{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:09:11Z","timestamp":1785521351875,"version":"3.56.0"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104178"],"award-info":[{"award-number":["82104178"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.intimp.2024.111535","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T22:58:40Z","timestamp":1705705120000},"page":"111535","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["ACE2 improves endothelial cell function and reduces acute lung injury by downregulating FAK expression"],"prefix":"10.1016","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4205-2574","authenticated-orcid":false,"given":"Yixuan","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baocai","family":"Gang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiesong","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoquan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4421-2326","authenticated-orcid":false,"given":"Wei","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 3","key":"10.1016\/j.intimp.2024.111535_b0005","first-page":"S353","article-title":"Acute lung injury - from pathophysiology to treatment","volume":"69","author":"Mokra","year":"2020","journal-title":"Physiol. Res."},{"key":"10.1016\/j.intimp.2024.111535_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104292","article-title":"Ablation of endothelial Pfkfb3 protects mice from acute lung injury in LPS-induced endotoxemia","volume":"146","author":"Wang","year":"2019","journal-title":"Pharmacol. Res."},{"issue":"26","key":"10.1016\/j.intimp.2024.111535_b0015","doi-asserted-by":"crossref","first-page":"12980","DOI":"10.1073\/pnas.1902165116","article-title":"Endothelial cell Piezo1 mediates pressure-induced lung vascular hyperpermeability via disruption of adherens junctions","volume":"116","author":"Friedrich","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"10","key":"10.1016\/j.intimp.2024.111535_b0020","doi-asserted-by":"crossref","first-page":"e108881","DOI":"10.1371\/journal.pone.0108881","article-title":"Podocalyxin regulates murine lung vascular permeability by altering endothelial cell adhesion","volume":"9","author":"Debruin","year":"2014","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.intimp.2024.111535_b0025","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1165\/rcmb.2018-0366OC","article-title":"TRIM21 Mitigates Human Lung Microvascular Endothelial Cells' Inflammatory Responses to LPS","volume":"61","author":"Li","year":"2019","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"3","key":"10.1016\/j.intimp.2024.111535_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.101695","article-title":"The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin alpha5beta1 and NF-kappaB signaling","volume":"298","author":"Robles","year":"2022","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.intimp.2024.111535_b0035","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00377-2021","article-title":"Between inflammation and thrombosis: endothelial cells in COVID-19","volume":"58","author":"Birnhuber","year":"2021","journal-title":"Eur. Respir. J."},{"issue":"2","key":"10.1016\/j.intimp.2024.111535_b0040","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00407-20","article-title":"Towards a Mechanism for Poly(I.C) Antiviral Priming in Oysters","volume":"11","author":"Martins","year":"2020","journal-title":"MBio"},{"issue":"1","key":"10.1016\/j.intimp.2024.111535_b0045","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1465-9921-10-43","article-title":"Long-term activation of TLR3 by poly(I:C) induces inflammation and impairs lung function in mice","volume":"10","author":"Stowell","year":"2009","journal-title":"Respir. Res."},{"key":"10.1016\/j.intimp.2024.111535_b0050","doi-asserted-by":"crossref","first-page":"1243851","DOI":"10.3389\/fimmu.2023.1243851","article-title":"Myeloid-derived suppressor cells exacerbate poly(I:C)-induced lung inflammation in mice with renal injury and older mice","volume":"14","author":"Xie","year":"2023","journal-title":"Front. Immunol."