{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:35:52Z","timestamp":1792067752946,"version":"4.4.0"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010854","name":"Jiangsu Provincial Commission of Health and Family Planning","doi-asserted-by":"publisher","award":["Z2020022"],"award-info":[{"award-number":["Z2020022"]}],"id":[{"id":"10.13039\/501100010854","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010854","name":"Jiangsu Provincial Commission of Health and Family Planning","doi-asserted-by":"publisher","award":["Z2021059"],"award-info":[{"award-number":["Z2021059"]}],"id":[{"id":"10.13039\/501100010854","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017962","name":"Jiangsu Commission of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017962","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018932","name":"Huai'an Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["HABL202260"],"award-info":[{"award-number":["HABL202260"]}],"id":[{"id":"10.13039\/100018932","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.intimp.2023.110864","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T08:50:17Z","timestamp":1694076617000},"page":"110864","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"PA","title":["Activation of Nrf2\/ARE pathway by Anisodamine (654-2) for Inhibition of cellular aging and alleviation of Radiation-Induced lung injury"],"prefix":"10.1016","volume":"124","author":[{"given":"Haochun","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanxu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingju","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3278-2591","authenticated-orcid":false,"given":"Juan","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanpeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.intimp.2023.110864_b0005","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1097\/JTO.0000000000000359","article-title":"Impact of pretreatment interstitial lung disease on radiation pneumonitis and survival after stereotactic body radiation therapy for lung cancer","volume":"10","author":"Ueki","year":"2015","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.intimp.2023.110864_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117743","article-title":"Ameliorative effect of 2-methoxyestradiol on radiation-induced lung injury","volume":"255","author":"Elzayat","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2023.110864_b0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154184","article-title":"Re-Du-Ning injection ameliorates radiation-induced pneumonitis and fibrosis by inhibiting AIM2 inflammasome and epithelial-mesenchymal transition","volume":"102","author":"Yang","year":"2022","journal-title":"Phytomedicine"},{"issue":"3","key":"10.1016\/j.intimp.2023.110864_b0020","doi-asserted-by":"crossref","first-page":"410","DOI":"10.3390\/clinpract11030056","article-title":"Radiation-Induced Lung Injury-Current Perspectives and Management","volume":"11","author":"Rahi","year":"2021","journal-title":"Clin Pract"},{"issue":"2","key":"10.1016\/j.intimp.2023.110864_b0025","doi-asserted-by":"crossref","first-page":"307","DOI":"10.21037\/tlcr-22-108","article-title":"Exploration of radiation-induced lung injury, from mechanism to treatment: a narrative review","volume":"11","author":"Yan","year":"2022","journal-title":"Transl Lung Cancer Res"},{"issue":"9","key":"10.1016\/j.intimp.2023.110864_b0030","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21093279","article-title":"Cellular Senescence in the Lung: The Central Role of Senescent Epithelial Cells","volume":"21","author":"Hansel","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2023.110864_b0035","doi-asserted-by":"crossref","DOI":"10.1186\/s13014-022-02184-2","article-title":"Radiation-induced senescence: therapeutic opportunities","volume":"18","author":"Kim","year":"2023","journal-title":"Radiat. Oncol."},{"key":"10.1016\/j.intimp.2023.110864_b0040","article-title":"Atorvastatin calcium alleviates 5-fluorouracil-induced intestinal damage by inhibiting cellular senescence and significantly enhances its antitumor efficacy","volume":"121","author":"Xia","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2023.110864_b0045","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.intimp.2018.10.024","article-title":"Wogonin mitigates intervertebral disc degeneration through the Nrf2\/ARE and MAPK signaling pathways","volume":"65","author":"Fang","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2023.110864_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107844","article-title":"Dimethyl fumarate improves cognitive deficits in chronic cerebral hypoperfusion rats by alleviating inflammation, oxidative stress, and ferroptosis via NRF2\/ARE\/NF-kappaB signal pathway","volume":"98","author":"Yan","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2023.110864_b0055","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.freeradbiomed.2017.08.026","article-title":"Loss of Nrf2 promotes alveolar type 2 cell loss in irradiated, fibrotic lung","volume":"112","author":"Traver","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.intimp.2023.110864_b0060","doi-asserted-by":"crossref","first-page":"542","DOI":"10.3389\/fonc.2018.00542","article-title":"Protective Role of Nuclear Factor-Erythroid 2-Related Factor 2 Against Radiation-Induced Lung Injury and Inflammation","volume":"8","author":"Tian","year":"2018","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.intimp.2023.110864_b0065","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/cdd.2012.72","article-title":"Ubiquitination and selective autophagy","volume":"20","author":"Shaid","year":"2013","journal-title":"Cell Death Differ."