{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T21:16:07Z","timestamp":1785446167717,"version":"3.56.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.intimp.2024.111613","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T21:48:33Z","timestamp":1710452913000},"page":"111613","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["CircRAPGEF5 sponges miR-582-3p and targets KIF3A to regulate bladder cancer cell proliferation, migration and invasion"],"prefix":"10.1016","volume":"131","author":[{"given":"Chao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5214-900X","authenticated-orcid":false,"given":"Xianxu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.intimp.2024.111613_b0005","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.intimp.2024.111613_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.eururo.2023.03.029","article-title":"Epidemiology of Bladder Cancer in 2023: A Systematic Review of Risk Factors","author":"Jubber","year":"2023","journal-title":"Eur. Urol."},{"issue":"19","key":"10.1016\/j.intimp.2024.111613_b0015","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1001\/jama.2020.17598","article-title":"Bladder Cancer: A Review","volume":"324","author":"Lenis","year":"2020","journal-title":"J. Am. Med. Assoc."},{"issue":"5","key":"10.1016\/j.intimp.2024.111613_b0020","doi-asserted-by":"crossref","first-page":"404","DOI":"10.3322\/caac.21631","article-title":"Treatment of muscle-invasive and advanced bladder cancer in 2020","volume":"70","author":"Patel","year":"2020","journal-title":"CA Cancer J. Clin."},{"issue":"6","key":"10.1016\/j.intimp.2024.111613_b0025","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.euo.2022.10.003","article-title":"Epidemiology, Screening, and Prevention of Bladder Cancer","volume":"5","author":"Lobo","year":"2022","journal-title":"Eur. Urol. Oncol."},{"key":"10.1016\/j.intimp.2024.111613_b0030","doi-asserted-by":"crossref","unstructured":"J. Dobruch, M. Oszczudlowski, Bladder Cancer: Current Challenges and Future Directions, Medicina (Kaunas) 57(8) (2021).","DOI":"10.3390\/medicina57080749"},{"issue":"22","key":"10.1016\/j.intimp.2024.111613_b0035","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21228591","article-title":"Circular RNA, the Key for Translation","volume":"21","author":"Prats","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2024.111613_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexmp.2023.104861","article-title":"The biogenesis, biological functions and modification of Circular RNAs","volume":"131","author":"Liu","year":"2023","journal-title":"Exp. Mol. Pathol."},{"issue":"4","key":"10.1016\/j.intimp.2024.111613_b0045","first-page":"319","article-title":"Circular RNAs in Cancer: Biogenesis, Function, and Clinical Significance, Trends","volume":"6","author":"Li","year":"2020","journal-title":"Cancer"},{"key":"10.1016\/j.intimp.2024.111613_b0050","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.canlet.2021.02.004","article-title":"CircRNA in cancer: Fundamental mechanism and clinical potential","volume":"505","author":"Chen","year":"2021","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.intimp.2024.111613_b0055","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12943-020-01300-8","article-title":"Expression profiles, biological functions and clinical significance of circRNAs in bladder cancer","volume":"20","author":"Yang","year":"2021","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.intimp.2024.111613_b0060","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.801842","article-title":"The Role of Circular RNAs in the Carcinogenesis of Bladder Cancer","volume":"12","author":"Ghafouri-Fard","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.intimp.2024.111613_b0065","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.omtn.2019.01.003","article-title":"circRAPGEF5 Contributes to Papillary Thyroid Proliferation and Metastatis by Regulation miR-198\/FGFR1","volume":"14","author":"Liu","year":"2019","journal-title":"Mol. Ther. Nucleic Acids"},{"issue":"5","key":"10.1016\/j.intimp.2024.111613_b0070","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s10863-021-09907-2","article-title":"Downregulation of hsa_circ_0001681 suppresses epithelial-mesenchymal transition in thyroid carcinoma via targeting to miR-942-5p\/TWIST1 signaling pathway","volume":"53","author":"Wang","year":"2021","journal-title":"J. Bioenerg. Biomembr."