},{"issue":"37","key":"10.1016\/j.intimp.2024.111535_b0055","doi-asserted-by":"crossref","first-page":"61025","DOI":"10.18632\/oncotarget.17731","article-title":"Orphan nuclear receptor Nur77 inhibits poly (I:C)-triggered acute liver inflammation by inducing the ubiquitin-editing enzyme A20","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget"},{"issue":"10","key":"10.1016\/j.intimp.2024.111535_b0060","doi-asserted-by":"crossref","first-page":"28118","DOI":"10.1007\/s11356-022-23987-6","article-title":"Effect of TLR3\/dsRNA complex inhibitor on Poly(I:C)-induced airway inflammation in Swiss albino mice","volume":"30","author":"Arora","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"6","key":"10.1016\/j.intimp.2024.111535_b0065","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.bbi.2010.04.004","article-title":"Systemic challenge with the TLR3 agonist poly I: C induces amplified IFNalpha\/beta and IL-1beta responses in the diseased brain and exacerbates chronic neurodegeneration","volume":"24","author":"Field","year":"2010","journal-title":"Brain Behav. Immun."},{"issue":"2","key":"10.1016\/j.intimp.2024.111535_b0070","first-page":"353","article-title":"Comparative studies of mouse acute lung injury models induced by lipopolysaccharide and polyinosinic-polycytidylic acid","volume":"36","author":"Zhang","year":"2022","journal-title":"J. Biol. Regul. Homeost. Agents"},{"issue":"12","key":"10.1016\/j.intimp.2024.111535_b0075","doi-asserted-by":"crossref","first-page":"e08555","DOI":"10.1016\/j.heliyon.2021.e08555","article-title":"ACE and ACE2: insights from Drosophila and implications for COVID-19","volume":"7","author":"Herrera","year":"2021","journal-title":"Heliyon"},{"key":"10.1016\/j.intimp.2024.111535_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2021.111254","article-title":"Renin-angiotensin system and inflammation update","volume":"529","author":"Cantero-Navarro","year":"2021","journal-title":"Mol. Cell. Endocrinol."},{"issue":"3","key":"10.1016\/j.intimp.2024.111535_b0085","doi-asserted-by":"crossref","first-page":"453","DOI":"10.3904\/kjim.2017.317","article-title":"Role of the renin-angiotensin system in hepatic fibrosis and portal hypertension","volume":"33","author":"Shim","year":"2018","journal-title":"Korean J. Intern. Med."},{"key":"10.1016\/j.intimp.2024.111535_b0090","article-title":"A Novel Modulator of the Renin-Angiotensin System, Benzoylaconitine, Attenuates Hypertension by Targeting ACE\/ACE2 in Enhancing Vasodilation and Alleviating Vascular Inflammation","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"5","key":"10.1016\/j.intimp.2024.111535_b0095","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.cell.2020.04.035","article-title":"SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues","volume":"181","author":"Ziegler","year":"2020","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.intimp.2024.111535_b0100","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1161\/CIRCRESAHA.120.317015","article-title":"Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System: Celebrating the 20th Anniversary of the Discovery of ACE2","volume":"126","author":"Gheblawi","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.intimp.2024.111535_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.mehy.2020.110320","article-title":"SARS-CoV-2 cell entry receptor ACE2 mediated endothelial dysfunction leads to vascular thrombosis in COVID-19 patients","volume":"145","author":"Kumar","year":"2020","journal-title":"Med. Hypotheses"},{"issue":"2","key":"10.1016\/j.intimp.2024.111535_b0110","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1161\/HYPERTENSIONAHA.121.18295","article-title":"Dysregulation of ACE (Angiotensin-Converting Enzyme)-2 and Renin-Angiotensin Peptides in SARS-CoV-2 Mediated Mortality and End-Organ Injuries","volume":"79","author":"Wang","year":"2022","journal-title":"Hypertension"},{"issue":"6","key":"10.1016\/j.intimp.2024.111535_b0115","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1164\/rccm.201205-0880OC","article-title":"Diminazene attenuates pulmonary hypertension and improves angiogenic progenitor cell functions in experimental models","volume":"187","author":"Shenoy","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.intimp.2024.111535_b0120","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.biopha.2018.07.170","article-title":"The ACE 2 activator diminazene aceturate (DIZE) improves left ventricular diastolic dysfunction following myocardial infarction in rats","volume":"107","author":"Castardeli","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2024.111535_b0125","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.maturitas.2020.07.002","article-title":"Could DIZE be the answer to COVID-19?","volume":"140","author":"Qaradakhi","year":"2020","journal-title":"Maturitas"},{"key":"10.1016\/j.intimp.2024.111535_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2021.110046","article-title":"Focal adhesion dynamics in cellular function and disease","volume":"85","author":"Mishra","year":"2021","journal-title":"Cell. Signal."