{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T04:33:00Z","timestamp":1789533180773,"version":"build-2803163510"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21961142009"],"award-info":[{"award-number":["21961142009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000793"],"award-info":[{"award-number":["82000793"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271347"],"award-info":[{"award-number":["82271347"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.intimp.2023.110066","type":"journal-article","created":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T12:17:39Z","timestamp":1681301859000},"page":"110066","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Tussilagone attenuates atherosclerosis through inhibiting MAPKs-mediated inflammation in macrophages"],"prefix":"10.1016","volume":"119","author":[{"given":"Sirui","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuqi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zimin","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaojun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhouqing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8278-849X","authenticated-orcid":false,"given":"Guang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.intimp.2023.110066_b0005","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1016\/j.cell.2022.04.004","article-title":"Atherosclerosis: Recent developments","volume":"185","author":"Bjorkegren","year":"2022","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.intimp.2023.110066_b0010","first-page":"389","article-title":"Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities","volume":"16","author":"Back","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"issue":"43","key":"10.1016\/j.intimp.2023.110066_b0015","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1093\/eurheartj\/ehx362","article-title":"Infections, atherosclerosis, and coronary heart disease","volume":"38","author":"Pothineni","year":"2017","journal-title":"Eur. Heart J."},{"issue":"4","key":"10.1016\/j.intimp.2023.110066_b0020","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1161\/CIRCRESAHA.115.306301","article-title":"Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis","volume":"118","author":"Gimbrone","year":"2016","journal-title":"Circ. Res."},{"issue":"11","key":"10.1016\/j.intimp.2023.110066_b0025","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s11883-017-0678-6","article-title":"Oxidative Stress in Atherosclerosis","volume":"19","author":"Kattoor","year":"2017","journal-title":"Curr. Atheroscler. Rep."},{"issue":"2","key":"10.1016\/j.intimp.2023.110066_b0030","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1161\/ATVBAHA.116.308768","article-title":"Monocytosis, Hypercholesterolemia, and the Kinase That Binds Them","volume":"37","author":"Fenn","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"2","key":"10.1016\/j.intimp.2023.110066_b0035","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nrcardio.2009.228","article-title":"Monocytes in atherosclerosis: subsets and functions","volume":"7","author":"Woollard","year":"2010","journal-title":"Nat. Rev. Cardiol."},{"issue":"5","key":"10.1016\/j.intimp.2023.110066_b0040","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1097\/MOL.0b013e3283309848","article-title":"Macrophage heterogeneity in atherosclerotic plaques","volume":"20","author":"Johnson","year":"2009","journal-title":"Curr. Opin. Lipidol."},{"issue":"6","key":"10.1016\/j.intimp.2023.110066_b0045","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1093\/eurheartj\/ehl445","article-title":"A review of high-dose statin therapy: targeting cholesterol and inflammation in atherosclerosis","volume":"28","author":"Patel","year":"2007","journal-title":"Eur. Heart J."},{"issue":"22","key":"10.1016\/j.intimp.2023.110066_b0050","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1161\/CIRCULATIONAHA.116.024436","article-title":"Polygenic Risk Score Identifies Subgroup With Higher Burden of Atherosclerosis and Greater Relative Benefit From Statin Therapy in the Primary Prevention Setting","volume":"135","author":"Natarajan","year":"2017","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.intimp.2023.110066_b0055","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/clinchem\/hvaa275","article-title":"Inflammation in Atherosclerosis-No Longer a Theory","volume":"67","author":"Libby","year":"2021","journal-title":"Clin. Chem."},{"issue":"1","key":"10.1016\/j.intimp.2023.110066_b0060","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41392-022-00955-7","article-title":"Inflammation and atherosclerosis: signaling pathways and therapeutic intervention","volume":"7","author":"Kong","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"issue":"3","key":"10.1016\/j.intimp.2023.110066_b0065","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1248\/bpb.28.455","article-title":"Neuroprotective and antioxidant effects of the ethyl acetate fraction prepared from Tussilago farfara L","volume":"28","author":"Cho","year":"2005","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.intimp.2023.110066_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113478","article-title":"A review of the ethnobotanical value, phytochemistry, pharmacology, toxicity and quality control of Tussilago farfara L. (coltsfoot)","volume":"267","author":"Chen","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"10","key":"10.1016\/j.intimp.2023.110066_b0075","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1021\/np990116c","article-title":"A new bisabolene epoxide from Tussilago farfara, and inhibition of nitric oxide synthesis in LPS-activated macrophages","volume":"62","author":"Ryu","year":"1999","journal-title":"J. Nat. Prod."