{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:09:29Z","timestamp":1792087769358,"version":"4.4.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007128","name":"Shaanxi Province Natural Science Foundation","doi-asserted-by":"publisher","award":["2024JC-YBQN-0812"],"award-info":[{"award-number":["2024JC-YBQN-0812"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360436"],"award-info":[{"award-number":["82360436"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81960403"],"award-info":[{"award-number":["81960403"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060405"],"award-info":[{"award-number":["82060405"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007764","name":"Lanzhou City Science and Technology Bureau","doi-asserted-by":"publisher","award":["2021-RC-102"],"award-info":[{"award-number":["2021-RC-102"]}],"id":[{"id":"10.13039\/501100007764","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022817","name":"Lanzhou University Second Hospital","doi-asserted-by":"publisher","award":["CY2021-MS-A07"],"award-info":[{"award-number":["CY2021-MS-A07"]}],"id":[{"id":"10.13039\/100022817","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004775","name":"Natural Science Foundation of Gansu Province","doi-asserted-by":"publisher","award":["22JR5RA943"],"award-info":[{"award-number":["22JR5RA943"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004775","name":"Natural Science Foundation of Gansu Province","doi-asserted-by":"publisher","award":["22JR5RA956"],"award-info":[{"award-number":["22JR5RA956"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004775","name":"Natural Science Foundation of Gansu Province","doi-asserted-by":"publisher","award":["23JRRA1500"],"award-info":[{"award-number":["23JRRA1500"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.intimp.2024.111671","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T19:03:56Z","timestamp":1708110236000},"page":"111671","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["A novel mechanism of Vildagliptin in regulating bone metabolism and mitigating osteoporosis"],"prefix":"10.1016","volume":"130","author":[{"given":"Jinwen","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dacheng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenghong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3771-8687","authenticated-orcid":false,"given":"Yayi","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.intimp.2024.111671_b0005","doi-asserted-by":"crossref","first-page":"544","DOI":"10.3803\/EnM.2021.301","article-title":"Long-term treatment of postmenopausal osteoporosis","volume":"36","author":"Brown","year":"2021","journal-title":"Endocrinol. Metab. (Seoul)"},{"issue":"4","key":"10.1016\/j.intimp.2024.111671_b0010","doi-asserted-by":"crossref","first-page":"159","DOI":"10.11622\/smedj.2021036","article-title":"Menopausal osteoporosis: screening, prevention and treatment","volume":"62","author":"Yong","year":"2021","journal-title":"Singapore Med. J."},{"issue":"Pt A","key":"10.1016\/j.intimp.2024.111671_b0015","article-title":"Single-cell RNA sequencing analysis dissected the osteo-immunology microenvironment and revealed key regulators in osteoporosis","volume":"113","author":"Wang","year":"2022","journal-title":"Int. Immunopharmacol."},{"issue":"9999","key":"10.1016\/j.intimp.2024.111671_b0020","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0140-6736(15)61120-5","article-title":"Denosumab and teriparatide transitions in postmenopausal osteoporosis (the DATA-Switch study): extension of a randomised controlled trial","volume":"386","author":"Leder","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.intimp.2024.111671_b0025","doi-asserted-by":"crossref","unstructured":"Management of osteoporosis in postmenopausal women: the 2021 position statement of The North American Menopause Society, Menopause 28(9) (2021) 973\u2013997.","DOI":"10.1097\/GME.0000000000001831"},{"issue":"Suppl 1","key":"10.1016\/j.intimp.2024.111671_b0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4158\/GL-2020-0524SUPPL","article-title":"American association of clinical endocrinologists\/american college of endocrinology clinical practice guidelines for the diagnosis and treatment of postmenopausal osteoporosis-2020 update","volume":"26","author":"Camacho","year":"2020","journal-title":"Endocr. Pract."