{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:34:20Z","timestamp":1790102060786,"version":"4.0.1"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100014768","name":"Jiaxing University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014768","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.intimp.2023.110380","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T23:31:48Z","timestamp":1685057508000},"page":"110380","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Lapachol treats non-alcoholic fatty liver disease by modulating the M1 polarization of Kupffer cells via PKM2"],"prefix":"10.1016","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2519-5217","authenticated-orcid":false,"given":"Yi","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjia","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.intimp.2023.110380_b0005","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1038\/s41401-020-00516-0","article-title":"Melittin ameliorates inflammation in mouse acute liver failure via inhibition of PKM2-mediated Warburg effect","volume":"42","author":"Fan","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.intimp.2023.110380_b0010","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jare.2020.09.001","article-title":"Iminostilbene, a novel small-molecule modulator of PKM2, suppresses macrophage inflammation in myocardial ischemia-reperfusion injury","volume":"29","author":"Lu","year":"2020","journal-title":"J. Adv. Res."},{"issue":"3","key":"10.1016\/j.intimp.2023.110380_b0015","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1248\/bpb.b20-00752","article-title":"Lycium barbarum Polysaccharide Antagonizes LPS-Induced Inflammation by Altering the Glycolysis and Differentiation of Macrophages by Triggering the Degradation of PKM2","volume":"44","author":"Ding","year":"2021","journal-title":"Biol. Pharm Bull."},{"key":"10.1016\/j.intimp.2023.110380_b0020","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.595316","article-title":"Activator-Mediated Pyruvate Kinase M2 Activation Contributes to Endotoxin Tolerance by Promoting Mitochondrial Biogenesis","volume":"11","author":"Yi","year":"2021","journal-title":"Front Immunol."},{"key":"10.1016\/j.intimp.2023.110380_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.110948","article-title":"Changes in energy metabolism and macrophage polarization: Potential mechanisms of arsenic-induced lung injury","volume":"204","author":"Wang","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"40","key":"10.1016\/j.intimp.2023.110380_b0030","doi-asserted-by":"crossref","first-page":"11182","DOI":"10.1021\/acs.jafc.0c04041","article-title":"Ketogenic Diet Elicits Antitumor Properties through Inducing Oxidative Stress, Inhibiting MMP-9 Expression, and Rebalancing M1\/M2 Tumor-Associated Macrophage Phenotype in a Mouse Model of Colon Cancer","volume":"68","author":"Zhang","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.intimp.2023.110380_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101634","article-title":"Annexin A5 regulates hepatic macrophage polarization via directly targeting PKM2 and ameliorates NASH","volume":"36","author":"Xu","year":"2020","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.intimp.2023.110380_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbabio.2022.148948","article-title":"Unveiling the membrane bound dihydroorotate: Quinone oxidoreductase from Staphylococcus aureus","volume":"1864","author":"Sousa","year":"2023","journal-title":"Biochim. Biophys. Acta Bioenerg."},{"key":"10.1016\/j.intimp.2023.110380_b0045","article-title":"Development of a microemulsion loaded with epoxy-\u03b1-lapachone against Leishmania (Leishmania) amazonensis murine infection","volume":"122864","author":"Figueiredo Peixoto","year":"2023","journal-title":"Int. J. Pharm."},{"issue":"1","key":"10.1016\/j.intimp.2023.110380_b0050","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3390\/molecules28010309","article-title":"Chemoselective Synthesis of Mannich Adducts from 1,4-Naphthoquinones and Profile as Autophagic Inducers in Oral Squamous Cell Carcinoma","volume":"28","author":"Borges","year":"2022","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.intimp.2023.110380_b0055","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1186\/s12967-023-04046-1","article-title":"Atf4 regulates angiogenic differences between alveolar bone and long bone macrophages by regulating M1 polarization, based on single-cell RNA sequencing, RNA-seq and ATAC-seq analysis","volume":"21","author":"Zhang","year":"2023","journal-title":"J. Transl. Med."