{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:44:25Z","timestamp":1793072665287,"version":"4.5.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1705305"],"award-info":[{"award-number":["2018YFC1705305"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8237445"],"award-info":[{"award-number":["8237445"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174383"],"award-info":[{"award-number":["82174383"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82004235"],"award-info":[{"award-number":["82004235"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204954"],"award-info":[{"award-number":["82204954"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012543","name":"Shanghai Science and Technology Development Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003024","name":"Shanghai Education Development Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010876","name":"Shanghai University of Traditional Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010876","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.intimp.2023.111033","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T19:03:24Z","timestamp":1698433404000},"page":"111033","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"special_numbering":"PA","title":["Rutin attenuates inflammation by downregulating AGE-RAGE signaling pathway in psoriasis: Network pharmacology analysis and experimental evidence"],"prefix":"10.1016","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2696-1518","authenticated-orcid":false,"given":"Mingxia","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxuan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunjie","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoya","family":"Fei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Kuai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2546-5694","authenticated-orcid":false,"given":"Jiankun","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2023.111033_b0005","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.semcancer.2017.07.001","article-title":"AGEs, RAGEs and s-RAGE; friend or foe for cancer","volume":"49","author":"Ahmad","year":"2018","journal-title":"Semin. Cancer Biol."},{"issue":"2","key":"10.1016\/j.intimp.2023.111033_b0010","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3390\/nano12020275","article-title":"Nanodelivery Strategies for Skin Diseases with Barrier Impairment: Focusing on Ceramides and Glucocorticoids","volume":"12","author":"Almeida","year":"2022","journal-title":"Nanomaterials (Basel)"},{"key":"10.1016\/j.intimp.2023.111033_b0015","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.ebiom.2018.12.036","article-title":"Identification of a natural inhibitor of methionine adenosyltransferase 2A regulating one-carbon metabolism in keratinocytes","volume":"39","author":"Bai","year":"2019","journal-title":"EBioMedicine"},{"issue":"6","key":"10.1016\/j.intimp.2023.111033_b0020","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1007\/s00484-022-02273-7","article-title":"Evaluation of the benefit of thermal spa therapy in plaque psoriasis: the PSOTHERMES randomized clinical trial","volume":"66","author":"Beylot-Barry","year":"2022","journal-title":"Int. J. Biometeorol."},{"issue":"11","key":"10.1016\/j.intimp.2023.111033_b0025","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.3390\/antiox9111122","article-title":"Effects of Rutin on Wound Healing in Hyperglycemic Rats","volume":"9","author":"Chen","year":"2020","journal-title":"Antioxidants (Basel)"},{"issue":"5","key":"10.1016\/j.intimp.2023.111033_b0030","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1001\/jamaophthalmol.2017.0569","article-title":"Risk of Uveitis Among People With Psoriasis: A Nationwide Cohort Study","volume":"135","author":"Chi","year":"2017","journal-title":"JAMA Ophthalmol"},{"issue":"1","key":"10.1016\/j.intimp.2023.111033_b0035","doi-asserted-by":"crossref","first-page":"55","DOI":"10.5021\/ad.2017.29.1.55","article-title":"The Advantage of Cyclosporine A and Methotrexate Rotational Therapy in Long-Term Systemic Treatment for Chronic Plaque Psoriasis in a Real World Practice","volume":"29","author":"Choi","year":"2017","journal-title":"Ann. Dermatol."