{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T21:23:44Z","timestamp":1782509024635,"version":"3.54.5"},"reference-count":109,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005756","name":"Shahrekord University of Medical Sciences","doi-asserted-by":"publisher","award":["6483"],"award-info":[{"award-number":["6483"]}],"id":[{"id":"10.13039\/501100005756","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.intimp.2023.110725","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T10:01:09Z","timestamp":1691402469000},"page":"110725","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Immunoinformatics-based multi-epitope vaccine design for the re-emerging monkeypox virus"],"prefix":"10.1016","volume":"123","author":[{"given":"Mahour","family":"Farzan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3434-5288","authenticated-orcid":false,"given":"Mahan","family":"Farzan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousef","family":"Mirzaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Aiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Azadegan-Dehkordi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5196-5513","authenticated-orcid":false,"given":"Nader","family":"Bagheri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2023.110725_b0005","first-page":"131","article-title":"Impact of Emerging, Re-Emerging and Zoonotic Viral Infectious Diseases, in a Virologist's Perspective, Open","volume":"12","author":"Kobayashi","year":"2018","journal-title":"Virol. J."},{"issue":"15","key":"10.1016\/j.intimp.2023.110725_b0010","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph19159081","article-title":"Emerging Infectious Diseases and One Health: Implication for Public Health","volume":"19","author":"Chen","year":"2022","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"8","key":"10.1016\/j.intimp.2023.110725_b0015","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1056\/NEJMoa2207323","article-title":"Monkeypox virus infection in humans across 16 countries\u2014April\u2013June 2022","volume":"387","author":"Thornhill","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.intimp.2023.110725_b0020","doi-asserted-by":"crossref","DOI":"10.1111\/bjh.18388","article-title":"The potential impact of monkeypox infection and vaccination on blood donor deferrals and the blood supply","author":"Jacobs","year":"2022","journal-title":"Br J Haematol. n\/a(n\/a)"},{"key":"10.1016\/j.intimp.2023.110725_b0025","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.985450","article-title":"Multi-epitope chimeric vaccine design against emerging Monkeypox virus via reverse vaccinology techniques- a bioinformatics and immunoinformatics approach","volume":"13","author":"Aiman","year":"2022","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.intimp.2023.110725_b0030","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/S1473-3099(22)00228-6","article-title":"Clinical features and management of human monkeypox: a retrospective observational study in the UK","volume":"22","author":"Adler","year":"2022","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.intimp.2023.110725_b0035","article-title":"The never-ending global emergence of viral zoonoses after COVID-19?","volume":"49","author":"Le\u00f3n-Figueroa","year":"2022","journal-title":"The rising concern of monkeypox in Europe, North America and beyond, Travel Med Infect Dis"},{"issue":"33","key":"10.1016\/j.intimp.2023.110725_b0040","doi-asserted-by":"crossref","first-page":"5077","DOI":"10.1016\/j.vaccine.2020.04.062","article-title":"Human monkeypox - After 40 years, an unintended consequence of smallpox eradication","volume":"38","author":"Simpson","year":"2020","journal-title":"Vaccine"},{"key":"10.1016\/j.intimp.2023.110725_b0045","doi-asserted-by":"crossref","unstructured":"M.S. Mehand, F. Al-Shorbaji, P. Millett, B. Murgue, The WHO R&D Blueprint: 2018 review of emerging infectious diseases requiring urgent research and development efforts, Antiviral Res 159 (2018) 63-67.","DOI":"10.1016\/j.antiviral.2018.09.009"},{"issue":"14","key":"10.1016\/j.intimp.2023.110725_b0050","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23147866","article-title":"Monkeypox: A New Threat?","volume":"23","author":"Kmiec","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2023.110725_b0055","doi-asserted-by":"crossref","first-page":"15983","DOI":"10.1038\/s41598-022-20397-z","article-title":"Novel multi epitope-based vaccine against monkeypox virus: vaccinomic approach","volume":"12","author":"Shantier","year":"2022","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.intimp.2023.110725_b0060","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1186\/1471-2105-14-S4-S3","article-title":"Prediction of conformational epitopes with the use of a knowledge-based energy function and geometrically related neighboring residue characteristics","volume":"14","author":"Lo","year":"2013","journal-title":"BMC Bioinf."