},{"issue":"5","key":"10.1016\/j.intimp.2024.111613_b0075","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.7150\/ijbs.66770","article-title":"CircRAPGEF5 Promotes the Proliferation and Metastasis of Lung Adenocarcinoma through the miR-1236-3p\/ZEB1 Axis and Serves as a Potential Biomarker","volume":"18","author":"Zhou","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.intimp.2024.111613_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102493","article-title":"CircRAPGEF5 interacts with RBFOX2 to confer ferroptosis resistance by modulating alternative splicing of TFRC in endometrial cancer","volume":"57","author":"Zhang","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.intimp.2024.111613_b0085","doi-asserted-by":"crossref","first-page":"1018285","DOI":"10.3389\/fonc.2022.1018285","article-title":"Identification of a dysregulated CircRNA-associated gene signature for predicting prognosis, immune landscape, and drug candidates in bladder cancer","volume":"12","author":"Shen","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.intimp.2024.111613_b0090","doi-asserted-by":"crossref","unstructured":"Y. Zhang, Z. Li, Y. Zhang, C. Shen, Z. Zhang, X. Ren, C. Guo, S. Yang, Z. Wang, H. Hu, circSOBP Inhibits Bladder Cancer Proliferation and Metastasis by Regulating the miR-200a-3p\/PTEN Axis and Participating in the Immune Response, Cell transplantation 32 (2023) 9636897231165874.","DOI":"10.1177\/09636897231165874"},{"issue":"11","key":"10.1016\/j.intimp.2024.111613_b0095","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/s41576-019-0158-7","article-title":"The biogenesis, biology and characterization of circular RNAs","volume":"20","author":"Kristensen","year":"2019","journal-title":"Nat. Rev. Genet."},{"issue":"1","key":"10.1016\/j.intimp.2024.111613_b0100","doi-asserted-by":"crossref","DOI":"10.3892\/or.2022.8449","article-title":"Research progress on the circRNA-mediated regulation of tumor angiogenesis through ceRNA mechanisms (Review)","volume":"49","author":"Meng","year":"2023","journal-title":"Oncol. Rep."},{"issue":"11","key":"10.1016\/j.intimp.2024.111613_b0105","doi-asserted-by":"crossref","first-page":"5971","DOI":"10.21037\/jtd-23-919","article-title":"CircRNA ARHGAP10 promotes osteogenic differentiation through the miR-335-3p\/RUNX2 pathway in aortic valve calcification","volume":"15","author":"Jiang","year":"2023","journal-title":"J. Thorac. Dis."},{"issue":"23","key":"10.1016\/j.intimp.2024.111613_b0110","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15235556","article-title":"Circular RNA CDR1as Mediated by Human Antigen R (HuR) Promotes Gastric Cancer Growth via miR-299-3p\/TGIF1 Axis","volume":"15","author":"Li","year":"2023","journal-title":"Cancers (basel)"},{"issue":"1","key":"10.1016\/j.intimp.2024.111613_b0115","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1186\/s12935-023-03026-1","article-title":"Hsa_circRNA_102051 regulates colorectal cancer proliferation and metastasis by mediating Notch pathway","volume":"23","author":"Chen","year":"2023","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.intimp.2024.111613_b0120","article-title":"hsa_circ_0002980 prevents proliferation, migration, invasion, and epithelial-mesenchymal transition of liver cancer cells through microRNA-1303\/cell adhesion molecule 2 axis","volume":"15","author":"Wang","year":"2023","journal-title":"Aging (Albany NY)"},{"issue":"5","key":"10.1016\/j.intimp.2024.111613_b0125","doi-asserted-by":"crossref","DOI":"10.3892\/or.2023.8540","article-title":"CircRPPH1 accelerates the proliferation and migration of bladder cancer via enhancing the STAT3 signaling pathway","volume":"49","author":"Liu","year":"2023","journal-title":"Oncol. Rep."