},{"issue":"1\u20132","key":"10.1016\/j.intimp.2023.110864_b0070","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.cell.2013.01.004","article-title":"SnapShot: Selective autophagy","volume":"152","author":"Jin","year":"2013","journal-title":"Cell"},{"issue":"11\u201312","key":"10.1016\/j.intimp.2023.110864_b0075","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.lfs.2011.07.008","article-title":"The antishock effect of anisodamine requires the upregulation of alpha7 nicotine acetylcholine receptors by IL-10","volume":"89","author":"Li","year":"2011","journal-title":"Life Sci."},{"issue":"2","key":"10.1016\/j.intimp.2023.110864_b0080","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/jat.1154","article-title":"The pharmacological properties of anisodamine","volume":"27","author":"Poupko","year":"2007","journal-title":"J. Appl. Toxicol."},{"issue":"1","key":"10.1016\/j.intimp.2023.110864_b0085","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1080\/10799893.2020.1713808","article-title":"Anisodamine alleviates lipopolysaccharide-induced pancreatic acinar cell injury through NLRP3 inflammasome and NF-kappaB signaling pathway","volume":"40","author":"Li","year":"2020","journal-title":"J. Recept. Signal Transduct. Res."},{"issue":"10","key":"10.1016\/j.intimp.2023.110864_b0090","doi-asserted-by":"crossref","first-page":"859","DOI":"10.21037\/atm-21-1750","article-title":"Protective effect of anisodamine on bleomycin-induced acute lung injury in immature rats via modulating oxidative stress, inflammation, and cell apoptosis by inhibiting the JAK2\/STAT3 pathway","volume":"9","author":"Zhao","year":"2021","journal-title":"Ann Transl Med"},{"issue":"1","key":"10.1016\/j.intimp.2023.110864_b0095","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1186\/s12882-019-1394-y","article-title":"Protective effect of anisodamine in rats with glycerol-induced acute kidney injury","volume":"20","author":"Li","year":"2019","journal-title":"BMC Nephrol."},{"issue":"7","key":"10.1016\/j.intimp.2023.110864_b0100","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20201812","article-title":"Protective effect of anisodamine hydrobromide on lipopolysaccharide-induced acute kidney injury","volume":"40","author":"Wan","year":"2020","journal-title":"Biosci. Rep."},{"issue":"12","key":"10.1016\/j.intimp.2023.110864_b0105","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1007\/s10495-017-1414-y","article-title":"Anisodamine inhibits endoplasmic reticulum stress-associated TXNIP\/NLRP3 inflammasome activation in rhabdomyolysis-induced acute kidney injury","volume":"22","author":"Yuan","year":"2017","journal-title":"Apoptosis"},{"key":"10.1016\/j.intimp.2023.110864_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107741","article-title":"The radioprotective effects of alpha-lipoic acid on radiotherapy-induced toxicities: A systematic review","volume":"96","author":"Sheikholeslami","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2023.110864_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154004","article-title":"Quercetin-3-Rutinoside alleviates radiation-induced lung inflammation and fibrosis via regulation of NF-kappaB\/TGF-beta1 signaling","volume":"99","author":"Verma","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2023.110864_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120518","article-title":"Amifostine analog, DRDE-30, alleviates radiation induced lung damage by attenuating inflammation and fibrosis","volume":"298","author":"Arora","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2023.110864_b0125","article-title":"Update on the sources, pharmacokinetics, pharmacological action, and clinical application of anisodamine","author":"Zhang","year":"2023","journal-title":"Biomed Pharmacother."