{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:40:42Z","timestamp":1792190442474,"version":"4.4.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018778","name":"Al-Azhar University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018778","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.intimp.2023.111179","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T14:42:50Z","timestamp":1700664170000},"page":"111179","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Lysosomal membrane stabilization by imipramine attenuates gentamicin-induced renal injury: Enhanced LAMP2 expression, down-regulation of cytoplasmic cathepsin D and tBid\/cytochrome c\/cleaved caspase-3 apoptotic signaling"],"prefix":"10.1016","volume":"126","author":[{"given":"Dina A.","family":"Hanna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basim A.S.","family":"Messiha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali A.","family":"Abo-Saif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fares E.M.","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4100-1918","authenticated-orcid":false,"given":"Amany A.","family":"Azouz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.intimp.2023.111179_b0005","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a027029","article-title":"Aminoglycosides: an overview","volume":"6","author":"Krause","year":"2016","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"9","key":"10.1016\/j.intimp.2023.111179_b0010","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1681\/ASN.2019020204","article-title":"Gentamicin-induced acute kidney injury in an animal model involves programmed necrosis of the collecting duct","volume":"31","author":"Huang","year":"2020","journal-title":"J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.intimp.2023.111179_b0015","doi-asserted-by":"crossref","first-page":"13689","DOI":"10.1038\/s41598-019-49835-1","article-title":"Pioglitazone attenuates kidney injury in an experimental model of gentamicin-induced nephrotoxicity in rats","volume":"9","author":"Medi\u0107","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2023.111179_b0020","first-page":"388","article-title":"Gentamicin nephrotoxicity in animals: Current knowledge and future perspectives","volume":"16","author":"Randjelovic","year":"2017","journal-title":"EXCLI J."},{"issue":"4","key":"10.1016\/j.intimp.2023.111179_b0025","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.bcp.2014.05.018","article-title":"Entry of aminoglycosides into renal tubular epithelial cells via endocytosis-dependent and endocytosis-independent pathways","volume":"90","author":"Nagai","year":"2014","journal-title":"Biochem. Pharmacol."},{"issue":"11","key":"10.1016\/j.intimp.2023.111179_b0030","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1007\/s00467-016-3533-z","article-title":"Aminoglycoside-induced nephrotoxicity in children","volume":"32","author":"McWilliam","year":"2017","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.intimp.2023.111179_b0035","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jad.2016.03.017","article-title":"Zinc and imipramine reverse the depression-like behavior in mice induced by chronic restraint stress","volume":"197","author":"Ding","year":"2016","journal-title":"J. Affect. Disord."},{"issue":"4","key":"10.1016\/j.intimp.2023.111179_b0040","doi-asserted-by":"crossref","first-page":"667","DOI":"10.3390\/cells11040667","article-title":"Administration of an Acidic Sphingomyelinase (ASMase) Inhibitor, Imipramine, Reduces Hypoglycemia-Induced Hippocampal Neuronal Death","volume":"11","author":"Kho","year":"2022","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.intimp.2023.111179_b0045","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/jre.12951","article-title":"Inhibition of acid sphingomyelinase by imipramine abolishes the synergy between metabolic syndrome and periodontitis on alveolar bone loss","volume":"57","author":"Li","year":"2022","journal-title":"J. Periodontal Res."},{"issue":"1","key":"10.1016\/j.intimp.2023.111179_b0050","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12989-017-0217-1","article-title":"Imipramine blocks acute silicosis in a mouse model","volume":"14","author":"Biswas","year":"2017","journal-title":"Part. Fibre Toxicol."