{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:53:58Z","timestamp":1792068838485,"version":"4.4.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["H2021209026"],"award-info":[{"award-number":["H2021209026"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["H2023209047"],"award-info":[{"award-number":["H2023209047"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009076","name":"University of Science and Technology of China","doi-asserted-by":"publisher","award":["KYTD202311"],"award-info":[{"award-number":["KYTD202311"]}],"id":[{"id":"10.13039\/501100009076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972746"],"award-info":[{"award-number":["81972746"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.intimp.2023.111002","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T13:30:36Z","timestamp":1696512636000},"page":"111002","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"PB","title":["HSC-derived exosomal miR-199a-5p promotes HSC activation and hepatocyte EMT via targeting SIRT1 in hepatic fibrosis"],"prefix":"10.1016","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0345-6500","authenticated-orcid":false,"given":"Hongjian","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronghua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shukun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yankun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meimei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9542-4986","authenticated-orcid":false,"given":"Guangling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5599-2429","authenticated-orcid":false,"given":"Jingwu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1028-4090","authenticated-orcid":false,"given":"Shuang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2023.111002_b0005","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/hep.32285","article-title":"Hepatic fibrosis 2022: Unmet needs and a blueprint for the future","volume":"75","author":"Friedman","year":"2022","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2023.111002_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101600","article-title":"Curcumin blunts epithelial-mesenchymal transition of hepatocytes to alleviate hepatic fibrosis through regulating oxidative stress and autophagy","volume":"36","author":"Kong","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.intimp.2023.111002_b0015","doi-asserted-by":"crossref","first-page":"5325431","DOI":"10.1155\/2022\/5325431","article-title":"Pathogenesis of Liver Fibrosis and Its TCM Therapeutic Perspectives","volume":"2022","author":"Nan","year":"2022","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.intimp.2023.111002_b0020","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau6977","article-title":"The biology, function, and biomedical applications of exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.intimp.2023.111002_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.104597","article-title":"M2 Macrophage-Derived Exosomal microRNA-411-5p Impedes the Activation of Hepatic Stellate Cells by Targeting CAMSAP1 in NASH Model","volume":"25","author":"Wan","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.intimp.2023.111002_b0030","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.3748\/wjg.v27.i14.1419","article-title":"Lipotoxic hepatocyte-derived exosomal miR-1297 promotes hepatic stellate cell activation through the PTEN signaling pathway in metabolic-associated fatty liver disease","volume":"27","author":"Luo","year":"2021","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.intimp.2023.111002_b0035","doi-asserted-by":"crossref","first-page":"3074","DOI":"10.1038\/s41598-022-05164-4","article-title":"Effects of microRNA-298 on APP and BACE1 translation differ according to cell type and 3'-UTR variation","volume":"12","author":"Wang","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2023.111002_b0040","article-title":"Exogenous Therapeutics of Microrna-29a Attenuates Development of Hepatic Fibrosis in Cholestatic Animal Model through Regulation of Phosphoinositide 3-Kinase p85 Alpha","volume":"21","author":"Yang","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2023.111002_b0045","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1093\/toxres\/tfac071","article-title":"E2F1 regulates miR-215-5p to aggravate paraquat-induced pulmonary fibrosis via repressing BMPR2 expression","volume":"11","author":"Huang","year":"2022","journal-title":"Toxicol Res (camb)"},{"key":"10.1016\/j.intimp.2023.111002_b0050","doi-asserted-by":"crossref","first-page":"e11374","DOI":"10.7717\/peerj.11374","article-title":"DZNep, an inhibitor of the histone methyltransferase EZH2, suppresses hepatic fibrosis through regulating miR-199a-5p\/SOCS7 pathway","volume":"9","author":"Ding","year":"2021","journal-title":"PeerJ"},{"key":"10.1016\/j.intimp.2023.111002_b0055","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22189799","article-title":"Identification of miR-199a-5p, miR-214-3p and miR-99b-5p as Fibrosis-Specific Extracellular Biomarkers and Promoters of HSC Activation","volume":"22","author":"Messner","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2023.111002_b0060","doi-asserted-by":"crossref","unstructured":"D. Wang, Z.l. Li, Y.K. Zhang, G.Z. Wang, M.H. Wei, Y. Hu, S. Ma, Y. Jiang, N.W. Che, X.F. Wang, J.H. Yao, J. Yin, Targeting