{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T21:22:31Z","timestamp":1780348951154,"version":"3.54.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:00:00Z","timestamp":1694044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2018A0303130189"],"award-info":[{"award-number":["2018A0303130189"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2020A1515010162"],"award-info":[{"award-number":["2020A1515010162"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800781"],"award-info":[{"award-number":["81800781"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81902172"],"award-info":[{"award-number":["81902172"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.intimp.2023.110895","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T03:59:16Z","timestamp":1694059156000},"page":"110895","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"PA","title":["Tuberous sclerosis complex 1 targeted depletion in macrophages promotes osteogenesis by modulating secretion of Oncostatin M in the inflammatory stage of bone healing"],"prefix":"10.1016","volume":"124","author":[{"given":"Zhenyu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dadi","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5789-3896","authenticated-orcid":false,"given":"Pinglin","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2023.110895_b0005","first-page":"S2090","article-title":"Targeting DNA methylation and demethylation in diabetic foot ulcers","volume":"25","author":"Deng","year":"2023","journal-title":"J Adv Res."},{"issue":"4","key":"10.1016\/j.intimp.2023.110895_b0010","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.hcl.2013.08.002","article-title":"Basic science of bone healing","volume":"29","author":"Sathyendra","year":"2013","journal-title":"Hand Clin."},{"issue":"5","key":"10.1016\/j.intimp.2023.110895_b0015","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/S0195-5616(99)50101-0","article-title":"Bone and bone healing","volume":"29","author":"Remedios","year":"1999","journal-title":"Vet. Clin. North Am. Small Anim. Pract."},{"key":"10.1016\/j.intimp.2023.110895_b0020","doi-asserted-by":"crossref","first-page":"913","DOI":"10.2147\/JIR.S281941","article-title":"Inflammation, bone healing and osteonecrosis: from bedside to bench","volume":"13","author":"Goodman","year":"2020","journal-title":"J. Inflamm. Res."},{"issue":"3","key":"10.1016\/j.intimp.2023.110895_b0025","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s11914-020-00585-4","article-title":"The effect of opiates on bone formation and bone healing","volume":"18","author":"Coluzzi","year":"2020","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.intimp.2023.110895_b0030","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1186\/s13287-022-02975-0","article-title":"BMSC-derived exosomes promote tendon-bone healing after anterior cruciate ligament reconstruction by regulating M1\/M2 macrophage polarization in rats","volume":"13","author":"Li","year":"2022","journal-title":"Stem Cell Res. Ther."},{"issue":"21","key":"10.1016\/j.intimp.2023.110895_b0035","doi-asserted-by":"crossref","first-page":"5467","DOI":"10.3390\/ijms20215467","article-title":"Immunomodulatory effects of MSCs in bone healing","volume":"20","author":"Medhat","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.intimp.2023.110895_b0040","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1302\/2046-3758.712.BJR-2017-0366.R2","article-title":"Different composition of leucocytes in cortical and cancellous bone healing in a mouse model","volume":"7","author":"T\u00e4tting","year":"2018","journal-title":"Bone Joint Res."},{"key":"10.1016\/j.intimp.2023.110895_b0045","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.bone.2017.04.004","article-title":"Temporal role of macrophages in cancellous bone healing","volume":"101","author":"Sandberg","year":"2017","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.intimp.2023.110895_b0050","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1146\/annurev-physiol-022516-034339","article-title":"Macrophage polarization","volume":"79","author":"Murray","year":"2017","journal-title":"Annu. Rev. Physiol."},{"issue":"1","key":"10.1016\/j.intimp.2023.110895_b0055","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1089\/wound.2011.0307","article-title":"Regulation of macrophage polarization and wound healing","volume":"1","author":"Ferrante","year":"2012","journal-title":"Adv. Wound Care (New Rochelle)"},{"issue":"12","key":"10.1016\/j.intimp.2023.110895_b0060","doi-asserted-by":"crossref","first-page":"3192","DOI":"10.1016\/j.ajpath.2014.08.017","article-title":"Fracture healing via periosteal callus formation requires macrophages for both initiation and progression of early endochondral ossification","volume":"184","author":"Raggatt","year":"2014","journal-title":"Am. J. Pathol."},{"issue":"6","key":"10.1016\/j.intimp.2023.110895_b0065","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.3390\/ijms19061801","article-title":"Role of human macrophage polarization in inflammation during infectious diseases","volume":"19","author":"Atri","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2023.110895_b0070","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1478-811X-11-29","article-title":"Cell plasticity in wound healing: paracrine factors of M1\/ M2 polarized macrophages influence the phenotypical state of dermal fibroblasts","volume":"11","author":"Ploeger","year":"2013","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.intimp.2023.110895_b0075","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s12964-019-0376-9","article-title":"Elevated Kallikrein-binding protein in diabetes impairs wound healing through inducing macrophage M1 polarization","volume":"17","author":"Feng","year":"2019","journal-title":"Cell Commun. Signal"},{"issue":"20","key":"10.1016\/j.intimp.2023.110895_b0080","first-page":"1900513","article-title":"Exosome-Guided Phenotypic Switch of M1 to M2 Macrophages for Cutaneous Wound Healing","volume":"6","author":"Kim","year":"2019","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.intimp.2023.110895_b0085","doi-asserted-by":"crossref","first-page":"17019","DOI":"10.1038\/boneres.2017.19","article-title":"RANKL-induced M1 macrophages are involved in bone formation","volume":"5","author":"Huang","year":"2017","journal-title":"Bone Res."