{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:05:48Z","timestamp":1789142748933,"version":"build-2803163510"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81430013"],"award-info":[{"award-number":["81430013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170622"],"award-info":[{"award-number":["82170622"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.intimp.2023.110491","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T01:30:54Z","timestamp":1686879054000},"page":"110491","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["15-deoxy-\u039412,14-prostaglandin J2 relieved acute liver injury by inhibiting macrophage migration inhibitory factor expression via PPAR\u03b3 in hepatocyte"],"prefix":"10.1016","volume":"121","author":[{"given":"Weiyang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieshi","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanru","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0470-2328","authenticated-orcid":false,"given":"Liying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.intimp.2023.110491_b0005","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0025-6196(12)60534-5","article-title":"Fulminant hepatitis: mayo clinic experience with 34 cases","volume":"60","author":"Rakela","year":"1985","journal-title":"Mayo Clin. Proc."},{"issue":"1","key":"10.1016\/j.intimp.2023.110491_b0010","first-page":"240","article-title":"Fulminant hepatic failure: summary of a workshop","volume":"21","author":"Hoofnagle","year":"1995","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2023.110491_b0015","doi-asserted-by":"crossref","DOI":"10.1007\/s10753-022-01776-0","article-title":"Fibrosis in liver and pancreas: a review on pathogenic significance, diagnostic options, and current management strategies","author":"Dasgupta","year":"2023","journal-title":"Inflammation"},{"issue":"12","key":"10.1016\/j.intimp.2023.110491_b0020","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1038\/s41591-020-1102-2","article-title":"Acute liver failure is regulated by MYC- and microbiome-dependent programs","volume":"26","author":"Kolodziejczyk","year":"2020","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.intimp.2023.110491_b0025","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.jcmgh.2021.09.003","article-title":"C-reactive protein protects against acetaminophen-induced liver injury by preventing complement overactivation","volume":"13","author":"Li","year":"2022","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"issue":"9","key":"10.1016\/j.intimp.2023.110491_b0030","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.3390\/cells8091069","article-title":"Single-cell transcriptomes reveal characteristic features of mouse hepatocytes with liver cholestatic injury","volume":"8","author":"Chang","year":"2019","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.intimp.2023.110491_b0035","doi-asserted-by":"crossref","first-page":"27665","DOI":"10.1038\/srep27665","article-title":"Macrophage migration inhibitor factor upregulates MCP-1 expression in an autocrine manner in hepatocytes during acute mouse liver injury","volume":"6","author":"Xie","year":"2016","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.intimp.2023.110491_b0040","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/83336","article-title":"PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation","volume":"7","author":"Chawla","year":"2001","journal-title":"Nat. Med."},{"issue":"10","key":"10.1016\/j.intimp.2023.110491_b0045","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1007\/s00109-017-1570-0","article-title":"miR-27b-3p, miR-181a-1-3p, and miR-326-5p are involved in the inhibition of macrophage activation in chronic liver injury","volume":"95","author":"Li","year":"2017","journal-title":"J. Mol. Med."},{"issue":"41","key":"10.1016\/j.intimp.2023.110491_b0050","doi-asserted-by":"crossref","first-page":"38152","DOI":"10.1074\/jbc.M101980200","article-title":"15-deoxy-Delta 12,14-prostaglandin J2 induces apoptosis of human hepatic myofibroblasts. A pathway involving oxidative stress independently of peroxisome-proliferator-activated receptors","volume":"276","author":"Li","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.intimp.2023.110491_b0055","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/hep.25672","article-title":"15-deoxy-\u039412,14-prostaglandin J2 reduces recruitment of bone marrow-derived monocyte\/macrophages in chronic liver injury in mice","volume":"56","author":"Han","year":"2012","journal-title":"Hepatology"},{"issue":"8","key":"10.1016\/j.intimp.2023.110491_b0060","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.ejcb.2012.03.004","article-title":"15-Deoxy-\u039412,14-prostaglandin J2 attenuates the biological activities of monocyte\/macrophage cell lines","volume":"91","author":"Liu","year":"2012","journal-title":"Eur. J. Cell Biol."},{"issue":"5","key":"10.1016\/j.intimp.2023.110491_b0065","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/aps.2016.108","article-title":"15-Deoxy-Delta(12,14)-prostaglandin J(2) alleviates hepatic ischemia-reperfusion injury in mice via inducing antioxidant response and inhibiting apoptosis and autophagy","volume":"38","author":"Chen","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.intimp.2023.110491_b0070","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.biopha.2016.03.012","article-title":"15d-PGJ2 alleviates ConA-induced acute liver injury in mice by up-regulating HO-1 and reducing hepatic cell autophagy","volume":"80","author":"Chen","year":"2016","journal-title":"Biomed. Pharmacother."