{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T05:37:42Z","timestamp":1770356262200,"version":"3.49.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20272"],"award-info":[{"award-number":["U22A20272"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.intimp.2023.110378","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T14:40:16Z","timestamp":1685025616000},"page":"110378","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Nogo-B inhibition restricts ulcerative colitis via inhibiting p68\/miR-155 signaling pathway"],"prefix":"10.1016","volume":"120","author":[{"given":"Juan","family":"Zheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengnan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengmeng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoning","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Ge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxiao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongmei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yajun","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lipei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0813-3847","authenticated-orcid":false,"given":"Yuanli","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.intimp.2023.110378_b0005","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/path.4527","article-title":"NF-kappaB1, NF-kappaB2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL\/6 mice","volume":"236","author":"Burkitt","year":"2015","journal-title":"J. Pathol."},{"key":"10.1016\/j.intimp.2023.110378_b0010","doi-asserted-by":"crossref","first-page":"9318721","DOI":"10.1155\/2022\/9318721","article-title":"The attenuation of chronic ulcerative colitis by (R)-salbutamol in repeated DSS-induced mice","volume":"2022","author":"Deng","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"6","key":"10.1016\/j.intimp.2023.110378_b0015","first-page":"5115","article-title":"Expression and correlation of miR-124 and miR-126 in breast cancer","volume":"17","author":"Li","year":"2019","journal-title":"Oncol. Lett."},{"issue":"1","key":"10.1016\/j.intimp.2023.110378_b0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1515\/jbcpp-2018-0036","article-title":"Immune response and inflammatory pathway of ulcerative colitis","volume":"30","author":"Tatiya-aphiradee","year":"2018","journal-title":"J. Basic Clin. Physiol. Pharmacol."},{"key":"10.1016\/j.intimp.2023.110378_b0025","doi-asserted-by":"crossref","first-page":"2617881","DOI":"10.1155\/2021\/2617881","article-title":"Ficus pandurata hance inhibits ulcerative colitis and colitis-associated secondary liver damage of mice by enhancing antioxidation activity","volume":"2021","author":"Dai","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.intimp.2023.110378_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105796","article-title":"Dioscin ameliorates murine ulcerative colitis by regulating macrophage polarization","volume":"172","author":"Wu","year":"2021","journal-title":"Pharmacol. Res."},{"issue":"5","key":"10.1016\/j.intimp.2023.110378_b0035","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1159\/000484061","article-title":"Nogo-B promotes angiogenesis in proliferative diabetic retinopathy via VEGF\/PI3K\/Akt pathway in an autocrine manner","volume":"43","author":"Zhang","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"issue":"8","key":"10.1016\/j.intimp.2023.110378_b0040","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1007\/s10571-021-01124-0","article-title":"A novel role of Nogo proteins: regulating macrophages in inflammatory Disease","volume":"42","author":"Zhang","year":"2022","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.intimp.2023.110378_b0045","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.biopha.2018.05.039","article-title":"Inhibition of Nogo-B promotes cardiac hypertrophy via endoplasmic reticulum stress","volume":"104","author":"Li","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.intimp.2023.110378_b0050","doi-asserted-by":"crossref","first-page":"111979","DOI":"10.1016\/j.yexcr.2020.111979","article-title":"Nogo-B fosters HCC progression by enhancing Yap\/Taz-mediated tumor-associated macrophages M2 polarization","volume":"391","author":"Zhao","year":"2020","journal-title":"Exp. Cell Res."},{"issue":"4","key":"10.1016\/j.intimp.2023.110378_b0055","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/nm1020","article-title":"A new role for Nogo as a regulator of vascular remodeling","volume":"10","author":"Acevedo","year":"2004","journal-title":"Nat. Med."