{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T04:25:29Z","timestamp":1788323129848,"version":"build-2803163510"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.intimp.2023.110441","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T21:45:05Z","timestamp":1688161505000},"page":"110441","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Neutrophil elastase in dexmedetomidine alleviating sepsis-related renal injury in rats"],"prefix":"10.1016","volume":"122","author":[{"given":"Lu","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanzhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4473-0855","authenticated-orcid":false,"given":"Kai","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2023.110441_b0005","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s40560-020-00465-0","article-title":"Epidemiology of sepsis and septic shock in intensive care units between sepsis-2 and sepsis-3 populations: sepsis prognostication in intensive care unit and emergency room (SPICE-ICU)","volume":"8","author":"Abe","year":"2020","journal-title":"J. Intensive Care"},{"issue":"2","key":"10.1016\/j.intimp.2023.110441_b0010","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S2352-4642(17)30010-X","article-title":"Epidemiology of blood culture-proven bacterial sepsis in children in Switzerland: a population-based cohort study","volume":"1","author":"Agyeman","year":"2017","journal-title":"Lancet Child Adolesc. Health"},{"issue":"1","key":"10.1016\/j.intimp.2023.110441_b0015","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s12873-020-00374-3","article-title":"A retrospective study of sepsis-associated encephalopathy: epidemiology, clinical features and adverse outcomes","volume":"20","author":"Chen","year":"2020","journal-title":"BMC Emerg. Med."},{"issue":"5","key":"10.1016\/j.intimp.2023.110441_b0020","first-page":"380","article-title":"Progress in epidemiology and etiology of pediatric sepsis","volume":"57","author":"Chen","year":"2019","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"10.1016\/j.intimp.2023.110441_b0025","doi-asserted-by":"crossref","first-page":"6765","DOI":"10.2147\/JIR.S340420","article-title":"Protective Effects of Dexmedetomidine on Sepsis-Induced Vascular Leakage by Alleviating Ferroptosis via Regulating Metabolic Reprogramming","volume":"14","author":"She","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.intimp.2023.110441_b0030","article-title":"The Effect of Dexmedetomidine as a Sedative Agent for Mechanically Ventilated Patients With Sepsis: A Systematic Review and Meta-Analysis","volume":"8","author":"Wang","year":"2021","journal-title":"Front. Med. (Lausanne)"},{"key":"10.1016\/j.intimp.2023.110441_b0035","doi-asserted-by":"crossref","first-page":"9339411","DOI":"10.1155\/2022\/9339411","article-title":"Cell-Free DNA, Neutrophil extracellular traps (NETs), and Endothelial Injury in Coronavirus Disease 2019- (COVID-19-) Associated Acute Kidney Injury","volume":"2022","author":"Henry","year":"2022","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.intimp.2023.110441_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108137","article-title":"A possible pathogenic correlation between neutrophil elastase (NE) enzyme and inflammation in the pathogenesis of coronavirus disease 2019 (COVID-19)","volume":"100","author":"Karampoor","year":"2021","journal-title":"Int. Immunopharmacol."},{"issue":"12","key":"10.1016\/j.intimp.2023.110441_b0045","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1111\/cea.13263","article-title":"Neutrophils induce smooth muscle hyperplasia via neutrophil elastase-induced FGF-2 in a mouse model of asthma with mixed inflammation","volume":"48","author":"Ogawa","year":"2018","journal-title":"Clin. Exp. Allergy"},{"issue":"1","key":"10.1016\/j.intimp.2023.110441_b0050","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/1440-1681.12499","article-title":"Increased ratio of neutrophil elastase to alpha1-antitrypsin is closely associated with liver inflammation in patients with nonalcoholic steatohepatitis","volume":"43","author":"Zang","year":"2016","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"1","key":"10.1016\/j.intimp.2023.110441_b0055","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3892\/mmr.2020.11114","article-title":"Dexmedetomidine alleviated sepsis-induced myocardial ferroptosis and septic heart injury","volume":"22","author":"Wang","year":"2020","journal-title":"Mol. Med. Rep."