{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T06:59:55Z","timestamp":1769756395959,"version":"3.49.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.intimp.2023.111037","type":"journal-article","created":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T04:20:40Z","timestamp":1696911640000},"page":"111037","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"PB","title":["The eNOS-induced leonurine's new role in improving the survival of random skin flap"],"prefix":"10.1016","volume":"124","author":[{"given":"Tingxiang","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuedong","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haosheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijie","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9070-3655","authenticated-orcid":false,"given":"Shi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2023.111037_b0005","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1097\/PRS.0b013e3181ef8ccf","article-title":"The basic science of vascular biology: implications for the practicing surgeon","volume":"126","author":"Glotzbach","year":"2010","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.intimp.2023.111037_b0010","doi-asserted-by":"crossref","first-page":"e100818","DOI":"10.1371\/journal.pone.0100818","article-title":"Local injection of deferoxamine improves neovascularization in ischemic diabetic random flap by increasing HIF-1\u03b1 and VEGF expression","volume":"9","author":"Wang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2023.111037_b0015","doi-asserted-by":"crossref","first-page":"6010","DOI":"10.1073\/pnas.1402679111","article-title":"An engineered muscle flap for reconstruction of large soft tissue defects","volume":"111","author":"Shandalov","year":"2014","journal-title":"PNAS"},{"key":"10.1016\/j.intimp.2023.111037_b0020","doi-asserted-by":"crossref","first-page":"6611668","DOI":"10.1155\/2021\/6611668","article-title":"Gastrodin Promotes the Survival of Random-Pattern Skin Flaps via Autophagy Flux Stimulation","volume":"2021","author":"Chen","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.intimp.2023.111037_b0025","doi-asserted-by":"crossref","first-page":"679","DOI":"10.2147\/DDDT.S297458","article-title":"Trans-Cinnamaldehyde Increases Random Pattern Flap Survival Through Activation of the Nitric Oxide Pathway","volume":"15","author":"Luo","year":"2021","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.intimp.2023.111037_b0030","doi-asserted-by":"crossref","unstructured":"A. Dehdashtian, K. Afshari, S. Zarifeh Jazaeri, N. Haddadi, M. Sheikhi, A. Abbaszadeh-Kasbi, S. Tavangar, F. Jazaeri, B. Amirlak, and A. Dehpour, Sumatriptan Increases Skin Flap Survival through Activation of 5-Hydroxytryptamine 1b\/1d Receptors in Rats: The Mediating Role of the Nitric Oxide Pathway. Plastic and reconstructive surgery 144 (2019) 70e-77e.","DOI":"10.1097\/PRS.0000000000005740"},{"key":"10.1016\/j.intimp.2023.111037_b0035","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1097\/SAP.0b013e3182586d67","article-title":"Comparing different postconditioning cycles after ischemia reperfusion injury in the rat skin flap","volume":"72","author":"Coskunfirat","year":"2014","journal-title":"Ann. Plast. Surg."},{"key":"10.1016\/j.intimp.2023.111037_b0040","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0007-1226(87)90185-8","article-title":"The vascular territories (angiosomes) of the body: experimental study and clinical applications","volume":"40","author":"Taylor","year":"1987","journal-title":"Br. J. Plast. Surg."},{"key":"10.1016\/j.intimp.2023.111037_b0045","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/s41419-019-1704-0","article-title":"Trehalose promotes the survival of random-pattern skin flaps by TFEB mediated autophagy enhancement","volume":"10","author":"Wu","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2023.111037_b0050","doi-asserted-by":"crossref","unstructured":"W. Lineaweaver, M. Lei, W. Mustain, T. Oswald, D. Cui, and F. Zhang, Vascular endothelium growth factor, surgical delay, and skin flap survival. Annals of surgery 239 (2004) 866-73; discussion 873-5.","DOI":"10.1097\/01.sla.0000128682.53915.92"},{"key":"10.1016\/j.intimp.2023.111037_b0055","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1097\/01.prs.0000260590.44798.9c","article-title":"Effect of venous superdrainage on a four-territory skin flap survival in rats","volume":"119","author":"Chang","year":"2007","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.intimp.2023.111037_b0060","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/01.PRS.0000095953.57320.2F","article-title":"Comparison of three different supercharging procedures in a rat skin flap model","volume":"113","author":"Chang","year":"2004","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.intimp.2023.111037_b0065","doi-asserted-by":"crossref","first-page":"954","DOI":"10.3892\/etm.2015.2620","article-title":"Combination of vascular endothelial growth factor-loaded microspheres and hyperbaric oxygen on random skin flap survival in