{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T15:07:06Z","timestamp":1776179226053,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M713539"],"award-info":[{"award-number":["2022M713539"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008111","name":"Hainan Provincial Department of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008111","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2500802"],"award-info":[{"award-number":["2021YFC2500802"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013072","name":"Major Science and Technology Project of Hainan Province","doi-asserted-by":"publisher","award":["ZDYF2020148"],"award-info":[{"award-number":["ZDYF2020148"]}],"id":[{"id":"10.13039\/501100013072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102281"],"award-info":[{"award-number":["82102281"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272207"],"award-info":[{"award-number":["82272207"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.intimp.2023.110024","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T14:54:20Z","timestamp":1679410460000},"page":"110024","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Leukadherin-1 inhibits NLRP3 inflammasome by blocking inflammasome assembly"],"prefix":"10.1016","volume":"118","author":[{"given":"Yening","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiufeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ningjie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songlin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YanJun","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3889-2118","authenticated-orcid":false,"given":"Kai","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2023.110024_b0005","doi-asserted-by":"crossref","unstructured":"Broz P, Dixit VM. Inflammasomes: Mechanism of Assembly, Regulation and Signalling. Nat Rev Immunol (2016) 16(7):407-20. Epub 2016\/06\/14. 10.1038\/nri.2016.58.","DOI":"10.1038\/nri.2016.58"},{"key":"10.1016\/j.intimp.2023.110024_b0010","doi-asserted-by":"crossref","unstructured":"Lamkanfi M, Dixit VM. Mechanisms and Functions of Inflammasomes. Cell (2014) 157(5):1013-2Epub 2014\/05\/27. 10.1016\/j.cell.2014.04.007.","DOI":"10.1016\/j.cell.2014.04.007"},{"key":"10.1016\/j.intimp.2023.110024_b0015","doi-asserted-by":"crossref","unstructured":"Swanson KV, Deng M, Ting JP. The Nlrp3 Inflammasome: Molecular Activation and Regulation to Therapeutics. Nat Rev Immunol (2019) 19(8):477-89. Epub 2019\/05\/01. 10.1038\/s41577-019-0165-0.","DOI":"10.1038\/s41577-019-0165-0"},{"key":"10.1016\/j.intimp.2023.110024_b0020","doi-asserted-by":"crossref","unstructured":"Hoffman HM, Mueller JL, Broide DH, Wanderer AA, Kolodner RD. Mutation of a New Gene Encoding a Putative Pyrin-Like Protein Causes Familial Cold Autoinflammatory Syndrome and Muckle-Wells Syndrome. Nat Genet (2001) 29(3):301-5. Epub 2001\/11\/01. 10.1038\/ng756.","DOI":"10.1038\/ng756"},{"key":"10.1016\/j.intimp.2023.110024_b0025","doi-asserted-by":"crossref","unstructured":"Aksentijevich I, Nowak M, Mallah M, Chae JJ, Watford WT, Hofmann SR, et al. De Novo Cias1 Mutations, Cytokine Activation, and Evidence for Genetic Heterogeneity in Patients with Neonatal-Onset Multisystem Inflammatory Disease (Nomid): A New Member of the Expanding Family of Pyrin-Associated Autoinflammatory Diseases. Arthritis Rheum (2002) 46(12):3340-8. Epub 2002\/12\/17. 10.1002\/art.10688.","DOI":"10.1002\/art.10688"},{"key":"10.1016\/j.intimp.2023.110024_b0030","doi-asserted-by":"crossref","unstructured":"Mariathasan S, Weiss DS, Newton K, McBride J, O'Rourke K, Roose-Girma M, et al. Cryopyrin Activates the Inflammasome in Response to Toxins and Atp. Nature (2006) 440(7081):228-32. Epub 2006\/01\/13. 