{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:45:41Z","timestamp":1790671541857,"version":"4.1.0"},"reference-count":134,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.intimp.2023.110063","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T18:21:30Z","timestamp":1680286890000},"page":"110063","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Nerve growth factor mediates activation of transient receptor potential vanilloid 1 in neurogenic pruritus of psoriasis"],"prefix":"10.1016","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8632-9744","authenticated-orcid":false,"given":"Lin","family":"Shang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijuan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinzhu","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingya","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3508-5695","authenticated-orcid":false,"given":"Yanling","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10281","key":"10.1016\/j.intimp.2023.110063_b0005","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(20)32549-6","volume":"397","author":"Griffiths","year":"2021","journal-title":"Psoriasis. Lancet."},{"key":"10.1016\/j.intimp.2023.110063_b0010","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2147\/CCID.S4465","article-title":"Itch in psoriasis: epidemiology, clinical aspects and treatment options","volume":"2","author":"Prignano","year":"2009","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"issue":"8","key":"10.1016\/j.intimp.2023.110063_b0015","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1111\/jdv.15450","article-title":"Itch: an under-recognized problem in psoriasis","volume":"33","author":"Elewski","year":"2019","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"2","key":"10.1016\/j.intimp.2023.110063_b0020","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1159\/000104261","article-title":"Experimental koebner phenomenon in patients with psoriasis","volume":"215","author":"Kalayciyan","year":"2007","journal-title":"Dermatology"},{"issue":"2","key":"10.1016\/j.intimp.2023.110063_b0025","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.clindermatol.2010.09.014","article-title":"The koebner phenomenon","volume":"29","author":"Sagi","year":"2011","journal-title":"Clin. Dermatol."},{"issue":"3","key":"10.1016\/j.intimp.2023.110063_b0030","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s00281-018-0675-z","article-title":"Skin neurogenic inflammation","volume":"40","author":"Choi","year":"2018","journal-title":"Semin. Immunopathol."},{"issue":"12","key":"10.1016\/j.intimp.2023.110063_b0035","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1093\/intimm\/dxab076","article-title":"The interaction between the immune system and the peripheral sensory nerves in pruritus","volume":"33","author":"Irie","year":"2021","journal-title":"Int. Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2023.110063_b0040","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.cell.2019.06.022","article-title":"Cutaneous trpv1(+) neurons trigger protective innate type 17 anticipatory immunity","volume":"178","author":"Cohen","year":"2019","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.intimp.2023.110063_b0045","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s12016-015-8488-5","article-title":"Mediators of chronic pruritus in atopic dermatitis: getting the itch out?","volume":"51","author":"Mollanazar","year":"2016","journal-title":"Clin. Rev. Allergy Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2023.110063_b0050","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jdermsci.2008.08.011","article-title":"Quantitative analysis of nerve growth factor (ngf) in the atopic dermatitis and psoriasis horny layer and effect of treatment on ngf in atopic dermatitis","volume":"53","author":"Yamaguchi","year":"2009","journal-title":"J. Dermatol. Sci."},{"issue":"2","key":"10.1016\/j.intimp.2023.110063_b0055","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.semarthrit.2009.03.002","article-title":"Nerve growth factor in rheumatic diseases","volume":"40","author":"Seidel","year":"2010","journal-title":"Semin. Arthritis Rheum."},{"issue":"48","key":"10.1016\/j.intimp.2023.110063_b0060","doi-asserted-by":"crossref","first-page":"30645","DOI":"10.1016\/S0021-9258(18)43862-8","article-title":"The low affinity neurotrophin receptor, p75lntr, is palmitoylated by thioester formation through cysteine 279","volume":"269","author":"Barker","year":"1994","journal-title":"J. Biol. Chem."},{"issue":"Pt 13","key":"10.1016\/j.intimp.2023.110063_b0065","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1242\/jcs.062612","article-title":"The p75ntr intracellular domain generated by neurotrophin-induced receptor cleavage potentiates trk signaling","volume":"123","author":"Ceni","year":"2010","journal-title":"J. Cell Sci."},{"issue":"1","key":"10.1016\/j.intimp.2023.110063_b0070","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/1523-1747.ep12388914","article-title":"Expression and function of nerve growth factor and nerve growth factor receptor on cultured keratinocytes","volume":"103","author":"Pincelli","year":"1994","journal-title":"J. Invest. Dermatol."},{"issue":"1","key":"10.1016\/j.intimp.2023.110063_b0075","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/s42003-020-01396-0","article-title":"Photosensitive tyrosine analogues unravel site-dependent phosphorylation in trka initiated mapk\/erk signaling","volume":"3","author":"Zhao","year":"2020","journal-title":"Commun. Biol."