{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T18:09:49Z","timestamp":1761588589055,"version":"build-2065373602"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873099","82374181"],"award-info":[{"award-number":["81873099","82374181"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.intimp.2023.111206","type":"journal-article","created":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T04:54:02Z","timestamp":1699678442000},"page":"111206","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"PB","title":["Triptolide attenuates CCL4-induced liver fibrosis by regulating the differentiation of CD4+ T cells in mice"],"prefix":"10.1016","volume":"125","author":[{"given":"Shiyuan","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9805-0353","authenticated-orcid":false,"given":"Jing","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanling","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingwei","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueming","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Lian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8864-0621","authenticated-orcid":false,"given":"Jian","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2023.111206_b0005","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.biopha.2018.05.088","article-title":"Broad targeting of triptolide to resistance and sensitization for cancer therapy","volume":"104","author":"Hou","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"15","key":"10.1016\/j.intimp.2023.111206_b0010","doi-asserted-by":"crossref","first-page":"7199","DOI":"10.7150\/thno.57745","article-title":"Triptolide: pharmacological spectrum, biosynthesis, chemical synthesis and derivatives","volume":"11","author":"Gao","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.intimp.2023.111206_b0015","article-title":"Friend or foe? The dual role of triptolide in the liver","volume":"161","author":"Jiang","year":"2023","journal-title":"kidney, and heart, Biomed Pharmacother"},{"key":"10.1016\/j.intimp.2023.111206_b0020","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.biopha.2017.04.003","article-title":"Toxicity of triptolide and the molecular mechanisms involved","volume":"90","author":"Xi","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"10","key":"10.1016\/j.intimp.2023.111206_b0025","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/j.intimp.2011.05.015","article-title":"Triptolide protects mice from ischemia\/reperfusion injury by inhibition of IL-17 production","volume":"11","author":"Wu","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2023.111206_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153739","article-title":"Activation of AMPK by triptolide alleviates nonalcoholic fatty liver disease by improving hepatic lipid metabolism, inflammation and fibrosis","volume":"92","author":"Huang","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2023.111206_b0035","doi-asserted-by":"crossref","first-page":"1032722","DOI":"10.3389\/fnut.2022.1032722","article-title":"Triptolide increases resistance to bile duct ligation-induced liver injury and fibrosis in mice by inhibiting RELB","volume":"9","author":"Yuan","year":"2022","journal-title":"Front. Nutr."},{"issue":"7","key":"10.1016\/j.intimp.2023.111206_b0040","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1002\/ptr.3381","article-title":"Antifibrotic effects of triptolide on hepatic stellate cells and dimethylnitrosamine-intoxicated rats","volume":"25","author":"Chong","year":"2011","journal-title":"Phytother. Res."},{"issue":"4","key":"10.1016\/j.intimp.2023.111206_b0045","doi-asserted-by":"crossref","DOI":"10.3390\/cells9040875","article-title":"Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives","volume":"9","author":"Roehlen","year":"2020","journal-title":"Cells"},{"issue":"10308","key":"10.1016\/j.intimp.2023.111206_b0050","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/S0140-6736(21)01374-X","article-title":"Liver cirrhosis","volume":"398","author":"Gin\u00e8s","year":"2021","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.intimp.2023.111206_b0055","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jhep.2018.09.014","article-title":"Burden of liver diseases in the world","volume":"70","author":"Asrani","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.intimp.2023.111206_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112442","article-title":"Advances in anti hepatic fibrotic therapy with Traditional Chinese Medicine herbal formula","volume":"251","author":"Li","year":"2020","journal-title":"J. Ethnopharmacol."},{"issue":"9","key":"10.1016\/j.intimp.2023.111206_b0065","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1007\/s40265-019-01126-9","article-title":"Fibrosis in Chronic Liver Disease: An Update on Diagnostic and Treatment Modalities","volume":"79","author":"Manka","year":"2019","journal-title":"Drugs"},{"key":"10.1016\/j.intimp.2023.111206_b0070","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.mam.2018.09.002","article-title":"Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues","volume":"65","author":"Parola","year":"2019","journal-title":"Mol. Aspects Med."},{"issue":"3","key":"10.1016\/j.intimp.2023.111206_b0075","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nri3623","article-title":"Liver fibrosis and repair: immune regulation of wound healing in a solid organ","volume":"14","author":"Pellicoro","year":"2014","journal-title":"Nat. Rev. Immunol."