},{"issue":"22","key":"10.1016\/j.intimp.2024.111613_b0130","first-page":"11536","article-title":"Advanced\/metastatic bladder cancer: current status and future directions","volume":"24","author":"Facchini","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.intimp.2024.111613_b0135","doi-asserted-by":"crossref","unstructured":"J.A. Witjes, H.M. Bruins, R. Cathomas, E.M. Comperat, N.C. Cowan, G. Gakis, V. Hernandez, E. Linares Espinos, A. Lorch, Y. Neuzillet, M. Rouanne, G.N. Thalmann, E. Veskimae, M.J. Ribal, A.G. van der Heijden, European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2020 Guidelines, Eur Urol 79(1) (2021) 82-104.","DOI":"10.1016\/j.eururo.2020.03.055"},{"issue":"7679","key":"10.1016\/j.intimp.2024.111613_b0140","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1038\/551S33a","article-title":"Bladder cancer","volume":"551","author":"Grayson","year":"2017","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.intimp.2024.111613_b0145","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s41419-023-05598-2","article-title":"Characterization of circSCL38A1 as a novel oncogene in bladder cancer via targeting ILF3\/TGF-beta2 signaling axis","volume":"14","author":"Li","year":"2023","journal-title":"Cell Death Dis."},{"issue":"8","key":"10.1016\/j.intimp.2024.111613_b0150","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1080\/15384101.2022.2164454","article-title":"CircHGS enhances the progression of bladder cancer by regulating the miR-513a-5p\/VEGFC axis and activating the AKT\/mTOR signaling pathway","volume":"22","author":"Zhu","year":"2023","journal-title":"Cell Cycle"},{"issue":"1","key":"10.1016\/j.intimp.2024.111613_b0155","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13046-023-02614-3","article-title":"HNRNPL induced circFAM13B increased bladder cancer immunotherapy sensitivity via inhibiting glycolysis through IGF2BP1\/PKM2 pathway","volume":"42","author":"Lv","year":"2023","journal-title":"J. Exp. Clini. Cancer Res.: CR"},{"key":"10.1016\/j.intimp.2024.111613_b0160","article-title":"CircSTK39 suppresses the proliferation and invasion of bladder cancer by regulating the miR-135a-5p\/NR3C2-mediated epithelial-mesenchymal transition signaling pathway","author":"Li","year":"2022","journal-title":"Cell Biol. Toxicol."},{"issue":"1","key":"10.1016\/j.intimp.2024.111613_b0165","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1186\/s13046-023-02813-y","article-title":"Circ-RAPGEF5 promotes intrahepatic cholangiocarcinoma progression by stabilizing SAE1 to facilitate SUMOylation","volume":"42","author":"Zheng","year":"2023","journal-title":"J. Exp. Cli. Cancer Res. : CR"},{"key":"10.1016\/j.intimp.2024.111613_b0170","doi-asserted-by":"crossref","unstructured":"J. Huang, H. Zhou, Y. Diao, Z. Yang, Hsa_circ_0000285 knockdown inhibits the progression of hepatocellular carcinoma by sponging miR-582-3p to regulate CCNB2 expression, Human & experimental toxicology 41 (2022) 9603271221115400.","DOI":"10.1177\/09603271221115400"},{"issue":"5","key":"10.1016\/j.intimp.2024.111613_b0175","doi-asserted-by":"crossref","first-page":"12876","DOI":"10.1080\/21655979.2022.2078026","article-title":"MicroRNA-582-3p targeting ribonucleotide reductase regulatory subunit M2 inhibits the tumorigenesis of hepatocellular carcinoma by regulating the Wnt\/beta-catenin signaling pathway","volume":"13","author":"Xu","year":"2022","journal-title":"Bioengineered"},{"key":"10.1016\/j.intimp.2024.111613_b0180","article-title":"Use of miRNA Sequencing to Reveal Hub miRNAs and the Effect of miR-582-3p\/SMAD2 in the Progression of Hepatocellular Carcinoma","volume":"13","author":"Zhao","year":"2022","journal-title":"Front. Genet."},{"key":"10.1016\/j.intimp.2024.111613_b0185","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s11658-019-0184-7","article-title":"MicroRNA-582-3p negatively regulates cell proliferation and cell cycle progression in acute myeloid leukemia by targeting cyclin B2","volume":"24","author":"Li","year":"2019","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"2","key":"10.1016\/j.intimp.2024.111613_b0190","first-page":"137","article-title":"Circ-SFMBT2 facilitates the malignant growth of acute myeloid leukemia cells by modulating miR-582-3p\/ZBTB20 pathway","volume":"37","author":"Chang","year":"2022","journal-title":"Histol. Histopathol."},{"issue":"1","key":"10.1016\/j.intimp.2024.111613_b0195","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s10528-022-10244-1","article-title":"Circ_0035381 Regulates Acute Myeloid Leukemia Development by Modulating YWHAZ Expression via Adsorbing miR-582-3p","volume":"61","author":"Xue","year":"2023","journal-title":"Biochem. Genet."