},{"issue":"3","key":"10.1016\/j.intimp.2023.110441_b0060","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1055\/a-1685-0482","article-title":"Assessment of Sumatriptan on Sepsis-Induced Kidney injury in the Cecal Ligation and Puncture Mice Model","volume":"72","author":"Yousefi-Manesh","year":"2022","journal-title":"Drug Res. (Stuttg)"},{"key":"10.1016\/j.intimp.2023.110441_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2022.105493","article-title":"Protective effect of vanillin on the management of cecal ligation and puncture induced sepsis rat model","volume":"165","author":"Tripathi","year":"2022","journal-title":"Microb. Pathog."},{"issue":"7","key":"10.1016\/j.intimp.2023.110441_b0070","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1177\/0960327120905957","article-title":"Protective effect of febuxostat in sepsis-induced liver and kidney injuries after cecal ligation and puncture with the impact of xanthine oxidase, interleukin 1beta, and c-Jun N-terminal kinases","volume":"39","author":"Ibrahim","year":"2020","journal-title":"Hum. Exp. Toxicol."},{"issue":"1","key":"10.1016\/j.intimp.2023.110441_b0075","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1038\/s41598-018-19350-w","article-title":"Influence of autophagy on acute kidney injury in a murine cecal ligation and puncture sepsis model","volume":"8","author":"Sunahara","year":"2018","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.intimp.2023.110441_b0080","first-page":"1554","article-title":"Sperm and testicular dysfunction during cecal ligation and puncture-induced sepsis in male rats and effects of tannic acid through reducing testicular oxidative stress and inflammation","volume":"24","author":"Pourmirzaei","year":"2021","journal-title":"Iran. J. Basic Med. Sci."},{"issue":"12","key":"10.1016\/j.intimp.2023.110441_b0085","doi-asserted-by":"crossref","first-page":"893","DOI":"10.14348\/molcells.2021.0159","article-title":"Contributory Role of BLT2 in the Production of Proinflammatory Cytokines in Cecal Ligation and Puncture-Induced Sepsis","volume":"44","author":"Park","year":"2021","journal-title":"Mol. Cells"},{"issue":"4","key":"10.1016\/j.intimp.2023.110441_b0090","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.jphs.2021.08.005","article-title":"Granisetron attenuates liver injury and inflammation in a rat model of cecal ligation and puncture-induced sepsis","volume":"147","author":"Aboyoussef","year":"2021","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.intimp.2023.110441_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.120033","article-title":"Metabolic syndrome improves cardiovascular dysfunction and survival during cecal ligation and puncture-induced mild sepsis in mice","volume":"286","author":"Nakama","year":"2021","journal-title":"Life Sci."},{"issue":"6","key":"10.1016\/j.intimp.2023.110441_b0100","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1053\/j.ajkd.2021.09.018","article-title":"Associations of Plasma Biomarkers of Inflammation, Fibrosis, and Kidney Tubular Injury With Progression of Diabetic Kidney Disease: A Cohort Study","volume":"79","author":"Gutierrez","year":"2022","journal-title":"Am. J. Kidney Dis."},{"issue":"3","key":"10.1016\/j.intimp.2023.110441_b0105","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1159\/000519265","article-title":"Unexpected Participation of Intercalated Cells in Renal Inflammation and Acute Kidney Injury","volume":"146","author":"Breton","year":"2022","journal-title":"Nephron"},{"key":"10.1016\/j.intimp.2023.110441_b0110","doi-asserted-by":"crossref","first-page":"p. eAO6828","DOI":"10.31744\/einstein_journal\/2022AO6828","article-title":"Relation between red blood cell distribution width and acute kidney injury in patients with sepsis","volume":"20","author":"Ramires","year":"2022","journal-title":"Einstein (Sao Paulo)"},{"issue":"1","key":"10.1016\/j.intimp.2023.110441_b0115","doi-asserted-by":"crossref","first-page":"62","DOI":"10.5937\/jomb0-33096","article-title":"Cul4a attenuates LPS-induced acute kidney injury via blocking NF-kB signaling pathway in sepsis","volume":"41","author":"Zhao","year":"2022","journal-title":"J. Med. Biochem."