{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T10:05:21Z","timestamp":1780049121617,"version":"3.53.1"},"reference-count":17,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104189"],"award-info":[{"award-number":["82104189"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273929"],"award-info":[{"award-number":["82273929"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82293680"],"award-info":[{"award-number":["82293680"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82293684"],"award-info":[{"award-number":["82293684"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFA0908004"],"award-info":[{"award-number":["2020YFA0908004"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014206","name":"National Key Laboratory Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014206","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.intimp.2023.110884","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:26:39Z","timestamp":1693527999000},"page":"110884","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"PA","title":["A synthetic derivative of bioactive constituents from Isatis indigotica ameliorates hypersensitivity and arthritis by inhibiting JAK2-STAT3 pathway in mice"],"prefix":"10.1016","volume":"124","author":[{"given":"Chengjuan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningyu","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengbo","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaona","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yazi","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baolian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5804-5293","authenticated-orcid":false,"given":"Tiantai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.intimp.2023.110884_b0005","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1056\/NEJM200108023450506","article-title":"Autoimmune diseases","volume":"345","author":"Davidson","year":"2001","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.intimp.2023.110884_b0010","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/ni.3691","article-title":"Mechanisms and consequences of Jak-STAT signaling in the immune system","volume":"18","author":"Villarino","year":"2017","journal-title":"Nat. Immunol."},{"issue":"21","key":"10.1016\/j.intimp.2023.110884_b0015","doi-asserted-by":"crossref","first-page":"3857","DOI":"10.1016\/j.cell.2022.09.023","article-title":"The JAK-STAT pathway at 30: much learned, much more to do","volume":"185","author":"Philips","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2023.110884_b0020","article-title":"JAK inhibitors and autoimmune rheumatic diseases","volume":"103276","author":"Benucci","year":"2023","journal-title":"Autoimmun. Rev."},{"issue":"12","key":"10.1016\/j.intimp.2023.110884_b0025","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1002\/art.41906","article-title":"A decade of JAK inhibitors: what have we learned and what may be the future?","volume":"73","author":"Liu","year":"2021","journal-title":"Arthritis Rheumatol."},{"issue":"5","key":"10.1016\/j.intimp.2023.110884_b0030","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1078\/09447110260571661","article-title":"Studies on the antinociceptive, anti-inflammatory and antipyretic effects of Isatis indigotica root","volume":"9","author":"Ho","year":"2002","journal-title":"Phytomedicine"},{"issue":"6","key":"10.1016\/j.intimp.2023.110884_b0035","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1021\/np3002833","article-title":"Alkaloids from the root of Isatis indigotica","volume":"75","author":"Chen","year":"2012","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.intimp.2023.110884_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112071","article-title":"Discovery, synthesis, and optimization of an N-alkoxy indolylacetamide against HIV-1 carrying NNRTI-resistant mutations from the Isatis indigotica root","volume":"189","author":"Xu","year":"2020","journal-title":"Eur. J. Med. Chem."},{"issue":"1","key":"10.1016\/j.intimp.2023.110884_b0045","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cclet.2020.09.062","article-title":"Aconapelsulfonines A and B, seco C20-diterpenoid alkaloids deriving via Criegee rearrangements of napelline skeleton from Aconitum carmichaelii","volume":"32","author":"Liu","year":"2021","journal-title":"Chin. Chem. Lett."},{"issue":"1","key":"10.1016\/j.intimp.2023.110884_b0050","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13046-019-1062-x","article-title":"Discovery and evaluation of ZT55, a novel highly-selective tyrosine kinase inhibitor of JAK2(V617F) against myeloproliferative neoplasms","volume":"38","author":"Hu","year":"2019","journal-title":"J. Exp. Clin. Cancer Res.: CR"},{"key":"10.1016\/j.intimp.2023.110884_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112148","article-title":"Design, synthesis, and pharmacological evaluation of 4- or 6-phenyl-pyrimidine derivatives as novel and selective Janus kinase 3 inhibitors","volume":"191","author":"Shu","year":"2020","journal-title":"Eur. J. Med. Chem."},{"issue":"33","key":"10.1016\/j.intimp.2023.110884_b0060","doi-asserted-by":"crossref","first-page":"eabo4363","DOI":"10.1126\/sciadv.abo4363","article-title":"A highly selective JAK3 inhibitor is developed for treating rheumatoid arthritis by suppressing \u03b3c cytokine related JAK-STAT signal","volume":"8","author":"Chen","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.intimp.2023.110884_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.apsb.2023.04.003","article-title":"Bone-derived MSCs encapsulated in alginate hydrogel prevent collagen-induced arthritis in mice through the activation of adenosine A2A\/2B receptors in tolerogenic dendritic cells","author":"Shi","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"issue":"6","key":"10.1016\/j.intimp.2023.110884_b0070","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1038\/leu.2013.72","article-title":"Myelofibrosis, JAK2 inhibitors and erythropoiesis","volume":"27","author":"Vainchenker","year":"2013","journal-title":"Leukemia"},{"issue":"10","key":"10.1016\/j.intimp.2023.110884_b0075","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1182\/blood.V98.10.2948","article-title":"Erythropoiesis in the absence of janus-kinase 2: BCR-ABL induces red cell formation in JAK2(-\/-) hematopoietic progenitors","volume":"98","author":"Ghaffari","year":"2001","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.intimp.2023.110884_b0080","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1146\/annurev.immunol.18.1.767","article-title":"Immunobiology of dendritic cells","volume":"18","author":"Banchereau","year":"2000","journal-title":"Annu. Rev. Immunol."},{"issue":"11","key":"10.1016\/j.intimp.2023.110884_b0085","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.1016\/j.apsb.2022.08.022","article-title":"Y Sun New opportunities and challenges of natural products research: when target identification meets single-cell multiomics","volume":"12","author":"Zhu","year":"2022","journal-title":"Acta Pharm. Sin. B"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923012092?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923012092?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T18:06:49Z","timestamp":1761588409000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576923012092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":17,"alternative-id":["S1567576923012092"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2023.110884","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A synthetic derivative of bioactive constituents from Isatis indigotica ameliorates hypersensitivity and arthritis by inhibiting JAK2-STAT3 pathway in mice","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2023.110884","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110884"}}