10.1038\/nature04515.","DOI":"10.1038\/nature04515"},{"key":"10.1016\/j.intimp.2023.110024_b0035","doi-asserted-by":"crossref","unstructured":"Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J. Gout-Associated Uric Acid Crystals Activate the Nalp3 Inflammasome. Nature (2006) 440(7081):237-41. Epub 2006\/01\/13. 10.1038\/nature04516.","DOI":"10.1038\/nature04516"},{"key":"10.1016\/j.intimp.2023.110024_b0040","doi-asserted-by":"crossref","unstructured":"Lee HM, Kim JJ, Kim HJ, Shong M, Ku BJ, Jo EK. Upregulated Nlrp3 Inflammasome Activation in Patients with Type 2 Diabetes. Diabetes (2013) 62(1):194-204. Epub 2012\/10\/23. 10.2337\/db12-0420.","DOI":"10.2337\/db12-0420"},{"key":"10.1016\/j.intimp.2023.110024_b0045","doi-asserted-by":"crossref","unstructured":"Ising C, Venegas C, Zhang S, Scheiblich H, Schmidt SV, Vieira-Saecker A, et al. Nlrp3 Inflammasome Activation Drives Tau Pathology. Nature (2019) 575(7784):669-73. Epub 2019\/11\/22. 10.1038\/s41586-019-1769-z.","DOI":"10.1038\/s41586-019-1769-z"},{"key":"10.1016\/j.intimp.2023.110024_b0050","doi-asserted-by":"crossref","unstructured":"Tang L, Zhou F. Inflammasomes in Common Immune-Related Skin Diseases. Front Immunol (2020) 11:882. Epub 2020\/06\/13. 10.3389\/fimmu.2020.00882.","DOI":"10.3389\/fimmu.2020.00882"},{"key":"10.1016\/j.intimp.2023.110024_b0055","doi-asserted-by":"crossref","unstructured":"Ciazynska M, Olejniczak-Staruch I, Sobolewska-Sztychny D, Narbutt J, Skibinska M, Lesiak A. The Role of Nlrp1, Nlrp3, and Aim2 Inflammasomes in Psoriasis: Review. Int J Mol Sci (2021) 22(11). Epub 2021\/06\/03. 10.3390\/ijms22115898.","DOI":"10.3390\/ijms22115898"},{"key":"10.1016\/j.intimp.2023.110024_b0060","doi-asserted-by":"crossref","unstructured":"Maiguel D, Faridi MH, Wei C, Kuwano Y, Balla KM, Hernandez D, et al. Small Molecule-Mediated Activation of the Integrin Cd11b\/Cd18 Reduces Inflammatory Disease. Sci Signal (2011) 4(189):ra57. Epub 2011\/09\/09. 10.1126\/scisignal.2001811.","DOI":"10.1126\/scisignal.2001811"},{"key":"10.1016\/j.intimp.2023.110024_b0065","doi-asserted-by":"crossref","unstructured":"Celik E, Faridi MH, Kumar V, Deep S, Moy VT, Gupta V. Agonist Leukadherin-1 Increases Cd11b\/Cd18-Dependent Adhesion Via Membrane Tethers. Biophys J (2013) 105(11):2517-27. Epub 2013\/12\/10. 10.1016\/j.bpj.2013.10.020.","DOI":"10.1016\/j.bpj.2013.10.020"},{"key":"10.1016\/j.intimp.2023.110024_b0070","doi-asserted-by":"crossref","unstructured":"DeNardo DG, Galkin A, Dupont J, Zhou L, Bendell J. Gb1275, a First-in-Class Cd11b Modulator: Rationale for Immunotherapeutic Combinations in Solid Tumors. J Immunother Cancer (2021) 9(8). Epub 2021\/08\/29. 10.1136\/jitc-2021-003005.","DOI":"10.1136\/jitc-2021-003005"},{"key":"10.1016\/j.intimp.2023.110024_b0075","doi-asserted-by":"crossref","unstructured":"Schmid MC, Khan SQ, Kaneda MM, Pathria P, Shepard R, Louis TL, et al. Integrin Cd11b Activation Drives Anti-Tumor Innate Immunity. Nat Commun (2018) 9(1):5379. Epub 2018\/12\/21. 10.1038\/s41467-018-07387-4.","DOI":"10.1038\/s41467-018-07387-4"},{"key":"10.1016\/j.intimp.2023.110024_b0080","unstructured":"Lin QY, Bai J, Zhang YL, Li HH. Integrin Cd11b Contributes to Hypertension and Vascular Dysfunction through Mediating Macrophage Adhesion and Migration. Hypertension (2022):101161HYPERTENSIONAHA12220328. Epub 2022\/11\/10.1161\/HYPERTENSIONAHA.122.20328."