{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T22:16:20Z","timestamp":1792880180118,"version":"4.5.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515012828"],"award-info":[{"award-number":["2023A1515012828"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010883","name":"Traditional Chinese Medicine Bureau of Guangdong Province","doi-asserted-by":"publisher","award":["20231103"],"award-info":[{"award-number":["20231103"]}],"id":[{"id":"10.13039\/501100010883","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010883","name":"Traditional Chinese Medicine Bureau of Guangdong Province","doi-asserted-by":"publisher","award":["20241081"],"award-info":[{"award-number":["20241081"]}],"id":[{"id":"10.13039\/501100010883","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.intimp.2023.111399","type":"journal-article","created":{"date-parts":[[2023,12,23]],"date-time":"2023-12-23T16:57:02Z","timestamp":1703350622000},"page":"111399","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Hydrogen gas alleviates acute ethanol-induced hepatotoxicity in mice via modulating TLR4\/9 innate immune signaling and pyroptosis"],"prefix":"10.1016","volume":"127","author":[{"given":"Luyao","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhai","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaying","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiean","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinwen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2023.111399_b0005","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41572-018-0014-7","article-title":"Alcoholic liver disease","volume":"4","author":"Seitz","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.intimp.2023.111399_b0010","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.jhep.2018.10.041","article-title":"Alcohol-related liver disease: Areas of consensus, unmet needs and opportunities for further study","volume":"70","author":"Thursz","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.intimp.2023.111399_b0015","unstructured":"Global status report on alcohol and health 2018. Geneva: World Health Organization; 2018. Licence: CC BY-NC-SA 3.0 IGO.Retrieved from: 'https:\/\/www.who.int\/publications\/i\/item\/9789241565639' [Online Resource]."},{"key":"10.1016\/j.intimp.2023.111399_b0020","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1136\/gutjnl-2019-320446","article-title":"Mortality in biopsy-proven alcohol-related liver disease: a population-based nationwide cohort study of 3453 patients","volume":"70","author":"Hagstr\u00f6m","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.intimp.2023.111399_b0025","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1146\/annurev-pathmechdis-031521-030435","article-title":"Recent advances in understanding of pathogenesis of alcohol-associated liver disease","volume":"18","author":"Wu","year":"2023","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.intimp.2023.111399_b0030","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1002\/hep.29240","article-title":"Main drivers of outcome differ between short term and long term in severe alcoholic hepatitis: A prospective study","volume":"66","author":"Louvet","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2023.111399_b0035","doi-asserted-by":"crossref","first-page":"453","DOI":"10.3892\/etm.2021.9884","article-title":"Hydrogen gas alleviates acute alcohol-induced liver injury by inhibiting JNK activation","volume":"21","author":"Zhang","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.intimp.2023.111399_b0040","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/nm1577","article-title":"Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals","volume":"13","author":"Ohsawa","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.intimp.2023.111399_b0045","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1016\/j.intimp.2011.09.007","article-title":"Hydrogen inhalation ameliorates lipopolysaccharide-induced acute lung injury in mice","volume":"11","author":"Qiu","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2023.111399_b0050","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.jhep.2010.08.011","article-title":"The protective role of hydrogen-rich saline in experimental liver injury in mice","volume":"54","author":"Sun","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.intimp.2023.111399_b0055","first-page":"1048","article-title":"Hydrogen-rich saline alleviates inflammation and apoptosis in myocardial I\/R injury via PINK-mediated autophagy","volume":"44","author":"Yao","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.intimp.2023.111399_b0060","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s00280-008-0924-2","article-title":"Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice","volume":"64","author":"Nakashima-Kamimura","year":"2009","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.intimp.2023.111399_b0065","article-title":"Oral hydrogen-rich water alleviates oxalate-induced kidney injury by suppressing oxidative stress, inflammation, and fibrosis","volume":"8","author":"Si","year":"2021","journal-title":"Front. Med. (Lausanne)"},{"key":"10.1016\/j.intimp.2023.111399_b0070","doi-asserted-by":"crossref","first-page":"877","DOI":"10.3389\/fphar.2020.00877","article-title":"Hydrogen: An endogenous regulator of liver homeostasis","volume":"11","author":"Zhang","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2023.111399_b0075","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1053\/j.gastro.2010.07.041","article-title":"Autophagy reduces acute ethanol-induced hepatotoxicity and steatosis in mice","volume":"139","author":"Ding","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.intimp.2023.111399_b0080","doi-asserted-by":"crossref","first-page":"276","DOI":"10.4103\/CJP.CJP_66_20","article-title":"Helium protects against lipopolysaccharide-induced cardiac dysfunction in mice via suppressing toll-like receptor 4-nuclear factor \u03baB-tumor necrosis factor-alpha\/ interleukin-18 signaling","volume":"63","author":"Zhang","year":"2020","journal-title":"Chin. J. Physiol."