},{"issue":"1618","key":"10.1016\/j.intimp.2023.110380_b0060","article-title":"Saxagliptin regulates M1\/M2 macrophage polarization via CaMKK\u03b2\/AMPK pathway to attenuate NAFLD[J]","volume":"503","author":"Yang","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"11","key":"10.1016\/j.intimp.2023.110380_b0065","doi-asserted-by":"crossref","first-page":"e0143380","DOI":"10.1371\/journal.pone.0143380","article-title":"Peripheral and Hepatic Vein Cytokine Levels in Correlation with Non-Alcoholic Fatty Liver Disease (NAFLD)-Related Metabolic, Histological, and Haemodynamic Features[J]","volume":"10","author":"Luisa","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.intimp.2023.110380_b0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/8162421","article-title":"The Role of Tissue Macrophage-Mediated Inflammation on NAFLD Pathogenesis and Its Clinical Implications[J]","volume":"2017","author":"Alisi","year":"2017","journal-title":"Mediators Inflamm."},{"issue":"6","key":"10.1016\/j.intimp.2023.110380_b0075","doi-asserted-by":"crossref","first-page":"G540","DOI":"10.1152\/ajpgi.00247.2014","article-title":"Chronic NOS inhibition accelerates NAFLD progression in an obese rat model[J]","volume":"308","author":"Sheldon","year":"2015","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"4","key":"10.1016\/j.intimp.2023.110380_b0080","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/S0016-5085(15)33312-6","article-title":"Tu2046 Early Compensatory Mechanism of the Liver After the Initial Accumulation of Fat in a Diet-Induced NAFLD Model[J]","volume":"148","author":"Smith","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.intimp.2023.110380_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101501","article-title":"Non-lethal sonodynamic therapy facilitates the M1-to-M2 transition in advanced atherosclerotic plaques via activating the ROS\u2013AMPK\u2013mTORC1\u2013autophagy pathway[J]","volume":"32","author":"Yang","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.intimp.2023.110380_b0090","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.taap.2019.01.022","article-title":"M1 macrophage mediated increased reactive oxygen species (ROS) influence wound healing via the MAPK signaling in vitro and in vivo[J]","volume":"366","author":"Deng","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"4","key":"10.1016\/j.intimp.2023.110380_b0095","doi-asserted-by":"crossref","first-page":"502","DOI":"10.3109\/17435390.2010.541604","article-title":"Inflammatory responses of RAW 264.7 macrophages upon exposure to nanoparticles: role of ROS-NF\u03baB signaling pathway.[J]","volume":"5","author":"Nishanth","year":"2011","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.intimp.2023.110380_b0100","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.canlet.2016.08.023","article-title":"Gemcitabine treatment promotes pancreatic cancer stemness through the Nox\/ROS\/NF-\u03baB\/STAT3 signaling cascade[J]","author":"Zhang","year":"2016","journal-title":"Cancer Lett."},{"issue":"3","key":"10.1016\/j.intimp.2023.110380_b0105","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1111\/jam.12273","article-title":"Lactobacillus brevis G-101 ameliorates colitis in mice by inhibiting NF-\u03baB, MAPK and AKT pathways and by polarizing M1 macrophages to M2-like macrophages.[J]","volume":"115","author":"Jang","year":"2013","journal-title":"J. Appl. Microbiol."},{"issue":"7","key":"10.1016\/j.intimp.2023.110380_b0110","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1080\/15548627.2019.1664705","article-title":"SQSTM1-dependent autophagic degradation of PKM2 inhibits the production of mature IL1B\/IL-1\u03b2 and contributes to LIPUS-mediated anti-inflammatory effect","volume":"16","author":"Zhang","year":"2020","journal-title":"Autophagy"},{"issue":"2","key":"10.1016\/j.intimp.2023.110380_b0115","first-page":"391","article-title":"Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity","volume":"31","author":"Angiari","year":"2020","journal-title":"CellMetab."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923007038?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923007038?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T18:08:38Z","timestamp":1761588518000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576923007038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":23,"alternative-id":["S1567576923007038"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2023.110380","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lapachol treats non-alcoholic fatty liver disease by modulating the M1 polarization of Kupffer cells via PKM2","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2023.110380","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110380"}}