},{"issue":"3","key":"10.1016\/j.intimp.2023.111179_b0055","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1124\/jpet.118.248351","article-title":"Pharmacological Characterization of H05, a Novel Serotonin and Noradrenaline Reuptake Inhibitor with Moderate 5-HT2A Antagonist Activity for the Treatment of Depression","volume":"365","author":"Xu","year":"2018","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"5","key":"10.1016\/j.intimp.2023.111179_b0060","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1601-5215.2011.00579.x","article-title":"Administration of cannabidiol and imipramine induces antidepressant-like effects in the forced swimming test and increases brain-derived neurotrophic factor levels in the rat amygdala","volume":"23","author":"R\u00e9us","year":"2011","journal-title":"Acta Neuropsychiatrica"},{"issue":"1","key":"10.1016\/j.intimp.2023.111179_b0065","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1196\/annals.1304.024","article-title":"Harmane Induces Anxiolysis and Antidepressant-Like Effects in Rats","volume":"1009","author":"Aricioglu","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"7","key":"10.1016\/j.intimp.2023.111179_b0075","first-page":"645","article-title":"Impact of Fractionated Gentamicin Dosing on Induction of Nephrotoxicity: An Experimental Study in Rats","volume":"66","author":"Hanna","year":"2023","journal-title":"Egypt. J. Chem."},{"issue":"1","key":"10.1016\/j.intimp.2023.111179_b0080","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1177\/0960327116689716","article-title":"Protective effect of apocynin against gentamicin-induced nephrotoxicity in rats","volume":"37","author":"Abdelrahman","year":"2018","journal-title":"Hum. Exp. Toxicol."},{"issue":"1","key":"10.1016\/j.intimp.2023.111179_b0085","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1210\/edrv-9-1-57","article-title":"Cachectin (tumor necrosis factor): a macrophage hormone governing cellular metabolism and inflammatory response","volume":"9","author":"Beutler","year":"1988","journal-title":"Endocr. Rev."},{"issue":"1\u20132","key":"10.1016\/j.intimp.2023.111179_b0090","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0304-3940(94)90933-4","article-title":"Penetration of interleukin-6 across the murine blood-brain barrier","volume":"179","author":"Banks","year":"1994","journal-title":"Neurosci. Lett."},{"issue":"4","key":"10.1016\/j.intimp.2023.111179_b0095","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2\u2212 \u0394\u0394CT Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"2","key":"10.1016\/j.intimp.2023.111179_b0100","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jsps.2021.12.013","article-title":"Interference with megalin expression\/endocytic function by montelukast mitigates gentamicin nephrotoxicity: Downregulation of ClC-5 expression","volume":"30","author":"Azouz","year":"2022","journal-title":"Saudi Pharm. J."},{"issue":"1","key":"10.1016\/j.intimp.2023.111179_b0105","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1365-2621.1996.tb14713.x","article-title":"Proteins as potential endpoint temperature indicators for ground beef patties","volume":"61","author":"Wang","year":"1996","journal-title":"J. Food Sci."},{"issue":"9","key":"10.1016\/j.intimp.2023.111179_b0110","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.1073\/pnas.76.9.4350","article-title":"Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications","volume":"76","author":"Towbin","year":"1979","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.intimp.2023.111179_b0115","unstructured":"J.D. Bancroft, M. Gamble, Theory and practice of histological techniques, 6th ed, Elsevier health sciences, USA, 2008."},{"issue":"1","key":"10.1016\/j.intimp.2023.111179_b0120","doi-asserted-by":"crossref","first-page":"e0147255","DOI":"10.1371\/journal.pone.0147255","article-title":"Klotho and S100A8\/A9 as discriminative markers between pre-renal and intrinsic acute kidney injury","volume":"11","author":"Kim","year":"2016","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.intimp.2023.111179_b0125","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1177\/29.4.6166661","article-title":"Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures","volume":"29","author":"Hsu","year":"1981","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.intimp.2023.111179_b0130","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.toxrep.2018.11.015","article-title":"Gentamicin induced acute renal damage and its evaluation using urinary biomarkers in rats","volume":"6","author":"Udupa","year":"2019","journal-title":"Toxicol. Rep."