},{"issue":"29","key":"10.1016\/j.intimp.2023.110378_b0060","doi-asserted-by":"crossref","first-page":"10997","DOI":"10.1073\/pnas.0602427103","article-title":"Identification of a receptor necessary for Nogo-B stimulated chemotaxis and morphogenesis of endothelial cells","volume":"103","author":"Miao","year":"2006","journal-title":"PNAS"},{"issue":"5","key":"10.1016\/j.intimp.2023.110378_b0065","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1002\/hep.26235","article-title":"Reticulon 4B (Nogo-B) facilitates hepatocyte proliferation and liver regeneration in mice","volume":"57","author":"Gao","year":"2013","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.intimp.2023.110378_b0070","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1002\/hep.29051","article-title":"An endoplasmic reticulum protein, Nogo-B, facilitates alcoholic liver disease through regulation of kupffer cell polarization","volume":"65","author":"Park","year":"2017","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.intimp.2023.110378_b0075","doi-asserted-by":"crossref","first-page":"101561","DOI":"10.1016\/j.jbc.2022.101561","article-title":"Inhibition of high-fat diet-induced obesity via reduction of ER-resident protein Nogo occurs through multiple mechanisms","volume":"298","author":"Wang","year":"2022","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.intimp.2023.110378_b0080","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/j.jhep.2020.07.034","article-title":"Reduced Nogo expression inhibits diet-induced metabolic disorders by regulating ChREBP and insulin activity","volume":"73","author":"Zhang","year":"2020","journal-title":"J. Hepatol."},{"issue":"16","key":"10.1016\/j.intimp.2023.110378_b0085","doi-asserted-by":"crossref","first-page":"3617","DOI":"10.1111\/bph.15193","article-title":"The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research","volume":"177","author":"Percie du Sert","year":"2020","journal-title":"Br. J. Pharmacol."},{"issue":"52","key":"10.1016\/j.intimp.2023.110378_b0090","doi-asserted-by":"crossref","first-page":"43340","DOI":"10.1074\/jbc.M112.403394","article-title":"Activation of liver X receptor induces macrophage interleukin-5 expression","volume":"287","author":"Chen","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.intimp.2023.110378_b0095","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1161\/ATVBAHA.114.305116","article-title":"Inhibition of ERK1\/2 and activation of LXR synergistically reduce atherosclerotic lesions in ApoE-deficient mice","volume":"35","author":"Chen","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"5","key":"10.1016\/j.intimp.2023.110378_b0100","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/iub.2599","article-title":"ENSMUST00000147869 regulates proliferation and fibrosis of mesangial cells in diabetic nephropathy by interacting with Hspa 9","volume":"74","author":"Wang","year":"2022","journal-title":"IUBMB Life"},{"issue":"3","key":"10.1016\/j.intimp.2023.110378_b0105","doi-asserted-by":"crossref","first-page":"6490","DOI":"10.1080\/21655979.2022.2031676","article-title":"Matrine protects colon mucosal epithelial cells against inflammation and apoptosis via the Janus kinase 2 \/signal transducer and activator of transcription 3 pathway","volume":"13","author":"Chen","year":"2022","journal-title":"Bioengineered"},{"issue":"6","key":"10.1016\/j.intimp.2023.110378_b0110","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1631\/jzus.B2100988","article-title":"Spirulina platensis aqueous extracts ameliorate colonic mucosal damage and modulate gut microbiota disorder in mice with ulcerative colitis by inhibiting inflammation and oxidative stress","volume":"23","author":"Wang","year":"2022","journal-title":"J. Zhejiang Univ. Sci. B"},{"issue":"4","key":"10.1016\/j.intimp.2023.110378_b0115","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/ecco-jcc\/jjaa214","article-title":"M2 macrophage-derived exosomal miR-590-3p attenuates DSS-induced mucosal damage and promotes epithelial repair via the LATS1\/YAP\/ beta-catenin signalling axis","volume":"15","author":"Deng","year":"2021","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.intimp.2023.110378_b0120","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.jconrel.2022.05.025","article-title":"Oral antimicrobial peptide-EGCG nanomedicines for synergistic treatment of ulcerative colitis","volume":"347","author":"Liu","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.intimp.2023.110378_b0125","doi-asserted-by":"crossref","first-page":"112112","DOI":"10.1016\/j.biopha.2021.112112","article-title":"The impact of non-coding RNAs on macrophage polarization","volume":"142","author":"Ghafouri-Fard","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2023.110378_b0130","doi-asserted-by":"crossref","unstructured":"N.A. Molodecky, I.S. Soon, D.M. Rabi, W.A. Ghali, M. Ferris, G. Chernoff, E.I. Benchimol, R. Panaccione, S. Ghosh, H.W. Barkema, G.G. Kaplan, Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review, Gastroenterology 142(1) (2012) 46-54.e42; quiz e30.","DOI":"10.1053\/j.gastro.2011.10.001"},{"issue":"1","key":"10.1016\/j.intimp.2023.110378_b0135","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s11938-017-0120-8","article-title":"Update on the use of biologic therapy in ulcerative colitis","volume":"15","author":"Aggarwal","year":"2017","journal-title":"Curr. Treat Options Gastroenterol."},{"issue":"12","key":"10.1016\/j.intimp.2023.110378_b0140","doi-asserted-by":"crossref","DOI":"10.1152\/ajpgi.00309.2014","article-title":"A new role for reticulon-4B\/NOGO-B in the intestinal epithelial barrier function and inflammatory bowel disease","volume":"308","author":"Rodriguez-Feo","year":"2015","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.intimp.2023.110378_b0145","doi-asserted-by":"crossref","first-page":"896591","DOI":"10.3389\/fcell.2022.896591","article-title":"The role of tissue-resident macrophages in the development and treatment of inflammatory bowel disease","volume":"10","author":"Ma","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.intimp.2023.110378_b0150","doi-asserted-by":"crossref","first-page":"999179","DOI":"10.3389\/fphar.2022.999179","article-title":"A potential therapeutic target in traditional Chinese medicine for ulcerative colitis: Macrophage polarization","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"12","key":"10.1016\/j.intimp.2023.110378_b0155","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1007\/s00011-020-01398-y","article-title":"Macrophage polarization in intestinal inflammation and gut homeostasis","volume":"69","author":"Moreira Lopes","year":"2020","journal-title":"Inflamm. Res."