{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:34:45Z","timestamp":1783571685121,"version":"3.55.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007765","name":"Shenyang Science and Technology Bureau","doi-asserted-by":"publisher","award":["21-173-9-71"],"award-info":[{"award-number":["21-173-9-71"]}],"id":[{"id":"10.13039\/501100007765","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.intimp.2023.110362","type":"journal-article","created":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T23:05:32Z","timestamp":1686438332000},"page":"110362","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["LMCD1 is involved in tubulointerstitial inflammation in the early phase of renal fibrosis by promoting NFATc1-mediated NLRP3 activation"],"prefix":"10.1016","volume":"121","author":[{"given":"Yu","family":"Bai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzhe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixia","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingsi","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beiru","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2023.110362_b0005","doi-asserted-by":"crossref","unstructured":"KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases, Kidney international 100(4s) (2021) S1-s276.","DOI":"10.1016\/j.kint.2021.05.021"},{"issue":"10075","key":"10.1016\/j.intimp.2023.110362_b0010","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/S0140-6736(16)32064-5","article-title":"Chronic Kidney Disease","volume":"389","author":"Webster","year":"2017","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.intimp.2023.110362_b0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cellsig.2017.11.005","article-title":"TGF-\u03b21\/p53 signaling in renal fibrogenesis","volume":"43","author":"Higgins","year":"2018","journal-title":"Cell. Signal."},{"key":"10.1016\/j.intimp.2023.110362_b0020","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.addr.2017.12.019","article-title":"Targeting renal fibrosis: Mechanisms and drug delivery systems","volume":"129","author":"Nastase","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.intimp.2023.110362_b0025","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1038\/ki.2010.418","article-title":"Mechanistic connection between inflammation and fibrosis","volume":"Supplement (119)","author":"Lee","year":"2010","journal-title":"Kidney Int."},{"key":"10.1016\/j.intimp.2023.110362_b0030","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/978-981-13-8871-2_18","article-title":"Inflammatory Mediators and Renal Fibrosis","volume":"1165","author":"Meng","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"issue":"3","key":"10.1016\/j.intimp.2023.110362_b0035","first-page":"164","article-title":"Targeting the chemokine network in renal inflammation","volume":"52","author":"Eis","year":"2004","journal-title":"Arch. Immunol. Ther. Exp. (Warsz.)"},{"issue":"9","key":"10.1016\/j.intimp.2023.110362_b0040","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nrneph.2014.114","article-title":"Inflammatory processes in renal fibrosis","volume":"10","author":"Meng","year":"2014","journal-title":"Nat. Rev. Nephrol."},{"issue":"3","key":"10.1016\/j.intimp.2023.110362_b0045","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.kint.2017.09.033","article-title":"Renal tubule injury: a driving force toward chronic kidney disease","volume":"93","author":"Liu","year":"2018","journal-title":"Kidney Int."},{"key":"10.1016\/j.intimp.2023.110362_b0050","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.3389\/fimmu.2018.02305","article-title":"Regulation of NLRP3 Inflammasome by Phosphorylation","volume":"9","author":"Song","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2023.110362_b0055","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3389\/fcell.2019.00379","article-title":"Effect and Regulation of the NLRP3 Inflammasome During Renal Fibrosis","volume":"7","author":"Zhang","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"issue":"10","key":"10.1016\/j.intimp.2023.110362_b0060","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1080\/15548627.2020.1848971","article-title":"Inhibiting NLRP3 inflammasome attenuates apoptosis