{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:59:56Z","timestamp":1785430796050,"version":"3.56.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["H2020105015"],"award-info":[{"award-number":["H2020105015"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017938","name":"Hebei Provincial\u00a0Postdoctoral Science\u00a0Foundation","doi-asserted-by":"publisher","award":["B2021003045"],"award-info":[{"award-number":["B2021003045"]}],"id":[{"id":"10.13039\/100017938","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.intimp.2023.110507","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T19:38:58Z","timestamp":1687635538000},"page":"110507","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Nanofibrous polycaprolactone\/amniotic membrane facilitates peripheral nerve regeneration by promoting macrophage polarization and regulating inflammatory microenvironment"],"prefix":"10.1016","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2941-0594","authenticated-orcid":false,"given":"Chunjie","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7247-223X","authenticated-orcid":false,"given":"Dengxiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Hui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8018-7937","authenticated-orcid":false,"given":"Lili","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2023.110507_b0005","first-page":"7","article-title":"Functional polymer-based nerve guide conduits to promote peripheral nerve regeneration","author":"Zhang","year":"2020","journal-title":"Adv. Mater.Interfaces."},{"key":"10.1016\/j.intimp.2023.110507_b0010","first-page":"21","article-title":"Peripheral nerve regeneration and muscle reinnervation","author":"Gordon","year":"2020","journal-title":"Int J Mol Sci."},{"key":"10.1016\/j.intimp.2023.110507_b0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121526","article-title":"Dual-functional hydrogel system for spinal cord regeneration with sustained release of arylsulfatase B alleviates fibrotic microenvironment and promotes axonal regeneration","volume":"284","author":"Park","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.intimp.2023.110507_b0020","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s12974-022-02395-0","article-title":"Typical and atypical properties of peripheral nerve allografts enable novel strategies to repair segmental-loss injuries","volume":"19","author":"Bittner","year":"2022","journal-title":"J Neuroinflammation."},{"key":"10.1016\/j.intimp.2023.110507_b0025","doi-asserted-by":"crossref","DOI":"10.1172\/JCI141964","article-title":"Macrophage monocarboxylate transporter 1 promotes peripheral nerve regeneration after injury in mice","volume":"131","author":"Jha","year":"2021","journal-title":"J Clin Invest."},{"key":"10.1016\/j.intimp.2023.110507_b0030","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/s41419-022-04671-6","article-title":"Erythropoietin promotes M2 macrophage phagocytosis of Schwann cells in peripheral nerve injury","volume":"13","author":"Govindappa","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2023.110507_b0035","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1186\/s12974-021-02292-y","article-title":"Macrophage-specific RhoA knockout delays Wallerian degeneration after peripheral nerve injury in mice","volume":"18","author":"Xu","year":"2021","journal-title":"J Neuroinflammation."},{"key":"10.1016\/j.intimp.2023.110507_b0040","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.it.2021.11.002","article-title":"Putative regulation of macrophage-mediated inflammation by catestatin","volume":"43","author":"Muntjewerff","year":"2022","journal-title":"Trends Immunol."},{"key":"10.1016\/j.intimp.2023.110507_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.matdes.2021.109484","article-title":"Physical and biological engineering of polymer scaffolds to potentiate repair of spinal cord injury","volume":"201","author":"Luo","year":"2021","journal-title":"Mater. Des."},{"key":"10.1016\/j.intimp.2023.110507_b0050","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00401-014-1369-9","article-title":"Collagen VI regulates peripheral nerve regeneration by modulating macrophage recruitment and polarization","volume":"129","author":"Chen","year":"2015","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.intimp.2023.110507_b0055","first-page":"6","article-title":"Therapeutics potentiating microglial p21-Nrf2 axis can rescue neurodegeneration caused by neuroinflammation","author":"Nakano-Kobayashi","year":"2020","journal-title":"Sci Adv."