},{"issue":"2","key":"10.1016\/j.intimp.2023.110063_b0080","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0896-6273(00)00035-0","article-title":"The trkb-shc site signals neuronal survival and local axon growth via mek and p13-kinase","volume":"27","author":"Atwal","year":"2000","journal-title":"Neuron"},{"issue":"6","key":"10.1016\/j.intimp.2023.110063_b0085","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/0092-8674(92)90075-N","article-title":"Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of map kinases","volume":"68","author":"Thomas","year":"1992","journal-title":"Cell"},{"issue":"13","key":"10.1016\/j.intimp.2023.110063_b0090","doi-asserted-by":"crossref","first-page":"5650","DOI":"10.1073\/pnas.88.13.5650","article-title":"Nerve growth factor rapidly stimulates tyrosine phosphorylation of phospholipase c-gamma 1 by a kinase activity associated with the product of the trk protooncogene","volume":"88","author":"Vetter","year":"1991","journal-title":"PNAS"},{"issue":"19","key":"10.1016\/j.intimp.2023.110063_b0095","doi-asserted-by":"crossref","first-page":"7325","DOI":"10.1523\/JNEUROSCI.20-19-07325.2000","article-title":"Ngf signals through trka to increase clathrin at the plasma membrane and enhance clathrin-mediated membrane trafficking","volume":"20","author":"Beattie","year":"2000","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.intimp.2023.110063_b0100","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1083\/jcb.200201063","article-title":"Pincher, a pinocytic chaperone for nerve growth factor\/trka signaling endosomes","volume":"157","author":"Shao","year":"2002","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.intimp.2023.110063_b0105","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1186\/1479-5876-10-239","article-title":"Nerve growth factor: from the early discoveries to the potential clinical use","volume":"10","author":"Aloe","year":"2012","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.intimp.2023.110063_b0110","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1146\/annurev.biochem.75.103004.142819","article-title":"Trp channels","volume":"76","author":"Venkatachalam","year":"2007","journal-title":"Annu. Rev. Biochem."},{"issue":"1","key":"10.1016\/j.intimp.2023.110063_b0115","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.alit.2016.10.003","article-title":"The molecular and cellular mechanisms of itch and the involvement of trp channels in the peripheral sensory nervous system and skin","volume":"66","author":"Kittaka","year":"2017","journal-title":"Allergol. Int."},{"key":"10.1016\/j.intimp.2023.110063_b0120","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1146\/annurev.physiol.68.040204.100431","article-title":"An introduction to trp channels","volume":"68","author":"Ramsey","year":"2006","journal-title":"Annu. Rev. Physiol."},{"issue":"2","key":"10.1016\/j.intimp.2023.110063_b0125","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s12016-020-08824-3","article-title":"New insights on the role of trp channels in calcium signalling and immunomodulation: review of pathways and implications for clinical practice","volume":"60","author":"Froghi","year":"2021","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.intimp.2023.110063_b0130","article-title":"Involvement of neuro-immune interactions in pruritus with special focus on receptor expressions","volume":"8","author":"Ruppenstein","year":"2021","journal-title":"Front Med (Lausanne)."},{"issue":"7478","key":"10.1016\/j.intimp.2023.110063_b0135","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nature12822","article-title":"Structure of the trpv1 ion channel determined by electron cryo-microscopy","volume":"504","author":"Liao","year":"2013","journal-title":"Nature"},{"issue":"7162","key":"10.1016\/j.intimp.2023.110063_b0140","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/nature06191","article-title":"Inhibition of nociceptors by trpv1-mediated entry of impermeant sodium channel blockers","volume":"449","author":"Binshtok","year":"2007","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.intimp.2023.110063_b0145","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/nn.2102","article-title":"Trpv1 shows dynamic ionic selectivity during agonist stimulation","volume":"11","author":"Chung","year":"2008","journal-title":"Nat. Neurosci."},{"issue":"9","key":"10.1016\/j.intimp.2023.110063_b0150","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1007\/s13238-017-0395-5","article-title":"Trpv1 and trpa1 in cutaneous neurogenic and chronic inflammation: pro-inflammatory response induced by their activation and their sensitization","volume":"8","author":"Gouin","year":"2017","journal-title":"Protein Cell"},{"issue":"1","key":"10.1016\/j.intimp.2023.110063_b0155","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1152\/physrev.00021.2006","article-title":"Transient receptor potential cation channels in disease","volume":"87","author":"Nilius","year":"2007","journal-title":"Physiol. Rev."},{"issue":"3","key":"10.1016\/j.intimp.2023.110063_b0160","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s13238-016-0353-7","article-title":"Understand spiciness: mechanism of trpv1 channel activation by capsaicin","volume":"8","author":"Yang","year":"2017","journal-title":"Protein Cell"},{"key":"10.1016\/j.intimp.2023.110063_b0165","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.neuroscience.2013.07.035","article-title":"Neural processing of itch","volume":"250","author":"Akiyama","year":"2013","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.intimp.2023.110063_b0170","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1152\/physrev.00017.2019","article-title":"Physiology and pathophysiology of itch","volume":"100","author":"Cevikbas","year":"2020","journal-title":"Physiol. Rev."