in contrast-induced acute kidney injury through the upregulation of HIF1A and BNIP3-mediated mitophagy","volume":"17","author":"Lin","year":"2021","journal-title":"Autophagy"},{"issue":"4","key":"10.1016\/j.intimp.2023.110362_b0065","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9040398","article-title":"Therapeutic Effect of Endothelin-Converting Enzyme Inhibitor on Chronic Kidney Disease through the Inhibition of Endoplasmic Reticulum Stress and the NLRP3 Inflammasome","volume":"9","author":"Hsu","year":"2021","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/j.intimp.2023.110362_b0070","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s13395-019-0214-1","article-title":"LIM and cysteine-rich domains 1 (LMCD1) regulates skeletal muscle hypertrophy, calcium handling, and force","volume":"9","author":"Ferreira","year":"2019","journal-title":"Skelet. Muscle"},{"issue":"1","key":"10.1016\/j.intimp.2023.110362_b0075","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1006\/geno.1999.6049","article-title":"Identification of a novel LIM domain gene, LMCD1, and chromosomal localization in human and mouse","volume":"63","author":"Bespalova","year":"2000","journal-title":"Genomics"},{"issue":"8","key":"10.1016\/j.intimp.2023.110362_b0080","doi-asserted-by":"crossref","first-page":"4712","DOI":"10.1074\/jbc.273.8.4712","article-title":"Interactions between LIM domains and the LIM domain-binding protein Ldb1","volume":"273","author":"Breen","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2023.110362_b0085","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jinorgbio.2012.05.009","article-title":"Femtomolar Zn2+ affinity of LIM domain of PDLIM1 protein uncovers crucial contribution of protein-protein interactions to protein stability","volume":"115","author":"Sikorska","year":"2012","journal-title":"J. Inorg. Biochem."},{"issue":"2","key":"10.1016\/j.intimp.2023.110362_b0090","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/pmic.201100492","article-title":"The interactome of LIM domain proteins: the contributions of LIM domain proteins to heart failure and heart development","volume":"12","author":"Li","year":"2012","journal-title":"Proteomics"},{"issue":"10","key":"10.1016\/j.intimp.2023.110362_b0095","doi-asserted-by":"crossref","first-page":"e13217","DOI":"10.1111\/acel.13217","article-title":"Testicular Lmcd1 regulates phagocytosis by Sertoli cells through modulation of NFAT1\/Txlna signaling pathway","volume":"19","author":"Jin","year":"2020","journal-title":"Aging Cell"},{"issue":"9","key":"10.1016\/j.intimp.2023.110362_b0100","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1074\/jbc.RA117.000866","article-title":"LIM and cysteine-rich domains 1 is required for thrombin-induced smooth muscle cell proliferation and promotes atherogenesis","volume":"293","author":"Janjanam","year":"2018","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.intimp.2023.110362_b0105","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1161\/ATVBAHA.119.312729","article-title":"NFATc1-E2F1-LMCD1-Mediated IL-33 Expression by Thrombin Is Required for Injury-Induced Neointima Formation","volume":"39","author":"Govatati","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"5","key":"10.1016\/j.intimp.2023.110362_b0110","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1161\/ATVBAHA.120.314147","article-title":"Myristoylation of LMCD1 Leads to Its Species-Specific Derepression of E2F1 and NFATc1 in the Modulation of CDC6 and IL-33 Expression During Development of Vascular Lesions","volume":"40","author":"Govatati","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"12","key":"10.1016\/j.intimp.2023.110362_b0115","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1136\/gutjnl-2021-325013","article-title":"NFATc1 signaling drives chronic ER stress responses to promote NAFLD progression","volume":"71","author":"Latif","year":"2022","journal-title":"Gut"},{"issue":"6","key":"10.1016\/j.intimp.2023.110362_b0120","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1158\/2159-8290.CD-13-0593","article-title":"Inflammation-induced NFATc1-STAT3 transcription complex promotes pancreatic cancer initiation by KrasG12D","volume":"4","author":"Baumgart","year":"2014","journal-title":"Cancer Discov."