},{"issue":"20","key":"10.1016\/j.intimp.2024.111535_b0135","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.259089","article-title":"New insights into FAK structure and function in focal adhesions","volume":"135","author":"Le Coq","year":"2022","journal-title":"J. Cell Sci."},{"issue":"2","key":"10.1016\/j.intimp.2024.111535_b0140","doi-asserted-by":"crossref","DOI":"10.3390\/biom10020179","article-title":"FAK Structure and Regulation by Membrane Interactions and Force in Focal Adhesions","volume":"10","author":"Tapial Martinez","year":"2020","journal-title":"Biomolecules"},{"issue":"3","key":"10.1016\/j.intimp.2024.111535_b0145","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1007\/s10753-022-01630-3","article-title":"MiR-15p-5p Mediates the Coordination of ICAM-1 and FAK to Promote Endothelial Cell Proliferation and Migration","volume":"45","author":"Gu","year":"2022","journal-title":"Inflammation"},{"issue":"8","key":"10.1016\/j.intimp.2024.111535_b0150","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13081871","article-title":"Inhibiting FAK-Paxillin Interaction Reduces Migration and Invadopodia-Mediated Matrix Degradation in Metastatic Melanoma Cells","volume":"13","author":"Mousson","year":"2021","journal-title":"Cancers (basel)"},{"issue":"4","key":"10.1016\/j.intimp.2024.111535_b0155","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1007\/s10120-023-01384-3","article-title":"FAK\/IL-8 axis promotes the proliferation and migration of gastric cancer cells","volume":"26","author":"Ma","year":"2023","journal-title":"Gastric Cancer"},{"issue":"2","key":"10.1016\/j.intimp.2024.111535_b0160","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/eji.201041303","article-title":"Endothelial paxillin and focal adhesion kinase (FAK) play a critical role in neutrophil transmigration","volume":"42","author":"Parsons","year":"2012","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.intimp.2024.111535_b0165","first-page":"54","article-title":"Reactive oxygen species increased focal adhesion kinase production in pulmonary microvascular endothelial cells","volume":"47","author":"Yang","year":"2004","journal-title":"Proc. West. Pharmacol. Soc."},{"issue":"16","key":"10.1016\/j.intimp.2024.111535_b0170","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.4161\/15384101.2015.941760","article-title":"A FAK scaffold inhibitor disrupts FAK and VEGFR-3 signaling and blocks melanoma growth by targeting both tumor and endothelial cells","volume":"13","author":"Kurenova","year":"2014","journal-title":"Cell Cycle"},{"issue":"2","key":"10.1016\/j.intimp.2024.111535_b0175","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/mc.23273","article-title":"Focal adhesion kinase (FAK) inhibitor-defactinib suppresses the malignant progression of human esophageal squamous cell carcinoma (ESCC) cells via effective blockade of PI3K\/AKT axis and downstream molecular network","volume":"60","author":"Zhang","year":"2021","journal-title":"Mol. Carcinog."},{"issue":"7","key":"10.1016\/j.intimp.2024.111535_b0180","doi-asserted-by":"crossref","first-page":"593","DOI":"10.2174\/187152011796817727","article-title":"Clinical importance and potential use of small molecule inhibitors of focal adhesion kinase","volume":"11","author":"Schultze","year":"2011","journal-title":"Anticancer Agents Med. Chem."