{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:32:28Z","timestamp":1790346748984,"version":"4.1.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:00:00Z","timestamp":1697414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670588"],"award-info":[{"award-number":["81670588"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070668"],"award-info":[{"award-number":["82070668"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070669"],"award-info":[{"award-number":["82070669"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.intimp.2023.110950","type":"journal-article","created":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T05:30:30Z","timestamp":1698211830000},"page":"110950","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"PA","title":["HDL inhibits pancreatic acinar cell NLRP3 inflammasome activation and protect against acinar cell pyroptosis in acute pancreatitis"],"prefix":"10.1016","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8487-8846","authenticated-orcid":false,"given":"Yingying","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baiqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingtian","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guotao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8483-6264","authenticated-orcid":false,"given":"Weiqin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.intimp.2023.110950_b0005","first-page":"357","article-title":"Acute pancreatitis - morphology, pathogenesis and prognosis","volume":"51","author":"Becker","year":"1980","journal-title":"Chirurg"},{"issue":"6","key":"10.1016\/j.intimp.2023.110950_b0010","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1194\/jlr.P800003-JLR200","article-title":"Safety, pharmacokinetics, and pharmacodynamics of oral apoA-I mimetic peptide D-4F in high-risk cardiovascular patients","volume":"49","author":"Bloedon","year":"2008","journal-title":"J. Lipid Res."},{"issue":"2","key":"10.1016\/j.intimp.2023.110950_b0015","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s10557-018-06846-w","article-title":"High-Density Lipoprotein Function and Dysfunction in Health and Disease","volume":"33","author":"Chiesa","year":"2019","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.intimp.2023.110950_b0020","doi-asserted-by":"crossref","first-page":"7864150","DOI":"10.1155\/2016\/7864150","article-title":"Sulforaphane Protects Pancreatic Acinar Cell Injury by Modulating Nrf2-Mediated Oxidative Stress and NLRP3 Inflammatory Pathway","volume":"2016","author":"Dong","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"5876","key":"10.1016\/j.intimp.2023.110950_b0025","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1126\/science.1156995","article-title":"Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica","volume":"320","author":"Dostert","year":"2008","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.intimp.2023.110950_b0030","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/cts.12487","article-title":"Oral Apolipoprotein A-I Mimetic D-4F Lowers HDL-Inflammatory Index in High-Risk Patients: A First-in-Human Multiple-Dose, Randomized Controlled Trial","volume":"10","author":"Dunbar","year":"2017","journal-title":"Clin. Transl. Sci."},{"issue":"17","key":"10.1016\/j.intimp.2023.110950_b0035","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1111\/bph.15499","article-title":"Acinar cell NLRP3 inflammasome and gasdermin D (GSDMD) activation mediates pyroptosis and systemic inflammation in acute pancreatitis","volume":"178","author":"Gao","year":"2021","journal-title":"Br. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.intimp.2023.110950_b0040","first-page":"171","article-title":"Anti-inflammatory Function of High-Density Lipoproteins via Autophagy of IkappaB Kinase. Cell Mol","volume":"1","author":"Gerster","year":"2015","journal-title":"Gastroenterol. Hepatol."},{"issue":"12","key":"10.1016\/j.intimp.2023.110950_b0045","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1161\/CIRCRESAHA.118.311362","article-title":"NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis","volume":"122","author":"Grebe","year":"2018","journal-title":"Circ. Res."