},{"issue":"17","key":"10.1016\/j.intimp.2023.110362_b0125","doi-asserted-by":"crossref","first-page":"9810","DOI":"10.1111\/jcmm.15562","article-title":"Tacrolimus ameliorates tubulointerstitial inflammation in diabetic nephropathy via inhibiting the NFATc1\/TRPC6 pathway","volume":"24","author":"Zhang","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.intimp.2023.110362_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108028","article-title":"Role of ITK signaling in acute kidney injury in mice: Amelioration of acute kidney injury associated clinical parameters and attenuation of inflammatory transcription factor signaling in CD4+ T cells by ITK inhibition","volume":"99","author":"Nadeem","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2023.110362_b0135","doi-asserted-by":"crossref","unstructured":"Z.Y. Bian, H. Huang, H. Jiang, D.F. Shen, L. Yan, L.H. Zhu, L. Wang, F. Cao, C. Liu, Q.Z. Tang, H. Li, LIM and cysteine-rich domains 1 regulates cardiac hypertrophy by targeting calcineurin\/nuclear factor of activated T cells signaling, Hypertension (Dallas, Tex. : 1979) 55(2) (2010) 257-63.","DOI":"10.1161\/HYPERTENSIONAHA.109.135665"},{"key":"10.1016\/j.intimp.2023.110362_b0140","doi-asserted-by":"crossref","unstructured":"G.S. Bogatkevich, I. Atanelishvili, A.M. Bogatkevich, R.M. Silver, Critical Role of LMCD1 in Promoting Profibrotic Characteristics of Lung Myofibroblasts in Experimental and Scleroderma-Associated Lung Fibrosis, Arthritis & rheumatology (Hoboken, N.J.) 75(3) (2023) 438-448.","DOI":"10.1002\/art.42344"},{"issue":"4","key":"10.1016\/j.intimp.2023.110362_b0145","article-title":"Suppression of LMCD1 ameliorates renal fibrosis by blocking the activation of ERK pathway","volume":"1869","author":"Yu","year":"2021","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.intimp.2023.110362_b0150","doi-asserted-by":"crossref","unstructured":"R. Yu, Y. Wu, P. He, Y. Bai, Y. Zhang, X. Bian, G. Sun, B. Zhang, LIM and Cysteine-Rich Domains 1 Promotes Transforming Growth Factor \u03b21-Induced Epithelial-Mesenchymal Transition in Human Kidney 2 Cells, Laboratory investigation; a journal of technical methods and pathology 103(2) (2023) 100016.","DOI":"10.1016\/j.labinv.2022.100016"},{"issue":"9","key":"10.1016\/j.intimp.2023.110362_b0155","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1369\/0022155419852932","article-title":"Renal Inflammation and Fibrosis: A Double-edged Sword","volume":"67","author":"Black","year":"2019","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.intimp.2023.110362_b0160","doi-asserted-by":"crossref","unstructured":"Y. Liu, Y. Wang, W. Ding, Y. Wang, Mito-TEMPO Alleviates Renal Fibrosis by Reducing Inflammation, Mitochondrial Dysfunction, and Endoplasmic Reticulum Stress, Oxidative medicine and cellular longevity 2018 (2018) 5828120.","DOI":"10.1155\/2018\/5828120"},{"issue":"6","key":"10.1016\/j.intimp.2023.110362_b0165","doi-asserted-by":"crossref","first-page":"F1430","DOI":"10.1152\/ajprenal.00230.2019","article-title":"BMP1 inhibitor UK383,367 attenuates renal fibrosis and inflammation in CKD","volume":"317","author":"Bai","year":"2019","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.intimp.2023.110362_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106249","article-title":"Hirudin improves renal interstitial fibrosis by reducing renal tubule injury and inflammation in unilateral ureteral obstruction (UUO) mice","volume":"81","author":"Xie","year":"2020","journal-title":"Int. Immunopharmacol."},{"issue":"11","key":"10.1016\/j.intimp.2023.110362_b0175","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1038\/ki.2009.86","article-title":"Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy","volume":"75","author":"Chevalier","year":"2009","journal-title":"Kidney Int."