rats","volume":"10","author":"Xie","year":"2015","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.intimp.2023.111037_b0070","doi-asserted-by":"crossref","first-page":"829-+","DOI":"10.1093\/eurheartj\/ehr304","article-title":"Nitric oxide synthases: regulation and function","volume":"33","author":"Forstermann","year":"2012","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.intimp.2023.111037_b0075","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1530\/JOE-11-0083","article-title":"eNOS activation and NO function: Structural motifs responsible for the posttranslational control of endothelial nitric oxide synthase activity","volume":"210","author":"Rafikov","year":"2011","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.intimp.2023.111037_b0080","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/S0008-6363(99)00094-2","article-title":"Signal transduction of eNOS activation","volume":"43","author":"Fleming","year":"1999","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.intimp.2023.111037_b0085","doi-asserted-by":"crossref","first-page":"e01995","DOI":"10.1002\/brb3.1995","article-title":"Leonurine, a potential drug for the treatment of cardiovascular system and central nervous system diseases","volume":"11","author":"Huang","year":"2021","journal-title":"Brain and Behavior"},{"key":"10.1016\/j.intimp.2023.111037_b0090","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/S0024-3205(00)00987-5","article-title":"Endothelium-independent vasorelaxation by leonurine, a plant alkaloid purified from Chinese motherwort","volume":"68","author":"Chen","year":"2001","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2023.111037_b0095","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1124\/jpet.119.264887","article-title":"eNOS-Nitric Oxide System Contributes to a Novel Antiatherogenic Effect of Leonurine via Inflammation Inhibition and Plaque Stabilization","volume":"373","author":"Ning","year":"2020","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.intimp.2023.111037_b0100","first-page":"1582","article-title":"Leonurine protects cardiac function following acute myocardial infarction through anti-apoptosis by the PI3K\/AKT\/GSK3\u03b2 signaling pathway","volume":"18","author":"Xu","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.intimp.2023.111037_b0105","doi-asserted-by":"crossref","first-page":"4519","DOI":"10.3892\/mmr.2020.11561","article-title":"Hesperidin ameliorates liver ischemia\/reperfusion injury via activation of the Akt pathway","volume":"22","author":"Li","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.intimp.2023.111037_b0110","series-title":"Berberine promotes the viability of random skin flaps via the PI3K\/Akt\/eNOS signaling pathway","author":"Chen","year":"2022"},{"key":"10.1016\/j.intimp.2023.111037_b0115","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/j.bjps.2009.08.011","article-title":"A new design of a dorsal flap in the rat to study skin necrosis and its prevention","volume":"63","author":"Kelly","year":"2010","journal-title":"J. Plast. Reconstr. Aesthet. Surg."},{"key":"10.1016\/j.intimp.2023.111037_b0120","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2152\/jmi.63.159","article-title":"Development of Skin Flaps for Reconstructive Surgery: Random Pattern Flap to Perforator Flap","volume":"63","author":"Hashimoto","year":"2016","journal-title":"The Journal of Medical Investigation : JMI"},{"key":"10.1016\/j.intimp.2023.111037_b0125","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.bjps.2011.12.014","article-title":"Why haematomas cause flap failure: an evidence-based paradigm","volume":"65","author":"Glass","year":"2012","journal-title":"J. Plast. Reconstr. Aesthet. Surg."},{"key":"10.1016\/j.intimp.2023.111037_b0130","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1097\/SAP.0000000000001054","article-title":"Microcirculatory Effects of Botulinum Toxin A in the Rat: Acute and Chronic Vasodilation","volume":"79","author":"Aru","year":"2017","journal-title":"Ann. Plast. Surg."},{"key":"10.1016\/j.intimp.2023.111037_b0135","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.mvr.2011.03.010","article-title":"N-acetylcysteine attenuates leukocytic inflammation and microvascular perfusion failure in critically ischemic random pattern flaps","volume":"82","author":"B\u00e4chle","year":"2011","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.intimp.2023.111037_b0140","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s10753-014-0009-9","article-title":"Leonurine exerts anti-inflammatory effect by regulating inflammatory signaling pathways and cytokines in LPS-induced mouse mastitis","volume":"38","author":"Song","year":"2015","journal-title":"Inflammation"},{"key":"10.1016\/j.intimp.2023.111037_b0145","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.3892\/etm.2021.10633","article-title":"Leonurine protects against ulcerative colitis by alleviating inflammation and modulating intestinal microflora in mouse models","volume":"22","author":"Zheng","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.intimp.2023.111037_b0150","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/FJC.0000000000000957","article-title":"Leonurine