},{"issue":"40","key":"10.1016\/j.intimp.2023.110491_b0075","doi-asserted-by":"crossref","first-page":"E8421","DOI":"10.1073\/pnas.1712288114","article-title":"MIF and D-DT are potential disease severity modifiers in male MS subjects","volume":"114","author":"Benedek","year":"2017","journal-title":"PNAS"},{"issue":"3","key":"10.1016\/j.intimp.2023.110491_b0080","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.4049\/jimmunol.1200485","article-title":"Macrophage migration inhibitory factor potentiates autoimmune-mediated neuroinflammation","volume":"191","author":"Cox","year":"2013","journal-title":"J. Immunol."},{"issue":"11","key":"10.1016\/j.intimp.2023.110491_b0085","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1016\/j.cell.2022.04.020","article-title":"PAAN\/MIF nuclease inhibition prevents neurodegeneration in Parkinson's disease","volume":"185","author":"Park","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2023.110491_b0090","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3389\/fmed.2019.00003","article-title":"The multitasking potential of alarmins and atypical chemokines","volume":"6","author":"Kapurniotu","year":"2019","journal-title":"Front. Med. (Lausanne)"},{"issue":"11","key":"10.1016\/j.intimp.2023.110491_b0095","doi-asserted-by":"crossref","first-page":"5191","DOI":"10.1073\/pnas.93.11.5191","article-title":"Crystal structure at 2.6-A resolution of human macrophage migration inhibitory factor","volume":"93","author":"Sun","year":"1996","journal-title":"PNAS"},{"issue":"3","key":"10.1016\/j.intimp.2023.110491_b0100","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1517\/14728220903551304","article-title":"Autoimmune diseases: MIF as a therapeutic target","volume":"14","author":"Greven","year":"2010","journal-title":"Expert Opin. Ther. Targets"},{"issue":"1","key":"10.1016\/j.intimp.2023.110491_b0105","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1038\/s41467-018-04581-2","article-title":"Macrophage migration inhibitory factor is required for NLRP3 inflammasome activation","volume":"9","author":"Lang","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2023.110491_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2020.109672","article-title":"CXCR4\/MIF axis amplifies tumor growth and epithelial-mesenchymal interaction in non-small cell lung cancer","volume":"73","author":"Jager","year":"2020","journal-title":"Cell. Signal."},{"issue":"23","key":"10.1016\/j.intimp.2023.110491_b0115","doi-asserted-by":"crossref","first-page":"e127171","DOI":"10.1172\/JCI127171","article-title":"MIF but not MIF-2 recruits inflammatory macrophages in an experimental polymicrobial sepsis model","volume":"131","author":"Tilstam","year":"2021","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.intimp.2023.110491_b0120","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.jhep.2017.06.014","article-title":"Hepatocyte-derived macrophage migration inhibitory factor mediates alcohol-induced liver injury in mice and patients","volume":"67","author":"Marin","year":"2017","journal-title":"J. Hepatol."},{"issue":"5","key":"10.1016\/j.intimp.2023.110491_b0125","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.hbpd.2021.07.002","article-title":"Gene knockout or inhibition of macrophage migration inhibitory factor alleviates lipopolysaccharide-induced liver injury via inhibiting inflammatory response","volume":"20","author":"Gu","year":"2021","journal-title":"Hepatobiliary Pancreat. Dis. Int."},{"issue":"6","key":"10.1016\/j.intimp.2023.110491_b0130","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.jhep.2009.01.028","article-title":"Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis","volume":"50","author":"Li","year":"2009","journal-title":"J. Hepatol."},{"issue":"9","key":"10.1016\/j.intimp.2023.110491_b0135","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1002\/jcp.22572","article-title":"Essential roles of sphingosine 1-phosphate receptor types 1 and 3 in human hepatic stellate cells motility and activation","volume":"226","author":"Liu","year":"2011","journal-title":"J. Cell. Physiol."},{"issue":"4","key":"10.1016\/j.intimp.2023.110491_b0140","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.2353\/ajpath.2009.090037","article-title":"Involvement of sphingosine 1-phosphate (SIP)\/S1P3 signaling in cholestasis-induced liver fibrosis","volume":"175","author":"Li","year":"2009","journal-title":"Am. J. Pathol."},{"issue":"13","key":"10.1016\/j.intimp.2023.110491_b0145","doi-asserted-by":"crossref","first-page":"4399","DOI":"10.1016\/j.celrep.2020.03.019","article-title":"Cyclopentenone prostaglandins and structurally related oxidized lipid species instigate and share distinct pro- and anti-inflammatory pathways","volume":"30","author":"Muri","year":"2020","journal-title":"Cell Rep."},{"issue":"6","key":"10.1016\/j.intimp.2023.110491_b0150","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.4049\/jimmunol.1401611","article-title":"The cyclopentenone prostaglandin 15d-PGJ2 inhibits the NLRP1 and NLRP3 inflammasomes","volume":"194","author":"Maier","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2023.110491_b0155","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/876160","article-title":"15-Deoxy-delta(12,14)-prostaglandin J2 inhibits homing of bone marrow-derived mesenchymal stem cells triggered by chronic liver injury via redox pathway","volume":"2015","author":"Liu","year":"2015","journal-title":"PPAR Res."