},{"issue":"1","key":"10.1016\/j.intimp.2023.110441_b0120","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s40001-022-00654-7","article-title":"Serum cystatin C, kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, klotho and fibroblast growth factor-23 in the early prediction of acute kidney injury associated with sepsis in a Chinese emergency cohort study","volume":"27","author":"Pei","year":"2022","journal-title":"Eur. J. Med. Res."},{"key":"10.1016\/j.intimp.2023.110441_b0125","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cca.2021.08.029","article-title":"Combination of hepcidin with neutrophil gelatinase-associated lipocalin for prediction of the development of sepsis-induced acute kidney injury","volume":"523","author":"Qiu","year":"2021","journal-title":"Clin. Chim. Acta"},{"issue":"Suppl 1","key":"10.1016\/j.intimp.2023.110441_b0130","first-page":"6","article-title":"The prognostic value of neutrophil gelatinase-associated lipocalin in sepsis-associated acute kidney injury: A prospective observational study","volume":"10","author":"Shyam","year":"2020","journal-title":"Int. J. Crit. Illn Inj. Sci."},{"key":"10.1016\/j.intimp.2023.110441_b0135","doi-asserted-by":"crossref","first-page":"8883404","DOI":"10.1155\/2020\/8883404","article-title":"Serum and Urine Neutrophil Gelatinase-Associated Lipocalin Levels Measured at Admission Predict Progression to Chronic Kidney Disease in Sepsis-Associated Acute Kidney Injury Patients","volume":"2020","author":"Tuan","year":"2020","journal-title":"Dis. Markers"},{"key":"10.1016\/j.intimp.2023.110441_b0140","doi-asserted-by":"crossref","first-page":"9742169","DOI":"10.1155\/2022\/9742169","article-title":"Panax notoginseng Alleviates Sepsis-Induced Acute Kidney Injury by Reducing Inflammation in Rats","volume":"2022","author":"Shou","year":"2022","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.intimp.2023.110441_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2022.136647","article-title":"Preexposure to heat stress attenuates sepsis-associated inflammation and cognitive decline in rats","volume":"780","author":"Jiang","year":"2022","journal-title":"Neurosci. Lett."},{"issue":"11","key":"10.1016\/j.intimp.2023.110441_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2022.166507","article-title":"Exogenous ketone ester administration attenuates systemic inflammation and reduces organ damage in a lipopolysaccharide model of sepsis","volume":"1868","author":"Soni","year":"2022","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.intimp.2023.110441_b0155","doi-asserted-by":"crossref","first-page":"1149582","DOI":"10.1155\/2022\/1149582","article-title":"Vaspin Alleviates Sepsis-Induced Cardiac Injury and Cardiac Inflammation by Inhibiting Kallikrein 7 in Mice","volume":"2022","author":"Yin","year":"2022","journal-title":"Mediators Inflamm."},{"issue":"12","key":"10.1016\/j.intimp.2023.110441_b0160","doi-asserted-by":"crossref","first-page":"4770","DOI":"10.1074\/jbc.C116.758748","article-title":"Neutrophil Elastase Regulates Emergency Myelopoiesis Preceding Systemic Inflammation in Diet-induced Obesity","volume":"292","author":"Huang","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.intimp.2023.110441_b0165","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.jcf.2014.03.004","article-title":"Neutrophil elastase-mediated increase in airway temperature during inflammation","volume":"13","author":"Schmidt","year":"2014","journal-title":"J. Cyst. Fibros."}],"updated-by":[{"DOI":"10.1016\/j.intimp.2024.111577","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:00:00Z","timestamp":1707955200000}}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923007646?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923007646?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T14:12:26Z","timestamp":1736431946000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576923007646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":33,"alternative-id":["S1567576923007646"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2023.110441","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neutrophil elastase in dexmedetomidine alleviating sepsis-related renal injury in rats","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2023.110441","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110441"}}