{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:24:49Z","timestamp":1786991089567,"version":"build-2736575974"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A201720"],"award-info":[{"award-number":["U22A201720"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018617","name":"xing liao yingcai jihua","doi-asserted-by":"publisher","award":["XLYC2002062"],"award-info":[{"award-number":["XLYC2002062"]}],"id":[{"id":"10.13039\/501100018617","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.intimp.2023.111282","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:42:30Z","timestamp":1701823350000},"page":"111282","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["SLAMF3 promotes Th17 differentiation and is reversed by iguratimod through JAK1\/STAT3 pathway in primary Sj\u00f6gren's syndrome"],"prefix":"10.1016","volume":"126","author":[{"given":"Peini","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunshu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haining","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingting","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.intimp.2023.111282_b0005","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.jaut.2009.10.004","article-title":"Characteristics of the minor salivary gland infiltrates in Sj\u00f6gren\u2019s syndrome","volume":"34","author":"Christodoulou","year":"2010","journal-title":"J. Autoimmun."},{"issue":"4","key":"10.1016\/j.intimp.2023.111282_b0010","first-page":"3","article-title":"One year in review 2020: pathogenesis of primary Sj\u00f6gren\u2019s syndrome","volume":"38","author":"Bombardieri","year":"2020","journal-title":"Clin. Exp. Rheumatol."},{"issue":"4","key":"10.1016\/j.intimp.2023.111282_b0015","first-page":"103","article-title":"Primary Sj\u00f6gren\u2019s syndrome: central and peripheral nervous system involvements","volume":"38","author":"Mekinian","year":"2020","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.intimp.2023.111282_b0020","first-page":"13","article-title":"Th17 cells in primary Sj\u00f6gren\u2019s syndrome negatively correlate with increased Roseburia and Coprococcus","author":"Xin","year":"2022","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2023.111282_b0025","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.2353\/ajpath.2009.090319","article-title":"Systemic and local interleukin-17 and linked cytokines associated with Sj\u00f6gren\u2019s syndrome immunopathogenesis","volume":"175","author":"Katsifis","year":"2009","journal-title":"Am. J. Pathol."},{"issue":"11","key":"10.1016\/j.intimp.2023.111282_b0030","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1084\/jem.20110462","article-title":"The Th17 immune response is controlled by the Rel-ROR\u03b3-ROR\u03b3 T transcriptional axis","volume":"208","author":"Ruan","year":"2011","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.intimp.2023.111282_b0035","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jaut.2017.11.003","article-title":"Th17 cells in primary Sj\u00f6gren\u2019s syndrome: Pathogenicity and plasticity","volume":"87","author":"Verstappen","year":"2018","journal-title":"J. Autoimmun."},{"issue":"4","key":"10.1016\/j.intimp.2023.111282_b0040","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1167\/iovs.14-15668","article-title":"Age-related conjunctival disease in the C57BL\/6.NOD-Aec1Aec2 mouse model of Sj\u00f6gren syndrome develops independent of lacrimal dysfunction","volume":"56","author":"You","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"7","key":"10.1016\/j.intimp.2023.111282_b0045","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.autrev.2018.01.018","article-title":"The SLAM family receptors: potential therapeutic targets for inflammatory and autoimmune diseases","volume":"17","author":"Dragovich","year":"2018","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.intimp.2023.111282_b0050","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.coi.2015.11.003","article-title":"SLAM family receptors in normal immunity and immune pathologies","volume":"38","author":"Wu","year":"2016","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.intimp.2023.111282_b0055","doi-asserted-by":"crossref","unstructured":"de Salort J, Cuenca M, Terhorst C, Engel P, Romero X. Ly9 (CD229) cell-surface receptor is crucial for the development of spontaneous autoantibody production to nuclear antigens. Front Immunol. 