{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T19:14:15Z","timestamp":1793128455034,"version":"4.5.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400309"],"award-info":[{"award-number":["81400309"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671957"],"award-info":[{"award-number":["81671957"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873951"],"award-info":[{"award-number":["81873951"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2701700"],"award-info":[{"award-number":["2021YFC2701700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.intimp.2023.109902","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T13:41:30Z","timestamp":1677073290000},"page":"109902","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["EGFR-TNFR1 pathway in endothelial cell facilitates acute lung injury by NF-\u03baB\/MAPK-mediated inflammation and RIP3-dependent necroptosis"],"prefix":"10.1016","volume":"117","author":[{"given":"Huiling","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuedi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxiu","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Change","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaodong","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziying","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiushuang","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichun","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.intimp.2023.109902_b0005","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1023\/B:IFLA.0000049049.81688.fe","article-title":"Systemic inflammation and disseminated intravascular coagulation in early stage of ALI and ARDS: role of neutrophil and endothelial activation","volume":"28","author":"Gando","year":"2004","journal-title":"Inflammation"},{"key":"10.1016\/j.intimp.2023.109902_b0010","doi-asserted-by":"crossref","unstructured":"Y. Imai, T. Kawano, S. Iwamoto, S. Nakagawa, M. Takata, K. Miyasaka K, Intratracheal anti-tumor necrosis factor-alpha antibody attenuates ventilator-induced lung injury in rabbits, J. Appl. Physiol. (1985) 87(2) (1999) 510\u2013515.","DOI":"10.1152\/jappl.1999.87.2.510"},{"issue":"1","key":"10.1016\/j.intimp.2023.109902_b0015","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1001\/jama.282.1.54","article-title":"Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial","volume":"282","author":"Ranieri","year":"1999","journal-title":"J. Am. Med. Assoc."},{"issue":"4","key":"10.1016\/j.intimp.2023.109902_b0020","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/0092-8674(94)90532-0","article-title":"A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor","volume":"78","author":"Rothe","year":"1994","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.intimp.2023.109902_b0025","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/0092-8674(95)90070-5","article-title":"The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation","volume":"81","author":"Hsu","year":"1995","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.intimp.2023.109902_b0030","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S1074-7613(00)80252-6","article-title":"TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex","volume":"4","author":"Hsu","year":"1996","journal-title":"Immunity"},{"issue":"7","key":"10.1016\/j.intimp.2023.109902_b0035","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0092-8674(00)80889-2","article-title":"A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction","volume":"101","author":"Park","year":"2000","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.intimp.2023.109902_b0040","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2008.03.036","article-title":"TNF-alpha induces two distinct caspase-8 activation pathways","volume":"133","author":"Wang","year":"2008","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.intimp.2023.109902_b0045","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0092-8674(03)00521-X","article-title":"Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes","volume":"114","author":"Micheau","year":"2003","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.intimp.2023.109902_b0050","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nchembio.83","article-title":"Identification of RIP1 kinase as a specific cellular target of necrostatins","volume":"4","author":"Degterev","year":"2008","journal-title":"Nat. Chem. Biol."},{"issue":"6","key":"10.1016\/j.intimp.2023.109902_b0055","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.cell.2009.05.021","article-title":"Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha","volume":"137","author":"He","year":"2009","journal-title":"Cell"},{"issue":"1\u20132","key":"10.1016\/j.intimp.2023.109902_b0060","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.cell.2011.11.031","article-title":"Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase","volume":"148","author":"Sun","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2023.109902_b0065","first-page":"141","article-title":"TNF in the inflammatory response","volume":"74","author":"Mannel","year":"2000","journal-title":"Chem. Immunol."