},{"issue":"11","key":"10.1016\/j.intimp.2023.110725_b0065","doi-asserted-by":"crossref","DOI":"10.3390\/v14112504","article-title":"Multi-Epitope Vaccine for Monkeypox Using Pan-Genome and Reverse Vaccinology Approaches","volume":"14","author":"Swetha","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.intimp.2023.110725_b0070","doi-asserted-by":"crossref","unstructured":"S. Sanami, S. Nazarian, S. Ahmad, E. Raeisi, M. Tahir Ul Qamar, S. Tahmasebian, H. Pazoki-Toroudi, M. Fazeli, M. Ghatreh Samani, In silico design and immunoinformatics analysis of a universal multi-epitope vaccine against monkeypox virus, PLoS One 18(5) (2023) e0286224.","DOI":"10.1371\/journal.pone.0286224"},{"issue":"9","key":"10.1016\/j.intimp.2023.110725_b0075","article-title":"Multi-Epitope-Based Vaccine Candidate for Monkeypox: An In Silico Approach","volume":"10","author":"Abdi","year":"2022","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.intimp.2023.110725_b0080","doi-asserted-by":"crossref","first-page":"1042997","DOI":"10.3389\/fimmu.2022.1042997","article-title":"Immunoinformatic-based design of immune-boosting multiepitope subunit vaccines against monkeypox virus and validation through molecular dynamics and immune simulation","volume":"13","author":"Suleman","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2023.110725_b0085","doi-asserted-by":"crossref","unstructured":"A. Ullah, F.A. Shahid, M.U. Haq, M. Tahir Ul Qamar, M. Irfan, B. Shaker, S. Ahmad, F. Alrumaihi, K.S. Allemailem, A. Almatroudi, An integrative reverse vaccinology, immunoinformatic, docking and simulation approaches towards designing of multi-epitopes based vaccine against monkeypox virus, J Biomol Struct Dyn (2022) 1-14.","DOI":"10.1080\/07391102.2022.2125441"},{"key":"10.1016\/j.intimp.2023.110725_b0090","first-page":"1","article-title":"Design of a novel multiple epitope-based vaccine: an immunoinformatics approach to combat monkeypox","author":"Hayat","year":"2022","journal-title":"J. Biomol. Struct. Dyn."},{"issue":"11","key":"10.1016\/j.intimp.2023.110725_b0095","doi-asserted-by":"crossref","DOI":"10.3390\/v14112374","article-title":"Immunoinformatics-Aided Design of a Peptide Based Multiepitope Vaccine Targeting Glycoproteins and Membrane Proteins against Monkeypox Virus","volume":"14","author":"Akhtar","year":"2022","journal-title":"Viruses"},{"issue":"12","key":"10.1016\/j.intimp.2023.110725_b0100","article-title":"Multi-Epitope Vaccine Design against Monkeypox Virus via Reverse Vaccinology Method Exploiting Immunoinformatic and Bioinformatic Approaches","volume":"10","author":"Bhattacharya","year":"2022","journal-title":"Vaccines (Basel)"},{"issue":"1","key":"10.1016\/j.intimp.2023.110725_b0105","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jiph.2022.11.033","article-title":"Designing multi-epitope monkeypox virus-specific vaccine using immunoinformatics approach","volume":"16","author":"Zaib","year":"2023","journal-title":"J. Infect. Public Health"},{"key":"10.1016\/j.intimp.2023.110725_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.tmaid.2022.102481","article-title":"Designing, characterization, and immune stimulation of a novel multi-epitopic peptide-based potential vaccine candidate against monkeypox virus through screening its whole genome encoded proteins: An immunoinformatics approach","volume":"50","author":"Bhattacharya","year":"2022","journal-title":"Travel Med. Infect. Dis."},{"key":"10.1016\/j.intimp.2023.110725_b0115","doi-asserted-by":"crossref","unstructured":"M. Abrahim, A. Guterres, P.C. da Costa Neves, A.P.D. Ano Bom, The emergence of new lineages of the Monkeypox virus could affect the 2022 outbreak, bioRxiv (2022) 2022.07.07.498743.","DOI":"10.1101\/2022.07.07.498743"},{"issue":"6","key":"10.1016\/j.intimp.2023.110725_b0120","doi-asserted-by":"crossref","first-page":"e0003850","DOI":"10.1371\/journal.pntd.0003850","article-title":"BoHV-4-Based Vector Single Heterologous Antigen Delivery Protects STAT1(-\/-) Mice from Monkeypoxvirus Lethal Challenge","volume":"9","author":"Franceschi","year":"2015","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"1","key":"10.1016\/j.intimp.2023.110725_b0125","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0042-6822(02)00038-7","article-title":"Four-gene-combination DNA vaccine protects mice against a lethal vaccinia virus challenge and elicits appropriate antibody responses in nonhuman primates","volume":"306","author":"Hooper","year":"2003","journal-title":"Virology"},{"issue":"Pt 5","key":"10.1016\/j.intimp.2023.110725_b0130","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1099\/0022-1317-83-5-1059","article-title":"Administration to mice of a monoclonal antibody that neutralizes the intracellular mature virus form of vaccinia virus limits virus replication efficiently under prophylactic and therapeutic conditions","volume":"83","author":"Ram\u00edrez","year":"2002","journal-title":"J. Gen. Virol."