},{"issue":"6352","key":"10.1016\/j.intimp.2023.110063_b0175","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1126\/science.aaf4918","article-title":"A central neural circuit for itch sensation","volume":"357","author":"Mu","year":"2017","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.intimp.2023.110063_b0180","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/1346-8138.14749","article-title":"Inflammatory mediators causing cutaneous chronic itch in some diseases via transient receptor potential channel subfamily v member 1 and subfamily a member 1","volume":"46","author":"Xie","year":"2019","journal-title":"J. Dermatol."},{"issue":"Pt 2","key":"10.1016\/j.intimp.2023.110063_b0185","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1113\/jphysiol.2003.039990","article-title":"Signalling pathways involved in the sensitisation of mouse nociceptive neurones by nerve growth factor","volume":"551","author":"Bonnington","year":"2003","journal-title":"J. Physiol."},{"issue":"38","key":"10.1016\/j.intimp.2023.110063_b0190","doi-asserted-by":"crossref","first-page":"8300","DOI":"10.1523\/JNEUROSCI.2893-04.2004","article-title":"Phosphatidylinositol 3-kinase activates erk in primary sensory neurons and mediates inflammatory heat hyperalgesia through trpv1 sensitization","volume":"24","author":"Zhuang","year":"2004","journal-title":"J. Neurosci."},{"issue":"5","key":"10.1016\/j.intimp.2023.110063_b0195","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1085\/jgp.200609576","article-title":"Phosphoinositide 3-kinase binds to trpv1 and mediates ngf-stimulated trpv1 trafficking to the plasma membrane","volume":"128","author":"Stein","year":"2006","journal-title":"J. Gen. Physiol."},{"issue":"1","key":"10.1016\/j.intimp.2023.110063_b0200","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1046\/j.1087-0024.2000.00013.x","article-title":"Neural regulation of endothelial cell-mediated inflammation","volume":"5","author":"Lindsey","year":"2000","journal-title":"J. Investig. Dermatol. Symp. Proc."},{"issue":"1","key":"10.1016\/j.intimp.2023.110063_b0205","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1152\/physrev.00031.2013","article-title":"Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease","volume":"94","author":"Steinhoff","year":"2014","journal-title":"Physiol. Rev."},{"issue":"3","key":"10.1016\/j.intimp.2023.110063_b0210","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1152\/jn.2000.83.3.1722","article-title":"Maturation of cutaneous sensory neurons from normal and ngf-overexpressing mice","volume":"83","author":"Ritter","year":"2000","journal-title":"J. Neurophysiol."},{"issue":"6","key":"10.1016\/j.intimp.2023.110063_b0215","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1111\/1523-1747.ep12326689","article-title":"Nerve growth factor is increased in psoriatic skin","volume":"105","author":"Fantini","year":"1995","journal-title":"J. Invest. Dermatol."},{"issue":"1","key":"10.1016\/j.intimp.2023.110063_b0220","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jdermsci.2006.12.007","article-title":"Changes in cutaneous sensory nerve fibers induced by skin-scratching in mice","volume":"46","author":"Yamaoka","year":"2007","journal-title":"J. Dermatol. Sci."},{"issue":"6","key":"10.1016\/j.intimp.2023.110063_b0225","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.jid.2017.12.029","article-title":"The genetics of chronic itch: gene expression in the skin of patients with atopic dermatitis and psoriasis with severe itch","volume":"138","author":"Nattkemper","year":"2018","journal-title":"J. Invest. Dermatol."},{"issue":"7503","key":"10.1016\/j.intimp.2023.110063_b0230","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/nature13199","article-title":"Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation","volume":"510","author":"Riol-Blanco","year":"2014","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.intimp.2023.110063_b0235","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jdermsci.2018.11.009","article-title":"Trpv1 mediates inflammation and hyperplasia in imiquimod (imq)-induced psoriasiform dermatitis (psd) in mice","volume":"92","author":"Zhou","year":"2018","journal-title":"J. Dermatol. Sci."},{"issue":"11","key":"10.1016\/j.intimp.2023.110063_b0240","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1097\/j.pain.0000000000000674","article-title":"Mouse model of imiquimod-induced psoriatic itch","volume":"157","author":"Sakai","year":"2016","journal-title":"Pain"},{"issue":"18","key":"10.1016\/j.intimp.2023.110063_b0245","doi-asserted-by":"crossref","first-page":"4300","DOI":"10.1523\/JNEUROSCI.5679-03.2004","article-title":"Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia","volume":"24","author":"Amadesi","year":"2004","journal-title":"J. Neurosci."},{"issue":"12","key":"10.1016\/j.intimp.2023.110063_b0250","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.tins.2010.09.002","article-title":"The multiple pathways for itch and their interactions with pain","volume":"33","author":"Davidson","year":"2010","journal-title":"Trends Neurosci."},{"issue":"7","key":"10.1016\/j.intimp.2023.110063_b0255","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/j.jid.2018.01.034","article-title":"Major role for trpv1 and insp3r in par2-elicited inflammatory mediator production in differentiated human keratinocytes","volume":"138","author":"Gouin","year":"2018","journal-title":"J. Invest. Dermatol."