{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T16:56:17Z","timestamp":1784912177346,"version":"3.55.0"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFC2004900"],"award-info":[{"award-number":["2020YFC2004900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672201"],"award-info":[{"award-number":["81672201"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871794"],"award-info":[{"award-number":["81871794"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["H0608"],"award-info":[{"award-number":["H0608"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.intimp.2023.110400","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T08:56:12Z","timestamp":1686128172000},"page":"110400","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Understanding necroptosis and its therapeutic target for intervertebral disc degeneration"],"prefix":"10.1016","volume":"121","author":[{"given":"Zheng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9260-2567","authenticated-orcid":false,"given":"Xinli","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.intimp.2023.110400_b0005","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.joca.2020.09.002","article-title":"The role of structure and function changes of sensory nervous system in intervertebral disc-related low back pain","volume":"29","author":"Zhang","year":"2021","journal-title":"Osteoarthritis Cartilage"},{"issue":"51\u201352","key":"10.1016\/j.intimp.2023.110400_b0010","first-page":"883","article-title":"Non-Specific Low Back Pain","volume":"114","author":"Chenot","year":"2017","journal-title":"Dtsch. Arztebl. Int."},{"issue":"1","key":"10.1016\/j.intimp.2023.110400_b0015","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41413-020-00125-x","article-title":"Painful intervertebral disc degeneration and inflammation: from laboratory evidence to clinical interventions","volume":"9","author":"Lyu","year":"2021","journal-title":"Bone Res."},{"issue":"3","key":"10.1016\/j.intimp.2023.110400_b0020","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.joca.2015.09.019","article-title":"Aging and age related stresses: a senescence mechanism of intervertebral disc degeneration","volume":"24","author":"Wang","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"issue":"6","key":"10.1016\/j.intimp.2023.110400_b0025","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s10495-012-0708-3","article-title":"Role of mitochondrial pathway in compression-induced apoptosis of nucleus pulposus cells","volume":"17","author":"Ding","year":"2012","journal-title":"Apoptosis"},{"issue":"3","key":"10.1016\/j.intimp.2023.110400_b0030","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.arr.2007.08.001","article-title":"The cell biology of intervertebral disc aging and degeneration","volume":"6","author":"Zhao","year":"2007","journal-title":"Ageing Res. Rev."},{"issue":"7","key":"10.1016\/j.intimp.2023.110400_b0035","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1038\/sj.cdd.4402148","article-title":"Cell death modalities: classification and pathophysiological implications","volume":"14","author":"Galluzzi","year":"2007","journal-title":"Cell Death Differ."},{"issue":"4","key":"10.1016\/j.intimp.2023.110400_b0040","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: a review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.intimp.2023.110400_b0045","doi-asserted-by":"crossref","unstructured":"L. Galluzzi, I. Vitale, S.A. Aaronson, J.M. Abrams, D. Adam, P. Agostinis, E.S. Alnemri, L. Altucci, I. Amelio, D.W. Andrews, M. Annicchiarico-Petruzzelli, A.V. Antonov, E. Arama, E.H. Baehrecke, N.A. Barlev, N.G. Bazan, F. Bernassola, M.J.M. Bertrand, K. Bianchi, M.V. Blagosklonny, K. Blomgren, C. Borner, P. Boya, C. Brenner, M. Campanella, E. Candi, D. Carmona-Gutierrez, F. Cecconi, F.K. Chan, N.S. Chandel, E.H. Cheng, J.E. Chipuk, J.A. Cidlowski, A. Ciechanover, G.M. Cohen, M. Conrad, J.R. Cubillos-Ruiz, P.E. Czabotar, V. D'Angiolella, T.M. Dawson, V.L. Dawson, V. De Laurenzi, R. De Maria, K.M. Debatin, R.J. DeBerardinis, M. Deshmukh, N. Di Daniele, F. Di