},{"key":"10.1016\/j.intimp.2023.110024_b0085","doi-asserted-by":"crossref","unstructured":"Kopec AK, Joshi N, Cline-Fedewa H, Wojcicki AV, Ray JL, Sullivan BP, et al. Fibrin(Ogen) Drives Repair after Acetaminophen-Induced Liver Injury Via Leukocyte \u0391(M)\u0392(2) Integrin-Dependent Upregulation of Mmp12. J Hepatol (2017) 66(4):787-97. Epub 2016\/12\/15. 10.1016\/j.jhep.2016.12.004.","DOI":"10.1016\/j.jhep.2016.12.004"},{"key":"10.1016\/j.intimp.2023.110024_b0090","doi-asserted-by":"crossref","unstructured":"Querrey M, Chiu S, Lecuona E, Wu Q, Sun H, Anderson M, et al. Cd11b Suppresses Tlr Activation of Nonclassical Monocytes to Reduce Primary Graft Dysfunction after Lung Transplantation. J Clin Invest (2022) 132(14):e157262. Epub 2022\/07\/16. 10.1172\/jci157262.","DOI":"10.1172\/JCI157262"},{"key":"10.1016\/j.intimp.2023.110024_b0095","doi-asserted-by":"crossref","unstructured":"Zhou M, Wang X, Shi Y, Ding Y, Li X, Xie T, et al. Deficiency of Itgam Attenuates Experimental Abdominal Aortic Aneurysm in Mice. J Am Heart Assoc (2021) 10(7):e019900. Epub 2021\/03\/23. 10.1161\/jaha.120.019900.","DOI":"10.1161\/JAHA.120.019900"},{"issue":"1","key":"10.1016\/j.intimp.2023.110024_b0100","first-page":"1","article-title":"Cd11b Agonist Leukadherin-1 Inhibits Activation of Tlr7 and Tlr9 in Mouse Bone Marrow-Derived Dendritic Cells by Blocking Nf-\u039ab P65 Pathway","volume":"37","author":"Zhai","year":"2021","journal-title":"Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi"},{"key":"10.1016\/j.intimp.2023.110024_b0105","doi-asserted-by":"crossref","unstructured":"Yao X, Dong G, Zhu Y, Yan F, Zhang H, Ma Q, et al. Leukadherin-1-Mediated Activation of Cd11b Inhibits Lps-Induced Pro-Inflammatory Response in Macrophages and Protects Mice against Endotoxic Shock by Blocking Lps-Tlr4 Interaction. Front Immunol (2019) 10:215. Epub 2019\/02\/28. 10.3389\/fimmu.2019.00215.","DOI":"10.3389\/fimmu.2019.00215"},{"key":"10.1016\/j.intimp.2023.110024_b0110","doi-asserted-by":"crossref","unstructured":"Dick MS, Sborgi L, Ruhl S, Hiller S, Broz P. Asc Filament Formation Serves as a Signal Amplification Mechanism for Inflammasomes. Nat Commun (2016) 7:11929. Epub 2016\/06\/23. 10.1038\/ncomms11929.","DOI":"10.1038\/ncomms11929"},{"key":"10.1016\/j.intimp.2023.110024_b0115","doi-asserted-by":"crossref","unstructured":"Fernandes-Alnemri T, Wu J, Yu JW, Datta P, Miller B, Jankowski W, et al. The Pyroptosome: A Supramolecular Assembly of Asc Dimers Mediating Inflammatory Cell Death Via Caspase-1 Activation. Cell Death Differ (2007) 14(9):1590-604. Epub 2007\/06\/30. 10.1038\/sj.cdd.4402194.","DOI":"10.1038\/sj.cdd.4402194"},{"key":"10.1016\/j.intimp.2023.110024_b0120","doi-asserted-by":"crossref","unstructured":"He Y, Zeng MY, Yang D, Motro B, Nunez G. Nek7 Is an Essential Mediator of Nlrp3 Activation Downstream of Potassium Efflux. Nature (2016) 530(7590):354-7. Epub 2016\/01\/28. 10.1038\/nature16959.","DOI":"10.1038\/nature16959"},{"key":"10.1016\/j.intimp.2023.110024_b0125","doi-asserted-by":"crossref","unstructured":"Xian H, Watari K, Sanchez-Lopez E, Offenberger J, Onyuru J, Sampath H, et al. Oxidized DNA Fragments Exit Mitochondria Via Mptp- and Vdac-Dependent Channels to Activate Nlrp3 Inflammasome and Interferon Signaling. Immunity (2022) 55(8):1370-85. Epub 2022\/07\/15. 10.1016\/j.immuni.2022.06.007.","DOI":"10.1016\/j.immuni.2022.06.007"},{"key":"10.1016\/j.intimp.2023.110024_b0130","doi-asserted-by":"crossref","unstructured":"Liu Q, Zhang D, Hu D, Zhou X, Zhou Y. The Role of Mitochondria in Nlrp3 Inflammasome Activation. Mol Immunol (2018) 103:115-24. Epub 2018\/09\/25. 