},{"issue":"2","key":"10.1016\/j.intimp.2023.110063_b0260","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0923-1811(96)00562-2","article-title":"Role of increased production of monocytes tnf-alpha, il-1beta and il-6 in psoriasis: relation to focal infection, disease activity and responses to treatments","volume":"14","author":"Mizutani","year":"1997","journal-title":"J. Dermatol. Sci."},{"issue":"5","key":"10.1016\/j.intimp.2023.110063_b0265","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1038\/jid.2013.485","article-title":"Polymorphisms in il-1b distinguish between psoriasis of early and late onset","volume":"134","author":"H\u00e9bert","year":"2014","journal-title":"J. Invest. Dermatol."},{"issue":"8","key":"10.1016\/j.intimp.2023.110063_b0270","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1073\/pnas.1222808110","article-title":"Nlrp1 haplotypes associated with vitiligo and autoimmunity increase interleukin-1\u03b2 processing via the nlrp1 inflammasome","volume":"110","author":"Levandowski","year":"2013","journal-title":"PNAS"},{"issue":"1","key":"10.1016\/j.intimp.2023.110063_b0275","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s12974-020-01807-3","article-title":"Spinal cord nlrp1 inflammasome contributes to dry skin induced chronic itch in mice","volume":"17","author":"Fan","year":"2020","journal-title":"J. Neuroinflammation"},{"issue":"26","key":"10.1016\/j.intimp.2023.110063_b0280","doi-asserted-by":"crossref","first-page":"12111","DOI":"10.7150\/thno.52135","article-title":"Resolvin d3 controls mouse and human trpv1-positive neurons and preclinical progression of psoriasis","volume":"10","author":"Lee","year":"2020","journal-title":"Theranostics."},{"issue":"8","key":"10.1016\/j.intimp.2023.110063_b0285","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1177\/0960327121991911","article-title":"Gene expression profiles of transient receptor potential (trp) channels in the peripheral blood mononuclear cells of psoriasis patients","volume":"40","author":"\u00d6zcan","year":"2021","journal-title":"Hum. Exp. Toxicol."},{"issue":"6","key":"10.1016\/j.intimp.2023.110063_b0290","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1111\/j.1365-4632.2004.02195.x","article-title":"Immunohistochemical study of serotonin in lesions of psoriasis","volume":"43","author":"Huang","year":"2004","journal-title":"Int. J. Dermatol."},{"issue":"437","key":"10.1016\/j.intimp.2023.110063_b0295","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aaf1047","article-title":"Facilitation of trpv4 by trpv1 is required for itch transmission in some sensory neuron populations","volume":"9","author":"Kim","year":"2016","journal-title":"Sci. Signal."},{"issue":"18","key":"10.1016\/j.intimp.2023.110063_b0300","doi-asserted-by":"crossref","first-page":"13180","DOI":"10.1074\/jbc.M607849200","article-title":"Transient receptor potential channel a1 is directly gated by calcium ions","volume":"282","author":"Doerner","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.intimp.2023.110063_b0305","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1007\/s00424-014-1497-z","article-title":"Direct evidence for functional trpv1\/trpa1 heteromers","volume":"466","author":"Fischer","year":"2014","journal-title":"Pflugers Arch."},{"issue":"22","key":"10.1016\/j.intimp.2023.110063_b0310","doi-asserted-by":"crossref","first-page":"9283","DOI":"10.1523\/JNEUROSCI.5318-12.2013","article-title":"The ion channel trpa1 is required for chronic itch","volume":"33","author":"Wilson","year":"2013","journal-title":"J. Neurosci."},{"issue":"7","key":"10.1016\/j.intimp.2023.110063_b0315","doi-asserted-by":"crossref","first-page":"4819","DOI":"10.1111\/jcmm.14392","article-title":"Transient receptor potential ankyrin 1 (trpa1) positively regulates imiquimod-induced, psoriasiform dermal inflammation in mice","volume":"23","author":"Zhou","year":"2019","journal-title":"J. Cell Mol. Med."},{"issue":"4","key":"10.1016\/j.intimp.2023.110063_b0320","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.neuroscience.2010.09.031","article-title":"Transient receptor potential v1 regulates activation and modulation of transient receptor potential a1 by ca2+","volume":"171","author":"Patil","year":"2010","journal-title":"Neuroscience"},{"issue":"10","key":"10.1016\/j.intimp.2023.110063_b0325","doi-asserted-by":"crossref","first-page":"3240","DOI":"10.1002\/(SICI)1521-4141(199810)28:10<3240::AID-IMMU3240>3.0.CO;2-U","article-title":"Role of nerve growth factor in a mouse model of allergic airway inflammation and asthma","volume":"28","author":"Braun","year":"1998","journal-title":"Eur. J. Immunol."},{"issue":"6205","key":"10.1016\/j.intimp.2023.110063_b0330","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/337362a0","article-title":"Nerve growth factor regulates expression of neuropeptide genes in adult sensory neurons","volume":"337","author":"Lindsay","year":"1989","journal-title":"Nature"},{"issue":"14","key":"10.1016\/j.intimp.2023.110063_b0335","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21144883","article-title":"Advances in understanding the initial steps of pruritoceptive itch: how the itch hits the switch","volume":"21","author":"Kahremany","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.intimp.2023.110063_b0340","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1111\/j.1365-2133.2011.10241.x","article-title":"Expression of tachykinins and their receptors in plaque psoriasis with pruritus","volume":"164","author":"Amatya","year":"2011","journal-title":"Br. J. Dermatol."},{"issue":"8","key":"10.1016\/j.intimp.2023.110063_b0345","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1046\/j.1365-4362.1998.00533.x","article-title":"Double-labeled immunofluorescence study of cutaneous nerves in psoriasis","volume":"37","author":"Jiang","year":"1998","journal-title":"Int. J. Dermatol."