},{"issue":"5","key":"10.1016\/j.intimp.2023.110950_b0050","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1097\/SHK.0000000000000887","article-title":"Exploring the Predictive Ability of Dysfunctional High-Density Lipoprotein for Adverse Outcomes in Emergency Department Patients with Sepsis: A Preliminary Investigation","volume":"48","author":"Guirgis","year":"2017","journal-title":"Shock"},{"issue":"5","key":"10.1016\/j.intimp.2023.110950_b0055","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1053\/j.gastro.2017.08.071","article-title":"Autophagy, Inflammation, and Immune Dysfunction in the Pathogenesis of Pancreatitis","volume":"153","author":"Gukovskaya","year":"2017","journal-title":"Gastroenterology"},{"issue":"7","key":"10.1016\/j.intimp.2023.110950_b0060","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1136\/gutjnl-2011-301364","article-title":"Apoptosis, necrosis and necroptosis: cell death regulation in the intestinal epithelium","volume":"62","author":"Gunther","year":"2013","journal-title":"Gut"},{"issue":"7","key":"10.1016\/j.intimp.2023.110950_b0065","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nm.3893","article-title":"Inflammasomes: mechanism of action, role in disease, and therapeutics","volume":"21","author":"Guo","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.intimp.2023.110950_b0070","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ebiom.2017.12.021","article-title":"Synthetic High-Density Lipoprotein-Mediated Targeted Delivery of Liver X Receptors Agonist Promotes Atherosclerosis Regression","volume":"28","author":"Guo","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.intimp.2023.110950_b0075","doi-asserted-by":"crossref","unstructured":"C.Y. Han, C. Tang, M.E. Guevara, H. Wei, T. Wietecha, B. Shao, . . . A. Chait, Serum amyloid A impairs the antiinflammatory properties of HDL. J. Clin. Invest., 126 (1) (2016) 266\u2013281. http:\/\/doi.org\/10.1172\/JCI83475.","DOI":"10.1172\/JCI83475"},{"issue":"6","key":"10.1016\/j.intimp.2023.110950_b0080","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.cell.2009.05.021","article-title":"Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha","volume":"137","author":"He","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2023.110950_b0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/1648385","article-title":"High-Density Lipoprotein Cholesterol, Blood Urea Nitrogen, and Serum Creatinine Can Predict Severe Acute Pancreatitis","volume":"2017","author":"Hong","year":"2017","journal-title":"Biomed Res. Int."},{"issue":"1","key":"10.1016\/j.intimp.2023.110950_b0090","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1053\/j.gastro.2011.03.041","article-title":"TLR9 and the NLRP3 inflammasome link acinar cell death with inflammation in acute pancreatitis","volume":"141","author":"Hoque","year":"2011","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.intimp.2023.110950_b0095","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1136\/gutjnl-2015-309363","article-title":"Caffeine protects against experimental acute pancreatitis by inhibition of inositol 1,4,5-trisphosphate receptor-mediated Ca2+ release","volume":"66","author":"Huang","year":"2017","journal-title":"Gut"},{"issue":"7575","key":"10.1016\/j.intimp.2023.110950_b0100","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/nature15541","article-title":"Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling","volume":"526","author":"Kayagaki","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2023.110950_b0105","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.g4379","article-title":"Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients","volume":"349","author":"Keene","year":"2014","journal-title":"BMJ"},{"issue":"4","key":"10.1016\/j.intimp.2023.110950_b0110","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1159\/000348438","article-title":"Serum lipid levels are associated with the severity of acute pancreatitis","volume":"87","author":"Khan","year":"2013","journal-title":"Digestion"},{"issue":"1","key":"10.1016\/j.intimp.2023.110950_b0115","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.pan.2011.12.006","article-title":"Serum lipid and fatty acid profiles are highly changed in patients with alcohol induced acute pancreatitis","volume":"12","author":"Khan","year":"2012","journal-title":"Pancreatology"},{"issue":"2","key":"10.1016\/j.intimp.2023.110950_b0120","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1056\/NEJMoa1001689","article-title":"Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis","volume":"364","author":"Khera","year":"2011","journal-title":"N. Engl. J. Med."