Virgilio, V.M. Dixit, S.J. Dixon, C.S. Duckett, B.D. Dynlacht, W.S. El-Deiry, J.W. Elrod, G.M. Fimia, S. Fulda, A.J. Garc\u00eda-S\u00e1ez, A.D. Garg, C. Garrido, E. Gavathiotis, P. Golstein, E. Gottlieb, D.R. Green, L.A. Greene, H. Gronemeyer, A. Gross, G. Hajnoczky, J.M. Hardwick, I.S. Harris, M.O. Hengartner, C. Hetz, H. Ichijo, M. J\u00e4\u00e4ttel\u00e4, B. Joseph, P.J. Jost, P.P. Juin, W.J. Kaiser, M. Karin, T. Kaufmann, O. Kepp, A. Kimchi, R.N. Kitsis, D.J. Klionsky, R.A. Knight, S. Kumar, S.W. Lee, J.J. Lemasters, B. Levine, A. Linkermann, S.A. Lipton, R.A. Lockshin, C. L\u00f3pez-Ot\u00edn, S.W. Lowe, T. Luedde, E. Lugli, M. MacFarlane, F. Madeo, M. Malewicz, W. Malorni, G. Manic, J.C. Marine, S.J. Martin, J.C. Martinou, J.P. Medema, P. Mehlen, P. Meier, S. Melino, E.A. Miao, J.D. Molkentin, U.M. Moll, C. Mu\u00f1oz-Pinedo, S. Nagata, G. Nu\u00f1ez, A. Oberst, M. Oren, M. Overholtzer, M. Pagano, T. Panaretakis, M. Pasparakis, J.M. Penninger, D.M. Pereira, S. Pervaiz, M.E. Peter, M. Piacentini, P. Pinton, J.H.M. Prehn, H. Puthalakath, G.A. Rabinovich, M. Rehm, R. Rizzuto, C.M.P. Rodrigues, D.C. Rubinsztein, T. Rudel, K.M. Ryan, E. Sayan, L. Scorrano, F. Shao, Y. Shi, J. Silke, H.U. Simon, A. Sistigu, B.R. Stockwell, A. Strasser, G. Szabadkai, S.W.G. Tait, D. Tang, N. Tavernarakis, A. Thorburn, Y. Tsujimoto, B. Turk, T. Vanden Berghe, P. Vandenabeele, M.G. Vander Heiden, A. Villunger, H.W. Virgin, K.H. Vousden, D. Vucic, E.F. Wagner, H. Walczak, D. Wallach, Y. Wang, J.A. Wells, W. Wood, J. Yuan, Z. Zakeri, B. Zhivotovsky, L. Zitvogel, G. Melino, G. Kroemer, Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018, Cell Death Differ 25(3) (2018) 486-541.","DOI":"10.1038\/s41418-017-0012-4"},{"key":"10.1016\/j.intimp.2023.110400_b0050","doi-asserted-by":"crossref","first-page":"3537471","DOI":"10.1155\/2018\/3537471","article-title":"Regulation of Tumor Progression by Programmed Necrosis","volume":"2018","author":"Lee","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.intimp.2023.110400_b0055","doi-asserted-by":"crossref","first-page":"e12941","DOI":"10.1111\/cpr.12941","article-title":"Acid-sensing ion channels regulate nucleus pulposus cell inflammation and pyroptosis via the NLRP3 inflammasome in intervertebral disc degeneration","volume":"54","author":"Zhao","year":"2021","journal-title":"Cell Prolif."},{"key":"10.1016\/j.intimp.2023.110400_b0060","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.freeradbiomed.2020.08.029","article-title":"Homocysteine induces oxidative stress and ferroptosis of nucleus pulposus via enhancing methylation of GPX4","volume":"160","author":"Zhang","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.intimp.2023.110400_b0065","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.semcdb.2015.02.003","article-title":"The molecular relationships between apoptosis, autophagy and necroptosis","volume":"39","author":"Lalaoui","year":"2015","journal-title":"Semin. Cell Dev. Biol."},{"issue":"11","key":"10.1016\/j.intimp.2023.110400_b0070","doi-asserted-by":"crossref","first-page":"999","DOI":"10.4161\/cbt.26428","article-title":"The mechanism of necroptosis in normal and cancer cells","volume":"14","author":"Fulda","year":"2013","journal-title":"Cancer Biol. Ther."},{"issue":"10","key":"10.1016\/j.intimp.2023.110400_b0075","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nrm2970","article-title":"Molecular mechanisms of necroptosis: an ordered cellular explosion","volume":"11","author":"Vandenabeele","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.intimp.2023.110400_b0080","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.cell.2012.06.019","article-title":"The RIP1\/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis","volume":"150","author":"Li","year":"2012","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.intimp.2023.110400_b0085","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.devcel.2007.09.007","article-title":"Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD","volume":"13","author":"Wright","year":"2007","journal-title":"Dev. Cell"},{"issue":"3","key":"10.1016\/j.intimp.2023.110400_b0090","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.molcel.2011.06.006","article-title":"The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs","volume":"43","author":"Tenev","year":"2011","journal-title":"Mol. Cell"},{"issue":"7","key":"10.1016\/j.intimp.2023.110400_b0095","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.cell.2008.10.044","article-title":"Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway","volume":"135","author":"Hitomi","year":"2008","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.intimp.2023.110400_b0100","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.critrevonc.2011.08.004","article-title":"Necroptosis: an emerging form of programmed cell death","volume":"82","author":"Wu","year":"2012","journal-title":"Crit. Rev. Oncol. Hematol."