp.2023.109810_b0025","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1002\/art.20990","article-title":"The challenge of diagnosis and classification in early ankylosing spondylitis: do we need new criteria?","volume":"52","author":"Rudwaleit","year":"2005","journal-title":"Arthritis Rheum."},{"issue":"4","key":"10.1016\/j.intimp.2023.109810_b0030","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/art.1780270401","article-title":"Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria","volume":"27","author":"van der Linden","year":"1984","journal-title":"Arthritis Rheum"},{"issue":"5","key":"10.1016\/j.intimp.2023.109810_b0035","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s11926-006-0061-z","article-title":"Mechanisms of pathologic new bone formation","volume":"8","author":"de Vlam","year":"2006","journal-title":"Curr. Rheumatol. Rep."},{"issue":"3","key":"10.1016\/j.intimp.2023.109810_b0040","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.rdc.2017.04.006","article-title":"Genetics and the causes of ankylosing spondylitis","volume":"43","author":"Hanson","year":"2017","journal-title":"Rheum. Dis. Clin. North Am."},{"key":"10.1016\/j.intimp.2023.109810_b0045","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.603726","article-title":"Perspectives on the genetic associations of ankylosing spondylitis","volume":"12","author":"Wordsworth","year":"2021","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2023.109810_b0050","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/art.38291","article-title":"Review: The interleukin-23\/interleukin-17 axis in spondyloarthritis pathogenesis: Th17 and beyond","volume":"66","author":"Smith","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.intimp.2023.109810_b0055","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41413-019-0057-8","article-title":"Ankylosing spondylitis: etiology, pathogenesis, and treatments","volume":"7","author":"Zhu","year":"2019","journal-title":"Bone Res."},{"issue":"3","key":"10.1016\/j.intimp.2023.109810_b0060","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1093\/rheumatology\/key128","article-title":"Modified stoke ankylosing spondylitis spinal score as an outcome measure to assess the impact of treatment on structural progression in ankylosing spondylitis","volume":"58","author":"van der Heijde","year":"2019","journal-title":"Rheumatology (Oxford)"},{"issue":"2","key":"10.1016\/j.intimp.2023.109810_b0065","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/art.40759","article-title":"Ustekinumab fails to show efficacy in a phase III axial spondyloarthritis program: the importance of negative results","volume":"71","author":"Mease","year":"2019","journal-title":"Arthritis Rheumatol."},{"issue":"26","key":"10.1016\/j.intimp.2023.109810_b0070","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1056\/NEJMoa1505066","article-title":"Secukinumab, an Interleukin-17A Inhibitor, in Ankylosing Spondylitis","volume":"373","author":"Baeten","year":"2015","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.intimp.2023.109810_b0075","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1002\/art.39298","article-title":"American college of rheumatology\/spondylitis association of america\/spondyloarthritis research and treatment network 2015 recommendations for the treatment of ankylosing spondylitis and nonradiographic axial spondyloarthritis","volume":"68","author":"Ward","year":"2016","journal-title":"Arthritis Rheumatol."},{"issue":"9","key":"10.1016\/j.intimp.2023.109810_b0080","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s11926-017-0679-z","article-title":"Wnt\/beta-catenin Signaling in osteoarthritis and in other forms of arthritis","volume":"19","author":"Zhou","year":"2017","journal-title":"Curr. Rheumatol. Rep."},{"issue":"6","key":"10.1016\/j.intimp.2023.109810_b0085","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1007\/s10067-014-2663-6","article-title":"Wnt signaling in ankylosing spondylitis","volume":"33","author":"Corr","year":"2014","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.intimp.2023.109810_b0090","doi-asserted-by":"crossref","first-page":"16009","DOI":"10.1038\/boneres.2016.9","article-title":"TGF-beta and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease","volume":"4","author":"Wu","year":"2016","journal-title":"Bone Res."