},{"issue":"18","key":"10.1016\/j.intimp.2023.110725_b0135","doi-asserted-by":"crossref","first-page":"9527","DOI":"10.1128\/JVI.00199-11","article-title":"Deletion of the monkeypox virus inhibitor of complement enzymes locus impacts the adaptive immune response to monkeypox virus in a nonhuman primate model of infection","volume":"85","author":"Estep","year":"2011","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.intimp.2023.110725_b0140","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.virol.2006.09.031","article-title":"Amino acid substitutions at multiple sites within the vaccinia virus D13 scaffold protein confer resistance to rifampicin","volume":"359","author":"Charity","year":"2007","journal-title":"Virology"},{"issue":"2","key":"10.1016\/j.intimp.2023.110725_b0145","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1006\/viro.2002.1446","article-title":"Analysis of the monkeypox virus genome","volume":"297","author":"Shchelkunov","year":"2002","journal-title":"Virology"},{"issue":"6","key":"10.1016\/j.intimp.2023.110725_b0150","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/1471-2105-14-S6-S4","article-title":"AllerTOP - a server for in silico prediction of allergens","volume":"14","author":"Dimitrov","year":"2013","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.intimp.2023.110725_b0155","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2105-8-4","article-title":"VaxiJen: a server for prediction of protective antigens, tumour antigens and subunit vaccines","volume":"8","author":"Doytchinova","year":"2007","journal-title":"BMC Bioinf."},{"issue":"6","key":"10.1016\/j.intimp.2023.110725_b0160","doi-asserted-by":"crossref","first-page":"e99368","DOI":"10.1371\/journal.pone.0099368","article-title":"CELLO2GO: a web server for protein subCELlular LOcalization prediction with functional gene ontology annotation","volume":"9","author":"Yu","year":"2014","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.intimp.2023.110725_b0165","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1006\/jmbi.2000.4315","article-title":"Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes","volume":"305","author":"Krogh","year":"2001","journal-title":"J. Mol. Biol."},{"issue":"1","key":"10.1016\/j.intimp.2023.110725_b0170","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1471-2105-9-62","article-title":"VirulentPred: a SVM based prediction method for virulent proteins in bacterial pathogens","volume":"9","author":"Garg","year":"2008","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.intimp.2023.110725_b0175","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1186\/1471-2105-8-424","article-title":"Large-scale validation of methods for cytotoxic T-lymphocyte epitope prediction","volume":"8","author":"Larsen","year":"2007","journal-title":"BMC Bioinf."},{"issue":"4","key":"10.1016\/j.intimp.2023.110725_b0180","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.4049\/jimmunol.171.4.1741","article-title":"Identifying MHC class I epitopes by predicting the TAP transport efficiency of epitope precursors","volume":"171","author":"Peters","year":"2003","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2023.110725_b0185","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1093\/bioinformatics\/btv639","article-title":"Gapped sequence alignment using artificial neural networks: application to the MHC class I system","volume":"32","author":"Andreatta","year":"2016","journal-title":"Bioinformatics"},{"issue":"5","key":"10.1016\/j.intimp.2023.110725_b0190","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1110\/ps.0239403","article-title":"Reliable prediction of T-cell epitopes using neural networks with novel sequence representations","volume":"12","author":"Nielsen","year":"2003","journal-title":"Protein Sci."