},{"issue":"1","key":"10.1016\/j.intimp.2023.111179_b0135","doi-asserted-by":"crossref","first-page":"e13479","DOI":"10.1111\/apha.13479","article-title":"Biomarkers and predicting acute kidney injury","volume":"231","author":"Luft","year":"2021","journal-title":"Acta Physiol."},{"issue":"8","key":"10.1016\/j.intimp.2023.111179_b0140","doi-asserted-by":"crossref","first-page":"720","DOI":"10.3109\/15563650.2011.615319","article-title":"Earlier recognition of nephrotoxicity using novel biomarkers of acute kidney injury","volume":"49","author":"Waring","year":"2011","journal-title":"Clin. Toxicol."},{"issue":"9","key":"10.1016\/j.intimp.2023.111179_b0145","first-page":"189","article-title":"Imipramine accelerates nonalcoholic fatty liver disease, renal impairment, diabetic retinopathy, insulin resistance, and urinary chromium loss in obese mice","volume":"8","author":"Chang","year":"2021","journal-title":"Vet. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2023.111179_b0150","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s12550-019-00366-8","article-title":"Enniatin B 1-induced lysosomal membrane permeabilization in mouse embryonic fibroblasts","volume":"36","author":"Oliveira","year":"2020","journal-title":"Mycotoxin Res."},{"issue":"5\u20136","key":"10.1016\/j.intimp.2023.111179_b0155","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.mam.2006.08.005","article-title":"Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy","volume":"27","author":"Eskelinen","year":"2006","journal-title":"Mol. Aspects Med."},{"issue":"9","key":"10.1016\/j.intimp.2023.111179_b0160","doi-asserted-by":"crossref","first-page":"e0162977","DOI":"10.1371\/journal.pone.0162977","article-title":"Up-regulated expression of LAMP2 and autophagy activity during neuroendocrine differentiation of prostate cancer LNCaP cells","volume":"11","author":"Morell","year":"2016","journal-title":"PLoS One"},{"issue":"23","key":"10.1016\/j.intimp.2023.111179_b0165","doi-asserted-by":"crossref","first-page":"21295","DOI":"10.1074\/jbc.M212837200","article-title":"Inhibition of phosphatidylinositol 3-kinase sensitizes vascular endothelial cells to cytokine-initiated cathepsin-dependent apoptosis","volume":"278","author":"Madge","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.intimp.2023.111179_b0170","doi-asserted-by":"crossref","first-page":"e12609","DOI":"10.1111\/cpr.12609","article-title":"Inhibition of PI3K\/mTOR increased the sensitivity of hepatocellular carcinoma cells to cisplatin via interference with mitochondrial-lysosomal crosstalk","volume":"52","author":"Sheng","year":"2019","journal-title":"Cell Prolif."},{"issue":"1","key":"10.1016\/j.intimp.2023.111179_b0175","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s10495-007-0151-z","article-title":"Renal cell apoptosis induced by nephrotoxic drugs: cellular and molecular mechanisms and potential approaches to modulation","volume":"13","author":"Servais","year":"2008","journal-title":"Apoptosis"},{"issue":"9","key":"10.1016\/j.intimp.2023.111179_b0180","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1016\/j.freeradbiomed.2011.07.015","article-title":"Role of oxidative stress in lysosomal membrane permeabilization and apoptosis induced by gentamicin, an aminoglycoside antibiotic","volume":"51","author":"Denamur","year":"2011","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.intimp.2023.111179_b0185","doi-asserted-by":"crossref","first-page":"e0173771","DOI":"10.1371\/journal.pone.0173771","article-title":"Lysosomal adaptation: How cells respond to lysosomotropic compounds","volume":"12","author":"Lu","year":"2017","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.intimp.2023.111179_b0190","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.ajpath.2010.10.030","article-title":"Attenuation of the lysosomal death pathway by lysosomal cholesterol accumulation","volume":"178","author":"Appelqvist","year":"2011","journal-title":"Am. J. Pathol."