{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:20:16Z","timestamp":1778620816585,"version":"3.51.4"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100016209","name":"Bilimsel Ara\u015ft\u0131rma Projeleri, Erciyes \u00dcniversitesi","doi-asserted-by":"publisher","award":["TTU-2020-10478"],"award-info":[{"award-number":["TTU-2020-10478"]}],"id":[{"id":"10.13039\/501100016209","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016209","name":"Bilimsel Ara\u015ft\u0131rma Projeleri, Erciyes \u00dcniversitesi","doi-asserted-by":"publisher","award":["4313"],"award-info":[{"award-number":["4313"]}],"id":[{"id":"10.13039\/501100016209","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004412","name":"Turkish Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020410","name":"T\u00dcSEB","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008967","name":"Bilim Akademisi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008967","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.intimp.2024.111560","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T22:58:40Z","timestamp":1705705120000},"page":"111560","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Alantolactone ameliorates graft versus host disease in mice"],"prefix":"10.1016","volume":"128","author":[{"given":"Gul Pelin","family":"Odabas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5952-906X","authenticated-orcid":false,"given":"Kubra","family":"Aslan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pinar Alisan","family":"Suna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Perihan Kader","family":"Kendirli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015eerife","family":"Erdem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"\u00c7ak\u0131r","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alper","family":"\u00d6zcan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebru","family":"Y\u0131lmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Musa","family":"Karakukcu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamiyet","family":"Donmez-Altuntas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arzu Hanim","family":"Yay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kemal","family":"Deniz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derya","family":"Altay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1906-7999","authenticated-orcid":false,"given":"Duran","family":"Arslan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0978-8311","authenticated-orcid":false,"given":"Halit","family":"Canatan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5816-0686","authenticated-orcid":false,"given":"Ahmet","family":"Eken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2691-4826","authenticated-orcid":false,"given":"Ekrem","family":"Unal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2024.111560_b0005","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3389\/fimmu.2017.00079","article-title":"Pathophysiology of GvHD and other HSCT-related major complications","volume":"8","author":"Ghimire","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2024.111560_b0010","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.det.2019.05.014","article-title":"Review of Graft-Versus-Host Disease","volume":"37","author":"Ramachandran","year":"2019","journal-title":"Dermatol. Clin."},{"key":"10.1016\/j.intimp.2024.111560_b0015","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1182\/blood-2011-06-364265","article-title":"Risk factors for acute GVHD and survival after hematopoietic cell transplantation","volume":"119","author":"Jagasia","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.intimp.2024.111560_b0020","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.bbmt.2005.09.004","article-title":"National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. Diagnosis and Staging Working Group Report","volume":"11","author":"Filipovich","year":"2005","journal-title":"Biol. Blood Marrow Transplant."},{"key":"10.1016\/j.intimp.2024.111560_b0025","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/hon.716","article-title":"Pathophysiology of acute graft-versus-host disease","volume":"21","author":"Reddy","year":"2003","journal-title":"Hematol. Oncol."