},{"issue":"3","key":"10.1016\/j.intimp.2023.110725_b0195","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/imm.12889","article-title":"Improved methods for predicting peptide binding affinity to MHC class II molecules","volume":"154","author":"Jensen","year":"2018","journal-title":"Immunology"},{"key":"10.1016\/j.intimp.2023.110725_b0200","doi-asserted-by":"crossref","unstructured":"T. Kar, U. Narsaria, S. Basak, D. Deb, F. Castiglione, D.M. Mueller, A.P. Srivastava, A candidate multi-epitope vaccine against SARS-CoV-2. Sci Rep 10: 10895, Link: https:\/\/go.nature.com\/3pUa0Mv (2020).","DOI":"10.1038\/s41598-020-67749-1"},{"issue":"2","key":"10.1016\/j.intimp.2023.110725_b0205","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/cmi.2017.92","article-title":"Multi-epitope vaccines: a promising strategy against tumors and viral infections","volume":"15","author":"Zhang","year":"2018","journal-title":"Cell. Mol. Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2023.110725_b0210","doi-asserted-by":"crossref","first-page":"e1000048","DOI":"10.1371\/journal.pcbi.1000048","article-title":"A systematic assessment of MHC class II peptide binding predictions and evaluation of a consensus approach","volume":"4","author":"Wang","year":"2008","journal-title":"PLoS Comput. Biol."},{"issue":"10","key":"10.1016\/j.intimp.2023.110725_b0215","doi-asserted-by":"crossref","first-page":"e1003266","DOI":"10.1371\/journal.pcbi.1003266","article-title":"Properties of MHC class I presented peptides that enhance immunogenicity","volume":"9","author":"Calis","year":"2013","journal-title":"PLoS Comput. Biol."},{"issue":"1","key":"10.1016\/j.intimp.2023.110725_b0220","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.5808\/gi.21065","article-title":"Designing a novel mRNA vaccine against Vibrio harveyi infection in fish: an immunoinformatics approach","volume":"20","author":"Islam","year":"2022","journal-title":"Genomics Inform"},{"key":"10.1016\/j.intimp.2023.110725_b0225","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1745-6150-8-30","article-title":"Designing of interferon-gamma inducing MHC class-II binders","volume":"8","author":"Dhanda","year":"2013","journal-title":"Biol. Direct"},{"key":"10.1016\/j.intimp.2023.110725_b0230","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/263952","article-title":"Prediction of IL4 Inducing Peptides","volume":"2013","author":"Dhanda","year":"2013","journal-title":"Clin. Dev. Immunol."},{"key":"10.1016\/j.intimp.2023.110725_b0235","doi-asserted-by":"crossref","first-page":"42851","DOI":"10.1038\/srep42851","article-title":"Computer-aided designing of immunosuppressive peptides based on IL-10 inducing potential","volume":"7","author":"Nagpal","year":"2017","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.intimp.2023.110725_b0240","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/prot.21078","article-title":"Prediction of continuous B-cell epitopes in an antigen using recurrent neural network","volume":"65","author":"Saha","year":"2006","journal-title":"Proteins"},{"key":"10.1016\/j.intimp.2023.110725_b0245","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.meegid.2017.04.009","article-title":"Development of a multi-epitope peptide vaccine inducing robust T cell responses against brucellosis using immunoinformatics based approaches","volume":"51","author":"Saadi","year":"2017","journal-title":"Infect. Genet. Evol."},{"issue":"3","key":"10.1016\/j.intimp.2023.110725_b0250","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/bit.21396","article-title":"Strategy for selecting and characterizing linker peptides for CBM9-tagged fusion proteins expressed in Escherichia coli","volume":"98","author":"Kavoosi","year":"2007","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.intimp.2023.110725_b0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.health.2022.100044","article-title":"In silico vaccine design: A tutorial in immunoinformatics","volume":"2","author":"Martinelli","year":"2022","journal-title":"Healthcare Analytics"},{"issue":"5","key":"10.1016\/j.intimp.2023.110725_b0260","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.4110\/in.2022.22.e41","article-title":"Application of Antimicrobial Peptide LL-37 as an Adjuvant for Middle East Respiratory Syndrome-Coronavirus Antigen Induces an Efficient Protective Immune Response Against Viral Infection After Intranasal Immunization","volume":"22","author":"Kim","year":"2022","journal-title":"Immune Netw"},{"key":"10.1016\/j.intimp.2023.110725_b0265","series-title":"The Proteomics Protocols Handbook","first-page":"571","article-title":"S.e. Duvaud, M.R. Wilkins, R.D. Appel, A. Bairoch, Protein Identification and Analysis Tools on the ExPASy Server","author":"Gasteiger","year":"2005"},{"issue":"6","key":"10.1016\/j.intimp.2023.110725_b0270","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1093\/bioinformatics\/btt619","article-title":"AllergenFP: allergenicity prediction by descriptor fingerprints","volume":"30","author":"Dimitrov","year":"2014","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.intimp.2023.110725_b0275","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1471-2334-7-50","article-title":"The association of RANTES polymorphism with severe acute respiratory syndrome in Hong Kong and Beijing Chinese","volume":"7","author":"Ng","year":"2007","journal-title":"BMC Infect. Dis."