},{"issue":"2","key":"10.1016\/j.intimp.2023.111179_b0195","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/s41419-019-1386-7","article-title":"Pasireotide protects mammalian cochlear hair cells from gentamicin ototoxicity by activating the PI3K\u2013Akt pathway","volume":"10","author":"Kucharava","year":"2019","journal-title":"Cell Death Dis."},{"issue":"2\u20133","key":"10.1016\/j.intimp.2023.111179_b0200","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.ejphar.2011.02.025","article-title":"Leptin reduces gentamicin-induced apoptosis in rat renal tubular cells via the PI3K-Akt signaling pathway","volume":"658","author":"Chen","year":"2011","journal-title":"Eur. J. Pharmacol."},{"issue":"11","key":"10.1016\/j.intimp.2023.111179_b0205","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1017\/S1461145714000534","article-title":"Differential effects of antidepressant drugs on mTOR signalling in rat hippocampal neurons","volume":"17","author":"Park","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.intimp.2023.111179_b0210","doi-asserted-by":"crossref","first-page":"27112","DOI":"10.1038\/srep27112","article-title":"Lysosomal protease cathepsin D; a new driver of apoptosis during acute kidney injury","volume":"6","author":"Cocchiaro","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2023.111179_b0215","first-page":"114","article-title":"The multifaceted role of the lysosomal protease cathepsins in kidney disease, Front Cell","volume":"5","author":"Cocchiaro","year":"2017","journal-title":"Dev. Biol."},{"key":"10.1016\/j.intimp.2023.111179_b0220","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3389\/fcimb.2017.00471","article-title":"Bid-induced release of AIF\/EndoG from mitochondria causes apoptosis of macrophages during infection with Leptospira interrogans","volume":"7","author":"Hu","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.intimp.2023.111179_b0225","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.freeradbiomed.2017.09.001","article-title":"The caspase-8\/Bid\/cytochrome c axis links signals from death receptors to mitochondrial reactive oxygen species production","volume":"112","author":"Kim","year":"2017","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.intimp.2023.111179_b0230","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.3892\/or.2017.5813","article-title":"Iodine-131 induces apoptosis in human cardiac muscle cells through the p53\/Bax\/caspase-3 and PIDD\/caspase-2\/t-BID\/cytochrome c\/caspase-3 signaling pathway","volume":"38","author":"Wang","year":"2017","journal-title":"Oncol. Rep."},{"issue":"2","key":"10.1016\/j.intimp.2023.111179_b0235","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1093\/toxsci\/kfq267","article-title":"An integrative overview on the mechanisms underlying the renal tubular cytotoxicity of gentamicin","volume":"119","author":"Quiros","year":"2011","journal-title":"Toxicol. Sci."},{"issue":"5","key":"10.1016\/j.intimp.2023.111179_b0240","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s10162-013-0404-1","article-title":"Bax, Bcl2, and p53 differentially regulate neomycin-and gentamicin-induced hair cell death in the zebrafish lateral line","volume":"14","author":"Coffin","year":"2013","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.intimp.2023.111179_b0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117760","article-title":"Ursodeoxycholic acid abrogates gentamicin-induced hepatotoxicity in rats: Role of NF-\u03baB-p65\/TNF-\u03b1, Bax\/Bcl-xl\/Caspase-3, and eNOS\/iNOS pathways","volume":"254","author":"Ali","year":"2020","journal-title":"Life Sci."},{"issue":"12","key":"10.1016\/j.intimp.2023.111179_b0250","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.bbalip.2011.09.005","article-title":"Complex modulation of peptidolytic activity of cathepsin D by sphingolipids","volume":"1811","author":"\u017debrakovsk\u00e1","year":"2011","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"issue":"19","key":"10.1016\/j.intimp.2023.111179_b0255","doi-asserted-by":"crossref","first-page":"10363","DOI":"10.3390\/ijms221910363","article-title":"Neuroprotective properties of kempferol derivatives from Maesa membranacea against oxidative stress-induced cell damage: An association with cathepsin D inhibition and PI3K\/Akt activation","volume":"22","author":"Jantas","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2023.111179_b0260","doi-asserted-by":"crossref","first-page":"148462","DOI":"10.1016\/j.brainres.2023.148462","article-title":"Dimethyl