},{"issue":"4","key":"10.1016\/j.intimp.2023.110063_b0350","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1046\/j.1365-2133.2003.05586.x","article-title":"Pruritogenic mediators in psoriasis vulgaris: comparative evaluation of itch-associated cutaneous factors","volume":"149","author":"Nakamura","year":"2003","journal-title":"Br. J. Dermatol."},{"issue":"5","key":"10.1016\/j.intimp.2023.110063_b0355","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1111\/j.1365-2133.2006.07518.x","article-title":"The role of neuropeptides in psoriasis","volume":"155","author":"Saraceno","year":"2006","journal-title":"Br. J. Dermatol."},{"issue":"4","key":"10.1016\/j.intimp.2023.110063_b0360","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2340\/00015555-0265","article-title":"Plasma neuropeptides and perception of pruritus in psoriasis","volume":"87","author":"Reich","year":"2007","journal-title":"Acta Derm. Venereol."},{"issue":"6779","key":"10.1016\/j.intimp.2023.110063_b0365","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1136\/bmj.302.6779.739","article-title":"Calcitonin gene related peptide","volume":"302","author":"O'Halloran","year":"1991","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.intimp.2023.110063_b0370","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.neuron.2013.01.030","article-title":"Peptidergic cgrp\u03b1 primary sensory neurons encode heat and itch and tonically suppress sensitivity to cold","volume":"78","author":"Mccoy","year":"2013","journal-title":"Neuron"},{"issue":"6","key":"10.1016\/j.intimp.2023.110063_b0375","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1111\/j.1365-2133.2007.07935.x","article-title":"Neuropeptides and their receptors in psoriatic skin in relation to pruritus","volume":"156","author":"Chang","year":"2007","journal-title":"Br. J. Dermatol."},{"issue":"6","key":"10.1016\/j.intimp.2023.110063_b0380","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1046\/j.1523-1747.2000.00142.x","article-title":"Acute effects of substance p and calcitonin gene-related peptide in human skin\u2013a microdialysis study","volume":"115","author":"Weidner","year":"2000","journal-title":"J, Invest. Dermatol."},{"issue":"2","key":"10.1016\/j.intimp.2023.110063_b0385","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jaad.2015.04.060","article-title":"Neurocutaneous disease: cutaneous neuroanatomy and mechanisms of itch and pain","volume":"74","author":"Chuquilin","year":"2016","journal-title":"J. Am. Acad. Dermatol."},{"issue":"6","key":"10.1016\/j.intimp.2023.110063_b0390","doi-asserted-by":"crossref","first-page":"e12677","DOI":"10.1111\/cpr.12677","article-title":"The importance of the neuro-immuno-cutaneous system on human skin equivalent design","volume":"52","author":"Vidal","year":"2019","journal-title":"Cell Prolif."},{"issue":"10","key":"10.1016\/j.intimp.2023.110063_b0395","doi-asserted-by":"crossref","first-page":"3981","DOI":"10.1172\/JCI85538","article-title":"Different activation signals induce distinct mast cell degranulation strategies","volume":"126","author":"Gaudenzio","year":"2016","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.intimp.2023.110063_b0400","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.npep.2003.09.005","article-title":"Production of tumor necrosis factor-alpha, interleukin 1-beta, interleukin 2, and interleukin 6 by rat leukocyte subpopulations after exposure to substance p","volume":"37","author":"Delgado","year":"2003","journal-title":"Neuropeptides"},{"issue":"10","key":"10.1016\/j.intimp.2023.110063_b0405","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1038\/modpathol.3800171","article-title":"Prognostic significance of her2\/neu, p53, and vascular endothelial growth factor expression in early stage conventional adenocarcinoma and bronchioloalveolar carcinoma of the lung","volume":"17","author":"Saad","year":"2004","journal-title":"Mod. Pathol."},{"issue":"1","key":"10.1016\/j.intimp.2023.110063_b0410","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/imr.12622","article-title":"Mast cell-neural interactions contribute to pain and itch","volume":"282","author":"Gupta","year":"2018","journal-title":"Immunol. Rev."},{"issue":"4","key":"10.1016\/j.intimp.2023.110063_b0415","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/sj.jid.5700169","article-title":"Functional characterization and expression analysis of the proteinase-activated receptor-2 in human cutaneous mast cells","volume":"126","author":"Moormann","year":"2006","journal-title":"J, Invest. Dermatol."},{"issue":"2","key":"10.1016\/j.intimp.2023.110063_b0420","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3109\/10520290009064152","article-title":"Localization of protease-activated receptors-1 and -2 in human mast cells: indications for an amplified mast cell degranulation cascade","volume":"75","author":"D'Andrea","year":"2000","journal-title":"Biotech. Histochem."},{"issue":"7","key":"10.1016\/j.intimp.2023.110063_b0425","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/89945","article-title":"Proteinase-activated receptor-2 and hyperalgesia: a novel pain pathway","volume":"7","author":"Vergnolle","year":"2001","journal-title":"Nat. Med."},{"issue":"6","key":"10.1016\/j.intimp.2023.110063_b0430","first-page":"865","article-title":"Il-32 is increased along with tryptase in lesional psoriatic skin and is up-regulated by substance p in human mast cells","volume":"20","author":"Kempuraj","year":"2010","journal-title":"Eur. J. Dermatol."