},{"issue":"8","key":"10.1016\/j.intimp.2023.110725_b0280","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1007\/s00705-021-05070-6","article-title":"Human gene polymorphisms and their possible impact on the clinical outcome of SARS-CoV-2 infection","volume":"166","author":"Hashemi","year":"2021","journal-title":"Arch. Virol"},{"key":"10.1016\/j.intimp.2023.110725_b0285","first-page":"e750","article-title":"Multi-epitope mRNA Vaccine Design that Exploits Variola Virus and Monkeypox Virus Proteins for Elicitation of Long-lasting Humoral and Cellular Protection Against Severe Disease, Journal of","author":"Kova\u010di\u0107","year":"2022","journal-title":"Med. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2023.110725_b0290","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/1471-2105-7-153","article-title":"Predicting population coverage of T-cell epitope-based diagnostics and vaccines","volume":"7","author":"Bui","year":"2006","journal-title":"BMC Bioinf."},{"issue":"4","key":"10.1016\/j.intimp.2023.110725_b0295","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1093\/bioinformatics\/16.4.404","article-title":"The PSIPRED protein structure prediction server","volume":"16","author":"McGuffin","year":"2000","journal-title":"Bioinformatics"},{"issue":"2","key":"10.1016\/j.intimp.2023.110725_b0300","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1006\/jmbi.1999.3091","article-title":"Protein secondary structure prediction based on position-specific scoring matrices","volume":"292","author":"Jones","year":"1999","journal-title":"J. Mol. Biol."},{"issue":"6","key":"10.1016\/j.intimp.2023.110725_b0305","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1093\/bioinformatics\/11.6.681","article-title":"SOPMA: significant improvements in protein secondary structure prediction by consensus prediction from multiple alignments","volume":"11","author":"Geourjon","year":"1995","journal-title":"Bioinformatics"},{"key":"10.1016\/j.intimp.2023.110725_b0310","unstructured":"J. Garnier, GOR secondary structure prediction method version IV, Meth. Enzym., RF Doolittle Ed. 266 (1998) 540-553."},{"issue":"1","key":"10.1016\/j.intimp.2023.110725_b0315","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nmeth.3213","article-title":"The I-TASSER Suite: protein structure and function prediction","volume":"12","author":"Yang","year":"2015","journal-title":"Nat. Methods"},{"issue":"W1","key":"10.1016\/j.intimp.2023.110725_b0320","doi-asserted-by":"crossref","first-page":"W384","DOI":"10.1093\/nar\/gkt458","article-title":"GalaxyRefine: Protein structure refinement driven by side-chain repacking","volume":"41","author":"Heo","year":"2013","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.intimp.2023.110725_b0325","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/pro.3289","article-title":"PDBsum: Structural summaries of PDB entries","volume":"27","author":"Laskowski","year":"2018","journal-title":"Protein Sci."},{"issue":"9","key":"10.1016\/j.intimp.2023.110725_b0330","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1002\/pro.5560020916","article-title":"Verification of protein structures: patterns of nonbonded atomic interactions","volume":"2","author":"Colovos","year":"1993","journal-title":"Protein Sci."},{"issue":"3","key":"10.1016\/j.intimp.2023.110725_b0335","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/prot.10286","article-title":"Structure validation by C\u03b1 geometry: \u03d5, \u03c8 and C\u03b2 deviation","volume":"50","author":"Lovell","year":"2003","journal-title":"Proteins Struct. Funct. Bioinf."