},{"issue":"4","key":"10.1016\/j.intimp.2024.111535_b0185","doi-asserted-by":"crossref","first-page":"e34747","DOI":"10.1371\/journal.pone.0034747","article-title":"Angiotensin converting enzyme (ACE) and ACE2 bind integrins and ACE2 regulates integrin signalling","volume":"7","author":"Clarke","year":"2012","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.intimp.2024.111535_b0190","doi-asserted-by":"crossref","first-page":"3994","DOI":"10.1016\/j.apsb.2021.04.013","article-title":"TMEM16A inhibits angiotensin II-induced basilar artery smooth muscle cell migration in a WNK1-dependent manner","volume":"11","author":"Zheng","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"issue":"1","key":"10.1016\/j.intimp.2024.111535_b0195","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2174\/157016106775203126","article-title":"Angiotensin II regulates vascular and endothelial dysfunction: recent topics of Angiotensin II type-1 receptor signaling in the vasculature","volume":"4","author":"Nakashima","year":"2006","journal-title":"Curr. Vasc. Pharmacol."},{"issue":"5","key":"10.1016\/j.intimp.2024.111535_b0200","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.cellsig.2006.11.004","article-title":"Differential FAK phosphorylation at Ser-910, Ser-843 and Tyr-397 induced by angiotensin II, LPA and EGF in Intestinal Epithelial Cells","volume":"19","author":"Jiang","year":"2007","journal-title":"Cell Signal"},{"issue":"4","key":"10.1016\/j.intimp.2024.111535_b0205","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.3892\/etm.2021.10599","article-title":"Angiotensin-converting enzyme 2 alleviates pulmonary artery hypertension through inhibition of focal adhesion kinase expression","volume":"22","author":"Wang","year":"2021","journal-title":"Exp. Ther. Med."},{"issue":"5","key":"10.1016\/j.intimp.2024.111535_b0210","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.immuni.2014.10.008","article-title":"Leukocyte migration into inflamed tissues","volume":"41","author":"Nourshargh","year":"2014","journal-title":"Immunity"},{"issue":"12","key":"10.1016\/j.intimp.2024.111535_b0215","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1016\/j.bcp.2009.01.014","article-title":"Regulators of endothelial and epithelial barrier integrity and function in acute lung injury","volume":"77","author":"Lucas","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.intimp.2024.111535_b0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.vph.2021.106829","article-title":"Endothelial cells and SARS-CoV-2: An intimate relationship","volume":"137","author":"Barbosa","year":"2021","journal-title":"Vasc.Pharmacol."},{"issue":"2","key":"10.1016\/j.intimp.2024.111535_b0225","doi-asserted-by":"crossref","first-page":"L477","DOI":"10.1152\/ajplung.00223.2021","article-title":"The SARS-CoV-2 spike protein subunit S1 induces COVID-19-like acute lung injury in Kappa18-hACE2 transgenic mice and barrier dysfunction in human endothelial cells","volume":"321","author":"Colunga Biancatelli","year":"2021","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.intimp.2024.111535_b0230","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.fsi.2022.09.064","article-title":"Poly I: C promotes malate to enhance innate immune response against bacterial infection","volume":"131","author":"Guo","year":"2022","journal-title":"Fish Shellfish Immunol."},{"issue":"6","key":"10.1016\/j.intimp.2024.111535_b0235","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.it.2023.04.001","article-title":"Emerging roles of SARS-CoV-2 Spike-ACE2 in immune evasion and pathogenesis","volume":"44","author":"Baldari","year":"2023","journal-title":"Trends Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2024.111535_b0240","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1152\/physiolgenomics.00087.2020","article-title":"SARS-CoV-2, ACE2 expression, and systemic organ invasion","volume":"53","author":"Ashraf","year":"2021","journal-title":"Physiol. Genomics"},{"issue":"23","key":"10.1016\/j.intimp.2024.111535_b0245","doi-asserted-by":"crossref","first-page":"3506","DOI":"10.2174\/092986711796642562","article-title":"Local renin-angiotensin II systems, angiotensin-converting enzyme and its homologue ACE2: their potential role in the pathogenesis of chronic obstructive pulmonary diseases, pulmonary hypertension and acute respiratory distress syndrome","volume":"18","author":"Kaparianos","year":"2011","journal-title":"Curr. Med. Chem."