},{"issue":"1","key":"10.1016\/j.intimp.2023.110400_b0105","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1038\/s41467-019-09690-0","article-title":"Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation","volume":"10","author":"Dondelinger","year":"2019","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.intimp.2023.110400_b0110","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/cdd.2015.70","article-title":"Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis","volume":"23","author":"Rodriguez","year":"2016","journal-title":"Cell Death Differ."},{"issue":"10","key":"10.1016\/j.intimp.2023.110400_b0115","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/j.str.2014.07.014","article-title":"A plug release mechanism for membrane permeation by MLKL","volume":"22","author":"Su","year":"2014","journal-title":"Structure"},{"issue":"1","key":"10.1016\/j.intimp.2023.110400_b0120","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/cr.2013.171","article-title":"Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death","volume":"24","author":"Chen","year":"2014","journal-title":"Cell Res."},{"issue":"4","key":"10.1016\/j.intimp.2023.110400_b0125","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.celrep.2014.04.026","article-title":"MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates","volume":"7","author":"Dondelinger","year":"2014","journal-title":"Cell Rep."},{"issue":"5","key":"10.1016\/j.intimp.2023.110400_b0130","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/cr.2016.26","article-title":"MLKL forms cation channels","volume":"26","author":"Xia","year":"2016","journal-title":"Cell Res."},{"key":"10.1016\/j.intimp.2023.110400_b0135","doi-asserted-by":"crossref","first-page":"e298","DOI":"10.1016\/j.wneu.2021.02.128","article-title":"Is the Distribution Pattern of Modic Changes in Vertebral End-plates Associated With the Severity of Intervertebral Disc Degeneration?: A Cross-sectional Analysis of 527 Caucasians","volume":"150","author":"\u00d6zcan-Ek\u015fi","year":"2021","journal-title":"World Neurosurg."},{"issue":"7","key":"10.1016\/j.intimp.2023.110400_b0140","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s10495-013-0839-1","article-title":"Cell death in intervertebral disc degeneration","volume":"18","author":"Ding","year":"2013","journal-title":"Apoptosis"},{"issue":"12","key":"10.1016\/j.intimp.2023.110400_b0145","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1007\/s10495-006-0290-7","article-title":"Programmed cell death in intervertebral disc degeneration","volume":"11","author":"Zhao","year":"2006","journal-title":"Apoptosis"},{"key":"10.1016\/j.intimp.2023.110400_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101394","article-title":"The potential role of melatonin in retarding intervertebral disc ageing and degeneration: A systematic review","volume":"70","author":"Cheng","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.intimp.2023.110400_b0155","doi-asserted-by":"crossref","first-page":"e1069","DOI":"10.1016\/j.wneu.2018.10.229","article-title":"Severe Lumbar Intervertebral Disc Degeneration Is Associated with Modic Changes and Fatty Infiltration in the Paraspinal Muscles at all Lumbar Levels, Except for L1\u2013L2: A Cross-Sectional Analysis of 50 Symptomatic Women and 50 Age-Matched Symptomatic Men","volume":"122","author":"\u00d6zcan-Ek\u015fi","year":"2019","journal-title":"World Neurosurg."},{"issue":"1","key":"10.1016\/j.intimp.2023.110400_b0160","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1186\/s12891-016-1297-z","article-title":"Lumbar disc degeneration is associated with modic change and high paraspinal fat content - a 3.0T magnetic resonance imaging study","volume":"17","author":"Teichtahl","year":"2016","journal-title":"BMC Musculoskelet. Disord."