{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T22:47:52Z","timestamp":1789512472089,"version":"build-2803163510"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["2020-zyy052"],"award-info":[{"award-number":["2020-zyy052"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["ZR2017MH055"],"award-info":[{"award-number":["ZR2017MH055"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.intimp.2023.110195","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T11:02:40Z","timestamp":1682074960000},"page":"110195","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Candidalysin amplifies the immune inflammatory response in Candida albicans keratitis through the TREM-1\/DAP12 pathway"],"prefix":"10.1016","volume":"119","author":[{"given":"Liting","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guitao","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiqiu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaodong","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2023.110195_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2019.103802","article-title":"Fungal keratitis: pathogenesis, diagnosis and prevention","volume":"138","author":"Niu","year":"2020","journal-title":"Microb. Pathog."},{"issue":"6","key":"10.1016\/j.intimp.2023.110195_b0010","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.ajo.2007.02.016","article-title":"Clinical Characteristics and Outcome of Candida Keratitis","volume":"143","author":"Sun","year":"2007","journal-title":"Am. J. Ophthalmol."},{"issue":"3","key":"10.1016\/j.intimp.2023.110195_b0015","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/QCO.0b013e32835fb920","article-title":"Pathogenesis of Invasive Fungal Infections","volume":"26","author":"Garcia-vidal","year":"2013","journal-title":"Curr. Opin. Infect. Dis."},{"key":"10.1016\/j.intimp.2023.110195_b0020","doi-asserted-by":"crossref","unstructured":"Leal jr SM,Pearlman E. The Role of Cytokines and Pathogen Recognition Molecules in Fungal Keratitis\u2013insights From Human Disease and Animal Models. Cytokine, 2012, 58(1): 107-111.","DOI":"10.1016\/j.cyto.2011.12.022"},{"key":"10.1016\/j.intimp.2023.110195_b0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-immunol-030409-101229","article-title":"Innate Antifungal Immunity: the Key Role of Phagocytes","volume":"29","author":"Brown","year":"2011","journal-title":"Annu. Rev. Immunol."},{"issue":"10","key":"10.1016\/j.intimp.2023.110195_b0030","doi-asserted-by":"crossref","first-page":"4991","DOI":"10.4049\/jimmunol.164.10.4991","article-title":"Cutting Edge: Inflammatory Responses Can Be Triggered By Trem-1, a Novel Receptor Expressed on Neutrophils and Monocytes","volume":"164","author":"Bouchon","year":"2000","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2023.110195_b0035","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1189\/jlb.0312145","article-title":"Trem-1: Intracellular Signaling Pathways and Interaction with Pattern Recognition Receptors","volume":"93","author":"Arts","year":"2013","journal-title":"J. Leukoc. Biol."},{"issue":"6","key":"10.1016\/j.intimp.2023.110195_b0040","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nri1106","article-title":"Trems in the Immune System and Beyond","volume":"3","author":"Colonna","year":"2003","journal-title":"Nat. Rev. Immunol."},{"issue":"6","key":"10.1016\/j.intimp.2023.110195_b0045","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nri2765","article-title":"The Syk Tyrosine Kinase: a Crucial Player in Diverse Biological Functions","volume":"10","author":"M\u00f3csai","year":"2010","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2023.110195_b0050","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.intimp.2014.09.011","article-title":"Role of Trem-1 in Response to Aspergillus Fumigatus Infection in Corneal Epithelial Cells","volume":"23","author":"Hu","year":"2014","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.intimp.2023.110195_b0055","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.micpath.2006.11.005","article-title":"Genetically Regulated Filamentation Contributes to Candida Albicans Virulence During Corneal Infection","volume":"42","author":"Jackson","year":"2007","journal-title":"Microb. Pathog."},{"issue":"7597","key":"10.1016\/j.intimp.2023.110195_b0060","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/nature17625","article-title":"Candidalysin Is a Fungal Peptide Toxin Critical for Mucosal Infection","volume":"532","author":"Moyes","year":"2016","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.intimp.2023.110195_b0065","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.chom.2010.08.002","article-title":"A Biphasic Innate Immune Mapk Response Discriminates Between the Yeast and Hyphal Forms of Candida Albicans in Epithelial Cells","volume":"8","author":"Moyes","year":"2010","journal-title":"Cell Host Microbe"},{"issue":"2","key":"10.1016\/j.intimp.2023.110195_b0070","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00645-17","article-title":"Candidalysin Drives Epithelial Signaling, Neutrophil Recruitment, and Immunopathology at the Vaginal Mucosa","volume":"86","author":"Richardson","year":"2018","journal-title":"Infect. Immun."