Attenuates Myocardial Fibrosis Through Upregulation of miR-29a-3p in Mice Post-myocardial Infarction","volume":"77","author":"Wang","year":"2021","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.intimp.2023.111037_b0155","doi-asserted-by":"crossref","first-page":"e0200705","DOI":"10.1371\/journal.pone.0200705","article-title":"Neuroprotective effects of leonurine against oxygen-glucose deprivation by targeting Cx36\/CaMKII in PC12 cells","volume":"13","author":"Li","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2023.111037_b0160","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s10753-019-01104-z","article-title":"Leonurine Hydrochloride Suppresses Inflammatory Responses and Ameliorates Cartilage Degradation in Osteoarthritis via NF-\u03baB Signaling Pathway","volume":"43","author":"Chen","year":"2020","journal-title":"Inflammation"},{"key":"10.1016\/j.intimp.2023.111037_b0165","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.ejphar.2010.08.056","article-title":"Leonurine (SCM-198) improves cardiac recovery in rat during chronic infarction","volume":"649","author":"Liu","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2023.111037_b0170","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1248\/bpb.33.1958","article-title":"Neuroprotective effects of leonurine on ischemia\/reperfusion-induced mitochondrial dysfunctions in rat cerebral cortex","volume":"33","author":"Qi","year":"2010","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.intimp.2023.111037_b0175","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/21218","article-title":"Regulation of endothelium-derived nitric oxide production by the protein kinase Akt","volume":"399","author":"Fulton","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2023.111037_b0180","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.biochi.2010.03.020","article-title":"eNOS phosphorylation in health and disease","volume":"92","author":"Kolluru","year":"2010","journal-title":"Biochimie"},{"key":"10.1016\/j.intimp.2023.111037_b0185","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1039\/C7FO01289F","article-title":"Upregulating mTOR\/ERK signaling with leonurine for promoting angiogenesis and tissue regeneration in a full-thickness cutaneous wound model","volume":"9","author":"Wang","year":"2018","journal-title":"Food Funct."},{"key":"10.1016\/j.intimp.2023.111037_b0190","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3389\/fphar.2017.00284","article-title":"Leonurine Improves Age-Dependent Impaired Angiogenesis: Possible Involvement of Mitochondrial Function and HIF-1\u03b1 Dependent VEGF Activation","volume":"8","author":"Qi","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2023.111037_b0195","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1097\/01.PRS.0000070965.28811.2C","article-title":"Evaluation of the mechanism of vascular endothelial growth factor improvement of ischemic flap survival in rats","volume":"112","author":"Pang","year":"2003","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.intimp.2023.111037_b0200","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jhazmat.2018.07.050","article-title":"Bisphenol A induced oxidative stress mediated genotoxicity in Drosophila melanogaster","volume":"370","author":"Anet","year":"2019","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.intimp.2023.111037_b0205","doi-asserted-by":"crossref","unstructured":"M. Kumar, E.R. Kasala, L.N. Bodduluru, V. Dahiya, and M. Lahkar, Baicalein protects isoproterenol induced myocardial ischemic injury in male Wistar rats by mitigating oxidative stress and inflammation. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 65 (2016) 613-22.","DOI":"10.1007\/s00011-016-0944-z"},{"key":"10.1016\/j.intimp.2023.111037_b0210","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1097\/01.prs.0000475768.68654.03","article-title":"Thioredoxin Protects Skin Flaps from Ischemia-Reperfusion Injury: A Novel Prognostic and Therapeutic Target","volume":"137","author":"Yin","year":"2016","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.intimp.2023.111037_b0215","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.005602","article-title":"Reoxygenation Reverses Hypoxic Pulmonary Arterial Remodeling by Inducing Smooth Muscle Cell Apoptosis via Reactive Oxygen Species-Mediated Mitochondrial Dysfunction","volume":"6","author":"Chen","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.intimp.2023.111037_b0220","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231710188","article-title":"Leonurine Reduces Oxidative Stress and Provides Neuroprotection against Ischemic Injury via Modulating Oxidative and NO\/NOS Pathway","volume":"23","author":"Deng","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2023.111037_b0225","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1021\/acschemneuro.1c00200","article-title":"Novel Stachydrine-Leonurine Conjugate SL06 as a Potent Neuroprotective Agent for Cerebral Ischemic Stroke","volume":"12","author":"Li","year":"2021","journal-title":"ACS Chem. Nerosci."