},{"issue":"9107","key":"10.1016\/j.intimp.2023.109902_b0070","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0140-6736(05)60602-2","article-title":"Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock. NORASEPT II Study Group","volume":"351","author":"Abraham","year":"1998","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.intimp.2023.109902_b0075","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1097\/CCM.0000000000000043","article-title":"Evaluating the efficacy and safety of two doses of the polyclonal anti-tumor necrosis factor-alpha fragment antibody AZD9773 in adult patients with severe sepsis and\/or septic shock: randomized, double-blind, placebo-controlled phase IIb study*","volume":"42","author":"Bernard","year":"2014","journal-title":"Crit. Care Med."},{"issue":"4","key":"10.1016\/j.intimp.2023.109902_b0080","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/01.shk.0000157301.87051.77","article-title":"Opposing effects of tumor necrosis factor receptor 1 and 2 in sepsis due to cecal ligation and puncture","volume":"23","author":"Ebach","year":"2005","journal-title":"Shock"},{"key":"10.1016\/j.intimp.2023.109902_b0085","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.3389\/fimmu.2019.02574","article-title":"A study of cecal ligation and puncture-induced sepsis in tissue-specific tumor necrosis factor receptor 1-deficient mice","volume":"10","author":"Vandewalle","year":"2019","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.intimp.2023.109902_b0090","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1136\/thoraxjnl-2017-210305","article-title":"Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury","volume":"73","author":"Proudfoot","year":"2018","journal-title":"Thorax"},{"issue":"2","key":"10.1016\/j.intimp.2023.109902_b0095","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22020587","article-title":"Updated insights on EGFR signaling pathways in glioma","volume":"22","author":"Oprita","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.intimp.2023.109902_b0100","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1038\/nn.4584","article-title":"A TNF-JNK-Axl-ERK signaling axis mediates primary resistance to EGFR inhibition in glioblastoma","volume":"20","author":"Guo","year":"2017","journal-title":"Nat. Neurosci."},{"issue":"11","key":"10.1016\/j.intimp.2023.109902_b0105","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.15252\/embr.201540337","article-title":"EGFR kinase activity is required for TLR4 signaling and the septic shock response","volume":"16","author":"Chattopadhyay","year":"2015","journal-title":"EMBO Rep."},{"issue":"2","key":"10.1016\/j.intimp.2023.109902_b0110","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s13238-019-00668-8","article-title":"EGFR signaling augments TLR4 cell surface expression and function in macrophages via regulation of Rab5a activation","volume":"11","author":"Tang","year":"2020","journal-title":"Protein Cell"},{"key":"10.1016\/j.intimp.2023.109902_b0115","article-title":"EGFR promotes the apoptosis of CD4(+) T lymphocytes through TBK1\/Glut1 induced Warburg effect in sepsis","author":"Huang","year":"2022","journal-title":"J. Adv. Res."},{"issue":"1","key":"10.1016\/j.intimp.2023.109902_b0120","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s41420-021-00571-4","article-title":"Erlotinib protests against LPS-induced parthanatos through inhibiting macrophage surface TLR4 expression","volume":"7","author":"Xue","year":"2021","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.intimp.2023.109902_b0125","first-page":"3641586","article-title":"Identification of bioactive components of stephania epigaea Lo and their potential therapeutic targets by UPLC-MS\/MS and network pharmacology","volume":"2022","author":"Li","year":"2022","journal-title":"Evid. Based Complement. Alternat. Med."},{"issue":"2","key":"10.1016\/j.intimp.2023.109902_b0130","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/jcmm.16117","article-title":"Anti-coronavirus disease 2019 (COVID-19) targets and mechanisms of puerarin","volume":"25","author":"Qin","year":"2021","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.intimp.2023.109902_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2020.104046","article-title":"In silico drug discovery of major metabolites from spices as SARS-CoV-2 main protease inhibitors","volume":"126","author":"Ibrahim","year":"2020","journal-title":"Comput. Biol. Med."},{"issue":"11","key":"10.1016\/j.intimp.2023.109902_b0140","doi-asserted-by":"crossref","first-page":"9268","DOI":"10.1074\/jbc.M110.179903","article-title":"The epidermal growth factor receptor mediates tumor necrosis factor-alpha-induced activation of the ERK\/GEF-H1\/RhoA pathway in tubular epithelium","volume":"286","author":"Kakiashvili","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.intimp.2023.109902_b0145","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jaci.2003.09.040","article-title":"Induction of the epidermal growth factor receptor and its ligands in nasal epithelium by ozone","volume":"113","author":"Polosa","year":"2004","journal-title":"J. Allergy Clin. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2023.109902_b0150","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1165\/rcmb.2009-0210ST","article-title":"Acute lung injury in animals study G: An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals","volume":"44","author":"Matute-Bello","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"5573","key":"10.1016\/j.intimp.2023.109902_b0155","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1126\/science.1071924","article-title":"TNF-R1 signaling: a beautiful pathway","volume":"296","author":"Chen","year":"2002","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.intimp.2023.109902_b0160","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/sj.cdd.4401189","article-title":"Tumor necrosis factor signaling","volume":"10","author":"Wajant","year":"2003","journal-title":"Cell Death Differ."