},{"issue":"8","key":"10.1016\/j.intimp.2023.110400_b0165","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/s12276-022-00829-6","article-title":"The Nrf2 antioxidant defense system in intervertebral disc degeneration: Molecular insights","volume":"54","author":"Xiang","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.intimp.2023.110400_b0170","doi-asserted-by":"crossref","first-page":"5915481","DOI":"10.1155\/2020\/5915481","article-title":"Hypoxia Helps Maintain Nucleus Pulposus Homeostasis by Balancing Autophagy and Apoptosis","volume":"2020","author":"Kim","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"3","key":"10.1016\/j.intimp.2023.110400_b0175","doi-asserted-by":"crossref","DOI":"10.3390\/cells11030394","article-title":"Causes of and Molecular Targets for the Treatment of Intervertebral Disc Degeneration: A Review","volume":"11","author":"Ohnishi","year":"2022","journal-title":"Cells"},{"issue":"11","key":"10.1016\/j.intimp.2023.110400_b0180","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1097\/00007632-199506000-00022","article-title":"Aging and degeneration of the human intervertebral disc","volume":"20","author":"Buckwalter","year":"1995","journal-title":"Spine (Phila Pa 1976)"},{"issue":"1","key":"10.1016\/j.intimp.2023.110400_b0185","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1186\/s12885-018-4655-4","article-title":"Prognostic and clinicopathological significance of MLKL expression in cancer patients: a meta-analysis","volume":"18","author":"Hu","year":"2018","journal-title":"BMC Cancer"},{"key":"10.1016\/j.intimp.2023.110400_b0190","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.994307","article-title":"Necroptosis of nucleus pulposus cells involved in intervertebral disc degeneration through MyD88 signaling","volume":"13","author":"Fan","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"23","key":"10.1016\/j.intimp.2023.110400_b0195","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1097\/BRS.0b013e318158dea6","article-title":"Evidence for skeletal progenitor cells in the degenerate human intervertebral disc","volume":"32","author":"Risbud","year":"2007","journal-title":"Spine (Phila Pa 1976)"},{"issue":"5\u20136","key":"10.1016\/j.intimp.2023.110400_b0200","doi-asserted-by":"crossref","first-page":"326","DOI":"10.3109\/08977194.2015.1088532","article-title":"TGF-\u03b23 and IGF-1 synergy ameliorates nucleus pulposus mesenchymal stem cell differentiation towards the nucleus pulposus cell type through MAPK\/ERK signaling","volume":"33","author":"Tao","year":"2015","journal-title":"Growth Factors"},{"key":"10.1016\/j.intimp.2023.110400_b0205","doi-asserted-by":"crossref","first-page":"685","DOI":"10.3389\/fcell.2020.00685","article-title":"Inhibiting Heat Shock Protein 90 Protects Nucleus Pulposus-Derived Stem\/Progenitor Cells From Compression-Induced Necroptosis and Apoptosis","volume":"8","author":"Hu","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"5","key":"10.1016\/j.intimp.2023.110400_b0210","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1007\/s10495-017-1358-2","article-title":"RIPK1\/RIPK3\/MLKL-mediated necroptosis contributes to compression-induced rat nucleus pulposus cells death","volume":"22","author":"Chen","year":"2017","journal-title":"Apoptosis"},{"issue":"2","key":"10.1016\/j.intimp.2023.110400_b0215","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ceb.2009.12.003","article-title":"Necroptosis as an alternative form of programmed cell death","volume":"22","author":"Christofferson","year":"2010","journal-title":"Curr. Opin. Cell Biol."},{"issue":"4","key":"10.1016\/j.intimp.2023.110400_b0220","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s12079-021-00616-4","article-title":"Sequence features, structure, ligand interaction, and diseases in small leucine rich repeat proteoglycans","volume":"15","author":"Matsushima","year":"2021","journal-title":"J Cell Commun Signal"},{"issue":"1","key":"10.1016\/j.intimp.2023.110400_b0225","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1533-2500.2007.00171.x","article-title":"Intervertebral disc: anatomy-physiology-pathophysiology-treatment","volume":"8","author":"Raj","year":"2008","journal-title":"Pain Pract."},{"issue":"8","key":"10.1016\/j.intimp.2023.110400_b0230","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1002\/jbmr.4009","article-title":"Intervertebral Disc Degeneration Is Associated With Aberrant Endplate Remodeling and Reduced Small Molecule Transport","volume":"35","author":"Ashinsky","year":"2020","journal-title":"J. Bone Miner. Res."