},{"issue":"1","key":"10.1016\/j.intimp.2023.109810_b0095","doi-asserted-by":"crossref","first-page":"6540","DOI":"10.1038\/s41467-021-26750-6","article-title":"Targeting chondrocytes for arresting bony fusion in ankylosing spondylitis","volume":"12","author":"Shao","year":"2021","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.intimp.2023.109810_b0100","doi-asserted-by":"crossref","DOI":"10.3390\/jdb4020020","article-title":"Hedgehog signaling in endochondral ossification","volume":"4","author":"Ohba","year":"2016","journal-title":"J Dev Biol"},{"key":"10.1016\/j.intimp.2023.109810_b0105","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.50208","article-title":"Activation of hedgehog signaling in mesenchymal stem cells induces cartilage and bone tumor formation via Wnt\/beta-Catenin","volume":"8","author":"Deng","year":"2019","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.intimp.2023.109810_b0110","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/s41392-022-01038-3","article-title":"Targeting protein phosphatases for the treatment of inflammation-related diseases: From signaling to therapy","volume":"7","author":"Pan","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"issue":"3","key":"10.1016\/j.intimp.2023.109810_b0115","doi-asserted-by":"crossref","first-page":"e14455","DOI":"10.15252\/emmm.202114455","article-title":"Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis","volume":"14","author":"Zhu","year":"2022","journal-title":"EMBO Mol. Med."},{"issue":"2","key":"10.1016\/j.intimp.2023.109810_b0120","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.apsb.2018.08.009","article-title":"SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade","volume":"9","author":"Zhao","year":"2019","journal-title":"Acta Pharm. Sin. B"},{"issue":"1","key":"10.1016\/j.intimp.2023.109810_b0125","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.apsb.2021.08.006","article-title":"Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in colon cancer by single-cell transcriptomics","volume":"12","author":"Gao","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"issue":"3","key":"10.1016\/j.intimp.2023.109810_b0130","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1002\/art.41988","article-title":"SH2 domain-containing phosphatase 2 inhibition attenuates osteoarthritis by maintaining homeostasis of cartilage metabolism via the docking protein 1\/uridine phosphorylase 1\/uridine cascade","volume":"74","author":"Liu","year":"2022","journal-title":"Arthritis Rheumatol."},{"issue":"31","key":"10.1016\/j.intimp.2023.109810_b0135","doi-asserted-by":"crossref","first-page":"10842","DOI":"10.1074\/jbc.RA119.011840","article-title":"Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet-induced hepatic steatosis and insulin resistance by elevating IL-18 levels","volume":"295","author":"Liu","year":"2020","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.intimp.2023.109810_b0140","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s41392-021-00474-x","article-title":"SHP2-mediated mitophagy boosted by lovastatin in neuronal cells alleviates parkinsonism in mice","volume":"6","author":"Liu","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.intimp.2023.109810_b0145","doi-asserted-by":"crossref","unstructured":"Y. Ding, Z. Ouyang, C. Zhang, Y. Zhu, Q. Xu, H. Sun, J. Qu, Y. Sun, Tyrosine phosphatase SHP2 exacerbates psoriasis-like skin inflammation in mice via ERK5-dependent NETosis, MedComm (2020) 3(1) (2022) e120.","DOI":"10.1002\/mco2.120"},{"issue":"4","key":"10.1016\/j.intimp.2023.109810_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.104009","article-title":"SHP2 allosteric inhibitor TK-453 alleviates psoriasis-like skin inflammation in mice via inhibition of IL-23\/Th17 axis","volume":"25","author":"Wang","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.intimp.2023.109810_b0155","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.3389\/fimmu.2017.01326","article-title":"Ptpn11 deletion in CD4(+) cells does not affect T cell development and functions but causes cartilage tumors in a T