},{"issue":"2","key":"10.1016\/j.intimp.2023.110063_b0435","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/72247","article-title":"Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism","volume":"6","author":"Steinhoff","year":"2000","journal-title":"Nat. Med."},{"issue":"10","key":"10.1016\/j.intimp.2023.110063_b0440","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1172\/JCI0214704","article-title":"Differential responses of mast cell toll-like receptors 2 and 4 in allergy and innate immunity","volume":"109","author":"Supajatura","year":"2002","journal-title":"J. Clin. Invest."},{"issue":"22","key":"10.1016\/j.intimp.2023.110063_b0445","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.1111\/bph.12823","article-title":"Anti-il-31 receptor antibody is shown to be a potential therapeutic option for treating itch and dermatitis in mice","volume":"171","author":"Kasutani","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.intimp.2023.110063_b0450","doi-asserted-by":"crossref","first-page":"419","DOI":"10.2147\/CCID.S257647","article-title":"Il-33\/13 axis and il-4\/31 axis play distinct roles in inflammatory process and itch in psoriasis and atopic dermatitis","volume":"13","author":"Bodoor","year":"2020","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"issue":"2","key":"10.1016\/j.intimp.2023.110063_b0455","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.jaci.2013.10.048","article-title":"A sensory neuron-expressed il-31 receptor mediates t helper cell-dependent itch: involvement of trpv1 and trpa1","volume":"133","author":"Cevikbas","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"issue":"619","key":"10.1016\/j.intimp.2023.110063_b0460","doi-asserted-by":"crossref","first-page":"e3037","DOI":"10.1126\/scitranslmed.abe3037","article-title":"Oncostatin m can sensitize sensory neurons in inflammatory pruritus","volume":"13","author":"Tseng","year":"2021","journal-title":"Sci. Transl. Med."},{"issue":"5","key":"10.1016\/j.intimp.2023.110063_b0465","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.cytogfr.2015.07.006","article-title":"Oncostatin m and interleukin-31: cytokines, receptors, signal transduction and physiology","volume":"26","author":"Hermanns","year":"2015","journal-title":"Cytokine Growth Factor Rev."},{"issue":"2","key":"10.1016\/j.intimp.2023.110063_b0470","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a028415","article-title":"Interleukin-6 family cytokines","volume":"10","author":"Rose-John","year":"2018","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.intimp.2023.110063_b0475","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/1744-8069-7-102","article-title":"Oncostatin m induces heat hypersensitivity by gp130-dependent sensitization of trpv1 in sensory neurons","volume":"7","author":"Langeslag","year":"2011","journal-title":"Mol. Pain"},{"issue":"10","key":"10.1016\/j.intimp.2023.110063_b0480","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.bbadis.2009.07.008","article-title":"Up-regulation of trpv1 in mononuclear cells of end-stage kidney disease patients increases susceptibility to n-arachidonoyl-dopamine (nada)-induced cell death","volume":"1792","author":"Saunders","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"issue":"14","key":"10.1016\/j.intimp.2023.110063_b0485","doi-asserted-by":"crossref","first-page":"5120","DOI":"10.1073\/pnas.0407780102","article-title":"Immunological role of neuronal receptor vanilloid receptor 1 expressed on dendritic cells","volume":"102","author":"Basu","year":"2005","journal-title":"PNAS"},{"key":"10.1016\/j.intimp.2023.110063_b0490","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1146\/annurev-immunol-032713-120225","article-title":"Immunology of psoriasis","volume":"32","author":"Lowes","year":"2014","journal-title":"Annu. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2023.110063_b0495","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/76923","article-title":"Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin","volume":"1","author":"Pandey","year":"2000","journal-title":"Nat. Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2023.110063_b0500","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1038\/jid.2011.404","article-title":"Overexpression of cathepsin s induces chronic atopic dermatitis in mice","volume":"132","author":"Kim","year":"2012","journal-title":"J. Invest. Dermatol."},{"issue":"1","key":"10.1016\/j.intimp.2023.110063_b0505","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/jcp.30923","article-title":"Keratinocyte tlr2 and tlr7 contribute to chronic itch through pruritic cytokines and chemokines in mice","volume":"238","author":"Wang","year":"2023","journal-title":"J. Cell. Physiol."},{"issue":"4","key":"10.1016\/j.intimp.2023.110063_b0510","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1600-0625.2007.00670.x","article-title":"The skin as a mirror of the soul: exploring the possible roles of serotonin","volume":"17","author":"Nordlind","year":"2008","journal-title":"Exp. Dermatol."