2013;4(JUL):1-12. 10.3389\/fimmu.2013.00225.","DOI":"10.3389\/fimmu.2013.00225"},{"issue":"11","key":"10.1016\/j.intimp.2023.111282_b0060","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.autrev.2012.02.010","article-title":"Slam-associated protein plays a key role in development of autoimmunity","volume":"11","author":"Sawada","year":"2012","journal-title":"Autoimmun. Rev."},{"issue":"1","key":"10.1016\/j.intimp.2023.111282_b0065","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1749-6632.2010.05824.x","article-title":"The role of SAP and SLAM family molecules in the humoral immune response","volume":"1217","author":"Ma","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"6","key":"10.1016\/j.intimp.2023.111282_b0070","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.4049\/jimmunol.1301022","article-title":"Systemic lupus erythematosus immune complexes increase the expression of SLAM family members CD319 (CRACC) and CD229 (LY-9) on plasmacytoid dendritic cells and CD319 on CD56 dim NK cells","volume":"191","author":"Hagberg","year":"2013","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2023.111282_b0075","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.4049\/jimmunol.1102773","article-title":"Increased expression of SLAM receptors SLAMF3 and SLAMF6 in systemic lupus erythematosus T lymphocytes promotes Th17 differentiation","volume":"188","author":"Chatterjee","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2023.111282_b0080","doi-asserted-by":"crossref","unstructured":"Ishibashi M, Takahashi R, Tsubota A, et al. SLAMF3-Mediated Signaling via ERK Pathway Activation Promotes Aggressive Phenotypic Behaviors in Multiple Myeloma. Published online 2020:1-13. 10.1158\/1541-7786.MCR-19-0391.","DOI":"10.1158\/1541-7786.MCR-19-0391"},{"issue":"8","key":"10.1016\/j.intimp.2023.111282_b0085","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-019-1791-y","article-title":"Upregulation of SLAMF3 on human T cells is induced by palmitic acid through the STAT5-PI3K\/Akt pathway and features the chronic inflammatory profiles of type 2 diabetes","volume":"10","author":"Zhou","year":"2019","journal-title":"Cell Death Dis."},{"issue":"12","key":"10.1016\/j.intimp.2023.111282_b0090","doi-asserted-by":"crossref","first-page":"5841","DOI":"10.4049\/jimmunol.1301435","article-title":"SLAM\u2013SAP signaling promotes differentiation of IL-17\u2013producing T cells and progression of experimental autoimmune encephalomyelitis","volume":"193","author":"Huang","year":"2014","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.intimp.2023.111282_b0095","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.4049\/jimmunol.1901082","article-title":"Critical role for SLAM\/SAP signaling in the thymic developmental programming of IL-17\u2013 and IFN-\u03b3\u2013producing \u03b3\u03b4 T cells","volume":"204","author":"Dienz","year":"2020","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2023.111282_b0100","doi-asserted-by":"crossref","unstructured":"Pu\u00f1et-Ortiz J, Moya MS, Cuenca M, Caleiras E, Lazaro A, Engel P. Ly9 (CD229) antibody targeting depletes marginal zone and germinal center b cells in lymphoid tissues and reduces salivary gland inflammation in a mouse model of sj\u00f6gren\u2019s syndrome. Front Immunol. 2018;9(NOV). 10.3389\/fimmu.2018.02661.","DOI":"10.3389\/fimmu.2018.02661"},{"key":"10.1016\/j.intimp.2023.111282_b0105","doi-asserted-by":"crossref","unstructured":"Jiang X pei, Huang X lin, Yang Z peng, et al. Iguratimod ameliorates inflammatory responses by modulating the Th17\/Treg paradigm in dextran sulphate sodium-induced murine colitis. Mol Immunol. 2018;93:9-19. 10.1016\/J.MOLIMM.2017.10.008.","DOI":"10.1016\/j.molimm.2017.10.008"},{"issue":"1","key":"10.1016\/j.intimp.2023.111282_b0110","doi-asserted-by":"crossref","first-page":"291","DOI":"10.4049\/jimmunol.176.1.291","article-title":"Ly9 (CD229)-deficient mice exhibit T cell defects yet do not share several phenotypic characteristics associated with SLAM- and SAP-deficient mice","volume":"176","author":"Graham","year":"2006","journal-title":"J. Immunol."