},{"issue":"8","key":"10.1016\/j.intimp.2023.111206_b0080","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nri1412","article-title":"Fibrotic disease and the T(H)1\/T(H)2 paradigm","volume":"4","author":"Wynn","year":"2004","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2023.111206_b0085","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/nri.2017.90","article-title":"Type 2 immunity in tissue repair and fibrosis","volume":"18","author":"Gieseck","year":"2018","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2023.111206_b0090","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2012.05.049","article-title":"Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice","volume":"143","author":"Meng","year":"2012","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.intimp.2023.111206_b0095","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.4049\/jimmunol.1203013","article-title":"IL-17A plays a critical role in the pathogenesis of liver fibrosis through hepatic stellate cell activation","volume":"191","author":"Tan","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2023.111206_b0100","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.3389\/fimmu.2020.01142","article-title":"T Cells in Fibrosis and Fibrotic Diseases","volume":"11","author":"Zhang","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2023.111206_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2022.105389","article-title":"Network pharmacology prediction and molecular docking-based strategy to explore the potential mechanism of Huanglian Jiedu Decoction against sepsis","volume":"144","author":"Li","year":"2022","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.intimp.2023.111206_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153837","article-title":"Network pharmacology to unveil the mechanism of Moluodan in the treatment of chronic atrophic gastritis","volume":"95","author":"Zhou","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2023.111206_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.131755","article-title":"Integrated network pharmacology and cellular assay for the investigation of an anti-obesity effect of 6-shogaol","volume":"374","author":"Jiao","year":"2022","journal-title":"Food Chem."},{"key":"10.1016\/j.intimp.2023.111206_b0120","article-title":"Ferulic Acid Ameliorates Hepatic Inflammation and Fibrotic Liver Injury by Inhibiting PTP1B Activity and Subsequent Promoting AMPK Phosphorylation","volume":"12","author":"Wu","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2023.111206_b0125","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/s12906-018-2276-8","article-title":"Protective effects of Liuweiwuling tablets on carbon tetrachloride-induced hepatic fibrosis in rats","volume":"18","author":"Liu","year":"2018","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.intimp.2023.111206_b0130","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.intimp.2019.01.005","article-title":"Dual effect of T helper cell 17 (Th17) and regulatory T cell (Treg) in liver pathological process: From occurrence to end stage of disease","volume":"69","author":"Zhang","year":"2019","journal-title":"Int. Immunopharmacol."},{"issue":"4","key":"10.1016\/j.intimp.2023.111206_b0135","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/cmi.2011.53","article-title":"Liver fibrosis: mechanisms of immune-mediated liver injury","volume":"9","author":"Xu","year":"2012","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.intimp.2023.111206_b0140","article-title":"Salvianolic acid B inhibits autophagy and activation of hepatic stellate cells induced by TGF-\u03b21 by downregulating the MAPK pathway","volume":"13","author":"Jiang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2023.111206_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116881","article-title":"Salvianolic acid B exerts anti-liver fibrosis effects via inhibition of MAPK-mediated phospho-Smad2\/3 at linker regions in vivo and in vitro","volume":"239","author":"Wu","year":"2019","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.intimp.2023.111206_b0150","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/bcpt.13880","article-title":"Triptolide alleviates collagen-induced arthritis in mice by modulating Treg\/Th17 imbalance through the JAK\/PTEN-STAT3 pathway","volume":"133","author":"Huang","year":"2023","journal-title":"Basic Clin. Paharmacol. Toxicol."},{"issue":"6","key":"10.1016\/j.intimp.2023.111206_b0155","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.apsb.2015.09.006","article-title":"Pharmacokinetic and pharmacodynamic study of triptolide-loaded liposome hydrogel patch under microneedles on rats with collagen-induced arthritis","volume":"5","author":"Chen","year":"2015","journal-title":"Acta Pharm. Sin. B"},{"issue":"4","key":"10.1016\/j.intimp.2023.111206_b0160","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1365-3083.2008.02147.x","article-title":"Triptolide inhibits the differentiation of Th17 cells and suppresses collagen-induced arthritis","volume":"68","author":"Wang","year":"2008","journal-title":"Scand. J. Immunol."