},{"key":"10.1016\/j.intimp.2023.111399_b0085","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3389\/fphys.2012.00193","article-title":"Acute alcohol-induced liver injury","volume":"3","author":"Massey","year":"2012","journal-title":"Front. Physiol."},{"key":"10.1016\/j.intimp.2023.111399_b0090","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1194\/jlr.R119000547","article-title":"Alcohol effects on hepatic lipid metabolism","volume":"61","author":"Jeon","year":"2020","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.intimp.2023.111399_b0095","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.1002\/hep.20957","article-title":"Alcohol and oxidative liver injury","volume":"43","author":"Dey","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2023.111399_b0100","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s00204-009-0432-0","article-title":"Role of oxidative stress in alcohol-induced liver injury","volume":"83","author":"Cederbaum","year":"2009","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.intimp.2023.111399_b0105","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1002\/hep.22470","article-title":"The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88","volume":"48","author":"Hritz","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2023.111399_b0110","doi-asserted-by":"crossref","first-page":"G30","DOI":"10.1152\/ajpgi.00031.2015","article-title":"TLR2 and TLR9 contribute to alcohol-mediated liver injury through induction of CXCL1 and neutrophil infiltration","volume":"309","author":"Roh","year":"2015","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.intimp.2023.111399_b0115","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1038\/s41401-020-00597-x","article-title":"Deletion of TLR4 attenuates lipopolysaccharide-induced acute liver injury by inhibiting inflammation and apoptosis","volume":"42","author":"Chen","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.intimp.2023.111399_b0120","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.jhep.2017.05.020","article-title":"Free cholesterol accumulation in liver sinusoidal endothelial cells exacerbates acetaminophen hepatotoxicity via TLR9 signaling","volume":"67","author":"Teratani","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.intimp.2023.111399_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106507","article-title":"Toll-like receptors and metabolic (dysfunction)-associated fatty liver disease","volume":"185","author":"Khanmohammadi","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.intimp.2023.111399_b0130","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.tibs.2016.09.002","article-title":"Mechanism and regulation of NLRP3 inflammasome activation","volume":"41","author":"He","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.intimp.2023.111399_b0135","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2023.111399_b0140","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2019102065","article-title":"Chopping GSDMD: caspase-8 has joined the team of pyroptosis-mediating caspases","volume":"38","author":"Gram","year":"2019","journal-title":"Embo. J."},{"key":"10.1016\/j.intimp.2023.111399_b0145","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature22393","article-title":"Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin","volume":"547","author":"Wang","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2023.111399_b0150","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0168-8278(00)80420-1","article-title":"Alcoholic liver disease: new insights in pathogenesis lead to new treatments","volume":"32","author":"Lieber","year":"2000","journal-title":"J. Hepatol."},{"key":"10.1016\/j.intimp.2023.111399_b0155","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.livres.2019.11.006","article-title":"Alcohol and drug-induced liver injury: Metabolism, mechanisms, pathogenesis and potential therapies(\u2606)","volume":"3","author":"Ding","year":"2019","journal-title":"Liver Res."},{"key":"10.1016\/j.intimp.2023.111399_b0160","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1053\/j.gastro.2011.09.002","article-title":"Alcoholic liver disease: pathogenesis and new therapeutic targets","volume":"141","author":"Gao","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.intimp.2023.111399_b0165","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.ajpath.2011.11.017","article-title":"Chronic alcohol exposure stimulates adipose tissue lipolysis in mice: role of reverse triglyceride transport in the pathogenesis of alcoholic steatosis","volume":"180","author":"Zhong","year":"2012","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.intimp.2023.111399_b0170","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nrgastro.2017.116","article-title":"Alcohol, adipose tissue and liver disease: mechanistic links and clinical considerations","volume":"15","author":"Parker","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.intimp.2023.111399_b0175","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.redox.2014.08.007","article-title":"Farnesoid X receptor regulates forkhead Box O3a activation in ethanol-induced autophagy and hepatotoxicity","volume":"2","author":"Manley","year":"2014","journal-title":"Redox. Biol."