},{"issue":"4","key":"10.1016\/j.intimp.2023.110362_b0180","doi-asserted-by":"crossref","DOI":"10.3390\/biom9040141","article-title":"Unilateral Ureteral Obstruction as a Model to Investigate Fibrosis-Attenuating Treatments","volume":"9","author":"Mart\u00ednez-Klimova","year":"2019","journal-title":"Biomolecules"},{"issue":"3","key":"10.1016\/j.intimp.2023.110362_b0185","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/1097-0029(20000801)50:3<184::AID-JEMT2>3.0.CO;2-H","article-title":"TNF alpha and the TNF receptor superfamily: structure-function relationship(s)","volume":"50","author":"Idriss","year":"2000","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.intimp.2023.110362_b0190","article-title":"Roxadustat (FG-4592) Facilitates Recovery From Renal Damage by Ameliorating Mitochondrial Dysfunction Induced by Folic Acid","volume":"12","author":"Li","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"23","key":"10.1016\/j.intimp.2023.110362_b0195","doi-asserted-by":"crossref","first-page":"3955","DOI":"10.1242\/jcs.207365","article-title":"Inflammasome activation and assembly at a glance","volume":"130","author":"Malik","year":"2017","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.intimp.2023.110362_b0200","doi-asserted-by":"crossref","unstructured":"H.L. Hutton, J.D. Ooi, S.R. Holdsworth, A.R. Kitching, The NLRP3 inflammasome in kidney disease and autoimmunity, Nephrology (Carlton, Vic.) 21(9) (2016) 736-44.","DOI":"10.1111\/nep.12785"},{"issue":"1","key":"10.1016\/j.intimp.2023.110362_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2019.07.001","article-title":"NLRP3 inflammasome inhibition attenuates cisplatin-induced renal fibrosis by decreasing oxidative stress and inflammation","volume":"383","author":"Li","year":"2019","journal-title":"Exp. Cell Res."},{"issue":"1","key":"10.1016\/j.intimp.2023.110362_b0210","first-page":"131","article-title":"Ghrelin attenuates UUO-induced renal fibrosis via attenuation of Nlrp3 inflammasome and endoplasmic reticulum stress","volume":"11","author":"Ling","year":"2019","journal-title":"Am. J. Transl. Res."},{"issue":"1","key":"10.1016\/j.intimp.2023.110362_b0215","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1093\/ckj\/sfz137","article-title":"Tumor necrosis factor-\u03b1 blockade ameliorates diabetic nephropathy in rats","volume":"14","author":"Cheng","year":"2021","journal-title":"Clin. Kidney J."},{"issue":"4","key":"10.1016\/j.intimp.2023.110362_b0220","doi-asserted-by":"crossref","first-page":"543","DOI":"10.2174\/1566524011313040007","article-title":"NFAT gene family in inflammation and cancer","volume":"13","author":"Pan","year":"2013","journal-title":"Curr. Mol. Med."},{"issue":"2","key":"10.1016\/j.intimp.2023.110362_b0225","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/s41401-019-0289-6","article-title":"Artesunate attenuates LPS-induced osteoclastogenesis by suppressing TLR4\/TRAF6 and PLC\u03b31-Ca(2+)-NFATc1 signaling pathway","volume":"41","author":"Zeng","year":"2020","journal-title":"Acta Pharmacol. Sin."},{"issue":"2","key":"10.1016\/j.intimp.2023.110362_b0230","doi-asserted-by":"crossref","first-page":"242","DOI":"10.2174\/1871530319666190715160630","article-title":"SRC-3\/AIB-1 may Enhance Hepatic NFATC1 Transcription and Mediate Inflammation in a Tissue-Specific Manner in Morbid Obesity","volume":"20","author":"Chasapi","year":"2020","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"issue":"16","key":"10.1016\/j.intimp.2023.110362_b0235","doi-asserted-by":"crossref","first-page":"10935","DOI":"10.1074\/jbc.M900465200","article-title":"Sumoylation of the transcription factor NFATc1 leads to its subnuclear relocalization and interleukin-2 repression by histone deacetylase","volume":"284","author":"Nayak","year":"2009","journal-title":"J. Biol. Chem."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923006859?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923006859?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T18:04:23Z","timestamp":1761588263000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576923006859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":47,"alternative-id":["S1567576923006859"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2023.110362","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LMCD1 is involved in tubulointerstitial inflammation in the early phase of renal fibrosis by promoting NFATc1-mediated NLRP3 activation","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2023.110362","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110362"}}