},{"key":"10.1016\/j.intimp.2023.111037_b0230","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/ptr.7621","article-title":"Berberine promotes the viability of random skin flaps via the PI3K\/Akt\/eNOS signaling pathway","volume":"37","author":"Chen","year":"2023","journal-title":"Phytotherapy Research : PTR"},{"key":"10.1016\/j.intimp.2023.111037_b0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.109875","article-title":"Upregulation of Nrf2 signaling and suppression of ferroptosis and NF-\u03baB pathway by leonurine attenuate iron overload-induced hepatotoxicity","volume":"356","author":"Salama","year":"2022","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.intimp.2023.111037_b0240","doi-asserted-by":"crossref","first-page":"621","DOI":"10.2147\/DDDT.S242521","article-title":"Hydrogen Sulfide Protects Against High Glucose-Induced Human Umbilical Vein Endothelial Cell Injury Through Activating PI3K\/Akt\/eNOS Pathway","volume":"14","author":"Lin","year":"2020","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.intimp.2023.111037_b0245","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1161\/CIRCRESAHA.108.178467","article-title":"An ezrin\/calpain\/PI3K\/AMPK\/eNOSs1179 signaling cascade mediating VEGF-dependent endothelial nitric oxide production","volume":"104","author":"Youn","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.intimp.2023.111037_b0250","first-page":"8112","article-title":"PI3K\/AKT signaling pathway plays a role in enhancement of eNOS activity by recombinant human angiotensin converting enzyme 2 in human umbilical vein endothelial cells","volume":"7","author":"Zhang","year":"2014","journal-title":"Int. J. Clin. Exp. Path."},{"key":"10.1016\/j.intimp.2023.111037_b0255","doi-asserted-by":"crossref","first-page":"9919466","DOI":"10.1155\/2021\/9919466","article-title":"Leonurine Ameliorates Oxidative Stress and Insufficient Angiogenesis by Regulating the PI3K\/Akt-eNOS Signaling Pathway in HO-Induced HUVECs","volume":"2021","author":"Liao","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.intimp.2023.111037_b0260","doi-asserted-by":"crossref","first-page":"6837982","DOI":"10.1155\/2020\/6837982","article-title":"Kaji-Ichigoside F1 and Rosamultin Protect Vascular Endothelial Cells against Hypoxia-Induced Apoptosis via the PI3K\/AKT or ERK1\/2 Signaling Pathway","volume":"2020","author":"Shi","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.intimp.2023.111037_b0265","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.742954","article-title":"Identification of the Antithrombotic Mechanism of Leonurine in Adrenalin Hydrochloride-Induced Thrombosis in Zebrafish via Regulating Oxidative Stress and Coagulation Cascade","volume":"12","author":"Liao","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2023.111037_b0270","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1080\/08923973.2022.2055565","article-title":"LY294002 attenuates inflammatory response in endotoxin-induced uveitis by downregulating JAK3 and inactivating the PI3K\/Akt signaling","volume":"44","author":"Wu","year":"2022","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.intimp.2023.111037_b0275","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1007\/s11011-017-0051-z","article-title":"LY294002, a PI3K inhibitor, attenuates Tourette syndrome in rats","volume":"32","author":"Hongyan","year":"2017","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.intimp.2023.111037_b0280","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.jss.2014.07.012","article-title":"Metformin improves skin flap survival through nitric oxide system","volume":"192","author":"Taleb","year":"2014","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.intimp.2023.111037_b0285","article-title":"Nicorandil reversed homocysteine-induced coronary microvascular dysfunction via regulating PI3K\/Akt\/eNOS pathway","volume":"127","author":"Zhan","year":"2020","journal-title":"Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie"},{"key":"10.1016\/j.intimp.2023.111037_b0290","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/j.bjps.2020.10.084","article-title":"Protective effect of modafinil on skin flap survival in the experimental random-pattern skin flap model in rats: The role of ATP-sensitive potassium channels and nitric oxide pathway","volume":"74","author":"Aryannejad","year":"2021","journal-title":"J. Plast. Reconstr. Aesthet. Surg."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923013632?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923013632?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T18:04:45Z","timestamp":1761588285000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576923013632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":58,"alternative-id":["S1567576923013632"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2023.111037","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The eNOS-induced leonurine's new role in improving the survival of random skin flap","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2023.111037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111037"}}