},{"issue":"6","key":"10.1016\/j.intimp.2023.111206_b0165","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1055\/s-0042-106083","article-title":"Triptolide Improves Diabetic Nephropathy by Regulating Th Cell Balance and Macrophage Infiltration in Rat Models of Diabetic Nephropathy","volume":"124","author":"Guo","year":"2016","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.intimp.2023.111206_b0170","doi-asserted-by":"crossref","first-page":"7468396","DOI":"10.1155\/2022\/7468396","article-title":"Triptolide Inhibits Th17 Response by Upregulating microRNA-204-5p and Suppressing STAT3 Phosphorylation in Psoriasis","volume":"2022","author":"He","year":"2022","journal-title":"Genet Res (Camb)"},{"issue":"4","key":"10.1016\/j.intimp.2023.111206_b0175","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.intimp.2012.09.016","article-title":"Triptolide attenuates idiopathic pneumonia syndrome in a mouse bone marrow transplantation model by down-regulation of IL-17","volume":"14","author":"Xu","year":"2012","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2023.111206_b0180","article-title":"CD4+ T cell activation and inflammation in NASH-related fibrosis","volume":"13","author":"Zhou","year":"2022","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.intimp.2023.111206_b0185","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1002\/hep.21419","article-title":"STAT1 inhibits liver fibrosis in mice by inhibiting stellate cell proliferation and stimulating NK cell cytotoxicity","volume":"44","author":"Jeong","year":"2006","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.intimp.2023.111206_b0190","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1136\/gutjnl-2011-300608","article-title":"Bone marrow transplantation improves hepatic fibrosis in Abcb4-\/- mice via Th1 response and matrix metalloproteinase activity","volume":"61","author":"Roderfeld","year":"2012","journal-title":"Gut"},{"issue":"3","key":"10.1016\/j.intimp.2023.111206_b0195","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s10875-011-9635-2","article-title":"The role of innate cells is coupled to a Th1-polarized immune response in pediatric nonalcoholic steatohepatitis","volume":"32","author":"Ferreyra Solari","year":"2012","journal-title":"J. Clin. Immunol."},{"issue":"6","key":"10.1016\/j.intimp.2023.111206_b0200","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1007\/s10875-011-9571-1","article-title":"Altered phenotype and functionality of circulating immune cells characterize adult patients with nonalcoholic steatohepatitis","volume":"31","author":"Inzaugarat","year":"2011","journal-title":"J. Clin. Immunol."},{"issue":"12","key":"10.1016\/j.intimp.2023.111206_b0205","doi-asserted-by":"crossref","first-page":"G891","DOI":"10.1152\/ajpgi.00193.2013","article-title":"IFN-\u03b3 deficiency attenuates hepatic inflammation and fibrosis in a steatohepatitis model induced by a methionine- and choline-deficient high-fat diet","volume":"305","author":"Luo","year":"2013","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.intimp.2023.111206_b0210","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev-immunol-061020-053702","article-title":"Cytokine Regulation and Function in T Cells","volume":"39","author":"Dong","year":"2021","journal-title":"Annu. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2023.111206_b0215","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.1501175","article-title":"Progression from Nonalcoholic Fatty Liver to Nonalcoholic Steatohepatitis Is Marked by a Higher Frequency of Th17 Cells in the Liver and an Increased Th17\/Resting Regulatory T Cell Ratio in Peripheral Blood and in the Liver","volume":"196","author":"Rau","year":"2016","journal-title":"J. Immunol."},{"issue":"7","key":"10.1016\/j.intimp.2023.111206_b0220","doi-asserted-by":"crossref","first-page":"4656","DOI":"10.4049\/jimmunol.181.7.4656","article-title":"Novel role of IL-13 in fibrosis induced by nonalcoholic steatohepatitis and its amelioration by IL-13R-directed cytotoxin in a rat model","volume":"181","author":"Shimamura","year":"2008","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.intimp.2023.111206_b0225","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1172\/JCI7325","article-title":"An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response","volume":"104","author":"Chiaramonte","year":"1999","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.intimp.2023.111206_b0230","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.clinre.2016.12.004","article-title":"Th17\/Treg imbalance is an indicator of liver cirrhosis process and a risk factor for HCC occurrence in HBV patients","volume":"41","author":"Li","year":"2017","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"issue":"4","key":"10.1016\/j.intimp.2023.111206_b0235","first-page":"2963","article-title":"Changes of Th17\/Treg ratio in the transition of chronic hepatitis B to liver cirrhosis and correlations with liver function and inflammation","volume":"17","author":"Mou","year":"2019","journal-title":"Exp. Ther. Med."},{"issue":"8","key":"10.1016\/j.intimp.2023.111206_b0240","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.3748\/wjg.v20.i8.2062","article-title":"Impaired balance of T helper 17\/T regulatory cells in carbon tetrachloride-induced liver fibrosis in mice","volume":"20","author":"Sun","year":"2014","journal-title":"World J. Gastroenterol."},{"issue":"2","key":"10.1016\/j.intimp.2023.111206_b0245","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.3892\/mmr.2016.5392","article-title":"Rapamycin ameliorates CCl4-induced liver fibrosis in mice through reciprocal regulation of the Th17\/Treg cell balance","volume":"14","author":"Gu","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.intimp.2023.111206_b0250","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1746-1596-8-40","article-title":"Expression of interleukin-17 associated with disease progression and liver fibrosis with hepatitis B virus infection: IL-17 in HBV infection","volume":"8","author":"Du","year":"2013","journal-title":"Diagn. Pathol."