cell-independent manner","volume":"8","author":"Miah","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2023.109810_b0160","doi-asserted-by":"crossref","unstructured":"H.K. Kim, O. Aruwajoye, D. Sucato, B.S. Richards, G.S. Feng, D. Chen, P.D. King, N. Kamiya, Induction of SHP2 deficiency in chondrocytes causes severe scoliosis and kyphosis in mice, Spine (Phila Pa 1976) 38(21) (2013) E1307-12.","DOI":"10.1097\/BRS.0b013e3182a3d370"},{"issue":"3","key":"10.1016\/j.intimp.2023.109810_b0165","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1002\/jbmr.2062","article-title":"Targeted disruption of Shp2 in chondrocytes leads to metachondromatosis with multiple cartilaginous protrusions","volume":"29","author":"Kim","year":"2014","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.intimp.2023.109810_b0170","article-title":"Juvenile spondyloarthritis: what more do we know about HLA-B27, Enthesitis, and new bone formation?","volume":"8","author":"Tay","year":"2021","journal-title":"Front Med (Lausanne)"},{"issue":"18","key":"10.1016\/j.intimp.2023.109810_b0175","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21186665","article-title":"Hedgehog signaling in skeletal development: roles of indian hedgehog and the mode of its action","volume":"21","author":"Ohba","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"7459","key":"10.1016\/j.intimp.2023.109810_b0180","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nature12396","article-title":"Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling","volume":"499","author":"Yang","year":"2013","journal-title":"Nature"},{"issue":"52","key":"10.1016\/j.intimp.2023.109810_b0185","doi-asserted-by":"crossref","first-page":"20200","DOI":"10.1074\/jbc.RA118.004751","article-title":"Parathyroid hormone(1\u201334) and its analogs differentially modulate osteoblastic Rankl expression via PKA\/SIK2\/SIK3 and PP1\/PP2A-CRTC3 signaling","volume":"293","author":"Ricarte","year":"2018","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.intimp.2023.109810_b0190","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1007\/s00774-021-01232-3","article-title":"FSH modulated cartilage ECM metabolism by targeting the PKA\/CREB\/SOX9 pathway","volume":"39","author":"Zhang","year":"2021","journal-title":"J. Bone Miner. Metab."},{"issue":"3","key":"10.1016\/j.intimp.2023.109810_b0195","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1002\/jcp.24171","article-title":"An activator of the cAMP\/PKA\/CREB pathway promotes osteogenesis from human mesenchymal stem cells","volume":"228","author":"Kim","year":"2013","journal-title":"J. Cell. Physiol."},{"issue":"6","key":"10.1016\/j.intimp.2023.109810_b0200","doi-asserted-by":"crossref","DOI":"10.3390\/nu9060588","article-title":"Osthole enhances osteogenesis in osteoblasts by elevating transcription factor osterix via cAMP\/CREB signaling in vitro and in vivo","volume":"9","author":"Zhang","year":"2017","journal-title":"Nutrients"},{"issue":"9","key":"10.1016\/j.intimp.2023.109810_b0205","doi-asserted-by":"crossref","first-page":"8120","DOI":"10.18632\/aging.103129","article-title":"Neuropeptide Y1 receptor antagonist promotes osteoporosis and microdamage repair and enhances osteogenic differentiation of bone marrow stem cells via cAMP\/PKA\/CREB pathway","volume":"12","author":"Xie","year":"2020","journal-title":"Aging (Albany NY)"},{"issue":"7602","key":"10.1016\/j.intimp.2023.109810_b0210","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/nature17668","article-title":"Activation of the A2A adenosine G-protein-coupled receptor by conformational selection","volume":"533","author":"Ye","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2023.109810_b0215","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1146\/annurev.pharmtox.40.1.563","article-title":"Pharmacology of cloned P2X receptors","volume":"40","author":"North","year":"2000","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.intimp.2023.109810_b0220","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.biopha.2018.05.097","article-title":"Role of innate immune system in the pathogenesis of ankylosing spondylitis","volume":"105","author":"Vanaki","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"5","key":"10.1016\/j.intimp.2023.109810_b0225","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1002\/art.41180","article-title":"Negative regulation of osteoclast commitment by intracellular protein phosphatase magnesium-dependent 1A","volume":"72","author":"Kwon","year":"2020","journal-title":"Arthritis Rheumatol."