},{"issue":"2","key":"10.1016\/j.intimp.2023.110063_b0515","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1124\/jpet.112.200063","article-title":"Topical surfactant-induced pruritus: involvement of histamine released from epidermal keratinocytes","volume":"344","author":"Inami","year":"2013","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"34","key":"10.1016\/j.intimp.2023.110063_b0520","doi-asserted-by":"crossref","first-page":"E3225","DOI":"10.1073\/pnas.1312933110","article-title":"Uvb radiation generates sunburn pain and affects skin by activating epidermal trpv4 ion channels and triggering endothelin-1 signaling","volume":"110","author":"Moore","year":"2013","journal-title":"PNAS"},{"issue":"2","key":"10.1016\/j.intimp.2023.110063_b0525","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cell.2013.08.057","article-title":"The epithelial cell-derived atopic dermatitis cytokine tslp activates neurons to induce itch","volume":"155","author":"Wilson","year":"2013","journal-title":"Cell"},{"issue":"20","key":"10.1016\/j.intimp.2023.110063_b0530","doi-asserted-by":"crossref","first-page":"14881","DOI":"10.1016\/S0021-9258(18)82415-2","article-title":"Mediator release from mast cells by nerve growth factor. Neurotrophin specificity and receptor mediation","volume":"268","author":"Horigome","year":"1993","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.intimp.2023.110063_b0535","doi-asserted-by":"crossref","DOI":"10.3390\/molecules21060797","article-title":"Capsaicin, nociception and pain","volume":"21","author":"Frias","year":"2016","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.intimp.2023.110063_b0540","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/0006-8993(82)90521-2","article-title":"Capsaicin applied to peripheral nerve inhibits axoplasmic transport of substance p and somatostatin","volume":"239","author":"Gamse","year":"1982","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.intimp.2023.110063_b0545","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2340\/00015555-2472","article-title":"Cost-effectiveness of an 8% capsaicin patch in the treatment of brachioradial pruritus and notalgia paraesthetica, two forms of neuropathic pruritus","volume":"97","author":"Steinke","year":"2017","journal-title":"Acta Derm. Venereol."},{"issue":"15","key":"10.1016\/j.intimp.2023.110063_b0550","doi-asserted-by":"crossref","first-page":"3515","DOI":"10.1021\/jm070190p","article-title":"Novel vanilloid receptor-1 antagonists: 2. Structure-activity relationships of 4-oxopyrimidines leading to the selection of a clinical candidate","volume":"50","author":"Doherty","year":"2007","journal-title":"J. Med. Chem."},{"issue":"1","key":"10.1016\/j.intimp.2023.110063_b0555","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1124\/jpet.104.079855","article-title":"Amg 9810 [(e)-3-(4-t-butylphenyl)-n-(2,3-dihydrobenzo[1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (trpv1) antagonist with antihyperalgesic properties","volume":"313","author":"Gavva","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"3","key":"10.1016\/j.intimp.2023.110063_b0560","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1021\/jm701007g","article-title":"Identification of (r)-1-(5-tert-butyl-2,3-dihydro-1h-inden-1-yl)-3-(1h-indazol-4-yl)urea (abt-102) as a potent trpv1 antagonist for pain management","volume":"51","author":"Gomtsyan","year":"2008","journal-title":"J. Med. Chem."},{"issue":"1","key":"10.1016\/j.intimp.2023.110063_b0565","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0028-3908(03)00305-8","article-title":"Identification and characterisation of sb-366791, a potent and selective vanilloid receptor (vr1\/trpv1) antagonist","volume":"46","author":"Gunthorpe","year":"2004","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/j.intimp.2023.110063_b0570","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1111\/j.1476-5381.2011.01601.x","article-title":"The thermo-trp ion channel family: properties and therapeutic implications","volume":"165","author":"Vay","year":"2012","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2023.110063_b0575","first-page":"8","article-title":"Trpv1 antagonist can suppress the atopic dermatitis-like symptoms by accelerating skin barrier recovery","volume":"62","author":"Yun","year":"2011","journal-title":"J. Dermatol. Sci."},{"issue":"4","key":"10.1016\/j.intimp.2023.110063_b0580","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1016\/j.jaci.2021.09.024","article-title":"Asivatrep, a trpv1 antagonist, for the topical treatment of atopic dermatitis: phase 3, randomized, vehicle-controlled study (captain-ad)","volume":"149","author":"Park","year":"2022","journal-title":"J. Allergy Clin. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2023.110063_b0585","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1124\/jpet.120.265074","article-title":"Topical application of asn008, a permanently charged sodium channel blocker, shows robust efficacy, a rapid onset, and long duration of action in a mouse model of pruritus","volume":"374","author":"Ramachandran","year":"2020","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"5","key":"10.1016\/j.intimp.2023.110063_b0590","doi-asserted-by":"crossref","first-page":"542","DOI":"10.2340\/00015555-2047","article-title":"Topical trka kinase inhibitor ct327 is an effective, novel therapy for the treatment of pruritus due to psoriasis: results from experimental studies, and efficacy and safety of ct327 in a phase 2b clinical trial in patients with psoriasis","volume":"95","author":"Roblin","year":"2015","journal-title":"Acta Derm. Venereol."},{"issue":"6","key":"10.1016\/j.intimp.2023.110063_b0595","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/j.jaad.2020.01.056","article-title":"Serlopitant for psoriatic pruritus: a phase 2 randomized, double-blind, placebo-controlled clinical trial","volume":"82","author":"Pariser","year":"2020","journal-title":"J. Am. Acad Dermatol."},{"key":"10.1016\/j.intimp.2023.110063_b0600","first-page":"1682972","article-title":"Trpv1 and plc participate in histamine h4 receptor-induced itch","author":"Jian","year":"2016","journal-title":"Neural. Plast."