{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:01:03Z","timestamp":1791313263616,"version":"4.3.1"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272231"],"award-info":[{"award-number":["82272231"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2501800"],"award-info":[{"award-number":["2021YFC2501800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.intimp.2023.111284","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T13:45:36Z","timestamp":1701092736000},"page":"111284","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Esketamine mitigates cognitive impairment following exposure to LPS by modulating the intestinal flora\/subdiaphragmatic vagus nerve\/spleen axis"],"prefix":"10.1016","volume":"126","author":[{"given":"Yuming","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangzhi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6415-1604","authenticated-orcid":false,"given":"Shiying","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2023.111284_b0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2013.09.015","article-title":"Endotoxin-induced experimental systemic inflammation in humans: a model to disentangle immune-to-brain communication","volume":"35","author":"Schedlowski","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.intimp.2023.111284_b0010","doi-asserted-by":"crossref","first-page":"5681","DOI":"10.1523\/JNEUROSCI.2876-19.2020","article-title":"Acute inflammation alters brain energy metabolism in mice and humans: role in suppressed spontaneous activity, impaired cognition, and delirium","volume":"40","author":"Kealy","year":"2020","journal-title":"J. Neurosci."},{"key":"10.1016\/j.intimp.2023.111284_b0015","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1038\/npp.2017.231","article-title":"Effort but not reward sensitivity is altered by acute sickness induced by experimental endotoxemia in humans","volume":"43","author":"Draper","year":"2018","journal-title":"Neuropsychopharmacology."},{"key":"10.1016\/j.intimp.2023.111284_b0020","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.3389\/fnins.2019.01340","article-title":"Microglial ultrastructure in the hippocampus of a lipopolysaccharide-induced sickness mouse model","volume":"13","author":"Savage","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.intimp.2023.111284_b0025","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.neurobiolaging.2010.04.002","article-title":"Systemic inflammation induces acute working memory deficits in the primed brain: relevance for delirium","volume":"33","author":"Murray","year":"2012","journal-title":"Neurobiol. Aging."},{"key":"10.1016\/j.intimp.2023.111284_b0030","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s41380-018-0076-7","article-title":"Leucine competes with kynurenine for blood-to-brain transport and prevents lipopolysaccharide-induced depression-like behavior in mice","volume":"24","author":"Walker","year":"2019","journal-title":"Mol. Psychiatry."},{"key":"10.1016\/j.intimp.2023.111284_b0035","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.bbi.2008.05.007","article-title":"Malaise in the water maze: untangling the effects of lps and il-1beta on learning and memory","volume":"22","author":"Cunningham","year":"2008","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.intimp.2023.111284_b0040","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1038\/s41380-019-0403-7","article-title":"Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable il-1-dependent mechanisms","volume":"24","author":"Skelly","year":"2019","journal-title":"Mol. Psychiatry."},{"key":"10.1016\/j.intimp.2023.111284_b0045","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s12974-015-0394-5","article-title":"Il-17a is implicated in lipopolysaccharide-induced neuroinflammation and cognitive impairment in aged rats via microglial activation","volume":"12","author":"Sun","year":"2015","journal-title":"J. Neuroinflammation."},{"key":"10.1016\/j.intimp.2023.111284_b0050","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1001\/jama.2016.2691","article-title":"Incidence, risk factors, and attributable mortality of secondary infections in the intensive care unit after admission for sepsis","volume":"315","author":"van Vught","year":"2016","journal-title":"Jama."},{"key":"10.1016\/j.intimp.2023.111284_b0055","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.immuni.2017.06.021","article-title":"Local modulation of antigen-presenting cell development after resolution of pneumonia induces long-term susceptibility to secondary infections","volume":"47","author":"Roquilly","year":"2017","journal-title":"Immunity."},{"key":"10.1016\/j.intimp.2023.111284_b0060","doi-asserted-by":"crossref","unstructured":"N. Nikkheslat, Targeting inflammation in depression: Ketamine as an anti-inflammatory antidepressant in psychiatric emergency, Brain Behav. Immun. Health. 18 (2021) 100383. 10.1016\/j.bbih.2021.100383. eCollection 2021 Dec.","DOI":"10.1016\/j.bbih.2021.100383"},{"issue":"2","key":"10.1016\/j.intimp.2023.111284_b0065","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1093\/bja\/aeq341","article-title":"Continuous S-(+)-ketamine administration during elective coronary artery bypass graft surgery attenuates pro-inflammatory cytokine response during and after cardiopulmonary bypass","volume":"106","author":"Welters","year":"2011","journal-title":"Br. J. Anaesth."