},{"key":"10.1016\/j.intimp.2024.111560_b0030","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1182\/blood.V95.9.2754.009k25_2754_2759","article-title":"The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation","volume":"95","author":"Hill","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.intimp.2024.111560_b0035","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.coi.2006.07.007","article-title":"The role of CD4+CD25hi regulatory T cells in the physiopathogeny of graft-versus-host disease","volume":"18","author":"Cohen","year":"2006","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.intimp.2024.111560_b0040","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1056\/NEJMoa022060","article-title":"Relation of an interleukin-10 promoter polymorphism to graft-versus-host disease and survival after hematopoietic-cell transplantation","volume":"349","author":"Lin","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.intimp.2024.111560_b0045","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1146\/annurev.immunol.18.1.593","article-title":"The role of chemokine receptors in primary, effector, and memory immune responses","volume":"18","author":"Sallusto","year":"2000","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.intimp.2024.111560_b0050","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/s41409-019-0700-4","article-title":"A novel mouse model of acute graft-versus-host disease based on chemotherapy conditioning and G-CSF mobilized graft","volume":"55","author":"Ye","year":"2020","journal-title":"Bone Marrow Transplant."},{"key":"10.1016\/j.intimp.2024.111560_b0055","doi-asserted-by":"crossref","first-page":"5467","DOI":"10.4049\/jimmunol.173.9.5467","article-title":"Target antigens determine graft-versus-host disease phenotype","volume":"173","author":"Kaplan","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2024.111560_b0060","doi-asserted-by":"crossref","unstructured":"T. Pintar, M. Alessiani, A. Pleskovi\u010d, A. Pleskovi\u010d, R. Zorc-Pleskovi\u010d, A. Milutinovi\u0107, Skin and kidney histological changes in graft-versus-host disease (GVHD) after kidney transplantation., Bosn. J. Basic Med. Sci. 11 (2011) 119\u2013123. 10.17305\/bjbms.2011.2594.","DOI":"10.17305\/bjbms.2011.2594"},{"key":"10.1016\/j.intimp.2024.111560_b0065","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/path.4475","article-title":"Glucocorticoids attenuate acute graft-versus-host disease by suppressing the cytotoxic capacity of CD8(+) T cells","volume":"235","author":"Theiss-Suennemann","year":"2015","journal-title":"J. Pathol."},{"key":"10.1016\/j.intimp.2024.111560_b0070","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1172\/JCI17601","article-title":"Memory CD4+ T cells do not induce graft-versus-host disease","volume":"112","author":"Anderson","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.intimp.2024.111560_b0075","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1182\/blood-2003-02-0489","article-title":"Sirolimus, tacrolimus, and low-dose methotrexate for graft-versus-host disease prophylaxis in mismatched related donor or unrelated donor transplantation","volume":"102","author":"Antin","year":"2003","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.intimp.2024.111560_b0080","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1016\/S2352-3026(14)00035-0","article-title":"A prognostic score for acute graft-versus-host disease based on biomarkers: a multicenter study","volume":"1","author":"Levine","year":"2015","journal-title":"Lancet Haematol."},{"key":"10.1016\/j.intimp.2024.111560_b0085","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.drudis.2010.06.002","article-title":"What made sesquiterpene lactones reach cancer clinical trials?","volume":"15","author":"Ghantous","year":"2010","journal-title":"Drug Discov. Today."},{"key":"10.1016\/j.intimp.2024.111560_b0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ph13080194","article-title":"Parthenolide as cooperating agent for anti-cancer treatment of various malignancies","volume":"13","author":"Sztiller-Sikorska","year":"2020","journal-title":"Pharmaceuticals."},{"key":"10.1016\/j.intimp.2024.111560_b0095","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.94","article-title":"Parthenolide and DMAPT exert cytotoxic effects on breast cancer stem-like cells by inducing oxidative stress, mitochondrial dysfunction and necrosis","volume":"7","author":"Carlisi","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2024.111560_b0100","doi-asserted-by":"crossref","first-page":"991","DOI":"10.3390\/pharmaceutics13070991","article-title":"Sesquiterpene lactones: promising natural compounds to fight inflammation","volume":"13","author":"Matos","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.intimp.2024.111560_b0105","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jep.2012.12.048","article-title":"Anti-inflammatory intestinal activity of Arctium lappa L. (Asteraceae) in TNBS colitis model","volume":"146","author":"De Almeida","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2024.111560_b0110","doi-asserted-by":"crossref","first-page":"16636","DOI":"10.1038\/s41598-019-53305-z","article-title":"Activation of pXR by alantolactone ameliorates DSS-induced experimental colitis via suppressing NF-\u03baB signaling pathway","volume":"9","author":"Ren","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2024.111560_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111231","article-title":"A comprehensive review of anticancer mechanisms of action of Alantolactone","volume":"136","author":"Babaei","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2024.111560_b0120","doi-asserted-by":"crossref","unstructured":"M. Shoaib, I. Shah, N. Ali, A. Adhikari, M. Nawaz Tahir, S. Wadood Ali Shah, S. Ishtiaq, J. Khan, S. Khan, M. Naveed Umer, Sesquiterpene lactone! a promising antioxidant, anticancer and moderate antinociceptive agent from Artemisia macrocephala jacquem, BMC Comp. Alt. Med. 17 (2017) 27. 