},{"issue":"7","key":"10.1016\/j.intimp.2023.110378_b0160","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1182\/blood-2010-04-281956","article-title":"Endothelial reticulon-4B (Nogo-B) regulates ICAM-1-mediated leukocyte transmigration and acute inflammation","volume":"117","author":"Di Lorenzo","year":"2011","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.intimp.2023.110378_b0165","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1084\/jem.20100786","article-title":"Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation","volume":"207","author":"Wright","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.intimp.2023.110378_b0170","doi-asserted-by":"crossref","first-page":"101745","DOI":"10.1016\/j.redox.2020.101745","article-title":"Nogo-B is a key mediator of hepatic ischemia and reperfusion injury","volume":"37","author":"Rao","year":"2020","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.intimp.2023.110378_b0175","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1097\/SHK.0000000000000604","article-title":"MiRNA-mediated macrophage polarization and its potential role in the regulation of inflammatory response","volume":"46","author":"Essandoh","year":"2016","journal-title":"Shock"},{"key":"10.1016\/j.intimp.2023.110378_b0180","doi-asserted-by":"crossref","first-page":"8060182","DOI":"10.1155\/2016\/8060182","article-title":"miR-155 regulated inflammation response by the SOCS1-STAT3-PDCD4 axis in atherogenesis","volume":"2016","author":"Ye","year":"2016","journal-title":"Mediators Inflamm."},{"issue":"15","key":"10.1016\/j.intimp.2023.110378_b0185","doi-asserted-by":"crossref","first-page":"8441","DOI":"10.1111\/jcmm.15388","article-title":"MiR-155 promotes interleukin-1\u03b2-induced chondrocyte apoptosis and catabolic activity by targeting PIK3R1-mediated PI3K\/Akt pathway","volume":"24","author":"Fan","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.intimp.2023.110378_b0190","doi-asserted-by":"crossref","first-page":"107218","DOI":"10.1016\/j.intimp.2020.107218","article-title":"Inhibition of miR-155 alleviates sepsis-induced inflammation and intestinal barrier dysfunction by inactivating NF-\u03baB signaling","volume":"90","author":"Cao","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2023.110378_b0195","doi-asserted-by":"crossref","first-page":"109909","DOI":"10.1016\/j.biopha.2020.109909","article-title":"miR-155 antagomir protect against DSS-induced colitis in mice through regulating Th17\/Treg cell balance by Jarid2\/Wnt\/\u03b2-catenin","volume":"126","author":"Zhu","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.intimp.2023.110378_b0200","doi-asserted-by":"crossref","first-page":"36","DOI":"10.2174\/2211536611666220218121640","article-title":"P68 RNA Helicase (DDX5) Required for the Formation of Various Specific and Mature miRNA Active RISC Complexes","volume":"11","author":"Kokolo","year":"2022","journal-title":"MicroRNA"},{"key":"10.1016\/j.intimp.2023.110378_b0205","doi-asserted-by":"crossref","first-page":"113444","DOI":"10.1016\/j.biopha.2022.113444","article-title":"Lack of Nogo-B expression ameliorates PPARgamma deficiency-aggravated liver fibrosis by regulating TLR4-NF-kappaB-TNF-alpha axis and macrophage polarization","volume":"153","author":"Zhao","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"9","key":"10.1016\/j.intimp.2023.110378_b0210","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1093\/neuonc\/nos131","article-title":"p68 RNA helicase promotes glioma cell proliferation in vitro and in vivo via direct regulation of NF-kappaB transcription factor p50","volume":"14","author":"Wang","year":"2012","journal-title":"Neuro Oncol."},{"issue":"9","key":"10.1016\/j.intimp.2023.110378_b0215","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1093\/neuonc\/nos131","article-title":"p68 RNA helicase promotes glioma cell proliferation in vitro and in vivo via direct regulation of NF-\u03baB transcription factor p50","volume":"14","author":"Wang","year":"2012","journal-title":"Neuro Oncol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923007014?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923007014?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T18:02:15Z","timestamp":1761588135000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576923007014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":43,"alternative-id":["S1567576923007014"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2023.110378","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nogo-B inhibition restricts ulcerative colitis via inhibiting p68\/miR-155 signaling pathway","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2023.110378","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110378"}}