},{"issue":"4","key":"10.1016\/j.intimp.2023.110066_b0080","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines8040086","article-title":"Tussilagone Reduces Tumorigenesis by Diminishing Inflammation in Experimental Colitis-Associated Colon Cancer","volume":"8","author":"Nam","year":"2020","journal-title":"Biomedicines"},{"issue":"12","key":"10.1016\/j.intimp.2023.110066_b0085","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18122744","article-title":"Tussilagone Inhibits the Inflammatory Response and Improves Survival in CLP-Induced Septic Mice","volume":"18","author":"Kim","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2023.110066_b0090","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.cbi.2018.08.022","article-title":"Tussilagone, a major active component in Tussilago farfara, ameliorates inflammatory responses in dextran sulphate sodium-induced murine colitis","volume":"294","author":"Cheon","year":"2018","journal-title":"Chem. Biol. Interact."},{"issue":"5","key":"10.1016\/j.intimp.2023.110066_b0095","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1002\/tox.23476","article-title":"Tussilagone protects acute lung injury from PM2.5 via alleviating Hif-1alpha\/NF-kappaB-mediated inflammatory response","volume":"37","author":"Lin","year":"2022","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.intimp.2023.110066_b0100","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/j.biopha.2017.08.092","article-title":"beta-Elemene attenuates atherosclerosis in apolipoprotein E-deficient mice via restoring NO levels and alleviating oxidative stress","volume":"95","author":"Liu","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2023.110066_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.102706","article-title":"Macrophage-derived myeloid differentiation protein 2 plays an essential role in ox-LDL-induced inflammation and atherosclerosis","volume":"53","author":"Chen","year":"2020","journal-title":"EBioMedicine"},{"key":"10.1016\/j.intimp.2023.110066_b0110","doi-asserted-by":"crossref","first-page":"764","DOI":"10.3389\/fphar.2019.00764","article-title":"Tussilagone Suppresses Angiogenesis by Inhibiting the VEGFR2 Signaling Pathway","volume":"10","author":"Li","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"12","key":"10.1016\/j.intimp.2023.110066_b0115","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19123761","article-title":"Role of p38 MAPK in Atherosclerosis and Aortic Valve Sclerosis","volume":"19","author":"Reustle","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2023.110066_b0120","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.intimp.2017.07.003","article-title":"Psoralidin suppresses osteoclastogenesis in BMMs and attenuates LPS-mediated osteolysis by inhibiting inflammatory cytokines","volume":"51","author":"Kong","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2023.110066_b0125","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.phrs.2018.01.014","article-title":"Sulforaphane attenuates microglia-mediated neuronal necroptosis through down-regulation of MAPK\/NF-kappaB signaling pathways in LPS-activated BV-2 microglia","volume":"133","author":"Qin","year":"2018","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.intimp.2023.110066_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154387","article-title":"Diacerein alleviates Ang II-induced cardiac inflammation and remodeling by inhibiting the MAPKs\/c-Myc pathway","volume":"106","author":"Wang","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2023.110066_b0135","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.intimp.2016.02.026","article-title":"Heme oxygenase-1-mediated anti-inflammatory effects of tussilagonone on macrophages and 12-O-tetradecanoylphorbol-13-acetate-induced skin inflammation in mice","volume":"34","author":"Lee","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2023.110066_b0140","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3389\/fphar.2020.00385","article-title":"Tussilagone Inhibits Osteoclastogenesis and Periprosthetic Osteolysis by Suppressing the NF-kappaB and P38 MAPK Signaling Pathways","volume":"11","author":"Hu","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"5","key":"10.1016\/j.intimp.2023.110066_b0145","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1161\/01.ATV.0000018287.03856.DD","article-title":"Interferon-gamma-mediated downregulation of cholesterol efflux and ABC1 expression is by the Stat1 pathway","volume":"22","author":"Wang","year":"2002","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"4","key":"10.1016\/j.intimp.2023.110066_b0150","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.cmet.2005.03.005","article-title":"Lipoproteins, macrophage function, and atherosclerosis: beyond the foam cell?","volume":"1","author":"Rader","year":"2005","journal-title":"Cell Metab."},{"issue":"10","key":"10.1016\/j.intimp.2023.110066_b0155","doi-asserted-by":"crossref","DOI":"10.1172\/JCI154217","article-title":"Disruption of USP9X in macrophages promotes foam cell formation and atherosclerosis","volume":"132","author":"Wang","year":"2022","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.intimp.2023.110066_b0160","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/cvr\/cvx253","article-title":"Endothelial-mesenchymal transition in atherosclerosis","volume":"114","author":"Souilhol","year":"2018","journal-title":"Cardiovasc. Res."},{"issue":"21","key":"10.1016\/j.intimp.2023.110066_b0165","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1161\/CIRCULATIONAHA.120.049922","article-title":"Fate and State of Vascular Smooth Muscle Cells in Atherosclerosis","volume":"143","author":"Miano","year":"2021","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.intimp.2023.110066_b0170","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.7150\/ijbs.7502","article-title":"The vascular endothelium and human diseases","volume":"9","author":"Rajendran","year":"2013","journal-title":"Int. J. Biol. Sci."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923003879?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923003879?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:25:56Z","timestamp":1785770756000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576923003879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":34,"alternative-id":["S1567576923003879"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2023.110066","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tussilagone attenuates atherosclerosis through inhibiting MAPKs-mediated inflammation in macrophages","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2023.110066","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110066"}}