},{"issue":"3","key":"10.1016\/j.intimp.2023.109902_b0165","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.immuni.2004.08.017","article-title":"Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesicles","volume":"21","author":"Schneider-Brachert","year":"2004","journal-title":"Immunity"},{"issue":"9","key":"10.1016\/j.intimp.2023.109902_b0170","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/nri1184","article-title":"Signalling pathways of the TNF superfamily: a double-edged sword","volume":"3","author":"Aggarwal","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.intimp.2023.109902_b0175","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1146\/annurev-biochem-060815-014830","article-title":"Necroptosis and Inflammation","volume":"85","author":"Newton","year":"2016","journal-title":"Annu. Rev. Biochem"},{"issue":"11","key":"10.1016\/j.intimp.2023.109902_b0180","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1172\/JCI23771","article-title":"Inhibition of TNF receptor 1 internalization by adenovirus 14.7K as a novel immune escape mechanism","volume":"116","author":"Schneider-Brachert","year":"2006","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.intimp.2023.109902_b0185","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.molcel.2008.11.023","article-title":"PKC phosphorylation of TRAF2 mediates IKKalpha\/beta recruitment and K63-linked polyubiquitination","volume":"33","author":"Li","year":"2009","journal-title":"Mol. Cell"},{"issue":"2","key":"10.1016\/j.intimp.2023.109902_b0190","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1161\/01.ATV.0000152114.00114.d8","article-title":"Superoxide dismutase inhibits the expression of vascular cell adhesion molecule-1 and intracellular cell adhesion molecule-1 induced by tumor necrosis factor-alpha in human endothelial cells through the JNK\/p38 pathways","volume":"25","author":"Lin","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"1","key":"10.1016\/j.intimp.2023.109902_b0195","doi-asserted-by":"crossref","first-page":"531","DOI":"10.4049\/jimmunol.175.1.531","article-title":"TNF-related activation-induced cytokine enhances leukocyte adhesiveness: induction of ICAM-1 and VCAM-1 via TNF receptor-associated factor and protein kinase C-dependent NF-kappaB activation in endothelial cells","volume":"175","author":"Min","year":"2005","journal-title":"J. Immunol."},{"issue":"8","key":"10.1016\/j.intimp.2023.109902_b0200","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1042\/BC20050091","article-title":"Xenopus death-domain-containing proteins FADD and RIP1 synergistically activate JNK and NF-kappaB","volume":"98","author":"Ishizawa","year":"2006","journal-title":"Biol. Cell"},{"issue":"9","key":"10.1016\/j.intimp.2023.109902_b0205","doi-asserted-by":"crossref","first-page":"E2001","DOI":"10.1073\/pnas.1722013115","article-title":"Death-domain dimerization-mediated activation of RIPK1 controls necroptosis and RIPK1-dependent apoptosis","volume":"115","author":"Meng","year":"2018","journal-title":"PNAS"},{"issue":"9","key":"10.1016\/j.intimp.2023.109902_b0210","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1038\/cdd.2016.46","article-title":"RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury","volume":"23","author":"Newton","year":"2016","journal-title":"Cell Death Differ."},{"issue":"4","key":"10.1016\/j.intimp.2023.109902_b0215","doi-asserted-by":"crossref","first-page":"807","DOI":"10.14336\/AD.2018.0728","article-title":"Necrostatin-1 prevents necroptosis in brains after ischemic stroke via inhibition of RIPK1-mediated RIPK3\/MLKL signaling","volume":"10","author":"Deng","year":"2019","journal-title":"Aging Dis."},{"issue":"4","key":"10.1016\/j.intimp.2023.109902_b0220","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/0006-2952(89)90208-6","article-title":"Tumor necrosis factor is a terminal mediator in galactosamine\/endotoxin-induced hepatitis in mice","volume":"38","author":"Tiegs","year":"1989","journal-title":"Biochem. Pharmacol."},{"issue":"26","key":"10.1016\/j.intimp.2023.109902_b0225","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1056\/NEJMcp052699","article-title":"Clinical practice. Acute pulmonary edema","volume":"353","author":"Ware","year":"2005","journal-title":"N. Engl. J. Med."},{"issue":"3\u20134","key":"10.1016\/j.intimp.2023.109902_b0230","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2119\/molmed.2010.00138","article-title":"Contribution of neutrophils to acute lung injury","volume":"17","author":"Grommes","year":"2011","journal-title":"Mol. Med."},{"issue":"1","key":"10.1016\/j.intimp.2023.109902_b0235","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/s10753-014-0028-6","article-title":"Lapatinib ameliorates experimental arthritis in rats","volume":"38","author":"Ozgen","year":"2015","journal-title":"Inflammation"},{"issue":"3","key":"10.1016\/j.intimp.2023.109902_b0240","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.4049\/jimmunol.1300133","article-title":"Activation of the epidermal growth factor receptor in macrophages regulates cytokine production and experimental colitis","volume":"192","author":"Lu","year":"2014","journal-title":"J. Immunol."