of microRNA-199a-5p protects against pilocarpine-induced status epilepticus and seizure damage via SIRT1-p53 cascade, Epilepsia, 57(2016) 706-716.","DOI":"10.1111\/epi.13348"},{"key":"10.1016\/j.intimp.2023.111002_b0065","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s13287-021-02215-x","article-title":"Inhibition of miR-199a-5p rejuvenates aged mesenchymal stem cells derived from patients with idiopathic pulmonary fibrosis and improves their therapeutic efficacy in experimental pulmonary fibrosis","volume":"12","author":"Shi","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.intimp.2023.111002_b0070","doi-asserted-by":"crossref","first-page":"e13680","DOI":"10.1111\/acel.13680","article-title":"Sirt1 overexpression improves senescence-associated pulmonary fibrosis induced by vitamin D deficiency through downregulating IL-11 transcription","volume":"21","author":"Zhou","year":"2022","journal-title":"Aging Cell"},{"key":"10.1016\/j.intimp.2023.111002_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.174858","article-title":"Acacetin ameliorates cardiac hypertrophy by activating Sirt1\/AMPK\/PGC-1alpha pathway","volume":"920","author":"Cui","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2023.111002_b0080","first-page":"3202","article-title":"Hepatic stellate cell-specific deletion of SIRT1 exacerbates liver fibrosis in mice.Biochimica et biophysica acta","author":"Li","year":"1863","journal-title":"Molecular Basis of Disease"},{"key":"10.1016\/j.intimp.2023.111002_b0085","doi-asserted-by":"crossref","unstructured":"T. Ramirez, Y.M. Li, S.Yin, M.J. Xu, D.C Feng, Z. Zhou, M.W. Zang, P. Mukhopadhyay, Z.V. Varga, P. Pacher, B. Gao, H. Wang, Aging aggravates alcoholic liver injury and fibrosis in mice by downregulating sirtuin 1 expression, Journal of hepatology, 66(2017) 601-609.","DOI":"10.1016\/j.jhep.2016.11.004"},{"key":"10.1016\/j.intimp.2023.111002_b0090","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1016\/j.ajpath.2016.07.011","article-title":"Fibrogenic Signaling Is Suppressed in Hepatic Stellate Cells through Targeting of Connective Tissue Growth Factor (CCN2) by Cellular or Exosomal MicroRNA-199a-5p","volume":"186","author":"Chen","year":"2016","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.intimp.2023.111002_b0095","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.freeradbiomed.2021.10.002","article-title":"REDD1 attenuates hepatic stellate cell activation and liver fibrosis via inhibiting of TGF-beta\/Smad signaling pathway","volume":"176","author":"Cho","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.intimp.2023.111002_b0100","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1177\/15353702221108379","article-title":"MiR-22-3p and miR-29a-3p synergistically inhibit hepatic stellate cell activation by targeting AKT3","volume":"247","author":"Wang","year":"2022","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.intimp.2023.111002_b0105","doi-asserted-by":"crossref","unstructured":"R. Zhang, M. Wang, H. Lu, J. Wang, X. Han, Z. Liu, L. Li, M. Li, X. Tian, S. Chen, G. Zhang, Y. Xiong, J. Li, A miR-340\/SPP1 axis inhibits the activation and proliferation of hepatic stellate cells by inhibiting the TGF-beta1\/Smads pathway, Adv Clin Exp Med, (2022).","DOI":"10.17219\/acem\/154996"},{"key":"10.1016\/j.intimp.2023.111002_b0110","doi-asserted-by":"crossref","first-page":"11686","DOI":"10.1039\/D1FO02657G","article-title":"Piperine inhibits AML-12 hepatocyte EMT and LX-2 HSC activation and alleviates mouse liver fibrosis provoked by CCl(4): roles in the activation of the Nrf2 cascade and subsequent suppression of the TGF-beta1\/Smad axis","volume":"12","author":"Shu","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.intimp.2023.111002_b0115","article-title":"Exosomes derived from hepatitis B virus-infected hepatocytes promote liver fibrosis via miR-222\/TFRC axis","author":"Zhang","year":"2022","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.intimp.2023.111002_b0120","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.jhep.2022.06.012","article-title":"Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease - novel insights into cellular communication circuits","volume":"77","author":"Peiseler","year":"2022","journal-title":"J. Hepatol."},{"key":"10.1016\/j.intimp.2023.111002_b0125","doi-asserted-by":"crossref","first-page":"5178","DOI":"10.1096\/fj.201902307RRR","article-title":"Exosomal miR-103-3p from LPS-activated THP-1 macrophage contributes to the activation of hepatic stellate cells","volume":"34","author":"Chen","year":"2020","journal-title":"FASEB J."},{"key":"10.1016\/j.intimp.2023.111002_b0130","doi-asserted-by":"crossref","first-page":"7746","DOI":"10.1080\/21655979.2022.2044252","article-title":"CDKN2B antisense RNA 1 expression alleviates idiopathic pulmonary fibrosis by functioning as a competing endogenouse RNA through the miR-199a-5p\/Sestrin-2 axis","volume":"13","author":"Yang","year":"2022","journal-title":"Bioengineered"},{"key":"10.1016\/j.intimp.2023.111002_b0135","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23158518","article-title":"miR-199a: A Tumor Suppressor with Noncoding RNA Network and Therapeutic Candidate in Lung Cancer","volume":"23","author":"Meng","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2023.111002_b0140","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1186\/s12967-020-02499-2","article-title":"MiR-199a-3p\/5p participated in TGF-beta and EGF induced EMT by targeting DUSP5\/MAP3K11 in pterygium","volume":"18","author":"He","year":"2020","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.intimp.2023.111002_b0145","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1007\/s12072-020-10096-0","article-title":"Exosomal miR-199a-5p promotes hepatic lipid accumulation by modulating MST1 expression and fatty acid metabolism","volume":"14","author":"Li","year":"2020","journal-title":"Hep. Intl."