},{"issue":"4","key":"10.1016\/j.intimp.2023.110725_b0340","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/BF00228148","article-title":"AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR","volume":"8","author":"Laskowski","year":"1996","journal-title":"J. Biomol. NMR"},{"issue":"12","key":"10.1016\/j.intimp.2023.110725_b0345","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1002\/prot.24403","article-title":"How good is automated protein docking?","volume":"81","author":"Kozakov","year":"2013","journal-title":"Proteins"},{"issue":"2","key":"10.1016\/j.intimp.2023.110725_b0350","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nprot.2016.169","article-title":"The ClusPro web server for protein-protein docking","volume":"12","author":"Kozakov","year":"2017","journal-title":"Nat. Protoc."},{"issue":"11","key":"10.1016\/j.intimp.2023.110725_b0355","doi-asserted-by":"crossref","first-page":"e910","DOI":"10.1002\/mgg3.910","article-title":"Docking-based approach for identification of mutations that disrupt binding between Bcl-2 and Bax proteins: Inducing apoptosis in cancer cells","volume":"7","author":"Raghav","year":"2019","journal-title":"Mol. Genet. Genomic Med."},{"issue":"1","key":"10.1016\/j.intimp.2023.110725_b0360","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1038\/s41598-022-20773-9","article-title":"Experimental and clinical data analysis for identification of COVID-19 resistant ACE2 mutations","volume":"13","author":"Raghav","year":"2023","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.intimp.2023.110725_b0365","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14020423","article-title":"Recent Advances in the Development of Toll-like Receptor Agonist-Based Vaccine Adjuvants for Infectious Diseases","volume":"14","author":"Yang","year":"2022","journal-title":"Pharmaceutics"},{"issue":"6","key":"10.1016\/j.intimp.2023.110725_b0370","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1021\/ct501090y","article-title":"Targeting Electrostatic Interactions in Accelerated Molecular Dynamics with Application to Protein Partial Unfolding","volume":"11","author":"Flores-Canales","year":"2015","journal-title":"J. Chem. Theory Comput."},{"key":"10.1016\/j.intimp.2023.110725_b0375","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1002\/(SICI)1096-987X(199709)18:12<1463::AID-JCC4>3.0.CO;2-H","article-title":"3 LINCS: a linear constraint solver for molecular simulations","volume":"18","author":"Hess","year":"1997","journal-title":"J. Comp. Chem."},{"issue":"3","key":"10.1016\/j.intimp.2023.110725_b0380","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.ijbiomac.2011.11.021","article-title":"Peptide screening to knockdown Bcl-2's anti-apoptotic activity: Implications in cancer treatment","volume":"50","author":"Raghav","year":"2012","journal-title":"Int. J. Biol. Macromol."},{"issue":"5","key":"10.1016\/j.intimp.2023.110725_b0385","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1007\/s00894-011-1201-6","article-title":"Molecular dynamics simulations of the Bcl-2 protein to predict the structure of its unordered flexible loop domain","volume":"18","author":"Raghav","year":"2012","journal-title":"J. Mol. Model."},{"issue":"Web Server issue","key":"10.1016\/j.intimp.2023.110725_b0390","doi-asserted-by":"crossref","first-page":"W526","DOI":"10.1093\/nar\/gki376","article-title":"JCat: a novel tool to adapt codon usage of a target gene to its potential expression host","volume":"33","author":"Grote","year":"2005","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"10.1016\/j.intimp.2023.110725_b0395","doi-asserted-by":"crossref","first-page":"e9862","DOI":"10.1371\/journal.pone.0009862","article-title":"Computational Immunology Meets Bioinformatics: The Use of Prediction Tools for Molecular Binding in the Simulation of the Immune System","volume":"5","author":"Rapin","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2023.110725_b0400","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/842329","article-title":"How the Interval between Prime and Boost Injection Affects the Immune Response in a Computational Model of the Immune System","volume":"2012","author":"Castiglione","year":"2012","journal-title":"Comput. Math. Methods Med."},{"issue":"5","key":"10.1016\/j.intimp.2023.110725_b0405","doi-asserted-by":"crossref","first-page":"339","DOI":"10.2174\/0929866526666190228144219","article-title":"Applicability of Instability Index for In vitro Protein Stability Prediction","volume":"26","author":"Gamage","year":"2019","journal-title":"Protein Pept. Lett."},{"issue":"4","key":"10.1016\/j.intimp.2023.110725_b0410","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nprot.2010.5","article-title":"I-TASSER: a unified platform for automated protein structure and function prediction","volume":"5","author":"Roy","year":"2010","journal-title":"Nat. Protoc."