},{"issue":"11","key":"10.1016\/j.intimp.2023.111033_b0040","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.3390\/antiox10111696","article-title":"A Comparative Study of Rutin and Rutin Glycoside: Antioxidant Activity, Anti-Inflammatory Effect, Effect on Platelet Aggregation and Blood Coagulation","volume":"10","author":"Choi","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.intimp.2023.111033_b0045","article-title":"Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory Diseases","volume":"2013","author":"Chuah","year":"2013","journal-title":"Int. J. Inflamm."},{"issue":"1","key":"10.1016\/j.intimp.2023.111033_b0050","doi-asserted-by":"crossref","first-page":"12754","DOI":"10.1038\/s41598-020-69537-3","article-title":"Metagenomic analysis of gut microbiota in non-treated plaque psoriasis patients stratified by disease severity: development of a new Psoriasis-Microbiome Index","volume":"10","author":"Dei-Cas","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2023.111033_b0055","doi-asserted-by":"crossref","first-page":"e120","DOI":"10.1002\/mco2.120","article-title":"Tyrosine phosphatase SHP2 exacerbates psoriasis-like skin inflammation in mice via ERK5-dependent NETosis","volume":"2020),3(1","author":"Ding","year":"2022","journal-title":"MedComm"},{"issue":"1","key":"10.1016\/j.intimp.2023.111033_b0060","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s40659-020-00316-0","article-title":"Daphnetin inhibits proliferation and inflammatory response in human HaCaT keratinocytes and ameliorates imiquimod-induced psoriasis-like skin lesion in mice","volume":"53","author":"Gao","year":"2020","journal-title":"Biol. Res."},{"issue":"1","key":"10.1016\/j.intimp.2023.111033_b0065","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s40360-020-00419-0","article-title":"18\u03b2-Glycyrrhetinic acid induces human HaCaT keratinocytes apoptosis through ROS-mediated PI3K-Akt signaling pathway and ameliorates IMQ-induced psoriasis-like skin lesions in mice","volume":"21","author":"Gao","year":"2020","journal-title":"BMC Pharmacol. Toxicol."},{"key":"10.1016\/j.intimp.2023.111033_b0070","first-page":"1","article-title":"Study on the Mechanism of Huanglian Jiedu Decoction in Treating Dyslipidemia Based on Network Pharmacology","volume":"2022","author":"Gong","year":"2022","journal-title":"J Healthc Eng"},{"issue":"1","key":"10.1016\/j.intimp.2023.111033_b0075","doi-asserted-by":"crossref","first-page":"20690","DOI":"10.1038\/s41598-022-23518-w","article-title":"Risk of malignancy in patients with psoriasis according to treatment modalities in Korea: a nationwide cohort study","volume":"12","author":"Hong","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2023.111033_b0080","doi-asserted-by":"crossref","first-page":"31119","DOI":"10.1038\/srep31119","article-title":"Neutrophil extracellular trap formation is increased in psoriasis and induces human \u03b2-defensin-2 production in epidermal keratinocytes","volume":"6","author":"Hu","year":"2016","journal-title":"Sci. Rep."},{"issue":"28","key":"10.1016\/j.intimp.2023.111033_b0085","doi-asserted-by":"crossref","first-page":"72930","DOI":"10.1007\/s11356-023-27166-z","article-title":"Rutin protects against gamma-irradiation and malathion-induced oxidative stress and inflammation through regulation of mir-129-3p, mir-200C-3p, and mir-210 gene expressions in rats' kidney","volume":"30","author":"Ismail","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"5","key":"10.1016\/j.intimp.2023.111033_b0090","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.3390\/biomedicines10051133","article-title":"Significantly Altered Serum Levels of NAD, AGE, RAGE, CRP, and Elastin as Potential Biomarkers of Psoriasis and Aging-A Case-Control Study","volume":"10","author":"Karas","year":"2022","journal-title":"Biomedicines"},{"issue":"6","key":"10.1016\/j.intimp.2023.111033_b0095","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.3390\/nu13061897","article-title":"Effects of Dietary Protein Intake on Cutaneous and Systemic Inflammation in Mice with Acute Experimental Psoriasis","volume":"13","author":"Knopp","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.intimp.2023.111033_b0100","doi-asserted-by":"crossref","first-page":"101350","DOI":"10.1016\/j.tranon.2022.101350","article-title":"Non-enzymatic glycoxidation linked