},{"key":"10.1016\/j.intimp.2023.111002_b0150","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1093\/toxsci\/kfy149","article-title":"Role of YAP activation in nuclear receptor CAR-mediated proliferation of mouse hepatocytes","volume":"165","author":"Abe","year":"2018","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.intimp.2023.111002_b0155","article-title":"Regulation of SIRT1 and Its Roles in Inflammation","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2023.111002_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105984","article-title":"Ampelopsin attenuates carbon tetrachloride-induced mouse liver fibrosis and hepatic stellate cell activation associated with the SIRT1\/TGF-beta1\/Smad3 and autophagy pathway","volume":"77","author":"Ma","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2023.111002_b0165","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1186\/s12967-022-03408-5","article-title":"SIRT1 prevents cigarette smoking-induced lung fibroblasts activation by regulating mitochondrial oxidative stress and lipid metabolism","volume":"20","author":"Zhang","year":"2022","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.intimp.2023.111002_b0170","doi-asserted-by":"crossref","DOI":"10.1172\/JCI157338","article-title":"The ZIP8\/SIRT1 axis regulates alveolar progenitor cell renewal in aging and idiopathic pulmonary fibrosis","volume":"132","author":"Liang","year":"2022","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.intimp.2023.111002_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110413","article-title":"Study on the relationship between hepatic fibrosis and epithelial-mesenchymal transition in intrahepatic cells","volume":"129","author":"Chen","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2023.111002_b0180","article-title":"Thymoquinone alleviates liver fibrosis via miR-30a-mediated epithelial-mesenchymal transition","author":"Geng","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.intimp.2023.111002_b0185","doi-asserted-by":"crossref","first-page":"4313","DOI":"10.1002\/jcp.30174","article-title":"SOD3 deficiency induces liver fibrosis by promoting hepatic stellate cell activation and epithelial-mesenchymal transition","volume":"236","author":"Sun","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.intimp.2023.111002_b0190","doi-asserted-by":"crossref","first-page":"4167","DOI":"10.1002\/ptr.7549","article-title":"Mangiferin prevents hepatocyte epithelial-mesenchymal transition in liver fibrosis via targeting HSP27-mediated JAK2\/STAT3 and TGF-beta1\/Smad pathway","volume":"36","author":"Zhang","year":"2022","journal-title":"Phytother. Res."},{"key":"10.1016\/j.intimp.2023.111002_b0195","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231911407","article-title":"Hepatoprotective Effects of a Natural Flavanol 3,3'-Diindolylmethane against CCl(4)-Induced Chronic Liver Injury in Mice and TGFbeta1-Induced EMT in Mouse Hepatocytes via Activation of Nrf2 Cascade","volume":"23","author":"Munakarmi","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2023.111002_b0200","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1136\/gutjnl-2020-323014","article-title":"Exosome-delivered CD44v6\/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment","volume":"71","author":"Xie","year":"2022","journal-title":"Gut"},{"key":"10.1016\/j.intimp.2023.111002_b0205","doi-asserted-by":"crossref","first-page":"8660","DOI":"10.7150\/thno.62820","article-title":"Exosomal miR-21 from tubular cells contributes to renal fibrosis by activating fibroblasts via targeting PTEN in obstructed kidneys","volume":"11","author":"Zhao","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.intimp.2023.111002_b0210","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.cmet.2022.05.008","article-title":"MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH","volume":"34","author":"Gao","year":"2022","journal-title":"Cell Metab."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923013279?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923013279?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T18:10:05Z","timestamp":1761588605000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576923013279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":42,"alternative-id":["S1567576923013279"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2023.111002","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HSC-derived exosomal miR-199a-5p promotes HSC activation and hepatocyte EMT via targeting SIRT1 in hepatic fibrosis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2023.111002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111002"}}