{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:56:18Z","timestamp":1793141778457,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100015286","name":"Hebei Provincial Key Research Projects","doi-asserted-by":"publisher","award":["2021BCA147"],"award-info":[{"award-number":["2021BCA147"]}],"id":[{"id":"10.13039\/501100015286","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672154"],"award-info":[{"award-number":["81672154"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272528"],"award-info":[{"award-number":["82272528"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007046","name":"Wuhan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.intimp.2023.110022","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T01:01:29Z","timestamp":1679014889000},"page":"110022","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Gastrodin alleviates rat chondrocyte senescence and mitochondrial dysfunction through Sirt3"],"prefix":"10.1016","volume":"118","author":[{"given":"Yubiao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyi","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sixing","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WenXiang","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YuJian","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4534-3440","authenticated-orcid":false,"given":"Hao","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 120(5)","key":"10.1016\/j.intimp.2023.110022_b0005","first-page":"3","article-title":"Osteoarthritis is a serious disease","volume":"37","author":"Hawker","year":"2019","journal-title":"Clin. Exp. Rheumatol."},{"issue":"7","key":"10.1016\/j.intimp.2023.110022_b0010","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nrrheum.2014.44","article-title":"The individual and socioeconomic impact of osteoarthritis","volume":"10","author":"Hunter","year":"2014","journal-title":"Nat. Rev. Rheumatol."},{"issue":"6","key":"10.1016\/j.intimp.2023.110022_b0015","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1136\/annrheumdis-2019-216515","article-title":"Global, regional and national burden of osteoarthritis 1990\u20132017: a systematic analysis of the Global Burden of Disease Study 2017","volume":"79","author":"Safiri","year":"2020","journal-title":"Ann. Rheum. Dis."},{"issue":"2","key":"10.1016\/j.intimp.2023.110022_b0020","doi-asserted-by":"crossref","first-page":"108","DOI":"10.2174\/1573397113666170829155149","article-title":"Current Treatment Options for Osteoarthritis","volume":"14","author":"Hermann","year":"2018","journal-title":"Curr. Rheumatol. Rev."},{"issue":"10182","key":"10.1016\/j.intimp.2023.110022_b0025","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/S0140-6736(19)30417-9","article-title":"Osteoarthritis","volume":"393","author":"Hunter","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.intimp.2023.110022_b0030","doi-asserted-by":"crossref","first-page":"101413","DOI":"10.1016\/j.arr.2021.101413","article-title":"Cellular senescence in knee osteoarthritis: molecular mechanisms and therapeutic implications","volume":"70","author":"Xie","year":"2021","journal-title":"Ageing Res. Rev."},{"issue":"4","key":"10.1016\/j.intimp.2023.110022_b0035","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1172\/JCI95148","article-title":"Mechanisms and functions of cellular senescence","volume":"128","author":"Herranz","year":"2018","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.intimp.2023.110022_b0040","doi-asserted-by":"crossref","first-page":"113836","DOI":"10.1016\/j.addr.2021.113836","article-title":"Extracellular vesicles from mesenchymal stromal cells: Therapeutic perspectives for targeting senescence in osteoarthritis","volume":"175","author":"Boulestreau","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"2","key":"10.1016\/j.intimp.2023.110022_b0045","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/acel.12562","article-title":"Cellular senescence in osteoarthritis pathology","volume":"16","author":"McCulloch","year":"2017","journal-title":"Aging Cell"},{"issue":"4","key":"10.1016\/j.intimp.2023.110022_b0050","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1172\/JCI95147","article-title":"Senescent cells and osteoarthritis: a painful connection","volume":"128","author":"Jeon","year":"2018","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.intimp.2023.110022_b0055","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41584-020-00533-7","article-title":"Mechanisms and therapeutic implications of cellular senescence in osteoarthritis","volume":"17","author":"Coryell","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.intimp.2023.110022_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.joca.2022.01.009","article-title":"Rhoifolin ameliorates osteoarthritis via the Nrf2\/NF-kappaB axis: in vitro and in vivo experiments","author":"Chen","year":"2022","journal-title":"Osteoarthritis Cartilage"},{"issue":"13","key":"10.1016\/j.intimp.2023.110022_b0065","doi-asserted-by":"crossref","first-page":"12750","DOI":"10.18632\/aging.103177","article-title":"Navitoclax (ABT263) reduces inflammation and promotes chondrogenic phenotype by clearing senescent osteoarthritic chondrocytes in osteoarthritis","volume":"12","author":"Yang","year":"2020","journal-title":"Aging (Albany NY)"},{"issue":"1","key":"10.1016\/j.intimp.2023.110022_b0070","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/s13287-020-01708-5","article-title":"Eliminating senescent chondrogenic progenitor cells enhances chondrogenesis under intermittent hydrostatic pressure for the treatment of OA","volume":"11","author":"Dai","year":"2020","journal-title":"Stem Cell Res. Ther."},{"issue":"6","key":"10.1016\/j.intimp.2023.110022_b0075","article-title":"Evidence of TWIST1 and transforming growth factor-B1 aberrant expressions as novel therapeutic targets in modulating the severity of osteoarthritis with focus on biologic agents","volume":"71","author":"Ye","year":"2020","journal-title":"J. Physiol. Pharmacol."},{"issue":"6","key":"10.1016\/j.intimp.2023.110022_b0080","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/s41584-018-0001-0","article-title":"Mitochondrial DNA variation and the pathogenesis of osteoarthritis phenotypes","volume":"14","author":"Blanco","year":"2018","journal-title":"Nat. Rev. Rheumatol."