with nutrition enhances the tumorigenic capacity of prostate cancer epithelia through AGE mediated activation of RAGE in cancer associated fibroblasts","volume":"17","author":"Krisanits","year":"2022","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.intimp.2023.111033_b0105","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.565285","article-title":"Improved Anti-Inflammatory Effects of Liposomal Astaxanthin on a Phthalic Anhydride-Induced Atopic Dermatitis Model","volume":"11","author":"Lee","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2023.111033_b0110","doi-asserted-by":"crossref","first-page":"8942301","DOI":"10.1155\/2020\/8942301","article-title":"Efficacy and Safety of Jueyin Granules for Patients with Mild-to-Moderate Psoriasis Vulgaris: Protocol for a Multicenter Randomized Placebo-Controlled Trial","volume":"2020","author":"Li","year":"2020","journal-title":"Evid. Based Complement. Alternat. Med."},{"issue":"1","key":"10.1016\/j.intimp.2023.111033_b0115","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3390\/jpm12010062","article-title":"Forsythoside A Alleviates Imiquimod-Induced Psoriasis-like Dermatitis in Mice by Regulating Th17 Cells and IL-17A Expression","volume":"12","author":"Lin","year":"2022","journal-title":"J Pers Med"},{"key":"10.1016\/j.intimp.2023.111033_b0120","doi-asserted-by":"crossref","first-page":"133395","DOI":"10.1016\/j.foodchem.2022.133395","article-title":"Sophora japonica flowers and their main phytochemical, rutin, regulate chemically induced murine colitis in association with targeting the NF-\u03baB signaling pathway and gut microbiota","volume":"393","author":"Liu","year":"2022","journal-title":"Food Chem."},{"issue":"22","key":"10.1016\/j.intimp.2023.111033_b0125","doi-asserted-by":"crossref","first-page":"694","DOI":"10.21037\/atm.2019.10.46","article-title":"Characteristics of psoriasis vulgaris in China: a prospective cohort study protocol","volume":"7","author":"Luo","year":"2019","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.intimp.2023.111033_b0130","doi-asserted-by":"crossref","unstructured":"Ma T., Jiang W.C., Li X., Chen J., Wu T.J., Nian H., Xu R., Huang Qy.Y., Xiao Q.Q., Jian Q., Li F.L., & Li B. (2014). Effects of chinese formula jueyin granules on psoriasis in an animal model. Evid Based Complement Alternat Med, 2014, 512562.","DOI":"10.1155\/2014\/512562"},{"key":"10.1016\/j.intimp.2023.111033_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116194","article-title":"Therapeutic effects and mechanisms of Ku-Gan formula on atopic dermatitis: A pilot clinical study and modular pharmacology analysis with animal validation","volume":"307","author":"Ma","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2023.111033_b0140","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1590\/abd1806-4841.20186123","article-title":"The potential role of Th17 lymphocytes in patients with psoriasis","volume":"93","author":"Mansouri","year":"2018","journal-title":"An. Bras. Dermatol."},{"key":"10.1016\/j.intimp.2023.111033_b0145","first-page":"1","article-title":"Bioinformatics Identification of Ferroptosis-Associated Biomarkers and Therapeutic Compounds in Psoriasis","volume":"2022","author":"Mao","year":"2022","journal-title":"J. Oncol."},{"key":"10.1016\/j.intimp.2023.111033_b0150","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.800154","article-title":"Transcriptome Analyses Reveal Systematic Molecular Pathology After Optic Nerve Crush","volume":"15","author":"Pan","year":"2022","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.intimp.2023.111033_b0155","doi-asserted-by":"crossref","first-page":"53","DOI":"10.2147\/JIR.S215196","article-title":"Clinical Evaluation of Risankizumab-rzaa in the Treatment of Plaque Psoriasis","volume":"13","author":"Reddy","year":"2020","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.intimp.2023.111033_b0160","doi-asserted-by":"crossref","first-page":"1089262","DOI":"10.3389\/fimmu.2022.1089262","article-title":"Advances in pathogenesis and nanoparticles (NPs)-mediated treatment of psoriasis","volume":"13","author":"Shen","year":"2022","journal-title":"Front. Immunol."