},{"issue":"9988","key":"10.1016\/j.intimp.2023.110950_b0125","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0140-6736(14)60649-8","article-title":"Acute pancreatitis","volume":"386","author":"Lankisch","year":"2015","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.intimp.2023.110950_b0130","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1136\/gut.2007.124230","article-title":"A mouse model of acute biliary pancreatitis induced by retrograde pancreatic duct infusion of Na-taurocholate","volume":"56","author":"Laukkarinen","year":"2007","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.intimp.2023.110950_b0135","doi-asserted-by":"crossref","DOI":"10.1186\/s13017-019-0247-0","article-title":"2019 WSES guidelines for the management of severe acute pancreatitis","volume":"14","author":"Lepp\u00e4niemi","year":"2019","journal-title":"World J. Emerg. Surg."},{"issue":"20","key":"10.1016\/j.intimp.2023.110950_b0140","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1056\/NEJMoa1609581","article-title":"Evacetrapib and Cardiovascular Outcomes in High-Risk Vascular Disease","volume":"376","author":"Lincoff","year":"2017","journal-title":"N. Engl. J. Med."},{"issue":"14","key":"10.1016\/j.intimp.2023.110950_b0145","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.7150\/ijms.27647","article-title":"Decreases in Paraoxonase-1 Activities Promote a Pro-inflammatory Effect of Lipids Peroxidation Products in Non-smoking and Smoking Patients with Acute Pancreatitis","volume":"15","author":"Marek","year":"2018","journal-title":"Int. J. Med. Sci."},{"issue":"3","key":"10.1016\/j.intimp.2023.110950_b0150","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/s41569-021-00613-5","article-title":"Apolipoproteins in vascular biology and atherosclerotic disease","volume":"19","author":"Mehta","year":"2022","journal-title":"Nat. Rev. Cardiol."},{"issue":"24","key":"10.1016\/j.intimp.2023.110950_b0155","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1161\/CIRCULATIONAHA.116.025687","article-title":"Safety and Tolerability of CSL112, a Reconstituted, Infusible, Plasma-Derived Apolipoprotein A-I, After Acute Myocardial Infarction: The AEGIS-I Trial (ApoA-I Event Reducing in Ischemic Syndromes I)","volume":"134","author":"Michael Gibson","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.intimp.2023.110950_b0160","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3389\/fphar.2015.00244","article-title":"HDL in sepsis - risk factor and therapeutic approach","volume":"6","author":"Morin","year":"2015","journal-title":"Front. Pharmacol."},{"issue":"10","key":"10.1016\/j.intimp.2023.110950_b0165","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/s41423-022-00902-0","article-title":"Redox regulation of the immune response","volume":"19","author":"Morris","year":"2022","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.intimp.2023.110950_b0170","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.neubiorev.2021.02.037","article-title":"The role of high-density lipoprotein cholesterol, apolipoprotein A and paraoxonase-1 in the pathophysiology of neuroprogressive disorders","volume":"125","author":"Morris","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"2","key":"10.1016\/j.intimp.2023.110950_b0175","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1136\/gutjnl-2017-315560","article-title":"Hypertriglyceridaemia delays pancreatic regeneration after acute pancreatitis in mice and patients","volume":"68","author":"Yang","year":"2019","journal-title":"Gut"},{"issue":"9","key":"10.1016\/j.intimp.2023.110950_b0180","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1001\/jamacardio.2018.2121","volume":"3","author":"Nicholls","year":"2018","journal-title":"JAMA Cardiol."},{"issue":"9","key":"10.1016\/j.intimp.2023.110950_b0185","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1001\/jamacardio.2018.2112","article-title":"Effect of Infusion of High-Density Lipoprotein Mimetic Containing Recombinant Apolipoprotein A-I Milano on Coronary Disease in Patients With an Acute Coronary Syndrome in the MILANO-PILOT Trial: A Randomized Clinical Trial","volume":"3","author":"Nicholls","year":"2018","journal-title":"JAMA Cardiol."