},{"issue":"19","key":"10.1016\/j.intimp.2023.110022_b0085","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.1007\/s00018-020-03497-9","article-title":"The role of SIRT3-mediated mitochondrial homeostasis in osteoarthritis","volume":"77","author":"He","year":"2020","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.intimp.2023.110022_b0095","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.ijbiomac.2021.02.029","article-title":"SIRT3 ameliorates osteoarthritis via regulating chondrocyte autophagy and apoptosis through the PI3K\/Akt\/mTOR pathway","volume":"175","author":"Xu","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"issue":"3","key":"10.1016\/j.intimp.2023.110022_b0105","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.joca.2020.11.006","article-title":"Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2\/NF-kappaB axis","volume":"29","author":"Shao","year":"2021","journal-title":"Osteoarthritis Cartilage"},{"issue":"8","key":"10.1016\/j.intimp.2023.110022_b0110","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.bcp.2013.01.020","article-title":"Gastrodin attenuation of the inflammatory response in H9c2 cardiomyocytes involves inhibition of NF-kappaB and MAPKs activation via the phosphatidylinositol 3-kinase signaling","volume":"85","author":"Yang","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.intimp.2023.110022_b0115","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.biopha.2016.09.106","article-title":"Proliferation-enhancing effects of gastrodin on RSC96 Schwann cells by regulating ERK1\/2 and PI3K signaling pathways","volume":"84","author":"Zuo","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2023.110022_b0120","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.biocel.2019.01.013","article-title":"Gastrodin protects rat cardiomyocytes H9c2 from hypoxia-induced injury by up-regulation of microRNA-21","volume":"109","author":"Xing","year":"2019","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"42","key":"10.1016\/j.intimp.2023.110022_b0130","doi-asserted-by":"crossref","first-page":"5958","DOI":"10.2174\/0929867325666180214123929","article-title":"Herbal Compounds with Special Reference to Gastrodin as Potential Therapeutic Agents for Microglia Mediated Neuroinflammation","volume":"25","author":"Li","year":"2018","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.intimp.2023.110022_b0135","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.biopha.2017.10.067","article-title":"Gastrodin reduces IL-1beta-induced apoptosis, inflammation, and matrix catabolism in osteoarthritis chondrocytes and attenuates rat cartilage degeneration in vivo","volume":"97","author":"Chen","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.intimp.2023.110022_b0145","first-page":"1225","article-title":"Panax notoginseng saponins prevent senescence and inhibit apoptosis by regulating the PI3KAKTmTOR pathway in osteoarthritic chondrocytes","volume":"45","author":"Zhang","year":"2020","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.intimp.2023.110022_b0150","doi-asserted-by":"crossref","first-page":"116941","DOI":"10.1016\/j.lfs.2019.116941","article-title":"Mitochondrial pyruvate carrier 2 mediates mitochondrial dysfunction and apoptosis in high glucose-treated podocytes","volume":"237","author":"Feng","year":"2019","journal-title":"Life Sci."},{"issue":"9","key":"10.1016\/j.intimp.2023.110022_b0155","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1080\/15548627.2020.1822097","article-title":"Mitophagy in degenerative joint diseases","volume":"17","author":"Sun","year":"2021","journal-title":"Autophagy"},{"issue":"6","key":"10.1016\/j.intimp.2023.110022_b0160","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.cell.2012.02.035","article-title":"Mitochondria: in sickness and in health","volume":"148","author":"Nunnari","year":"2012","journal-title":"Cell"},{"issue":"14","key":"10.1016\/j.intimp.2023.110022_b0165","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.7150\/ijbs.46627","article-title":"The Role of Autophagy and Mitophagy in Bone Metabolic Disorders","volume":"16","author":"Wang","year":"2020","journal-title":"Int. J. Biol. Sci."},{"issue":"4","key":"10.1016\/j.intimp.2023.110022_b0170","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.joca.2020.02.027","article-title":"The PI3K\/AKT\/mTOR signaling pathway in osteoarthritis: a narrative review","volume":"28","author":"Sun","year":"2020","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"10.1016\/j.intimp.2023.110022_b0175","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/jcmm.16073","article-title":"Gastrodin prevents homocysteine-induced human umbilical vein endothelial cells injury via PI3K\/Akt\/eNOS and Nrf2\/ARE pathway","volume":"25","author":"Chen","year":"2021","journal-title":"J. Cell Mol. Med."},{"issue":"6","key":"10.1016\/j.intimp.2023.110022_b0180","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1093\/bib\/bby063","article-title":"A brief history of bioinformatics","volume":"20","author":"Gauthier","year":"2019","journal-title":"Brief Bioinform."},{"issue":"6","key":"10.1016\/j.intimp.2023.110022_b0185","doi-asserted-by":"crossref","first-page":"605","DOI":"10.5582\/bst.2018.01263","article-title":"Protective effects of metformin against osteoarthritis through upregulation of SIRT3-mediated PINK1\/Parkin-dependent mitophagy in primary chondrocytes","volume":"12","author":"Wang","year":"2019","journal-title":"Biosci. Trends"},{"issue":"2","key":"10.1016\/j.intimp.2023.110022_b0190","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1002\/jor.23728","article-title":"Effect of biomechanical stress on endogenous antioxidant networks in bovine articular cartilage","volume":"36","author":"Issa","year":"2018","journal-title":"J. Orthopaedic Res.: Offic. Publ. Orthopaedic Res. Soc."},{"issue":"Suppl 3","key":"10.1016\/j.intimp.2023.110022_b0195","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1016\/j.joca.2010.05.030","article-title":"The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the rat","volume":"18","author":"Gerwin","year":"2010","journal-title":"Osteoarthritis Cartilage"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923003430?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923003430?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:49:33Z","timestamp":1761587373000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576923003430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":35,"alternative-id":["S1567576923003430"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2023.110022","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gastrodin alleviates rat chondrocyte senescence and mitochondrial dysfunction through Sirt3","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2023.110022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110022"}}