},{"issue":"1","key":"10.1016\/j.intimp.2023.110725_b0415","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.bj.2020.09.005","article-title":"Development of multi-epitope peptide-based vaccines against SARS-CoV-2","volume":"44","author":"Lim","year":"2021","journal-title":"Biomed J."},{"issue":"1","key":"10.1016\/j.intimp.2023.110725_b0420","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-022-20397-z","article-title":"Novel multi epitope-based vaccine against monkeypox virus: Vaccinomic approach","volume":"12","author":"Shantier","year":"2022","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.intimp.2023.110725_b0425","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1093\/infdis\/jiaa559","article-title":"Exportation of monkeypox virus from the African continent","volume":"225","author":"Mauldin","year":"2022","journal-title":"J Infect Dis"},{"issue":"2","key":"10.1016\/j.intimp.2023.110725_b0430","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3390\/vaccines4020012","article-title":"Recent advances in subunit vaccine carriers","volume":"4","author":"Vartak","year":"2016","journal-title":"Vaccines"},{"issue":"36","key":"10.1016\/j.intimp.2023.110725_b0435","doi-asserted-by":"crossref","first-page":"5013","DOI":"10.1016\/j.vaccine.2009.05.009","article-title":"Therapeutic efficacy of a multi-epitope vaccine against Helicobacter pylori infection in BALB\/c mice model","volume":"27","author":"Zhou","year":"2009","journal-title":"Vaccine"},{"issue":"3","key":"10.1016\/j.intimp.2023.110725_b0440","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1006\/meth.1996.0054","article-title":"Mapping epitope structure and activity: from one-dimensional prediction to four-dimensional description of antigenic specificity","volume":"9","author":"Van Regenmortel","year":"1996","journal-title":"Methods"},{"key":"10.1016\/j.intimp.2023.110725_b0445","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.compbiomed.2016.06.015","article-title":"Effect of linker length and residues on the structure and stability of a fusion protein with malaria vaccine application","volume":"76","author":"Shamriz","year":"2016","journal-title":"Comput. Biol. Med."},{"issue":"Supplement_3","key":"10.1016\/j.intimp.2023.110725_b0450","doi-asserted-by":"crossref","first-page":"S266","DOI":"10.1086\/313883","article-title":"Improving vaccine performance with adjuvants","volume":"30","author":"Vogel","year":"2000","journal-title":"Clin. Infect. Dis."},{"issue":"2","key":"10.1016\/j.intimp.2023.110725_b0455","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3390\/vaccines2020297","article-title":"Vaccine potentiation by combination adjuvants","volume":"2","author":"Levast","year":"2014","journal-title":"Vaccines"},{"issue":"10","key":"10.1016\/j.intimp.2023.110725_b0460","doi-asserted-by":"crossref","first-page":"3991","DOI":"10.1128\/AAC.49.10.3991-3996.2005","article-title":"From the Th1\/Th2 paradigm towards a Toll-like receptor\/T-helper bias","volume":"49","author":"Netea","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"issue":"8","key":"10.1016\/j.intimp.2023.110725_b0465","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/protein\/14.8.529","article-title":"Design of the linkers which effectively separate domains of a bifunctional fusion protein","volume":"14","author":"Arai","year":"2001","journal-title":"Protein Eng."},{"issue":"2","key":"10.1016\/j.intimp.2023.110725_b0470","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3390\/vaccines8020288","article-title":"Multiepitope-based subunit vaccine design and evaluation against respiratory syncytial virus using reverse vaccinology approach","volume":"8","author":"Tahir ul Qamar","year":"2020","journal-title":"Vaccines"},{"issue":"4","key":"10.1016\/j.intimp.2023.110725_b0475","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1007\/s10989-020-10020-y","article-title":"Exploring the Zika genome to design a potential multiepitope vaccine using an immunoinformatics approach","volume":"26","author":"Mittal","year":"2020","journal-title":"Int. J. Pept. Res. Ther."},{"key":"10.1016\/j.intimp.2023.110725_b0480","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2020.105375","article-title":"High throughput and comprehensive approach to develop multiepitope vaccine against minacious COVID-19","volume":"151","author":"Ojha","year":"2020","journal-title":"Eur. J. Pharm. Sci."},{"issue":"5","key":"10.1016\/j.intimp.2023.110725_b0485","doi-asserted-by":"crossref","DOI":"10.4110\/in.2022.22.e41","article-title":"Application of Antimicrobial Peptide LL-37 as an Adjuvant for Middle East Respiratory Syndrome-Coronavirus Antigen Induces an Efficient Protective Immune Response Against Viral Infection After Intranasal Immunization","volume":"22","author":"Kim","year":"2022","journal-title":"Immune Netw."