},{"key":"10.1016\/j.intimp.2023.111399_b0180","doi-asserted-by":"crossref","first-page":"G324","DOI":"10.1152\/ajpgi.00108.2015","article-title":"Parkin regulates mitophagy and mitochondrial function to protect against alcohol-induced liver injury and steatosis in mice","volume":"309","author":"Williams","year":"2015","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.intimp.2023.111399_b0185","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nrgastro.2015.35","article-title":"Alcoholic liver disease: mechanisms of injury and targeted treatment","volume":"12","author":"Louvet","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.intimp.2023.111399_b0190","doi-asserted-by":"crossref","first-page":"8082","DOI":"10.3748\/wjg.v20.i25.8082","article-title":"Oxidative stress as a crucial factor in liver diseases","volume":"20","author":"Cicho\u017c-Lach","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.intimp.2023.111399_b0195","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.intimp.2019.03.021","article-title":"Hydrogen gas inhalation attenuates sepsis-induced liver injury in a FUNDC1-dependent manner","volume":"71","author":"Yan","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2023.111399_b0200","doi-asserted-by":"crossref","first-page":"G450","DOI":"10.1152\/ajpgi.00158.2020","article-title":"Hydrogen-rich water protects against liver injury in nonalcoholic steatohepatitis through HO-1 enhancement via IL-10 and Sirt 1 signaling","volume":"320","author":"Li","year":"2021","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.intimp.2023.111399_b0205","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1038\/s41467-017-02325-2","article-title":"Pro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomeric TLR4-MD2 complex","volume":"8","author":"Kim","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2023.111399_b0210","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1084\/jem.20070247","article-title":"HMGB1 release induced by liver ischemia involves Toll-like receptor 4 dependent reactive oxygen species production and calcium-mediated signaling","volume":"204","author":"Tsung","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.intimp.2023.111399_b0215","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1128\/IAI.02870-14","article-title":"Toll-Like receptor 2 (TLR2) and TLR9 play opposing roles in host innate immunity against Salmonella enterica serovar Typhimurium infection","volume":"83","author":"Zhan","year":"2015","journal-title":"Infect. Immun."},{"key":"10.1016\/j.intimp.2023.111399_b0220","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/ni1200","article-title":"ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity","volume":"6","author":"Matsuzawa","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.intimp.2023.111399_b0225","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.molmet.2018.05.015","article-title":"Hepatocyte toll-like receptor 4 deficiency protects against alcohol-induced fatty liver disease","volume":"14","author":"Jia","year":"2018","journal-title":"Mol. Metab."},{"key":"10.1016\/j.intimp.2023.111399_b0230","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.biopha.2016.01.018","article-title":"Ligustrazine disrupts lipopolysaccharide-activated NLRP3 inflammasome pathway associated with inhibition of Toll-like receptor 4 in hepatocytes","volume":"78","author":"Zhang","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2023.111399_b0235","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nature13683","article-title":"Inflammatory caspases are innate immune receptors for intracellular LPS","volume":"514","author":"Shi","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2023.111399_b0240","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1002\/hep.29725","article-title":"Pyroptosis, A novel player for alcoholic hepatitis?","volume":"67","author":"Wang","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2023.111399_b0245","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/nature15541","article-title":"Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling","volume":"526","author":"Kayagaki","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2023.111399_b0250","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nature18590","article-title":"Pore-forming activity and structural autoinhibition of the gasdermin family","volume":"535","author":"Ding","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2023.111399_b0255","doi-asserted-by":"crossref","first-page":"E10888","DOI":"10.1073\/pnas.1809548115","article-title":"Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection","volume":"115","author":"Sarhan","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.intimp.2023.111399_b0260","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.coi.2015.01.007","article-title":"Non-canonical activation of inflammatory caspases by cytosolic LPS in innate immunity","volume":"32","author":"Yang","year":"2015","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.intimp.2023.111399_b0265","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1002\/hep.29645","article-title":"Pyroptosis by caspase11\/4-gasdermin-D pathway in alcoholic hepatitis in mice and patients","volume":"67","author":"Khanova","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2023.111399_b0270","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.678118","article-title":"Non-invasive biomarkers of liver inflammation and cell death in response to alcohol detoxification","volume":"12","author":"Neuman","year":"2021","journal-title":"Front. Physiol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923017265?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576923017265?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T18:16:28Z","timestamp":1761588988000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576923017265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":54,"alternative-id":["S1567576923017265"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2023.111399","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hydrogen gas alleviates acute ethanol-induced hepatotoxicity in mice via modulating TLR4\/9 innate immune signaling and pyroptosis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2023.111399","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"111399"}}