},{"issue":"2","key":"10.1016\/j.intimp.2023.111284_b0070","doi-asserted-by":"crossref","first-page":"282","DOI":"10.4103\/aer.AER_28_17","article-title":"Effect of Single Compared to Repeated Doses of Intravenous S(+) Ketamine on the Release of Pro-inflammatory Cytokines in Patients Undergoing Radical Prostatectomy","volume":"11","author":"Ali","year":"2017","journal-title":"Anesth Essays Res."},{"key":"10.1016\/j.intimp.2023.111284_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2019.112238","article-title":"Prophylactic (r, s)-ketamine selectively protects against inflammatory stressors","volume":"378","author":"Mastrodonato","year":"2020","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.intimp.2023.111284_b0080","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/fcp.12508","article-title":"Ketamine inhibits lps-mediated bv2 microglial inflammation via nmda receptor blockage","volume":"34","author":"Lu","year":"2020","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.intimp.2023.111284_b0085","doi-asserted-by":"crossref","first-page":"3193725","DOI":"10.1155\/2020\/3193725","article-title":"Coadministration of ketamine and perampanel improves behavioral function and reduces inflammation in acute traumatic brain injury mouse model","volume":"2020","author":"Alqahtani","year":"2020","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.intimp.2023.111284_b0090","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.3389\/fphys.2018.01858","article-title":"Ketamine reduces inflammation pathways in the hypothalamus and hippocampus following transient hypoxia in the late-gestation fetal sheep","volume":"9","author":"Chang","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.intimp.2023.111284_b0095","first-page":"1471","article-title":"Effects of ketamine on endotoxin and traumatic brain injury induced cytokine production in the rat","volume":"70","author":"Ward","year":"2011","journal-title":"J. Trauma."},{"key":"10.1016\/j.intimp.2023.111284_b0100","doi-asserted-by":"crossref","first-page":"e43","DOI":"10.1016\/j.biopsych.2016.12.020","article-title":"(r)-ketamine shows greater potency and longer lasting antidepressant effects than its metabolite (2r,6r)-hydroxynorketamine","volume":"82","author":"Yang","year":"2017","journal-title":"Biol. Psychiatry."},{"key":"10.1016\/j.intimp.2023.111284_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2020.172904","article-title":"Neuronal brain injury after cerebral ischemic stroke is ameliorated after subsequent administration of (r)-ketamine, but not (s)-ketamine","volume":"191","author":"Xiong","year":"2020","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.intimp.2023.111284_b0110","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00213-019-05346-5","article-title":"Mptp-induced dopaminergic neurotoxicity in mouse brain is attenuated after subsequent intranasal administration of (r)-ketamine: a role of trkb signaling","volume":"237","author":"Fujita","year":"2020","journal-title":"Psychopharmacology (Berl)."},{"key":"10.1016\/j.intimp.2023.111284_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.173954","article-title":"Dextran sulfate sodium-induced inflammation and colitis in mice are ameliorated by (r)-ketamine, but not (s)-ketamine: a role of trkb signaling","volume":"897","author":"Fujita","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2023.111284_b0120","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1007\/s00508-017-1299-3","article-title":"S(+)-ketamine : current trends in emergency and intensive care medicine","volume":"130","author":"Trimmel","year":"2018","journal-title":"Wien Klin Wochenschr."},{"key":"10.1016\/j.intimp.2023.111284_b0125","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1093\/bja\/aeq341","article-title":"Continuous s-(+)-ketamine administration during elective coronary artery bypass graft surgery attenuates pro-inflammatory cytokine response during and after cardiopulmonary bypass","volume":"106","author":"Welters","year":"2011","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.intimp.2023.111284_b0130","doi-asserted-by":"crossref","first-page":"1128924","DOI":"10.3389\/fphar.2023.1128924","article-title":"S-ketamine attenuates inflammatory effect and modulates the immune response in patients undergoing modified radical mastectomy: a prospective randomized controlled trial","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2023.111284_b0135","doi-asserted-by":"crossref","first-page":"5318","DOI":"10.18632\/aging.102952","article-title":"Dexmedetomidine alleviates sleep-restriction-mediated exaggeration of postoperative immunosuppression via splenic tff2 in aged mice","volume":"12","author":"Wang","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.intimp.2023.111284_b0140","doi-asserted-by":"crossref","first-page":"10517","DOI":"10.1038\/ncomms10517","article-title":"Neural innervation stimulates splenic tff2 to arrest myeloid cell expansion and cancer","volume":"7","author":"Dubeykovskaya","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2023.111284_b0145","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.4049\/jimmunol.181.5.3535","article-title":"Splenectomy protects