},{"issue":"17","key":"10.1016\/j.intimp.2023.110195_b0075","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aam8834","article-title":"Oral Epithelial Cells Orchestrate Innate Type 17 Responses to Candida Albicans Through the Virulence Factor Candidalysin","volume":"2","author":"Verma","year":"2017","journal-title":"Sci. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2023.110195_b0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-018-06607-1","article-title":"The Fungal Peptide Toxin Candidalysin Activates the Nlrp3 Inflammasome and Causes Cytolysis in Mononuclear Phagocytes","volume":"9","author":"Kasper","year":"2018","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.intimp.2023.110195_b0085","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1167\/iovs.02-0446","article-title":"Experimental keratomycosis in a mouse model","volume":"44","author":"Wu","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"10.1016\/j.intimp.2023.110195_b0090","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1167\/iovs.17-21887","article-title":"Aspergillus Fumigatus Increased Par-2 Expression and Elevated Proinflammatory Cytokines Expression Through the Pathway of Par-2\/erk1\/2 in Cornea","volume":"59","author":"Niu","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.intimp.2023.110195_b0095","doi-asserted-by":"crossref","first-page":"4363","DOI":"10.2741\/3533","article-title":"How the Host Fights Against Candida Infections","volume":"14","author":"Richardson","year":"2009","journal-title":"Front Biosci"},{"issue":"4","key":"10.1016\/j.intimp.2023.110195_b0100","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.jmb.2004.07.089","article-title":"Crystal structure of human triggering receptor expressed on myeloid cells 1","volume":"342","author":"Kelker","year":"2004","journal-title":"J Mol Biol."},{"issue":"5","key":"10.1016\/j.intimp.2023.110195_b0105","doi-asserted-by":"crossref","DOI":"10.1152\/ajplung.00195.2015","article-title":"Trem-1-accentuated Lung Injury Via Mir-155 Is Inhibited By Lp17 Nanomedicine","volume":"310","author":"Yuan","year":"2016","journal-title":"Am. J. Physiology-lung Cell. Mol. Physiol."},{"issue":"10","key":"10.1016\/j.intimp.2023.110195_b0110","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.tips.2006.08.004","article-title":"Immune Cell Signaling: a Novel Mechanistic Model Reveals New Therapeutic Targets","volume":"27","author":"Sigalov","year":"2006","journal-title":"Trends Pharmacol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2023.110195_b0115","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.intimp.2014.05.001","article-title":"A Novel Ligand-independent Peptide Inhibitor of Trem-1 Suppresses Tumor Growth in Human Lung Cancer Xenografts and Prolongs Survival of Mice with Lipopolysaccharide-induced Septic Shock","volume":"21","author":"Sigalov","year":"2014","journal-title":"Int. Immunopharmacol."},{"issue":"10","key":"10.1016\/j.intimp.2023.110195_b0120","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1111\/jcmm.13173","article-title":"Rationally Designed Ligand-independent Peptide Inhibitors of Trem-1 Ameliorate Collagen-induced Arthritis","volume":"21","author":"Shen","year":"2017","journal-title":"J. Cell Mol. Med."},{"issue":"9","key":"10.1016\/j.intimp.2023.110195_b0125","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1016\/j.bbadis.2018.05.001","article-title":"Blockade of Trem-1 Prevents Vitreoretinal Neovascularization in Mice with Oxygen-induced Retinopathy","volume":"1864","author":"Rojas","year":"2018","journal-title":"Biochimica Et Biophysica Acta (bba)-molecular Basis of Disease"},{"issue":"1","key":"10.1016\/j.intimp.2023.110195_b0130","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00430-011-0209-y","article-title":"Activation of Mapk\/c-fos Induced Responses in Oral Epithelial Cells Is Specific to Candida Albicans and Candida Dubliniensis Hyphae","volume":"201","author":"Moyes","year":"2012","journal-title":"Med. Microbiol. Immunol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923005167?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923005167?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:33:08Z","timestamp":1785771188000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576923005167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":26,"alternative-id":["S1567576923005167"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2023.110195","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Candidalysin amplifies the immune inflammatory response in Candida albicans keratitis through the TREM-1\/DAP12 pathway","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2023.110195","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110195"}}