},{"issue":"8","key":"10.1016\/j.intimp.2023.110725_b0490","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.4161\/hv.29590","article-title":"Strong HCV NS3\/4a, NS4b, NS5a, NS5b-specific cellular immune responses induced in Rhesus macaques by a novel HCV genotype 1a\/1b consensus DNA vaccine","volume":"10","author":"Latimer","year":"2014","journal-title":"Hum. Vaccin. Immunother."},{"issue":"2","key":"10.1016\/j.intimp.2023.110725_b0495","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.ijpharm.2008.04.036","article-title":"Vaccine adjuvant systems: enhancing the efficacy of sub-unit protein antigens","volume":"364","author":"Perrie","year":"2008","journal-title":"Int. J. Pharm."},{"issue":"suppl_2","key":"10.1016\/j.intimp.2023.110725_b0500","doi-asserted-by":"crossref","first-page":"W407","DOI":"10.1093\/nar\/gkm290","article-title":"ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins","volume":"35","author":"Wiederstein","year":"2007","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.intimp.2023.110725_b0505","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.jaci.2009.12.980","article-title":"Overview of the immune response","volume":"125","author":"Chaplin","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2023.110725_b0510","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.jhep.2014.04.026","article-title":"The role of Kupffer cells in hepatitis B and hepatitis C virus infections","volume":"61","author":"Boltjes","year":"2014","journal-title":"J. Hepatol."},{"issue":"4","key":"10.1016\/j.intimp.2023.110725_b0515","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1089\/vim.2011.0099","article-title":"SARS-CoV regulates immune function-related gene expression in human monocytic cells","volume":"25","author":"Hu","year":"2012","journal-title":"Viral Immunol."},{"key":"10.1016\/j.intimp.2023.110725_b0520","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/6491738","article-title":"Middle East respiratory syndrome coronavirus (MERS-CoV): infection, immunological response, and vaccine development","volume":"2019","author":"Mubarak","year":"2019","journal-title":"J. Immunol. Res."},{"issue":"4","key":"10.1016\/j.intimp.2023.110725_b0525","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1517\/13543784.2016.1154040","article-title":"Advances in antiviral therapies targeting toll-like receptors","volume":"25","author":"Shah","year":"2016","journal-title":"Expert Opin. Invest. Drugs"},{"key":"10.1016\/j.intimp.2023.110725_b0530","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1035924","article-title":"Immuno-informatics profiling of monkeypox virus cell surface binding protein for designing a next generation multi-valent peptide-based vaccine","volume":"13","author":"Yousaf","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2023.110725_b0535","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1004804","article-title":"Contriving multi-epitope vaccine ensemble for monkeypox disease using an immunoinformatics approach","volume":"13","author":"Aziz","year":"2022","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.intimp.2023.110725_b0540","doi-asserted-by":"crossref","first-page":"e109","DOI":"10.1371\/journal.pcbi.0030109","article-title":"Modeling systems-level regulation of host immune responses","volume":"3","author":"Thakar","year":"2007","journal-title":"PLoS Comput Biol."},{"issue":"11","key":"10.1016\/j.intimp.2023.110725_b0545","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.3390\/cells10113014","article-title":"In silico designing of a multitope vaccine against rhizopus microsporus with potential activity against other mucormycosis causing fungi","volume":"10","author":"Soltan","year":"2021","journal-title":"Cells"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923010500?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923010500?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T14:32:28Z","timestamp":1736433148000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576923010500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":109,"alternative-id":["S1567576923010500"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2023.110725","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunoinformatics-based multi-epitope vaccine design for the re-emerging monkeypox virus","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2023.110725","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110725"}}