against sepsis lethality and reduces serum hmgb1 levels","volume":"181","author":"Huston","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2023.111284_b0150","doi-asserted-by":"crossref","first-page":"23739","DOI":"10.18632\/aging.103940","article-title":"Red light exaggerated sepsis-induced learning impairments and anxiety-like behaviors","volume":"12","author":"Xie","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.intimp.2023.111284_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118736","article-title":"A key role of gut microbiota-vagus nerve\/spleen axis in sleep deprivation-mediated aggravation of systemic inflammation after lps administration","volume":"265","author":"Zhang","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2023.111284_b0160","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1126\/science.1175202","article-title":"Identification of splenic reservoir monocytes and their deployment to inflammatory sites","volume":"325","author":"Swirski","year":"2009","journal-title":"Science."},{"key":"10.1016\/j.intimp.2023.111284_b0165","doi-asserted-by":"crossref","first-page":"6277","DOI":"10.1523\/JNEUROSCI.0450-11.2011","article-title":"Beta-adrenergic receptor antagonism prevents anxiety-like behavior and microglial reactivity induced by repeated social defeat","volume":"31","author":"Wohleb","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.intimp.2023.111284_b0170","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jneuroim.2003.11.011","article-title":"Effects of repeated social stress on leukocyte distribution in bone marrow, peripheral blood and spleen","volume":"148","author":"Engler","year":"2004","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.intimp.2023.111284_b0175","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.biopsych.2015.07.010","article-title":"Sympathetic release of splenic monocytes promotes recurring anxiety following repeated social defeat","volume":"79","author":"McKim","year":"2016","journal-title":"Biol. Psychiatry."},{"key":"10.1016\/j.intimp.2023.111284_b0180","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.biopsych.2013.11.029","article-title":"Re-establishment of anxiety in stress-sensitized mice is caused by monocyte trafficking from the spleen to the brain","volume":"75","author":"Wohleb","year":"2014","journal-title":"Biol. Psychiatry."},{"key":"10.1016\/j.intimp.2023.111284_b0185","doi-asserted-by":"crossref","first-page":"e666","DOI":"10.1038\/tp.2015.157","article-title":"Bdnf-trkb signaling in the nucleus accumbens shell of mice has key role in methamphetamine withdrawal symptoms","volume":"5","author":"Ren","year":"2015","journal-title":"Transl. Psychiatry."},{"key":"10.1016\/j.intimp.2023.111284_b0190","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.18632\/aging.101464","article-title":"Abnormal gut microbiota composition contributes to cognitive dysfunction in samp8 mice","volume":"10","author":"Zhan","year":"2018","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.intimp.2023.111284_b0195","doi-asserted-by":"crossref","first-page":"29874","DOI":"10.1038\/srep29874","article-title":"Battery of behavioral tests in mice to study postoperative delirium","volume":"6","author":"Peng","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2023.111284_b0200","first-page":"413","article-title":"Hyperforin improves post-stroke social isolationinduced exaggeration of psd and psa via tgf-beta","volume":"43","author":"Zhang","year":"2019","journal-title":"Int. J. Mol. Med."},{"issue":"9","key":"10.1016\/j.intimp.2023.111284_b0205","doi-asserted-by":"crossref","first-page":"e632","DOI":"10.1038\/tp.2015.136","article-title":"R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects","volume":"5","author":"Yang","year":"2015","journal-title":"Transl. Psychiatry"},{"issue":"4","key":"10.1016\/j.intimp.2023.111284_b0210","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/0272-0590(91)90165-Z","article-title":"Pretreatment with drinking water solutions containing trichloroethylene or chloroform enhances the hepatotoxicity of carbon tetrachloride in Fischer 344 rats","volume":"16","author":"Steup","year":"1991","journal-title":"Fundam. Appl. Toxicol."},{"issue":"1","key":"10.1016\/j.intimp.2023.111284_b0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1189\/jlb.0306164","article-title":"DAMPs, PAMPs and alarmins: all we need to know about danger","volume":"81","author":"Bianchi","year":"2007","journal-title":"J. Leukoc Biol."},{"issue":"4\u20136","key":"10.1016\/j.intimp.2023.111284_b0220","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1159\/000156474","article-title":"Neuroinflammation associated with aging sensitizes the brain to the effects of infection or stress","volume":"15","author":"Sparkman","year":"2008","journal-title":"Neuroimmunomodulation."},{"key":"10.1016\/j.intimp.2023.111284_b0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2023.109646","article-title":"Complement C1q drives microglia-dependent synaptic loss and cognitive impairments in a mouse model of lipopolysaccharide-induced neuroinflammation","volume":"237","author":"Wu","year":"2023","journal-title":"Neuropharmacology."