},{"issue":"6","key":"10.1016\/j.intimp.2023.110400_b0235","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1111\/j.1469-7580.2007.00816.x","article-title":"Inhibition of vertebral endplate perfusion results in decreased intervertebral disc intranuclear diffusive transport","volume":"211","author":"van der Werf","year":"2007","journal-title":"J. Anat."},{"issue":"6","key":"10.1016\/j.intimp.2023.110400_b0240","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.joca.2019.01.013","article-title":"Nutrient supply and nucleus pulposus cell function: effects of the transport properties of the cartilage endplate and potential implications for intradiscal biologic therapy","volume":"27","author":"Wong","year":"2019","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"10.1016\/j.intimp.2023.110400_b0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00441-022-03662-5","article-title":"Extracellular matrix in intervertebral disc: basic and translational implications","volume":"390","author":"Zhang","year":"2022","journal-title":"Cell Tissue Res."},{"issue":"30","key":"10.1016\/j.intimp.2023.110400_b0250","doi-asserted-by":"crossref","first-page":"e2202620","DOI":"10.1002\/advs.202202620","article-title":"Sensory Nerve Maintains Intervertebral Disc Extracellular Matrix Homeostasis Via CGRP\/CHSY1 Axis","volume":"9","author":"Hu","year":"2022","journal-title":"Adv Sci (Weinh)"},{"issue":"11","key":"10.1016\/j.intimp.2023.110400_b0255","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.7150\/ijms.75285","article-title":"Insights into Exosome in the Intervertebral Disc: Emerging Role for Disc Homeostasis and Normal Function","volume":"19","author":"Zhao","year":"2022","journal-title":"Int. J. Med. Sci."},{"issue":"10","key":"10.1016\/j.intimp.2023.110400_b0260","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22105281","article-title":"Regeneration in Spinal Disease: Therapeutic Role of Hypoxia-Inducible Factor-1 Alpha in Regeneration of Degenerative Intervertebral Disc","volume":"22","author":"Kim","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2023.110400_b0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101733","article-title":"The role of nerve fibers and their neurotransmitters in regulating intervertebral disc degeneration","volume":"81","author":"Sun","year":"2022","journal-title":"Ageing Res. Rev."},{"issue":"2","key":"10.1016\/j.intimp.2023.110400_b0270","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nchembio711","article-title":"Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury","volume":"1","author":"Degterev","year":"2005","journal-title":"Nat. Chem. Biol."},{"issue":"5","key":"10.1016\/j.intimp.2023.110400_b0275","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nchembio.83","article-title":"Identification of RIP1 kinase as a specific cellular target of necrostatins","volume":"4","author":"Degterev","year":"2008","journal-title":"Nat. Chem. Biol."},{"issue":"11","key":"10.1016\/j.intimp.2023.110400_b0280","doi-asserted-by":"crossref","first-page":"e437","DOI":"10.1038\/cddis.2012.176","article-title":"Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models","volume":"3","author":"Takahashi","year":"2012","journal-title":"Cell Death Dis."},{"issue":"18","key":"10.1016\/j.intimp.2023.110400_b0285","doi-asserted-by":"crossref","first-page":"4932","DOI":"10.1016\/j.bmcl.2008.08.058","article-title":"Structure-activity relationship study of a novel necroptosis inhibitor, necrostatin-7","volume":"18","author":"Zheng","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"4","key":"10.1016\/j.intimp.2023.110400_b0290","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1021\/acs.jmedchem.6b01751","article-title":"Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases","volume":"60","author":"Harris","year":"2017","journal-title":"J. Med. Chem."},{"issue":"3","key":"10.1016\/j.intimp.2023.110400_b0295","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1021\/acs.jmedchem.6b01196","article-title":"Discovery of a Highly Potent, Selective, and Metabolically Stable Inhibitor of Receptor-Interacting Protein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome","volume":"60","author":"Ren","year":"2017","journal-title":"J. Med. Chem."