},{"issue":"7","key":"10.1016\/j.intimp.2023.109810_b0230","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1002\/art.40468","article-title":"inflammation intensity-dependent expression of osteoinductive Wnt proteins is critical for ectopic new bone formation in ankylosing spondylitis","volume":"70","author":"Li","year":"2018","journal-title":"Arthritis Rheumatol."},{"issue":"12","key":"10.1016\/j.intimp.2023.109810_b0235","doi-asserted-by":"crossref","first-page":"e12109","DOI":"10.15252\/emmm.202012109","article-title":"Aberrant upregulation of CaSR promotes pathological new bone formation in ankylosing spondylitis","volume":"12","author":"Li","year":"2020","journal-title":"EMBO Mol. Med."},{"issue":"14","key":"10.1016\/j.intimp.2023.109810_b0240","doi-asserted-by":"crossref","first-page":"eabl8054","DOI":"10.1126\/sciadv.abl8054","article-title":"CXCL12\/CXCR4-Rac1-mediated migration of osteogenic precursor cells contributes to pathological new bone formation in ankylosing spondylitis","volume":"8","author":"Cui","year":"2022","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.intimp.2023.109810_b0245","doi-asserted-by":"crossref","first-page":"5373","DOI":"10.1038\/s41467-021-25710-4","article-title":"TNF-alpha-mediated m(6)A modification of ELMO1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis","volume":"12","author":"Xie","year":"2021","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.intimp.2023.109810_b0250","doi-asserted-by":"crossref","first-page":"5357","DOI":"10.1172\/JCI125212","article-title":"HLA-B27-mediated activation of TNAP phosphatase promotes pathogenic syndesmophyte formation in ankylosing spondylitis","volume":"129","author":"Liu","year":"2019","journal-title":"J. Clin. Invest."},{"issue":"23","key":"10.1016\/j.intimp.2023.109810_b0255","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.2106\/JBJS.22.00947","article-title":"What's new in musculoskeletal basic science","volume":"104","author":"Gugala","year":"2022","journal-title":"J. Bone Joint Surg. Am."},{"issue":"6","key":"10.1016\/j.intimp.2023.109810_b0260","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1172\/JCI23738","article-title":"Modulation of bone morphogenetic protein signaling inhibits the onset and progression of ankylosing enthesitis","volume":"115","author":"Lories","year":"2005","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.intimp.2023.109810_b0265","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1136\/annrheumdis-2011-200216","article-title":"High level of functional dickkopf-1 predicts protection from syndesmophyte formation in patients with ankylosing spondylitis","volume":"71","author":"Heiland","year":"2012","journal-title":"Ann. Rheum. Dis."},{"issue":"6","key":"10.1016\/j.intimp.2023.109810_b0270","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.semarthrit.2015.01.004","article-title":"Anti-TNFalpha treatment decreases the previously increased serum Indian Hedgehog levels in patients with ankylosing spondylitis and affects the expression of functional Hedgehog pathway target genes","volume":"44","author":"Daoussis","year":"2015","journal-title":"Semin. Arthritis Rheum."},{"issue":"8","key":"10.1016\/j.intimp.2023.109810_b0275","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1136\/annrheumdis-2016-210886","article-title":"Tracking JAKs in spondyloarthritis: rationale and expectations","volume":"76","author":"Miceli-Richard","year":"2017","journal-title":"Ann. Rheum. Dis."},{"issue":"1","key":"10.1016\/j.intimp.2023.109810_b0280","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41413-021-00140-6","article-title":"Chondrogenesis mediates progression of ankylosing spondylitis through heterotopic ossification","volume":"9","author":"Yu","year":"2021","journal-title":"Bone Res."