},{"issue":"33","key":"10.1016\/j.intimp.2023.109902_b0245","doi-asserted-by":"crossref","first-page":"34530","DOI":"10.1074\/jbc.M405703200","article-title":"Epidermal growth factor receptor transactivation mediates tumor necrosis factor-induced hepatocyte replication","volume":"279","author":"Argast","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"34","key":"10.1016\/j.intimp.2023.109902_b0250","doi-asserted-by":"crossref","first-page":"35478","DOI":"10.18632\/oncotarget.6071","article-title":"The activation of EGFR promotes myocardial tumor necrosis factor-alpha production and cardiac failure in endotoxemia","volume":"6","author":"Sun","year":"2015","journal-title":"Oncotarget"},{"issue":"9","key":"10.1016\/j.intimp.2023.109902_b0255","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1210\/endo.138.9.5389","article-title":"The epidermal growth factor receptor is not required for tumor necrosis factor-alpha action in normal mammary epithelial cells","volume":"138","author":"Varela","year":"1997","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.intimp.2023.109902_b0260","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41467-017-00406-w","article-title":"Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis","volume":"8","author":"Geng","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2023.109902_b0265","doi-asserted-by":"crossref","unstructured":"F. Yan, H. Cao, R. Chaturvedi, U. Krishna, S.S. Hobbs, P.J. Dempsey, R.M. Peek, Jr., T.L. Cover, M.K. Washington, K.T. Wilson et al., Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis, Gastroenterology 136(4) (2009) 1297-1307, e1291-1293.","DOI":"10.1053\/j.gastro.2008.12.059"},{"issue":"16","key":"10.1016\/j.intimp.2023.109902_b0270","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20164021","article-title":"Blockade of EGFR activation promotes TNF-induced lung epithelial cell apoptosis and pulmonary injury","volume":"20","author":"Yamaoka","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.intimp.2023.109902_b0275","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1097\/JTO.0b013e31823c5aee","article-title":"EGFR-mutant lung adenocarcinomas treated first-line with the novel EGFR inhibitor, XL647, can subsequently retain moderate sensitivity to erlotinib","volume":"7","author":"Chmielecki","year":"2012","journal-title":"J. Thorac. Oncol."},{"issue":"6","key":"10.1016\/j.intimp.2023.109902_b0280","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1158\/2159-8290.CD-16-0075","article-title":"EGFR fusions as novel therapeutic targets in lung cancer","volume":"6","author":"Konduri","year":"2016","journal-title":"Cancer Discov."},{"issue":"7","key":"10.1016\/j.intimp.2023.109902_b0285","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1158\/0008-5472.CAN-14-1801","article-title":"Adaptive upregulation of EGFR limits attenuation of tumor growth by neutralizing IL6 antibodies, with implications for combined therapy in ovarian cancer","volume":"75","author":"Milagre","year":"2015","journal-title":"Cancer Res."},{"issue":"27","key":"10.1016\/j.intimp.2023.109902_b0290","doi-asserted-by":"crossref","first-page":"3807","DOI":"10.1038\/onc.2017.23","article-title":"EGFR-mediated macrophage activation promotes colitis-associated tumorigenesis","volume":"36","author":"Hardbower","year":"2017","journal-title":"Oncogene"},{"issue":"10","key":"10.1016\/j.intimp.2023.109902_b0295","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1158\/2159-8290.CD-12-0108","article-title":"HER2 amplification: a potential mechanism of acquired resistance to EGFR inhibition in EGFR-mutant lung cancers that lack the second-site EGFRT790M mutation","volume":"2","author":"Takezawa","year":"2012","journal-title":"Cancer Discov."},{"issue":"6","key":"10.1016\/j.intimp.2023.109902_b0300","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1172\/JCI96148","article-title":"TNF-driven adaptive response mediates resistance to EGFR inhibition in lung cancer","volume":"128","author":"Gong","year":"2018","journal-title":"J. Clin. Invest."},{"issue":"12","key":"10.1016\/j.intimp.2023.109902_b0305","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1093\/neuonc\/noz127","article-title":"Efficacy of EGFR plus TNF inhibition in a preclinical model of temozolomide-resistant glioblastoma","volume":"21","author":"Guo","year":"2019","journal-title":"Neuro Oncol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923002229?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923002229?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:48:09Z","timestamp":1761587289000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576923002229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":61,"alternative-id":["S1567576923002229"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2023.109902","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"EGFR-TNFR1 pathway in endothelial cell facilitates acute lung injury by NF-\u03baB\/MAPK-mediated inflammation and RIP3-dependent necroptosis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2023.109902","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109902"}}