},{"key":"10.1016\/j.intimp.2023.111284_b0230","first-page":"2540","article-title":"Effect of splenectomy on attenuation of lps-induced aki through gts-21-induced cholinergic anti-inflammatory pathway","volume":"11","author":"Gao","year":"2019","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.intimp.2023.111284_b0235","article-title":"Abnormalities of the composition of the gut microbiota and short-chain fatty acids in mice after splenectomy","volume":"11","author":"Wei","year":"2021","journal-title":"Brain Behav. Immun. Health."},{"key":"10.1016\/j.intimp.2023.111284_b0240","doi-asserted-by":"crossref","first-page":"16050","DOI":"10.1073\/pnas.1102999108","article-title":"Ingestion of lactobacillus strain regulates emotional behavior and central gaba receptor expression in a mouse via the vagus nerve","volume":"108","author":"Bravo","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.intimp.2023.111284_b0245","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.bbi.2020.12.032","article-title":"A role of the subdiaphragmatic vagus nerve in depression-like phenotypes in mice after fecal microbiota transplantation from chrna7 knock-out mice with depression-like phenotypes","volume":"94","author":"Pu","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.intimp.2023.111284_b0250","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/s41398-020-00878-3","article-title":"A key role of the subdiaphragmatic vagus nerve in the depression-like phenotype and abnormal composition of gut microbiota in mice after lipopolysaccharide administration","volume":"10","author":"Zhang","year":"2020","journal-title":"Transl. Psychiatry."},{"key":"10.1016\/j.intimp.2023.111284_b0255","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.nlm.2018.02.012","article-title":"Spermine protects from lps-induced memory deficit via bdnf and trkb activation","volume":"149","author":"Fruhauf-Perez","year":"2018","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.intimp.2023.111284_b0260","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/sj.mp.4001957","article-title":"Hippocampus-specific deletion of bdnf in adult mice impairs spatial memory and extinction of aversive memories","volume":"12","author":"Heldt","year":"2007","journal-title":"Mol. Psychiatry."},{"key":"10.1016\/j.intimp.2023.111284_b0265","first-page":"3775","article-title":"Neonatal immune challenge with lipopolysaccharide triggers long-lasting sex- and age-related behavioral and immune\/neurotrophic alterations in mice: relevance to autism spectrum disorders","volume":"55","author":"Custodio","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.intimp.2023.111284_b0270","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/s12974-017-0964-9","article-title":"Lentivirus-mediated interleukin-1beta (il-1beta) knock-down in the hippocampus alleviates lipopolysaccharide (lps)-induced memory deficits and anxiety- and depression-like behaviors in mice","volume":"14","author":"Li","year":"2017","journal-title":"J. Neuroinflammation."},{"key":"10.1016\/j.intimp.2023.111284_b0275","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00213-016-4483-7","article-title":"Antidepressant effects of combination of brexpiprazole and fluoxetine on depression-like behavior and dendritic changes in mice after inflammation","volume":"234","author":"Ma","year":"2017","journal-title":"Psychopharmacology (Berl)."},{"key":"10.1016\/j.intimp.2023.111284_b0280","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.bbi.2019.07.003","article-title":"Interplay between inflammation and neural plasticity: both immune activation and suppression impair ltp and bdnf expression","volume":"81","author":"Golia","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.intimp.2023.111284_b0285","doi-asserted-by":"crossref","first-page":"10343","DOI":"10.1523\/JNEUROSCI.0584-15.2015","article-title":"Vgf and its c-terminal peptide tlqp-62 regulate memory formation in hippocampus via a bdnf-trkb-dependent mechanism","volume":"35","author":"Lin","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.intimp.2023.111284_b0290","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1177\/1073858417697037","article-title":"Neurotrophins and proneurotrophins: focus on synaptic activity and plasticity in the brain","volume":"23","author":"Gibon","year":"2017","journal-title":"Neuroscientist."},{"key":"10.1016\/j.intimp.2023.111284_b0295","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1146\/annurev-psych-010814-015031","article-title":"The cognitive neuroscience of working memory","volume":"66","author":"D'Esposito","year":"2015","journal-title":"Annu. Rev. Psychol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923016119?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923016119?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T18:07:20Z","timestamp":1761588440000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576923016119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":59,"alternative-id":["S1567576923016119"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2023.111284","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Esketamine mitigates cognitive impairment following exposure to LPS by modulating the intestinal flora\/subdiaphragmatic vagus nerve\/spleen axis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2023.111284","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"111284"}}