},{"issue":"6","key":"10.1016\/j.intimp.2023.110491_b0160","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1159\/000438567","article-title":"Peroxisome proliferator-activated receptor gamma negatively regulates the differentiation of bone marrow-derived mesenchymal stem cells toward myofibroblasts in liver fibrogenesis","volume":"37","author":"Jia","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"issue":"2","key":"10.1016\/j.intimp.2023.110491_b0165","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jhep.2021.09.040","article-title":"Hepatocyte glutathione S-transferase mu 2 prevents non-alcoholic steatohepatitis by suppressing ASK1 signaling","volume":"76","author":"Lan","year":"2022","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.intimp.2023.110491_b0170","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1053\/j.gastro.2022.09.027","article-title":"Hepatocyte adenosine kinase promotes excessive fat deposition and liver inflammation","volume":"164","author":"Li","year":"2023","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.intimp.2023.110491_b0175","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/hep.32112","article-title":"Hepatocyte-specific deletion of adipose triglyceride lipase (adipose triglyceride lipase\/patatin-like phospholipase domain containing 2) ameliorates dietary induced steatohepatitis in mice","volume":"75","author":"Fuchs","year":"2022","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.intimp.2023.110491_b0180","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.jhep.2022.02.028","article-title":"Transcriptional switch of hepatocytes initiates macrophage recruitment and T-cell suppression in endotoxemia","volume":"77","author":"Sun","year":"2022","journal-title":"J. Hepatol."},{"issue":"5","key":"10.1016\/j.intimp.2023.110491_b0185","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1002\/hep.26169","article-title":"Macrophage migration inhibitory factor contributes to ethanol-induced liver injury by mediating cell injury, steatohepatitis, and steatosis","volume":"57","author":"Barnes","year":"2013","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.intimp.2023.110491_b0190","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1189\/jlb.3A0614-280R","article-title":"Macrophage migration inhibitory factor is required for recruitment of scar-associated macrophages during liver fibrosis","volume":"97","author":"Barnes","year":"2015","journal-title":"J. Leukoc. Biol."},{"issue":"5","key":"10.1016\/j.intimp.2023.110491_b0195","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nm1567","article-title":"MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment","volume":"13","author":"Bernhagen","year":"2007","journal-title":"Nat. Med."},{"issue":"5","key":"10.1016\/j.intimp.2023.110491_b0200","doi-asserted-by":"crossref","first-page":"e21418","DOI":"10.1096\/fj.202001605R","article-title":"Macrophage migration inhibitory factor promotes the migration of dendritic cells through CD74 and the activation of the Src\/PI3K\/myosin II pathway","volume":"35","author":"Ives","year":"2021","journal-title":"FASEB J."},{"issue":"5","key":"10.1016\/j.intimp.2023.110491_b0205","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1002\/JLB.3A0420-242RRR","article-title":"Macrophage migration inhibitory factor inhibits neutrophil apoptosis by inducing cytokine release from mononuclear cells","volume":"110","author":"Schindler","year":"2021","journal-title":"J. Leukoc. Biol."},{"issue":"1","key":"10.1016\/j.intimp.2023.110491_b0210","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1073\/pnas.012511599","article-title":"Macrophage migration inhibitory factor (MIF) sustains macrophage proinflammatory function by inhibiting p53: regulatory role in the innate immune response","volume":"99","author":"Mitchell","year":"2002","journal-title":"PNAS"},{"key":"10.1016\/j.intimp.2023.110491_b0215","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.590027","article-title":"Long non-coding RNA LRNA9884 promotes acute kidney injury via regulating NF-kB-mediated transcriptional activation of MIF","volume":"11","author":"Zhang","year":"2020","journal-title":"Front. Physiol."},{"issue":"7059","key":"10.1016\/j.intimp.2023.110491_b0220","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/nature03988","article-title":"A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma","volume":"437","author":"Pascual","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2023.110491_b0225","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.3389\/fimmu.2019.02229","article-title":"MiRNA regulation of MIF in SLE and attenuation of murine lupus nephritis with miR-654","volume":"10","author":"Tu","year":"2019","journal-title":"Front. Immunol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923008147?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923008147?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T18:15:06Z","timestamp":1761588906000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576923008147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":45,"alternative-id":["S1567576923008147"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2023.110491","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"15-deoxy-\u039412,14-prostaglandin J2 relieved acute liver injury by inhibiting macrophage migration inhibitory factor expression via PPAR\u03b3 in hepatocyte","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2023.110491","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110491"}}