},{"key":"10.1016\/j.intimp.2023.110507_b0060","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.semcdb.2021.06.013","article-title":"Macrophage-mediated inflammation in diabetic wound repair","volume":"119","author":"Wolf","year":"2021","journal-title":"Semin Cell Dev Biol."},{"key":"10.1016\/j.intimp.2023.110507_b0065","doi-asserted-by":"crossref","first-page":"e202200077","DOI":"10.1002\/tcr.202200077","article-title":"Biomaterial-based therapeutic approaches to osteoarthritis and cartilage repair through macrophage polarization","author":"Das","year":"2022","journal-title":"Chem Rec."},{"key":"10.1016\/j.intimp.2023.110507_b0070","doi-asserted-by":"crossref","DOI":"10.1002\/JLB.6MR0522-685R","article-title":"A novel strategy to dissect multifaceted macrophage function in human diseases","author":"Karlinsey","year":"2022","journal-title":"J Leukoc Biol."},{"key":"10.1016\/j.intimp.2023.110507_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113909","article-title":"IL-4 expressing cells are recruited to nerve after injury and promote regeneration","volume":"347","author":"Pan","year":"2022","journal-title":"Exp Neurol."},{"key":"10.1016\/j.intimp.2023.110507_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.matdes.2021.110106","article-title":"Composite electrospun scaffold containing decellularized amniotic matrix for pelvic organ prolapse","volume":"210","author":"Yang","year":"2021","journal-title":"Mater. Des."},{"key":"10.1016\/j.intimp.2023.110507_b0085","article-title":"Designing highly customizable human based platforms for cell culture using proteins from the amniotic membrane","author":"Deus","year":"2021","journal-title":"Mater Sci Eng C Mater Biol Appl."},{"key":"10.1016\/j.intimp.2023.110507_b0090","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.actbio.2022.03.039","article-title":"Construction of tissue-engineered human corneal endothelium for corneal endothelial regeneration using a crosslinked amniotic membrane scaffold","volume":"147","author":"Zhao","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.intimp.2023.110507_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2022.109775","article-title":"Comparing the standard surgical dressing with dehydrated amnion and platelet-derived growth factor dressings in the healing rate of diabetic foot ulcer: A randomized clinical trial","volume":"185","author":"Mohammadi Tofigh","year":"2022","journal-title":"Diabetes Res Clin Pract."},{"key":"10.1016\/j.intimp.2023.110507_b0100","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13287-021-02684-0","article-title":"Applications of the amniotic membrane in tissue engineering and regeneration: the hundred-year challenge","volume":"13","author":"Elkhenany","year":"2022","journal-title":"Stem Cell Res Ther."},{"key":"10.1016\/j.intimp.2023.110507_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.matdes.2020.108773","article-title":"Engineering cartilage tissue based on cartilage-derived extracellular matrix cECM\/PCL hybrid nanofibrous scaffold","volume":"193","author":"Feng","year":"2020","journal-title":"Mater. Des."},{"key":"10.1016\/j.intimp.2023.110507_b0110","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12974-021-02121-2","article-title":"The influence of BACE1 on macrophage recruitment and activity in the injured peripheral nerve","volume":"18","author":"Fissel","year":"2021","journal-title":"J Neuroinflammation."},{"issue":"1458\u20131472","key":"10.1016\/j.intimp.2023.110507_b0115","first-page":"e1454","article-title":"Macrophage-derived slit3 controls cell migration and axon pathfinding in the peripheral nerve bridge","volume":"26","author":"Dun","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.intimp.2023.110507_b0120","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s12974-022-02454-6","article-title":"The macrophage: A key player in the pathophysiology of peripheral neuropathies","volume":"19","author":"Msheik","year":"2022","journal-title":"J Neuroinflammation."},{"key":"10.1016\/j.intimp.2023.110507_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2021.102172","article-title":"Neuroimmune interactions and immunoengineering strategies in peripheral nerve repair","volume":"208","author":"Wofford","year":"2022","journal-title":"Prog Neurobiol."