},{"issue":"7","key":"10.1016\/j.intimp.2023.110063_b0605","doi-asserted-by":"crossref","first-page":"e100610","DOI":"10.1371\/journal.pone.0100610","article-title":"A randomised trial evaluating the effects of the trpv1 antagonist sb705498 on pruritus induced by histamine, and cowhage challenge in healthy volunteers","volume":"9","author":"Gibson","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2023.110063_b0610","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.2147\/JPR.S217439","article-title":"Effects of an intrathecal trpv1 antagonist, sb366791, on morphine-induced itch, body temperature, and antinociception in mice","volume":"12","author":"Sakakibara","year":"2019","journal-title":"J. Pain Res."},{"issue":"1","key":"10.1016\/j.intimp.2023.110063_b0615","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1186\/s13063-021-05864-8","article-title":"Rationale and design of the multicentric, double-blind, double-placebo, randomized trial aprepitant versus hydroxyzine in association with cytoreductive treatments for patients with myeloproliferative neoplasia suffering from persistent aquagenic pruritus","volume":"22","author":"Le Gall-Ianotto","year":"2021","journal-title":"Trial acronym: aphypap. Trials."},{"issue":"5","key":"10.1016\/j.intimp.2023.110063_b0620","doi-asserted-by":"crossref","first-page":"e338","DOI":"10.1111\/jdv.17090","article-title":"Neurokinin-1 receptor antagonist tradipitant has mixed effects on itch in atopic dermatitis: results from epione, a randomized clinical trial","volume":"35","author":"Welsh","year":"2021","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.intimp.2023.110063_b0625","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118906","article-title":"Trpa1 deficiency alleviates inflammation of atopic dermatitis by reducing macrophage infiltration","volume":"266","author":"Zeng","year":"2021","journal-title":"Life Sci."},{"issue":"9","key":"10.1016\/j.intimp.2023.110063_b0630","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.1096\/fj.13-229948","article-title":"Trpa1 controls inflammation and pruritogen responses in allergic contact dermatitis","volume":"27","author":"Liu","year":"2013","journal-title":"FASEB J."},{"issue":"3","key":"10.1016\/j.intimp.2023.110063_b0635","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.neulet.2011.02.009","article-title":"Role of transient receptor potential ankyrin subfamily member 1 in pruritus induced by endothelin-1","volume":"492","author":"Liang","year":"2011","journal-title":"Neurosci. Lett."},{"issue":"2","key":"10.1016\/j.intimp.2023.110063_b0640","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.jaci.2017.05.051","article-title":"Transient receptor potential vanilloid 4-expressing macrophages and keratinocytes contribute differentially to allergic and nonallergic chronic itch","volume":"141","author":"Luo","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.intimp.2023.110063_b0645","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.772941","article-title":"Cutaneous neuroimmune interactions of tslp and trpv4 play pivotal roles in dry skin-induced pruritus","volume":"12","author":"Lee","year":"2021","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2023.110063_b0650","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/JID.2015.388","article-title":"Involvement of trpv4 in serotonin-evoked scratching","volume":"136","author":"Akiyama","year":"2016","journal-title":"J. Invest. Dermatol."},{"issue":"19","key":"10.1016\/j.intimp.2023.110063_b0655","doi-asserted-by":"crossref","first-page":"10252","DOI":"10.1074\/jbc.M116.716464","article-title":"Transient receptor potential vanilloid 4 ion channel functions as a pruriceptor in epidermal keratinocytes to evoke histaminergic itch","volume":"291","author":"Chen","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.intimp.2023.110063_b0660","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1053\/j.gastro.2021.03.049","article-title":"Epithelia-sensory neuron cross talk underlies cholestatic itch induced by lysophosphatidylcholine","volume":"161","author":"Chen","year":"2021","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.intimp.2023.110063_b0665","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/bjd.20873","article-title":"Nemolizumab plus topical agents in patients with atopic dermatitis (ad) and moderate-to-severe pruritus provide improvement in pruritus and signs of ad for up to 68 weeks: results from two phase iii, long-term studies","volume":"186","author":"Kabashima","year":"2022","journal-title":"Br J. Dermatol."},{"issue":"14","key":"10.1016\/j.intimp.2023.110063_b0670","doi-asserted-by":"crossref","DOI":"10.2340\/00015555-3505","article-title":"Oncostatin m induction of monocyte chemoattractant protein 1 is inhibited by anti-oncostatin m receptor beta monoclonal antibody kpl-716","volume":"100","author":"Richards","year":"2020","journal-title":"Acta. Derm. Venereol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923003843?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923003843?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:50:45Z","timestamp":1761587445000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576923003843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":134,"alternative-id":["S1567576923003843"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2023.110063","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nerve growth factor mediates activation of transient receptor potential vanilloid 1 in neurogenic pruritus of psoriasis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2023.110063","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110063"}}