},{"issue":"7","key":"10.1016\/j.intimp.2023.111033_b0165","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.3390\/antiox10071127","article-title":"Hydroxytyrosol Selectively Affects Non-Enzymatic Glycation in Human Insulin and Protects by AGEs Cytotoxicity","volume":"10","author":"Sirangelo","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.intimp.2023.111033_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114571","article-title":"Deciphering the mechanism of Fang-Ji-Di-Huang-Decoction in ameliorating psoriasis-like skin inflammation via the inhibition of IL-23\/Th17 cell axis","volume":"281","author":"Song","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2023.111033_b0175","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.850108","article-title":"Classification and biomarker gene selection of pyroptosis-related gene expression in psoriasis using a random forest algorithm","volume":"13","author":"Song","year":"2022","journal-title":"Front. Genet."},{"key":"10.1016\/j.intimp.2023.111033_b0180","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.2147\/DDDT.S200147","article-title":"Infliximab and biosimilar infliximab in psoriasis: efficacy, loss of efficacy, and adverse events","volume":"13","author":"Subedi","year":"2019","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.intimp.2023.111033_b0185","first-page":"2733","article-title":"\u2018Psoriasis 1\u2019 reduces psoriasis-like skin inflammation by inhibiting the VDR-mediated nuclear NF-\u03baB and STAT signaling pathways","volume":"18","author":"Sun","year":"2018","journal-title":"Mol. Med. Rep."},{"issue":"1","key":"10.1016\/j.intimp.2023.111033_b0190","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1186\/s13063-020-4209-3","article-title":"Our Choice: study protocol for a randomized controlled trial for optimal implementation of psoriasis treatment by the integration of Chinese and western medicine","volume":"21","author":"Sun","year":"2020","journal-title":"Trials"},{"key":"10.1016\/j.intimp.2023.111033_b0195","first-page":"1","article-title":"Network Pharmacology-Based Analysis of the Potential Biological Mechanisms of Coix Seed against Colorectal Cancer","volume":"2022","author":"Sun","year":"2022","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.intimp.2023.111033_b0200","doi-asserted-by":"crossref","first-page":"43310","DOI":"10.1038\/srep43310","article-title":"CCN1 promotes IL-1\u03b2 production in keratinocytes by activating p38 MAPK signaling in psoriasis","volume":"7","author":"Sun","year":"2017","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.intimp.2023.111033_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.104009","article-title":"SHP2 allosteric inhibitor TK-453 alleviates psoriasis-like skin inflammation in mice via inhibition of IL-23\/Th17 axis","volume":"25","author":"Wang","year":"2022","journal-title":"iScience"},{"issue":"3","key":"10.1016\/j.intimp.2023.111033_b0210","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1159\/000510029","article-title":"The Efficacy and Safety of Topical \u03b2-Blockers in Treating Infantile Hemangiomas: A Meta-Analysis Including 11 Randomized Controlled Trials","volume":"237","author":"Wang","year":"2021","journal-title":"Dermatology"},{"key":"10.1016\/j.intimp.2023.111033_b0215","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.659700","article-title":"Gene Cascade Shift and Pathway Enrichment in Rat Kidney Induced by Acarbose Through Comparative Analysis","volume":"9","author":"Weng","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"1","key":"10.1016\/j.intimp.2023.111033_b0220","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12931-020-01372-6","article-title":"SN50 attenuates alveolar hypercoagulation and fibrinolysis inhibition in acute respiratory distress syndrome mice through inhibiting NF-\u03baB p65 translocation","volume":"21","author":"Wu","year":"2020","journal-title":"Respir. Res."},{"issue":"3","key":"10.1016\/j.intimp.2023.111033_b0225","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1002\/cbin.11960","article-title":"Protective effect of rutin on ferroptosis-induced oxidative stress in aging laying hens through Nrf2\/HO-1 signaling","volume":"47","author":"Wu","year":"2023","journal-title":"Cell Biol. Int."