},{"issue":"17","key":"10.1016\/j.intimp.2023.110950_b0190","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1001\/jama.290.17.2292","article-title":"Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes: a randomized controlled trial","volume":"290","author":"Nissen","year":"2003","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.intimp.2023.110950_b0195","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.715211","article-title":"Gasdermin D Mediates Inflammation-Induced Defects in Reverse Cholesterol Transport and Promotes Atherosclerosis","volume":"9","author":"Opoku","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"5","key":"10.1016\/j.intimp.2023.110950_b0200","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/s41423-021-00670-3","article-title":"An update on the regulatory mechanisms of NLRP3 inflammasome activation","volume":"18","author":"Paik","year":"2021","journal-title":"Cell. Mol. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2023.110950_b0205","doi-asserted-by":"crossref","DOI":"10.1186\/s13054-015-0832-x","article-title":"Serum levels of apolipoprotein A-I and high-density lipoprotein can predict organ failure in acute pancreatitis","volume":"19","author":"Peng","year":"2015","journal-title":"Crit. Care"},{"issue":"3","key":"10.1016\/j.intimp.2023.110950_b0210","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1097\/00000658-200003000-00008","article-title":"Pathophysiologic role of oxygen free radicals in acute pancreatitis: initiating event or mediator of tissue damage?","volume":"231","author":"Rau","year":"2000","journal-title":"Ann. Surg."},{"issue":"2","key":"10.1016\/j.intimp.2023.110950_b0215","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11020073","article-title":"High-Density Lipoprotein from Chronic Kidney Disease Patients Modulates Polymorphonuclear Leukocytes","volume":"11","author":"Raupachova","year":"2019","journal-title":"Toxins (Basel)"},{"issue":"1","key":"10.1016\/j.intimp.2023.110950_b0220","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/BF02927069","article-title":"Morphometric characteristics and homogeneity of a new model of acute pancreatitis in the rat","volume":"12","author":"Schmidt","year":"1992","journal-title":"Int. J. Pancreatol."},{"issue":"11","key":"10.1016\/j.intimp.2023.110950_b0225","doi-asserted-by":"crossref","DOI":"10.3390\/genes13111968","article-title":"Importance of Polymorphisms in the Gene of Paraoxonase-1 (SNP rs662) and Apolipoprotein A-I (SNP rs670 and rs5069) in Non-Smoking and Smoking Healthy Subjects and Patients with Acute Pancreatitis","volume":"13","author":"Sciskalska","year":"2022","journal-title":"Genes (Basel)"},{"issue":"3","key":"10.1016\/j.intimp.2023.110950_b0230","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1053\/j.gastro.2017.10.018","article-title":"Cathepsin B-Mediated Activation of Trypsinogen in Endocytosing Macrophages Increases Severity of Pancreatitis in Mice","volume":"154","author":"Sendler","year":"2018","journal-title":"Gastroenterology"},{"issue":"7575","key":"10.1016\/j.intimp.2023.110950_b0235","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"issue":"34","key":"10.1016\/j.intimp.2023.110950_b0240","doi-asserted-by":"crossref","first-page":"13257","DOI":"10.1074\/jbc.RA118.002428","article-title":"High-density lipoprotein inhibits serum amyloid A-mediated reactive oxygen species generation and NLRP3 inflammasome activation","volume":"293","author":"Shridas","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2023.110950_b0245","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ijcard.2019.08.043","article-title":"Anti-atherosclerotic effects of an improved apolipoprotein A-I mimetic peptide","volume":"297","author":"Suematsu","year":"2019","journal-title":"Int. J. Cardiol."},{"issue":"46","key":"10.1016\/j.intimp.2023.110950_b0250","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.1093\/eurheartj\/ehu171","article-title":"Effects of the high-density lipoprotein mimetic agent CER-001 on coronary atherosclerosis in patients with acute coronary syndromes: a randomized trial","volume":"35","author":"Tardif","year":"2014","journal-title":"Eur. Heart J."},{"issue":"15","key":"10.1016\/j.intimp.2023.110950_b0255","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1001\/jama.297.15.jpc70004","article-title":"Effects of reconstituted high-density lipoprotein infusions on coronary atherosclerosis: a randomized controlled trial","volume":"297","author":"Tardif","year":"2007","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.intimp.2023.110950_b0260","doi-asserted-by":"crossref","unstructured":"S. Tenner, J. Baillie, J. DeWitt, S.S. Vege, American College of, G., American College of Gastroenterology guideline: management of acute pancreatitis, Am. J. Gastroenterol., 108 (9) (2013) 1400\u20131415; 1416. 