},{"key":"10.1016\/j.intimp.2023.110864_b0130","article-title":"Activation of the Cholinergic Anti-Inflammatory Pathway as a Novel Therapeutic Strategy for COVID-19","volume":"11","author":"Qin","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2023.110864_b0135","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/5818107","article-title":"Network Pharmacology Integrated Molecular Docking Reveals the Mechanism of Anisodamine Hydrobromide Injection against Novel Coronavirus Pneumonia","volume":"2020","author":"Su","year":"2020","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.intimp.2023.110864_b0140","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bbrc.2022.05.024","article-title":"Anisodamine potently inhibits SARS-CoV-2 infection in vitro and targets its main protease","volume":"616","author":"Wei","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2023.110864_b0145","doi-asserted-by":"crossref","first-page":"14532","DOI":"10.1038\/ncomms14532","article-title":"Cellular senescence mediates fibrotic pulmonary disease","volume":"8","author":"Schafer","year":"2017","journal-title":"Nat. Commun."},{"issue":"19","key":"10.1016\/j.intimp.2023.110864_b0150","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1093\/jnci\/djt212","article-title":"Role of type II pneumocyte senescence in radiation-induced lung fibrosis","volume":"105","author":"Citrin","year":"2013","journal-title":"J. Natl Cancer Inst."},{"issue":"6","key":"10.1016\/j.intimp.2023.110864_b0155","doi-asserted-by":"crossref","first-page":"L1164","DOI":"10.1152\/ajplung.00220.2017","article-title":"IPF lung fibroblasts have a senescent phenotype","volume":"313","author":"Alvarez","year":"2017","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"4","key":"10.1016\/j.intimp.2023.110864_b0160","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.ijrobp.2016.07.026","article-title":"Mammalian Target of Rapamycin Inhibition With Rapamycin Mitigates Radiation-Induced Pulmonary Fibrosis in a Murine Model","volume":"96","author":"Chung","year":"2016","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"issue":"3","key":"10.1016\/j.intimp.2023.110864_b0165","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1474-9726.2010.00567.x","article-title":"Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status","volume":"9","author":"Le","year":"2010","journal-title":"Aging Cell"},{"issue":"8","key":"10.1016\/j.intimp.2023.110864_b0170","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1038\/ncb3195","article-title":"MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation","volume":"17","author":"Laberge","year":"2015","journal-title":"Nat Cell Biol"},{"issue":"2","key":"10.1016\/j.intimp.2023.110864_b0175","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.ijrobp.2017.02.216","article-title":"Inhibition of Bcl-2\/xl With ABT-263 Selectively Kills Senescent Type II Pneumocytes and Reverses Persistent Pulmonary Fibrosis Induced by Ionizing Radiation in Mice","volume":"99","author":"Pan","year":"2017","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"issue":"2","key":"10.1016\/j.intimp.2023.110864_b0180","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02367-2016","article-title":"Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo","volume":"50","author":"Lehmann","year":"2017","journal-title":"Eur. Respir. J."},{"issue":"1","key":"10.1016\/j.intimp.2023.110864_b0185","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17010102","article-title":"Cellular Pathways in Response to Ionizing Radiation and Their Targetability for Tumor Radiosensitization","volume":"17","author":"Maier","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2023.110864_b0190","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1080\/09553002.2018.1532619","article-title":"Modeling radiation-induced lung injury: lessons learned from whole thorax irradiation","volume":"96","author":"Beach","year":"2020","journal-title":"Int J Radiat Biol."},{"issue":"5","key":"10.1016\/j.intimp.2023.110864_b0195","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/icb\/icq034","article-title":"Nrf2, a guardian of healthspan and gatekeeper of species longevity","volume":"50","author":"Lewis","year":"2010","journal-title":"Integr. Comp. Biol."},{"issue":"Pt A","key":"10.1016\/j.intimp.2023.110864_b0200","article-title":"Epoxymicheliolide prevents dextran sulfate sodium-induced colitis in mice by inhibiting TAK1-NF-kappaB pathway and activating Keap1-NRF2 signaling in macrophages","volume":"113","author":"He","year":"2022","journal-title":"Int. Immunopharmacol."},{"issue":"14","key":"10.1016\/j.intimp.2023.110864_b0205","doi-asserted-by":"crossref","first-page":"8984","DOI":"10.1074\/jbc.M709040200","article-title":"Multiple nuclear localization signals function in the nuclear import of the transcription factor Nrf2","volume":"283","author":"Theodore","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.intimp.2023.110864_b0210","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1002\/jcp.29219","article-title":"Nrf2-ARE signaling in cellular protection: Mechanism of action and the regulatory mechanisms","volume":"235","author":"Shaw","year":"2020","journal-title":"J. Cell. Physiol."