},{"key":"10.1016\/j.intimp.2023.109810_b0285","doi-asserted-by":"crossref","first-page":"9702","DOI":"10.12659\/MSM.918766","article-title":"Serum uric acid shows inverted \u201cU\u201d type correlation with osteoporosis in chinese ankylosing spondylitis patients: a retrospective study","volume":"25","author":"Chen","year":"2019","journal-title":"Med. Sci. Monit."},{"issue":"6","key":"10.1016\/j.intimp.2023.109810_b0290","doi-asserted-by":"crossref","first-page":"968","DOI":"10.3899\/jrheum.140850","article-title":"Low levels of serum uric Acid increase the risk of low bone mineral density in young male patients with ankylosing spondylitis","volume":"42","author":"Kang","year":"2015","journal-title":"J. Rheumatol."},{"issue":"1","key":"10.1016\/j.intimp.2023.109810_b0295","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1186\/s12891-022-05657-3","article-title":"The serum uric acid is longitudinally related to patients global assessment of disease activity in male patients with axial spondyloarthritis","volume":"23","author":"Cai","year":"2022","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.intimp.2023.109810_b0300","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.583105","article-title":"Inhibition of Y1 Receptor promotes osteogenesis in bone marrow stromal cells via cAMP\/PKA\/CREB pathway","volume":"11","author":"Yu","year":"2020","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.intimp.2023.109810_b0305","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1017\/erm.2013.2","article-title":"Differentiation of mesenchymal stem cells to osteoblasts and chondrocytes: a focus on adenosine receptors","volume":"15","author":"Carroll","year":"2013","journal-title":"Expert Rev. Mol. Med."},{"issue":"10","key":"10.1016\/j.intimp.2023.109810_b0310","doi-asserted-by":"crossref","first-page":"e1469","DOI":"10.1038\/cddis.2014.444","article-title":"Identification and characterization of the novel Col10a1 regulatory mechanism during chondrocyte hypertrophic differentiation","volume":"5","author":"Gu","year":"2014","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.intimp.2023.109810_b0315","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.97903","article-title":"PTHrP targets HDAC4 and HDAC5 to repress chondrocyte hypertrophy","volume":"4","author":"Nishimori","year":"2019","journal-title":"JCI Insight"},{"issue":"1","key":"10.1016\/j.intimp.2023.109810_b0320","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/jcp.22013","article-title":"Impact of growth factors and PTHrP on early and late chondrogenic differentiation of human mesenchymal stem cells","volume":"223","author":"Weiss","year":"2010","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.intimp.2023.109810_b0325","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41413-018-0013-z","article-title":"SHP2 regulates skeletal cell fate by modifying SOX9 expression and transcriptional activity","volume":"6","author":"Zuo","year":"2018","journal-title":"Bone Res."},{"issue":"1","key":"10.1016\/j.intimp.2023.109810_b0330","doi-asserted-by":"crossref","first-page":"12699","DOI":"10.1038\/s41598-017-12767-9","article-title":"SHP2 regulates the osteogenic fate of growth plate hypertrophic chondrocytes","volume":"7","author":"Wang","year":"2017","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.intimp.2023.109810_b0335","doi-asserted-by":"crossref","first-page":"e1004364","DOI":"10.1371\/journal.pgen.1004364","article-title":"SHP2 regulates chondrocyte terminal differentiation, growth plate architecture and skeletal cell fates","volume":"10","author":"Bowen","year":"2014","journal-title":"PLoS Genet."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923001339?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923001339?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T12:24:02Z","timestamp":1719231842000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576923001339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":67,"alternative-id":["S1567576923001339"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2023.109810","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Purine metabolites promote ectopic new bone formation in ankylosing spondylitis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2023.109810","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109810"}}