},{"issue":"1","key":"10.1016\/j.intimp.2023.111033_b0230","doi-asserted-by":"crossref","first-page":"8772","DOI":"10.1038\/s41598-019-45145-8","article-title":"Pseudomonas donghuensis HYS virulence towards Caenorhabditis elegans is regulated by the Cbr\/Crc system","volume":"9","author":"Xie","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.intimp.2023.111033_b0235","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/s12906-020-02954-z","article-title":"Network pharmacology to dissect the mechanisms of Yinlai Decoction for pneumonia","volume":"20","author":"Xu","year":"2020","journal-title":"BMC Complement Med Ther"},{"key":"10.1016\/j.intimp.2023.111033_b0240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/1723791","article-title":"Bellidifolin Inhibits Proliferation of A549 Cells by Regulating STAT3\/COX-2 Expression and Protein Activity","volume":"2020","author":"Yan","year":"2020","journal-title":"J. Oncol."},{"key":"10.1016\/j.intimp.2023.111033_b0245","first-page":"1","article-title":"Analysis of Molecular Mechanism of Erxian Decoction in Treating Osteoporosis Based on Formula Optimization Model","volume":"2021","author":"Yang","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"19","key":"10.1016\/j.intimp.2023.111033_b0250","doi-asserted-by":"crossref","first-page":"11773","DOI":"10.3390\/ijms231911773","article-title":"Protective Effect of Rutin on Triethylene Glycol Dimethacrylate-Induced Toxicity through the Inhibition of Caspase Activation and Reactive Oxygen Species Generation in Macrophages","volume":"23","author":"Yang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2023.111033_b0255","doi-asserted-by":"crossref","first-page":"1013052","DOI":"10.3389\/fonc.2022.1013052","article-title":"Exploring the nucleotide molecular mechanism of compound kushen injection for lung adenocarcinoma based on network pharmacology and molecular docking","volume":"12","author":"Ye","year":"2022","journal-title":"Front. Oncol."},{"issue":"6","key":"10.1016\/j.intimp.2023.111033_b0260","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20203520","article-title":"Exploring the mechanisms underlying the therapeutic effect of Salvia miltiorrhiza in diabetic nephropathy using network pharmacology and molecular docking","volume":"41","author":"Zhang","year":"2021","journal-title":"Biosci. Rep."},{"issue":"13","key":"10.1016\/j.intimp.2023.111033_b0265","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.7150\/ijbs.62471","article-title":"Rutin attenuates Sorafenib-induced Chemoresistance and Autophagy in Hepatocellular Carcinoma by regulating BANCR\/miRNA-590-5P\/OLR1 Axis","volume":"17","author":"Zhou","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.intimp.2023.111033_b0270","first-page":"1","article-title":"Uncovering the Key Targets and Therapeutic Mechanisms of Qizhen Capsule in Gastric Cancer through Network Pharmacology and Bioinformatic Analyses","volume":"2022","author":"Zhou","year":"2022","journal-title":"Comput. Math. Methods Med."},{"issue":"11","key":"10.1016\/j.intimp.2023.111033_b0275","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.1016\/j.apsb.2022.08.022","article-title":"New opportunities and challenges of natural products research: When target identification meets single-cell multiomics","volume":"12","author":"Zhu","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"issue":"3","key":"10.1016\/j.intimp.2023.111033_b0280","doi-asserted-by":"crossref","first-page":"e14455","DOI":"10.15252\/emmm.202114455","article-title":"Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis","volume":"14","author":"Zhu","year":"2022","journal-title":"EMBO Mol. Med."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923013589?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923013589?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:52:29Z","timestamp":1778820749000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576923013589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":56,"alternative-id":["S1567576923013589"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2023.111033","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rutin attenuates inflammation by downregulating AGE-RAGE signaling pathway in psoriasis: Network pharmacology analysis and experimental evidence","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2023.111033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111033"}}