},{"issue":"2","key":"10.1016\/j.intimp.2023.111206_b0255","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/hep.22680","article-title":"The interleukin-17 pathway is involved in human alcoholic liver disease","volume":"49","author":"Lemmers","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2023.111206_b0260","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.584048","article-title":"Foxp3+ Regulatory T Cells Inhibit CCl4-Induced Liver Inflammation and Fibrosis by Regulating Tissue Cellular Immunity","volume":"11","author":"Ikeno","year":"2020","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2023.111206_b0265","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.4049\/jimmunol.1004077","article-title":"Obstructive jaundice expands intrahepatic regulatory T cells, which impair liver T lymphocyte function but modulate liver cholestasis and fibrosis","volume":"187","author":"Katz","year":"2011","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2023.111206_b0270","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41420-023-01347-8","article-title":"Regulatory T cells (Tregs) in liver fibrosis","volume":"9","author":"Wu","year":"2023","journal-title":"Cell Death Discov"},{"issue":"1","key":"10.1016\/j.intimp.2023.111206_b0275","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.intimp.2011.11.010","article-title":"Ex vivo induced regulatory T cells regulate inflammatory response of Kupffer cells by TGF-beta and attenuate liver ischemia reperfusion injury","volume":"12","author":"Feng","year":"2012","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2023.111206_b0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellimm.2020.104251","article-title":"Role of orally induced regulatory T cells in immunotherapy and tolerance","volume":"359","author":"Bertolini","year":"2021","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.intimp.2023.111206_b0285","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.matbio.2015.01.004","article-title":"Matrix metalloproteinases in liver injury, repair and fibrosis","volume":"44\u201346","author":"Duarte","year":"2015","journal-title":"Matrix Biol."},{"issue":"2","key":"10.1016\/j.intimp.2023.111206_b0290","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.jhep.2014.08.038","article-title":"Regulatory CD4+ T cells modulate the interaction between NK cells and hepatic stellate cells by acting on either cell type","volume":"62","author":"Langhans","year":"2015","journal-title":"J. Hepatol."},{"issue":"6","key":"10.1016\/j.intimp.2023.111206_b0295","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1158\/0008-5472.CAN-04-3232","article-title":"Increased populations of regulatory T cells in peripheral blood of patients with hepatocellular carcinoma","volume":"65","author":"Ormandy","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.intimp.2023.111206_b0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115422","article-title":"Th17\/Treg imbalance mediates hepatic intolerance to exogenous lipopolysaccharide and exacerbates liver injury in triptolide induced excessive immune response","volume":"295","author":"Zhang","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2023.111206_b0305","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.intimp.2017.09.026","article-title":"Quercetin protects mouse liver against triptolide-induced hepatic injury by restoring Th17\/Treg balance through Tim-3 and TLR4-MyD88-NF-\u03baB pathway","volume":"53","author":"Wei","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2023.111206_b0310","doi-asserted-by":"crossref","first-page":"18694","DOI":"10.1038\/srep18694","article-title":"A deleterious role for Th9\/IL-9 in hepatic fibrogenesis","volume":"6","author":"Qin","year":"2016","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.intimp.2023.111206_b0315","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1111\/liv.15612","article-title":"Double-negative T cells regulate the progression of liver fibrosis through Th9 cells differentiation","volume":"43","author":"Han","year":"2023","journal-title":"Liver Int."},{"issue":"6","key":"10.1016\/j.intimp.2023.111206_b0320","doi-asserted-by":"crossref","first-page":"765","DOI":"10.17219\/acem\/94062","article-title":"The clinical significance of intrahepatic Th22 cells in liver cirrhosis","volume":"28","author":"Qin","year":"2019","journal-title":"Adv. Clin. Exp. Med."},{"issue":"4","key":"10.1016\/j.intimp.2023.111206_b0325","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1111\/jgh.14866","article-title":"CXCR5+ CD4+ T cell subsets and their relationship to immune dysfunction in chronic hepatitis B-associated liver cirrhosis","volume":"35","author":"Zhao","year":"2020","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"2","key":"10.1016\/j.intimp.2023.111206_b0330","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/hep.27306","article-title":"CXCR5+ CD4+ T follicular helper cells participate in the pathogenesis of primary biliary cirrhosis","volume":"61","author":"Wang","year":"2015","journal-title":"Hepatology"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923015333?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923015333?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T18:04:53Z","timestamp":1761588293000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576923015333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":66,"alternative-id":["S1567576923015333"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2023.111206","relation":{},"ISSN":["1567-5769"],"issn-type":[{"type":"print","value":"1567-5769"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Triptolide attenuates CCL4-induced liver fibrosis by regulating the differentiation of CD4+ T cells in mice","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2023.111206","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111206"}}