},{"key":"10.1016\/j.intimp.2023.110507_b0130","doi-asserted-by":"crossref","first-page":"4993","DOI":"10.7150\/thno.74571","article-title":"Biomechanical microenvironment in peripheral nerve regeneration: from pathophysiological understanding to tissue engineering development","volume":"12","author":"Kong","year":"2022","journal-title":"Theranostics."},{"key":"10.1016\/j.intimp.2023.110507_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.matdes.2020.108982","article-title":"Cyclic tensile stimulation enrichment of schwann cell-laden auxetic hydrogel scaffolds towards peripheral nerve tissue engineering[J]","volume":"195","author":"Chen","year":"2020","journal-title":"Mater. Des."},{"key":"10.1016\/j.intimp.2023.110507_b0140","doi-asserted-by":"crossref","first-page":"e2101979","DOI":"10.1002\/adhm.202101979","article-title":"Expanding the repertoire of electrospinning: New and emerging biopolymers, techniques, and applications","volume":"11","author":"Madruga","year":"2022","journal-title":"Adv Healthc Mater."},{"key":"10.1016\/j.intimp.2023.110507_b0145","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13287-021-02676-0","article-title":"Functional tissue-engineered microtissue formed by self-aggregation of cells for peripheral nerve regeneration","volume":"13","author":"Zhang","year":"2022","journal-title":"Stem Cell Res Ther."},{"key":"10.1016\/j.intimp.2023.110507_b0150","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1021\/acs.biomac.6b01028","article-title":"Polycaprolactone microfibrous scaffolds to navigate neural stem cells","volume":"17","author":"Sharifi","year":"2016","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.intimp.2023.110507_b0155","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s10856-021-06519-5","article-title":"Fabrication and evaluation of porous and conductive nanofibrous scaffolds for nerve tissue engineering","volume":"32","author":"Pooshidani","year":"2021","journal-title":"J Mater Sci Mater Med."},{"key":"10.1016\/j.intimp.2023.110507_b0160","doi-asserted-by":"crossref","first-page":"e2202102","DOI":"10.1002\/advs.202202102","article-title":"Magnesium-encapsulated injectable hydrogel and 3D-engineered polycaprolactone conduit facilitate peripheral nerve regeneration","volume":"9","author":"Yao","year":"2022","journal-title":"Adv Sci (Weinh)."},{"key":"10.1016\/j.intimp.2023.110507_b0165","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23052852","article-title":"Controlling the spatiotemporal release of nerve growth factor by chitosan\/polycaprolactone conduits for use in peripheral nerve regeneration","volume":"23","author":"Nawrotek","year":"2022","journal-title":"Int J Mol Sci."},{"key":"10.1016\/j.intimp.2023.110507_b0170","first-page":"12","article-title":"Long-gap peripheral nerve repair through sustained release of a neurotrophic factor in nonhuman primates","author":"Fadia","year":"2020","journal-title":"Sci Transl Med."},{"key":"10.1016\/j.intimp.2023.110507_b0175","doi-asserted-by":"crossref","first-page":"19943","DOI":"10.1039\/C9NR04521J","article-title":"Synergistic effects of dual-presenting VEGF- and BDNF-mimetic peptide epitopes from self-assembling peptide hydrogels on peripheral nerve regeneration","volume":"11","author":"Lu","year":"2019","journal-title":"Nanoscale"},{"key":"10.1016\/j.intimp.2023.110507_b0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1021\/acsbiomaterials.1c00942","article-title":"Potent particle-based vehicles for growth factor delivery from electrospun meshes: Fabrication and functionalization strategies for effective tissue regeneration","volume":"8","author":"Shaw","year":"2022","journal-title":"ACS Biomater Sci Eng."},{"key":"10.1016\/j.intimp.2023.110507_b0185","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.neulet.2011.03.090","article-title":"Assessment of processed human amniotic membrane as a protective barrier in rat model of sciatic nerve injury","volume":"496","author":"Meng","year":"2011","journal-title":"Neurosci Lett."},{"key":"10.1016\/j.intimp.2023.110507_b0190","doi-asserted-by":"crossref","first-page":"3362","DOI":"10.1002\/jcp.27299","article-title":"Nerve repair and regeneration: Biological tubulization limits and future perspectives","volume":"234","author":"Riccio","year":"2019","journal-title":"J Cell Physiol."