fumarate ameliorates Parkinsonian pathology by modulating autophagy and apoptosis via Nrf2-TIGAR-LAMP2\/Cathepsin D axis","volume":"1818","author":"Khot","year":"2023","journal-title":"Brain Res"},{"key":"10.1016\/j.intimp.2023.111179_b0265","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s43440-019-00009-w","article-title":"Neuroprotective effects of mirtazapine and imipramine and their effect in pro-and anti-apoptotic gene expression in human neuroblastoma cells","volume":"72","author":"Lieberknecht","year":"2020","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.intimp.2023.111179_b0270","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.3389\/fphar.2019.01687","article-title":"Imipramine and Venlafaxine Differentially Affect Primary Glial Cultures of Prenatally Stressed Rats","volume":"10","author":"Obuchowicz","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.intimp.2023.111179_b0275","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/hep.21285","article-title":"Critical role of acidic sphingomyelinase in murine hepatic ischemia-reperfusion injury","volume":"44","author":"Llacuna","year":"2006","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.intimp.2023.111179_b0280","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22254","article-title":"Candesartan and epigallocatechin-3-gallate ameliorate gentamicin-induced renal damage in rats through p38-MAPK and NF-\u03baB pathways","volume":"33","author":"Ahmed","year":"2019","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"5","key":"10.1016\/j.intimp.2023.111179_b0285","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1080\/08860220902835863","article-title":"Atorvastatin prevents gentamicin-induced renal damage in rats through the inhibition of p38-MAPK and NF-kB pathways","volume":"31","author":"Ozbek","year":"2009","journal-title":"Ren. Fail."},{"key":"10.1016\/j.intimp.2023.111179_b0290","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/j.biopha.2018.07.066","article-title":"Protective effect of Rotula aquatica Lour against gentamicin induced oxidative stress and nephrotoxicity in Wistar rats","volume":"106","author":"Vysakh","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2023.111179_b0295","doi-asserted-by":"crossref","first-page":"6670007","DOI":"10.1155\/2021\/6670007","article-title":"D-Limonene Alleviates Acute Kidney Injury Following Gentamicin Administration in Rats: Role of NF-\u03baB Pathway, Mitochondrial Apoptosis, Oxidative Stress, and PCNA","volume":"2021","author":"Babaeenezhad","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"issue":"7","key":"10.1016\/j.intimp.2023.111179_b0300","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.3390\/ijms21072346","article-title":"Understanding MAPK signaling pathways in apoptosis","volume":"21","author":"Yue","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.intimp.2023.111179_b0305","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.neuropharm.2008.06.045","article-title":"Inhibition of glial inflammatory activation and neurotoxicity by tricyclic antidepressants","volume":"55","author":"Hwang","year":"2008","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/j.intimp.2023.111179_b0310","first-page":"185","article-title":"Non-antibiotic compounds affecting the growth of urinary pathogens during urine culture: a preliminary in vitro study","volume":"90","author":"Gajd\u00e1cs","year":"2020","journal-title":"Acta Pharm. Hung."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923015059?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923015059?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T18:13:09Z","timestamp":1761588789000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576923015059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":61,"alternative-id":["S1567576923015059"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2023.111179","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lysosomal membrane stabilization by imipramine attenuates gentamicin-induced renal injury: Enhanced LAMP2 expression, down-regulation of cytoplasmic cathepsin D and tBid\/cytochrome c\/cleaved caspase-3 apoptotic signaling","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2023.111179","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111179"}}