},{"issue":"1","key":"10.1016\/j.intimp.2024.111613_b0200","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s12943-020-01208-3","article-title":"Exosomal circSHKBP1 promotes gastric cancer progression via regulating the miR-582-3p\/HUR\/VEGF axis and suppressing HSP90 degradation","volume":"19","author":"Xie","year":"2020","journal-title":"Mol. Cancer"},{"issue":"2","key":"10.1016\/j.intimp.2024.111613_b0205","doi-asserted-by":"crossref","first-page":"12755","DOI":"10.1080\/21655979.2021.1997696","article-title":"Circular RNA circ_0000423 promotes gastric cancer cell proliferation, migration and invasion via the microR-582-3p\/Disheveled-Axin domain containing 1 axis","volume":"12","author":"Huang","year":"2021","journal-title":"Bioengineered"},{"key":"10.1016\/j.intimp.2024.111613_b0210","doi-asserted-by":"crossref","first-page":"e3036","DOI":"10.6061\/clinics\/2021\/e3036","article-title":"CircularRNA_0119872 regulates the microRNA-582-3p\/E2F transcription factor 3 pathway to promote the progression of malignant melanoma","volume":"76","author":"Qu","year":"2021","journal-title":"Clinics (Sao Paulo)"},{"issue":"1","key":"10.1016\/j.intimp.2024.111613_b0215","doi-asserted-by":"crossref","first-page":"20230726","DOI":"10.1515\/med-2023-0726","article-title":"hsa_circ_0000285 sponging miR-582-3p promotes neuroblastoma progression by regulating the Wnt\/\u03b2-catenin signaling pathway","volume":"18","author":"Du","year":"2023","journal-title":"Open Med (wars)"},{"issue":"3","key":"10.1016\/j.intimp.2024.111613_b0220","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/mt.2012.269","article-title":"Therapeutic effects of microRNA-582-5p and -3p on the inhibition of bladder cancer progression","volume":"21","author":"Uchino","year":"2013","journal-title":"Mol. Ther."},{"issue":"3","key":"10.1016\/j.intimp.2024.111613_b0225","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s00018-018-2940-7","article-title":"Regulatory network of miRNA on its target: coordination between transcriptional and post-transcriptional regulation of gene expression","volume":"76","author":"Pu","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"issue":"4","key":"10.1016\/j.intimp.2024.111613_b0230","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.047662","article-title":"miRNA interplay: mechanisms and consequences in cancer","volume":"14","author":"Hill","year":"2021","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.intimp.2024.111613_b0235","doi-asserted-by":"crossref","unstructured":"S. Liu, Y. He, S. Li, X. Gao, F. Yang, Kinesin family member 3A induces related diseases via wingless-related integration site\/beta-catenin signaling pathway, Sci Prog 106(1) (2023) 368504221148340.","DOI":"10.1177\/00368504221148340"},{"issue":"5","key":"10.1016\/j.intimp.2024.111613_b0240","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1002\/2211-5463.12768","article-title":"Kinesin family member 3A stimulates cell proliferation, migration, and invasion of bladder cancer cells in vitro and in vivo","volume":"11","author":"Zhou","year":"2021","journal-title":"FEBS Open Bio"},{"issue":"7","key":"10.1016\/j.intimp.2024.111613_b0245","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/s41419-022-04936-0","article-title":"Tumor suppressive role of microRNA-139-5p in bone marrow mesenchymal stem cells-derived extracellular vesicles in bladder cancer through regulation of the KIF3A\/p21 axis","volume":"13","author":"Xiang","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2024.111613_b0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108686","article-title":"lncRNA MIR600HG induces the proliferation and invasion of colorectal cancer cells via regulating miR-144-3p\/KIF3A","volume":"108","author":"Huang","year":"2022","journal-title":"Int. Immunopharmacol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924001310?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924001310?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T06:42:24Z","timestamp":1731739344000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924001310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":50,"alternative-id":["S1567576924001310"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.111613","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CircRAPGEF5 sponges miR-582-3p and targets KIF3A to regulate bladder cancer cell proliferation, migration and invasion","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.111613","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111613"}}