},{"issue":"7","key":"10.1016\/j.intimp.2023.111282_b0115","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1093\/rheumatology\/kex078","article-title":"Altered expression of signalling lymphocyte activation molecule receptors in T-cells from lupus nephritis patients-A potential biomarker of disease activity","volume":"56","author":"Stratigou","year":"2017","journal-title":"Rheumatology (United Kingdom)"},{"issue":"1","key":"10.1016\/j.intimp.2023.111282_b0120","article-title":"Artesunate suppresses Th17 response via inhibiting IRF4-mediated glycolysis and ameliorates Sjog\u0308ren\u2019s syndrome","volume":"7","author":"Xiao","year":"2022","journal-title":"Signal. Transduct. Target Ther."},{"issue":"10","key":"10.1016\/j.intimp.2023.111282_b0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0186073","article-title":"Expression patterns of signaling lymphocytic activation molecule family members in peripheral blood mononuclear cell subsets in patients with systemic lupus erythematosus","volume":"12","author":"Karampetsou","year":"2017","journal-title":"PLoS One"},{"issue":"45","key":"10.1016\/j.intimp.2023.111282_b0130","doi-asserted-by":"crossref","first-page":"38168","DOI":"10.1074\/jbc.M112.415067","article-title":"CD3-T cell receptor co-stimulation through SLAMF3 and SLAMF6 receptors enhances ROR\u03b3t recruitment to the IL17A promoter in human T lymphocytes","volume":"287","author":"Chatterjee","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2023.111282_b0135","doi-asserted-by":"crossref","unstructured":"Pincus SH, Stackhouse M, Watt C, et al. Soluble CD4 and low molecular weight CD4-mimetic compounds sensitize cells to be killed by anti-HIV cytotoxic immunoconjugates. Kirchhoff F, ed. J Virol. 2023;97(10). 10.1128\/JVI.01154-23.","DOI":"10.1128\/jvi.01154-23"},{"issue":"1","key":"10.1016\/j.intimp.2023.111282_b0140","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19010239","article-title":"Implication of soluble forms of cell adhesion molecules in infectious disease and tumor: Insights from transgenic animal models","volume":"19","author":"Ono","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.intimp.2023.111282_b0145","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1007\/s10792-020-01490-6","article-title":"The efficacy and mechanism for action of iguratimod in primary Sj\u00f6gren\u2019s syndrome patients","volume":"40","author":"Jiang","year":"2020","journal-title":"Int. Ophthalmol."},{"key":"10.1016\/j.intimp.2023.111282_b0150","first-page":"13","article-title":"A systematic review and meta-analysis of 19 randomized controlled trials of iguratimod combined with other therapies for Sjogren\u2019s syndrome","author":"Zeng","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2023.111282_b0155","unstructured":"Wen L, Jiang W, Zhou M, Wu Z. Original Article Effect of Combined Application of Iguratimod in the Treatment of Active Rheumatoid Arthritis on Bone Metabolism, Th17 Cells and Treg Cells. Vol 13.; 2021. www.ajtr.org."},{"key":"10.1016\/j.intimp.2023.111282_b0160","first-page":"96","article-title":"Iguratimod ameliorates nephritis by modulating the Th17\/Treg paradigm in pristane-induced lupus","author":"Xia","year":"2021","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2023.111282_b0165","doi-asserted-by":"crossref","DOI":"10.1186\/s13075-023-03109-4","article-title":"Iguratimod suppresses Tfh cell differentiation in primary Sj\u00f6gren\u2019s syndrome patients through inhibiting Akt\/mTOR\/STAT3 signaling","volume":"25","author":"Lyu","year":"2023","journal-title":"Arthritis Res. Ther."},{"issue":"1","key":"10.1016\/j.intimp.2023.111282_b0170","article-title":"Effects of iguratimod on inflammatory factors and apoptosis of submandibular gland epithelial cells in NOD mice","volume":"13","author":"Wang","year":"2023","journal-title":"Sci. Rep."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923016090?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923016090?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T18:09:23Z","timestamp":1761588563000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576923016090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":34,"alternative-id":["S1567576923016090"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2023.111282","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SLAMF3 promotes Th17 differentiation and is reversed by iguratimod through JAK1\/STAT3 pathway in primary Sj\u00f6gren's syndrome","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2023.111282","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111282"}}