},{"issue":"3","key":"10.1016\/j.intimp.2024.111535_b0250","doi-asserted-by":"crossref","first-page":"e0073521","DOI":"10.1128\/Spectrum.00735-21","article-title":"SARS-CoV-2 Spike Protein Destabilizes Microvascular Homeostasis","volume":"9","author":"Panigrahi","year":"2021","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.intimp.2024.111535_b0255","doi-asserted-by":"crossref","first-page":"1028613","DOI":"10.3389\/fimmu.2022.1028613","article-title":"Pathophysiological conditions induced by SARS-CoV-2 infection reduce ACE2 expression in the lung","volume":"13","author":"Miura","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2024.111535_b0260","article-title":"ACE2 Shedding and the Role in COVID-19","volume":"11","author":"Wang","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"1","key":"10.1016\/j.intimp.2024.111535_b0265","doi-asserted-by":"crossref","first-page":"6791","DOI":"10.1038\/s41467-021-27097-8","article-title":"ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury","volume":"12","author":"Yamaguchi","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2024.111535_b0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexmp.2019.104350","article-title":"ACE2 exhibits protective effects against LPS-induced acute lung injury in mice by inhibiting the LPS-TLR4 pathway","volume":"113","author":"Ye","year":"2020","journal-title":"Exp. Mol. Pathol."},{"issue":"7047","key":"10.1016\/j.intimp.2024.111535_b0275","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nature03712","article-title":"Angiotensin-converting enzyme 2 protects from severe acute lung failure","volume":"436","author":"Imai","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2024.111535_b0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.108971","article-title":"Sini decoction ameliorates sepsis-induced acute lung injury via regulating ACE2-Ang (1\u20137)-Mas axis and inhibiting the MAPK signaling pathway","volume":"115","author":"Chen","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2024.111535_b0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2022.110418","article-title":"The Apelin-APJ axis alleviates LPS-induced pulmonary fibrosis and endothelial mesenchymal transformation in mice by promoting Angiotensin-Converting Enzyme 2","volume":"98","author":"Wang","year":"2022","journal-title":"Cell. Signal."},{"issue":"23","key":"10.1016\/j.intimp.2024.111535_b0290","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1042\/CS20201022","article-title":"ACE2 activator diminazene aceturate exerts renoprotective effects in gentamicin-induced acute renal injury in rats","volume":"134","author":"Silva de Almeida","year":"2020","journal-title":"Clin. Sci. (Lond)"},{"key":"10.1016\/j.intimp.2024.111535_b0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.mvr.2023.104544","article-title":"The ACE2 activator diminazene aceturate ameliorates colitis by repairing the gut-vascular barrier in mice","volume":"148","author":"Zhang","year":"2023","journal-title":"Microvasc. Res."},{"issue":"5","key":"10.1016\/j.intimp.2024.111535_b0300","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1097\/MNH.0000000000000254","article-title":"Angiotensin converting enzyme 2 and diminazene: role in cardiovascular and blood pressure regulation","volume":"25","author":"Velkoska","year":"2016","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"issue":"5","key":"10.1016\/j.intimp.2024.111535_b0305","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1111\/1440-1681.13251","article-title":"The potential actions of angiotensin-converting enzyme II (ACE2) activator diminazene aceturate (DIZE) in various diseases","volume":"47","author":"Qaradakhi","year":"2020","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"3","key":"10.1016\/j.intimp.2024.111535_b0310","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1124\/jpet.121.000907","article-title":"Angiotensin-Converting Enzyme 2 Inhibits Lipopolysaccharide-Caused Lung Fibrosis via Downregulating the Transforming Growth Factor beta-1\/Smad2\/Smad3 Pathway","volume":"381","author":"Lin","year":"2022","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.intimp.2024.111535_b0315","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.713632","article-title":"Diminazen Aceturate Protects Pulmonary Ischemia-Reperfusion Injury via Inhibition of ADAM17-Mediated Angiotensin-Converting Enzyme 2 Shedding","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2024.111535_b0320","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ejphar.2016.01.007","article-title":"Angiotensin converting enzyme versus angiotensin converting enzyme-2 selectivity of MLN-4760 and DX600 in human and murine bone marrow-derived cells","volume":"774","author":"Joshi","year":"2016","journal-title":"Eur. J. Pharmacol."