},{"key":"10.1016\/j.intimp.2023.110895_b0090","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.1038\/ncomms3834","article-title":"The TSC-mTOR pathway regulates macrophage polarization","volume":"4","author":"Byles","year":"2013","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.intimp.2023.110895_b0095","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1136\/annrheumdis-2018-213450","article-title":"Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially through R-spondin-2","volume":"77","author":"Zhang","year":"2018","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.intimp.2023.110895_b0100","doi-asserted-by":"crossref","unstructured":"K. Hu, B.R. Olsen, Osteoblast-derived VEGF regulates osteoblast differentiation and bone formation during bone repair, J. Clin. Invest. 126 (2016) 509\u2013526.","DOI":"10.1172\/JCI82585"},{"issue":"12","key":"10.1016\/j.intimp.2023.110895_b0105","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1359\/jbmr.070802","article-title":"Bone regeneration is regulated by wnt signaling","volume":"22","author":"Kim","year":"2007","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.intimp.2023.110895_b0110","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1159\/000430306","article-title":"Tsc1 is a critical regulator of macrophage survival and function","volume":"36","author":"Fang","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.intimp.2023.110895_b0115","article-title":"TSC1 affects the process of renal ischemia-reperfusion injury by controlling macrophage polarization","volume":"12","author":"Hu","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2023.110895_b0120","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.3389\/fimmu.2019.02443","article-title":"Compromised bone healing in aged rats is associated with impaired M2 macrophage function","volume":"10","author":"Loffler","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2023.110895_b0125","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/s41572-021-00289-8","article-title":"Non-union bone fractures","volume":"7","author":"Wildemann","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"7677","key":"10.1016\/j.intimp.2023.110895_b0130","doi-asserted-by":"crossref","first-page":"S193","DOI":"10.1038\/550S193a","article-title":"Non-union bone fracture: a quicker fix","volume":"550","author":"Holmes","year":"2017","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.intimp.2023.110895_b0135","doi-asserted-by":"crossref","first-page":"492","DOI":"10.3390\/jcm9020492","article-title":"Dynamics of early signalling events during fracture healing and potential serum biomarkers of fracture non-union in humans","volume":"9","author":"Burska","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.intimp.2023.110895_b0140","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1002\/jor.23735","article-title":"CXCL10 is upregulated in synovium and cartilage following articular fracture","volume":"36","author":"Furman","year":"2018","journal-title":"J. Orthop. Res."},{"issue":"4","key":"10.1016\/j.intimp.2023.110895_b0145","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.immuni.2015.03.011","article-title":"C-Myb(+) erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages","volume":"42","author":"Hoeffel","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2023.110895_b0150","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1182\/blood-2018-01-829663","article-title":"Self-repopulating recipient bone marrow resident macrophages promote long-term hematopoietic stem cell engraftment","volume":"132","author":"Kaur","year":"2018","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.intimp.2023.110895_b0155","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.exphem.2005.05.002","article-title":"Human mesenchymal stem cells require monocyte-mediated activation to suppress alloreactive T cells","volume":"33","author":"Groh","year":"2005","journal-title":"Exp. Hematol."},{"issue":"1","key":"10.1016\/j.intimp.2023.110895_b0160","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/nm.1905","article-title":"Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production","volume":"15","author":"N\u00e9meth","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.intimp.2023.110895_b0165","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1182\/blood-2004-04-1559","article-title":"Human mesenchymal stem cells modulate allogeneic immune cell responses","volume":"105","author":"Aggarwal","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.intimp.2023.110895_b0170","doi-asserted-by":"crossref","first-page":"115737","DOI":"10.1016\/j.bone.2020.115737","article-title":"Interleukin-6 (IL-6) deficiency enhances intramembranous osteogenesis following stress fracture in mice","volume":"143","author":"Coates","year":"2021","journal-title":"Bone"},{"issue":"5","key":"10.1016\/j.intimp.2023.110895_b0175","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nm.4307","article-title":"Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease","volume":"23","author":"West","year":"2017","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.intimp.2023.110895_b0180","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00223-002-2120-4","article-title":"Establishment of a model of cortical bone repair in mice","volume":"73","author":"Campbell","year":"2003","journal-title":"Calcif. Tissue Int."},{"issue":"7","key":"10.1016\/j.intimp.2023.110895_b0185","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1002\/jbmr.354","article-title":"Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model","volume":"26","author":"Alexander","year":"2011","journal-title":"J. Bone Miner. Res."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923012201?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923012201?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T18:03:19Z","timestamp":1761588199000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576923012201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":37,"alternative-id":["S1567576923012201"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2023.110895","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tuberous sclerosis complex 1 targeted depletion in macrophages promotes osteogenesis by modulating secretion of Oncostatin M in the inflammatory stage of bone healing","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2023.110895","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"110895"}}