},{"key":"10.1016\/j.intimp.2023.110507_b0195","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1111\/jcmm.13512","article-title":"SPION-mediated miR-141 promotes the differentiation of HuAESCs into dopaminergic neuron-like cells via suppressing lncRNA-HOTAIR","volume":"22","author":"Liu","year":"2018","journal-title":"J Cell Mol Med."},{"key":"10.1016\/j.intimp.2023.110507_b0200","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3389\/fimmu.2019.00238","volume":"10","author":"Abbasi-Kangevari","year":"2019","journal-title":"Front Immunol."},{"key":"10.1016\/j.intimp.2023.110507_b0205","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.actbio.2017.11.042","article-title":"Transplantation of human amnion prevents recurring adhesions and ameliorates fibrosis in a rat model of sciatic nerve scarring","volume":"66","author":"Lemke","year":"2018","journal-title":"Acta Biomater."},{"key":"10.1016\/j.intimp.2023.110507_b0210","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.4103\/1673-5374.253510","article-title":"Role of macrophages in peripheral nerve injury and repair","volume":"14","author":"Liu","year":"2019","journal-title":"Neural Regen Res."},{"key":"10.1016\/j.intimp.2023.110507_b0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcn.2021.103590","article-title":"Macrophage roles in peripheral nervous system injury and pathology: Allies in neuromuscular junction recovery","volume":"111","author":"Rios","year":"2021","journal-title":"Mol Cell Neurosci."},{"key":"10.1016\/j.intimp.2023.110507_b0220","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1186\/s13287-022-02947-4","article-title":"Implantation of a nerve protector embedded with human GMSC-derived Schwann-like cells accelerates regeneration of crush-injured rat sciatic nerves","volume":"13","author":"Zhang","year":"2022","journal-title":"Stem Cell Res Ther."},{"key":"10.1016\/j.intimp.2023.110507_b0225","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.3727\/096368912X659907","article-title":"Transplantation of human umbilical cord blood or amniotic epithelial stem cells alleviates mechanical allodynia after spinal cord injury in rats","volume":"22","author":"Roh","year":"2013","journal-title":"Cell Transplant."},{"key":"10.1016\/j.intimp.2023.110507_b0230","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1186\/s13287-021-02607-z","article-title":"CM from intact hAM: an easily obtained product with relevant implications for translation in regenerative medicine","volume":"12","author":"Silini","year":"2021","journal-title":"Stem Cell Res Ther."},{"key":"10.1016\/j.intimp.2023.110507_b0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108404","article-title":"The remarkable effect of menstrual blood stem cells seeded on bilayer scaffold composed of amniotic membrane and silk fibroin aiming to promote wound healing in diabetic mice","volume":"102","author":"Mirzadegan","year":"2022","journal-title":"Int Immunopharmacol."},{"key":"10.1016\/j.intimp.2023.110507_b0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2023.120934","article-title":"Natural polysaccharides and their derivatives as potential medical materials and drug delivery systems for the treatment of peripheral nerve injuries","volume":"315","author":"Solomevich","year":"2023","journal-title":"Carbohydr Polym."},{"issue":"9","key":"10.1016\/j.intimp.2023.110507_b0245","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.3390\/molecules26092712","article-title":"Polymer Scaffolds for Biomedical Applications in Peripheral Nerve Reconstruction","volume":"26","author":"Zhang","year":"2021","journal-title":"Molecules"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923008305?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923008305?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T18:16:25Z","timestamp":1761588985000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576923008305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":49,"alternative-id":["S1567576923008305"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2023.110507","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nanofibrous polycaprolactone\/amniotic membrane facilitates peripheral nerve regeneration by promoting macrophage polarization and regulating inflammatory microenvironment","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2023.110507","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110507"}}