},{"issue":"9","key":"10.1016\/j.intimp.2024.111535_b0325","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1016\/j.apsb.2021.01.004","article-title":"Integrins as attractive targets for cancer therapeutics","volume":"11","author":"Li","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"issue":"3","key":"10.1016\/j.intimp.2024.111535_b0330","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s00441-014-1945-2","article-title":"Focal adhesion kinase (FAK) perspectives in mechanobiology: implications for cell behaviour","volume":"357","author":"Tomakidi","year":"2014","journal-title":"Cell Tissue Res."},{"issue":"38","key":"10.1016\/j.intimp.2024.111535_b0335","doi-asserted-by":"crossref","first-page":"36661","DOI":"10.1074\/jbc.M301253200","article-title":"Vascular endothelial growth factor regulates focal adhesion assembly in human brain microvascular endothelial cells through activation of the focal adhesion kinase and related adhesion focal tyrosine kinase","volume":"278","author":"Avraham","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2024.111535_b0340","doi-asserted-by":"crossref","first-page":"1160301","DOI":"10.3389\/fimmu.2023.1160301","article-title":"Human IL-32thetaA94V mutant attenuates monocyte-endothelial adhesion by suppressing the expression of ICAM-1 and VCAM-1 via binding to cell surface receptor integrin alphaVbeta3 and alphaVbeta6 in TNF-alpha-stimulated HUVECs","volume":"14","author":"Park","year":"2023","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.intimp.2024.111535_b0345","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1007\/s10753-021-01509-9","article-title":"ATN-161 Ameliorates Ischemia\/Reperfusion-induced Oxidative Stress, Fibro-inflammation, Mitochondrial damage, and Apoptosis-mediated Tight Junction Disruption in bEnd. 3 Cells","volume":"44","author":"Amruta","year":"2021","journal-title":"Inflammation"},{"key":"10.1016\/j.intimp.2024.111535_b0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175623","article-title":"ACE2\/ANG-(1\u20137)\/Mas receptor axis activation prevents inflammation and improves cognitive functions in streptozotocin induced rat model of Alzheimer's disease-like phenotypes","volume":"946","author":"Tiwari","year":"2023","journal-title":"Eur. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.intimp.2024.111535_b0355","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/s41568-021-00340-6","article-title":"Targeting FAK in anticancer combination therapies","volume":"21","author":"Dawson","year":"2021","journal-title":"Nat. Rev. Cancer"},{"issue":"7","key":"10.1016\/j.intimp.2024.111535_b0360","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/s41419-022-05046-7","article-title":"FAK mediates LPS-induced inflammatory lung injury through interacting TAK1 and activating TAK1-NFkappaB pathway","volume":"13","author":"Chen","year":"2022","journal-title":"Cell Death Dis."},{"issue":"18","key":"10.1016\/j.intimp.2024.111535_b0365","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22189997","article-title":"Collagen XV Promotes ER Stress-Induced Inflammation through Activating Integrin beta1\/FAK Signaling Pathway and M1 Macrophage Polarization in Adipose Tissue","volume":"22","author":"Li","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.intimp.2024.111535_b0370","doi-asserted-by":"crossref","first-page":"457","DOI":"10.4161\/cam.5.6.18219","article-title":"Central role of paxillin phosphorylation in regulation of LFA-1 integrins activity and lymphocyte migration","volume":"5","author":"Romanova","year":"2011","journal-title":"Cell Adh. Migr."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924000535?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924000535?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T18:20:15Z","timestamp":1761589215000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924000535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":74,"alternative-id":["S1567576924000535"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.111535","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ACE2 improves endothelial cell function and reduces acute lung injury by downregulating FAK expression","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.111535","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111535"}}