10.1038\/ajg.2013.218.","DOI":"10.1038\/ajg.2013.218"},{"issue":"3","key":"10.1016\/j.intimp.2023.110950_b0265","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/imm.12638","article-title":"High-density lipoprotein reduces inflammation from cholesterol crystals by inhibiting inflammasome activation","volume":"149","author":"Thacker","year":"2016","journal-title":"Immunology"},{"issue":"6","key":"10.1016\/j.intimp.2023.110950_b0270","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1136\/gut.42.6.850","article-title":"Oxidative stress: an important phenomenon with pathogenetic significance in the progression of acute pancreatitis","volume":"42","author":"Tsai","year":"1998","journal-title":"Gut"},{"issue":"11","key":"10.1016\/j.intimp.2023.110950_b0275","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1136\/gutjnl-2016-313595","article-title":"Acute pancreatitis: recent advances through randomised trials","volume":"66","author":"van Dijk","year":"2017","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.intimp.2023.110950_b0280","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1096\/fj.10-165670","article-title":"4F Peptide reduces nascent atherosclerosis and induces natural antibody production in apolipoprotein E-null mice","volume":"25","author":"Wool","year":"2011","journal-title":"FASEB J."},{"key":"10.1016\/j.intimp.2023.110950_b0285","doi-asserted-by":"crossref","unstructured":"I.A.P.A.P.A.A.P.G. Working Group, IAP\/APA evidence-based guidelines for the management of acute pancreatitis, Pancreatology, 13 (4 Suppl 2) (2013) e1-15. http:\/\/doi.org\/10.1016\/j.pan.2013.07.063.","DOI":"10.1016\/j.pan.2013.07.063"},{"issue":"8","key":"10.1016\/j.intimp.2023.110950_b0290","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1038\/cr.2013.91","article-title":"Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis","volume":"23","author":"Wu","year":"2013","journal-title":"Cell Res."},{"issue":"2","key":"10.1016\/j.intimp.2023.110950_b0295","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.canlet.2008.09.029","article-title":"Naturally-occurring shikonin analogues\u2013a class of necroptotic inducers that circumvent cancer drug resistance","volume":"274","author":"Xuan","year":"2009","journal-title":"Cancer Lett."},{"issue":"11","key":"10.1016\/j.intimp.2023.110950_b0300","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.it.2019.09.005","article-title":"Emerging Activators and Regulators of Inflammasomes and Pyroptosis","volume":"40","author":"Xue","year":"2019","journal-title":"Trends Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2023.110950_b0305","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/MPA.0000000000000273","article-title":"A multicenter study on etiology of acute pancreatitis in Beijing during 5 years","volume":"44","author":"Zheng","year":"2015","journal-title":"Pancreas"},{"issue":"1","key":"10.1016\/j.intimp.2023.110950_b0310","article-title":"Decreased high density lipoprotein cholesterol is an independent predictor for persistent organ failure, pancreatic necrosis and mortality in acute pancreatitis","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2023.110950_b0315","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.cca.2017.11.028","article-title":"Early prediction of persistent organ failure by serum apolipoprotein A-I and high-density lipoprotein cholesterol in patients with acute pancreatitis","volume":"476","author":"Zhou","year":"2018","journal-title":"Clin. Chim. Acta"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923012754?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923012754?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T18:06:24Z","timestamp":1761588384000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576923012754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":63,"alternative-id":["S1567576923012754"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2023.110950","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HDL inhibits pancreatic acinar cell NLRP3 inflammasome activation and protect against acinar cell pyroptosis in acute pancreatitis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2023.110950","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"110950"}}