},{"issue":"2","key":"10.1016\/j.intimp.2023.110400_b0300","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41419-017-0245-7","article-title":"RIPK1-dependent cell death: a novel target of the Aurora kinase inhibitor Tozasertib (VX-680)","volume":"9","author":"Martens","year":"2018","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.intimp.2023.110400_b0305","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.molcel.2014.10.021","article-title":"RIP3 induces apoptosis independent of pronecrotic kinase activity","volume":"56","author":"Mandal","year":"2014","journal-title":"Mol. Cell"},{"issue":"3","key":"10.1016\/j.intimp.2023.110400_b0310","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1021\/ml4000063","article-title":"Discovery of Dabrafenib: A Selective Inhibitor of Raf Kinases with Antitumor Activity against B-Raf-Driven Tumors","volume":"4","author":"Rheault","year":"2013","journal-title":"ACS Med. Chem. Lett."},{"issue":"6","key":"10.1016\/j.intimp.2023.110400_b0315","doi-asserted-by":"crossref","first-page":"e1278","DOI":"10.1038\/cddis.2014.241","article-title":"The B-Raf(V600E) inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury","volume":"5","author":"Li","year":"2014","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.intimp.2023.110400_b0320","doi-asserted-by":"crossref","first-page":"252","DOI":"10.4103\/1673-5374.226394","article-title":"Dabrafenib, an inhibitor of RIP3 kinase-dependent necroptosis, reduces ischemic brain injury","volume":"13","author":"Cruz","year":"2018","journal-title":"Neural Regen. Res."},{"issue":"9","key":"10.1016\/j.intimp.2023.110400_b0325","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-018-0152-8","article-title":"HS-1371, a novel kinase inhibitor of RIP3-mediated necroptosis","volume":"50","author":"Park","year":"2018","journal-title":"Exp. Mol. Med."},{"issue":"1\u20132","key":"10.1016\/j.intimp.2023.110400_b0330","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.cell.2011.11.031","article-title":"Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase","volume":"148","author":"Sun","year":"2012","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.intimp.2023.110400_b0335","first-page":"2683","article-title":"Necrosulfonamide (NSA) protects intervertebral disc degeneration via necroptosis and apoptosis inhibition","volume":"24","author":"Zhang","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"42","key":"10.1016\/j.intimp.2023.110400_b0340","doi-asserted-by":"crossref","first-page":"15072","DOI":"10.1073\/pnas.1408987111","article-title":"Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death","volume":"111","author":"Hildebrand","year":"2014","journal-title":"PNAS"},{"issue":"42","key":"10.1016\/j.intimp.2023.110400_b0345","doi-asserted-by":"crossref","first-page":"17514","DOI":"10.1074\/jbc.M117.799353","article-title":"Thioredoxin-1 actively maintains the pseudokinase MLKL in a reduced state to suppress disulfide bond-dependent MLKL polymer formation and necroptosis","volume":"292","author":"Reynoso","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2023.110400_b0350","doi-asserted-by":"crossref","first-page":"6670497","DOI":"10.1155\/2021\/6670497","article-title":"Ferroportin-Dependent Iron Homeostasis Protects against Oxidative Stress-Induced Nucleus Pulposus Cell Ferroptosis and Ameliorates Intervertebral Disc Degeneration In Vivo","volume":"2021","author":"Lu","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"2","key":"10.1016\/j.intimp.2023.110400_b0355","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/s12276-022-00729-9","article-title":"Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis","volume":"54","author":"Zhang","year":"2022","journal-title":"Exp. Mol. Med."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923007233?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923007233?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:10:17Z","timestamp":1777619417000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576923007233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":71,"alternative-id":["S1567576923007233"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2023.110400","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Understanding necroptosis and its therapeutic target for intervertebral disc degeneration","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2023.110400","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110400"}}