10.1186\/s12906-016-1517-y.","DOI":"10.1186\/s12906-016-1517-y"},{"key":"10.1016\/j.intimp.2024.111560_b0125","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s12931-020-01358-4","article-title":"Alantolactone suppresses inflammation, apoptosis and oxidative stress in cigarette smoke-induced human bronchial epithelial cells through activation of Nrf2\/HO-1 and inhibition of the NF-\u03baB pathways","volume":"21","author":"Dang","year":"2020","journal-title":"Respir. Res."},{"key":"10.1016\/j.intimp.2024.111560_b0130","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1080\/10915810600961531","article-title":"Nonclinical vehicle use in studies by multiple routes in multiple species","volume":"25","author":"Gad","year":"2006","journal-title":"Int. J. Toxicol."},{"key":"10.1016\/j.intimp.2024.111560_b0135","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/bjh.12142","article-title":"Advances in predicting acute GVHD","volume":"160","author":"Harris","year":"2013","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.intimp.2024.111560_b0140","article-title":"Alantolactone Suppresses Proliferation and the Inflammatory Response in Human Hacat Keratinocytes and Ameliorates Imiquimod-Induced Skin Lesions in a Psoriasis-like Mouse Model","volume":"11","author":"Chuo","year":"2021","journal-title":"Life (Basel, Switzerland)"},{"key":"10.1016\/j.intimp.2024.111560_b0145","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/bmt.2008.261","article-title":"GVHD after chemotherapy conditioning in allogeneic transplanted mice","volume":"42","author":"Sadeghi","year":"2008","journal-title":"Bone Marrow Transplant."},{"key":"10.1016\/j.intimp.2024.111560_b0150","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1080\/13880209.2021.1876102","article-title":"Alantolactone alleviates collagen-induced arthritis and inhibits Th17 cell differentiation through modulation of STAT3 signalling","volume":"59","author":"Chen","year":"2021","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.intimp.2024.111560_b0155","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1055\/s-2001-16478","article-title":"Cytotoxic sesquiterpene lactones mediate their death-inducing effect in leukemia T cells by triggering apoptosis","volume":"67","author":"Dirsch","year":"2001","journal-title":"Planta Med."},{"key":"10.1016\/j.intimp.2024.111560_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.110170","article-title":"Secreted osteopontin from CD4(+) T cells limits acute graft-versus-host disease","volume":"37","author":"Aggarwal","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.intimp.2024.111560_b0165","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/tan.12497","article-title":"Insights into the pathogenesis of GvHD: what mice can teach us about man","volume":"85","author":"H\u00fclsd\u00fcnker","year":"2015","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.intimp.2024.111560_b0170","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20190945","article-title":"GM-CSF in inflammation","volume":"217","author":"Hamilton","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.intimp.2024.111560_b0175","doi-asserted-by":"crossref","unstructured":"B.C. Betts, E.T.S. Angelo, M. Kennedy, J.W. Young, Brief report Anti \u2013 IL6-receptor-alpha (tocilizumab) does not inhibit human monocyte-derived dendritic cell maturation or alloreactive T-cell responses, 118 (2011) 1\u20133. 10.1182\/blood-2011-06-363390.","DOI":"10.1182\/blood-2011-06-363390"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692400078X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692400078X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:57:00Z","timestamp":1778619420000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156757692400078X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":35,"alternative-id":["S156757692400078X"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.111560","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alantolactone ameliorates graft versus host disease in mice","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.111560","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111560"}}