},{"issue":"6","key":"10.1016\/j.intimp.2023.110864_b0215","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.freeradbiomed.2011.05.038","article-title":"NRF2 deficiency reduces life span of mice administered thoracic irradiation","volume":"51","author":"Travis","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.intimp.2023.110864_b0220","article-title":"Activation of the P62-Keap1-NRF2 Pathway Protects against Ferroptosis in Radiation-Induced Lung Injury","volume":"2022","author":"Li","year":"2022","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.intimp.2023.110864_b0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117838","article-title":"Nrf2 knockout dysregulates iron metabolism and increases the hemolysis through ROS in aging mice","volume":"255","author":"Liu","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2023.110864_b0230","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.lfs.2018.04.018","article-title":"Ontogeny and aging of Nrf2 pathway genes in livers of rats","volume":"203","author":"Xu","year":"2018","journal-title":"Life Sci."},{"issue":"5","key":"10.1016\/j.intimp.2023.110864_b0235","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1007\/s00705-018-3739-4","article-title":"Respiratory syncytial virus infection up-regulates TLR7 expression by inducing oxidative stress via the Nrf2\/ARE pathway in A549 cells","volume":"163","author":"Sun","year":"2018","journal-title":"Arch. Virol"},{"issue":"4","key":"10.1016\/j.intimp.2023.110864_b0240","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/acel.12482","article-title":"Reduced Nrf2 expression mediates the decline in neural stem cell function during a critical middle-age period","volume":"15","author":"Corenblum","year":"2016","journal-title":"Aging Cell"},{"issue":"11","key":"10.1016\/j.intimp.2023.110864_b0245","doi-asserted-by":"crossref","first-page":"8171","DOI":"10.1074\/jbc.M109.031575","article-title":"Nuclear erythroid factor 2-mediated proteasome activation delays senescence in human fibroblasts","volume":"285","author":"Kapeta","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.intimp.2023.110864_b0250","first-page":"1327","article-title":"Nrf2 protects against diabetic dysfunction of endothelial progenitor cells via regulating cell senescence","volume":"42","author":"Wang","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.intimp.2023.110864_b0255","first-page":"1","article-title":"Bailcalin Protects against Diabetic Cardiomyopathy through Keap1\/Nrf2\/AMPK-Mediated Antioxidative and Lipid-Lowering Effects","volume":"2019","author":"Li","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.intimp.2023.110864_b0260","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.intimp.2019.04.040","article-title":"Protective effects of pyrroloquinoline quinine against oxidative stress-induced cellular senescence and inflammation in human renal tubular epithelial cells via Keap1\/Nrf2 signaling pathway","volume":"72","author":"Wang","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2023.110864_b0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116944","article-title":"The PERK\/Nrf2 pathway mediates endoplasmic reticulum stress-induced injury by upregulating endoplasmic reticulophagy in H9c2 cardiomyoblasts","volume":"237","author":"Tao","year":"2019","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/j.intimp.2023.110864_b0270","doi-asserted-by":"crossref","first-page":"e12951","DOI":"10.1111\/acel.12951","article-title":"1,25-Dihydroxyvitamin D exerts an antiaging role by activation of Nrf2-antioxidant signaling and inactivation of p16\/p53-senescence signaling","volume":"18","author":"Chen","year":"2019","journal-title":"Aging Cell"},{"issue":"3","key":"10.1016\/j.intimp.2023.110864_b0275","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/acel.12587","article-title":"Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism","volume":"16","author":"Wang","year":"2017","journal-title":"Aging Cell"},{"issue":"3","key":"10.1016\/j.intimp.2023.110864_b0280","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/ncb2021","article-title":"The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1","volume":"12","author":"Komatsu","year":"2010","journal-title":"Nat. Cell Biol."},{"issue":"13","key":"10.1016\/j.intimp.2023.110864_b0285","doi-asserted-by":"crossref","first-page":"3275","DOI":"10.1128\/MCB.00248-10","article-title":"A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62","volume":"30","author":"Lau","year":"2010","journal-title":"Mol. Cell Biol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692301189X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692301189X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T18:04:29Z","timestamp":1761588269000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156757692301189X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":57,"alternative-id":["S156757692301189X"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2023.110864","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation of Nrf2\/ARE pathway by Anisodamine (654-2) for Inhibition of cellular aging and alleviation of Radiation-Induced lung injury","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2023.110864","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110864"}}