10.1016\/j.molimm.2018.09.010.","DOI":"10.1016\/j.molimm.2018.09.010"},{"key":"10.1016\/j.intimp.2023.110024_b0135","doi-asserted-by":"crossref","unstructured":"Petrilli V, Papin S, Dostert C, Mayor A, Martinon F, Tschopp J. Activation of the Nalp3 Inflammasome Is Triggered by Low Intracellular Potassium Concentration. Cell Death Differ (2007) 14(9):1583-9. Epub 2007\/06\/30. 10.1038\/sj.cdd.4402195.","DOI":"10.1038\/sj.cdd.4402195"},{"key":"10.1016\/j.intimp.2023.110024_b0140","doi-asserted-by":"crossref","unstructured":"Green JP, Yu S, Martin-Sanchez F, Pelegrin P, Lopez-Castejon G, Lawrence CB, et al. Chloride Regulates Dynamic Nlrp3-Dependent Asc Oligomerization and Inflammasome Priming. Proc Natl Acad Sci U S A (2018) 115(40):E9371-E80. Epub 2018\/09\/21. 10.1073\/pnas.1812744115.","DOI":"10.1073\/pnas.1812744115"},{"key":"10.1016\/j.intimp.2023.110024_b0145","doi-asserted-by":"crossref","unstructured":"Yang X, Wang R, Zhou H, Wang L, Wang R, Li H, et al. Beta-Hydroxybutyrate Alleviates Learning and Memory Impairment through the Sirt1 Pathway in D-Galactose-Injured Mice. Front Pharmacol (2021) 12:751028. Epub 2021\/12\/10. 10.3389\/fphar.2021.751028.","DOI":"10.3389\/fphar.2021.751028"},{"key":"10.1016\/j.intimp.2023.110024_b0150","doi-asserted-by":"crossref","unstructured":"Leu WJ, Chen JC, Guh JH. Extract from Plectranthus Amboinicus Inhibit Maturation and Release of Interleukin 1beta through Inhibition of Nf-Kappab Nuclear Translocation and Nlrp3 Inflammasome Activation. Front Pharmacol (2019) 10:573. Epub 2019\/06\/14. 10.3389\/fphar.2019.00573.","DOI":"10.3389\/fphar.2019.00573"},{"key":"10.1016\/j.intimp.2023.110024_b0155","doi-asserted-by":"crossref","unstructured":"Mangan MSJ, Olhava EJ, Roush WR, Seidel HM, Glick GD, Latz E. Targeting the Nlrp3 Inflammasome in Inflammatory Diseases. Nat Rev Drug Discov (2018) 17(9):688. Epub 2018\/08\/18. 10.1038\/nrd.2018.149.","DOI":"10.1038\/nrd.2018.149"},{"key":"10.1016\/j.intimp.2023.110024_b0160","doi-asserted-by":"crossref","unstructured":"Farjadian F, Ghasemi A, Gohari O, Roointan A, Karimi M, Hamblin MR. Nanopharmaceuticals and Nanomedicines Currently on the Market: Challenges and Opportunities. Nanomedicine (Lond) (2019) 14(1):93-126. Epub 2018\/11\/20. 10.2217\/nnm-2018-0120.","DOI":"10.2217\/nnm-2018-0120"},{"key":"10.1016\/j.intimp.2023.110024_b0165","doi-asserted-by":"crossref","unstructured":"Damiani G, Pacifico A, Linder DM, Pigatto PDM, Conic R, Grada A, et al. Nanodermatology-Based Solutions for Psoriasis: State-of-the Art and Future Prospects. Dermatol Ther (2019) 32(6):e13113. Epub 2019\/10\/11. 10.1111\/dth.13113.","DOI":"10.1111\/dth.13113"},{"key":"10.1016\/j.intimp.2023.110024_b0170","doi-asserted-by":"crossref","unstructured":"Damiani G, Bragazzi NL, Karimkhani Aksut C, Wu D, Alicandro G, McGonagle D, et al. The Global, Regional, and National Burden of Psoriasis: Results and Insights from the Global Burden of Disease 2019 Study. Front Med (Lausanne) (2021) 8:743180. Epub 2022\/01\/04. 10.3389\/fmed.2021.743180.","DOI":"10.3389\/fmed.2021.743180"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923003454?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923003454?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:53:23Z","timestamp":1761587603000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576923003454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":34,"alternative-id":["S1567576923003454"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2023.110024","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Leukadherin-1 inhibits NLRP3 inflammasome by blocking inflammasome assembly","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2023.110024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110024"}}