},{"issue":"6","key":"10.1016\/j.intimp.2024.111671_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.beem.2021.101551","article-title":"Menopausal hormone therapy for the management of osteoporosis","volume":"35","author":"Gosset","year":"2021","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.intimp.2024.111671_b0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/EJE-11-0132","article-title":"Osteoblasts in osteoporosis: past, emerging, and future anabolic targets","volume":"165","author":"Marie","year":"2011","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.intimp.2024.111671_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107518","article-title":"Combination of vitamin D and dipeptidyl peptidase-4 inhibitors (VIDPP-4i) as an immunomodulation therapy for autoimmune diabetes","volume":"95","author":"Pinheiro","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2024.111671_b0050","doi-asserted-by":"crossref","unstructured":"L. Glorie, P.C. D'haese, A. Verhulst, Boning up on DPP4, DPP4 substrates, and DPP4-adipokine interactions: Logical reasoning and known facts about bone related effects of DPP4 inhibitors, Bone 92 (2016) 37\u201349.","DOI":"10.1016\/j.bone.2016.08.009"},{"key":"10.1016\/j.intimp.2024.111671_b0055","article-title":"The multiple biological functions of dipeptidyl peptidase-4 in bone metabolism","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"3","key":"10.1016\/j.intimp.2024.111671_b0060","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1093\/cei\/uxac071","article-title":"Elevated expression of TAM receptor tyrosine kinase in synovial fluid and synovial tissue of rheumatoid arthritis","volume":"209","author":"Zheng","year":"2022","journal-title":"Clin. Exp. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2024.111671_b0065","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/s12943-019-1090-3","article-title":"AXL receptor tyrosine kinase as a promising anti-cancer approach: functions, molecular mechanisms and clinical applications","volume":"18","author":"Zhu","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.intimp.2024.111671_b0070","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/2387614","article-title":"TAM receptor pathways at the crossroads of neuroinflammation and neurodegeneration","volume":"2019","author":"Tondo","year":"2019","journal-title":"Dis. Markers"},{"issue":"1","key":"10.1016\/j.intimp.2024.111671_b0075","doi-asserted-by":"crossref","first-page":"7689","DOI":"10.1038\/s41467-022-33938-x","article-title":"Regulation of bone homeostasis by MERTK and TYRO3","volume":"13","author":"Engelmann","year":"2022","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.intimp.2024.111671_b0080","article-title":"The ARRIVE guidelines 2.0: updated guidelines for reporting animal research","volume":"18","author":"Percie Du Sert","year":"2020","journal-title":"PLoS Biol."},{"key":"10.1016\/j.intimp.2024.111671_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2022.136579","article-title":"Vildagliptin improves neurological function by inhibiting apoptosis and ferroptosis following intracerebral hemorrhage in mice","volume":"776","author":"Zhang","year":"2022","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.intimp.2024.111671_b0090","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13098-017-0232-2","article-title":"Vildagliptin has the same safety profile as a sulfonylurea on bone metabolism and bone mineral density in post-menopausal women with type 2 diabetes: a randomized controlled trial","volume":"9","author":"Vianna","year":"2017","journal-title":"Diabetol. Metab. Syndr."},{"issue":"10","key":"10.1016\/j.intimp.2024.111671_b0095","doi-asserted-by":"crossref","first-page":"3621","DOI":"10.1210\/jc.2017-00042","article-title":"Type 2 diabetes and osteoporosis: a guide to optimal management","volume":"102","author":"Paschou","year":"2017","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.intimp.2024.111671_b0100","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bbrc.2020.01.027","article-title":"Inhibition of inflammation-mediated DPP-4 expression by linagliptin increases M2 macrophages in atherosclerotic lesions","volume":"524","author":"Nishida","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2024.111671_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.106092","article-title":"Novel hit of DPP-4Is as promising antihyperglycemic agents with dual antioxidant\/anti-inflammatory effects for type 2 diabetes with\/without COVID-19","volume":"128","author":"Mahgoub","year":"2022","journal-title":"Bioorg. Chem."},{"issue":"1","key":"10.1016\/j.intimp.2024.111671_b0110","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3803\/EnM.2016.31.1.93","article-title":"High levels of serum DPP-4 activity are associated with low bone mineral density in obese postmenopausal women","volume":"31","author":"Kim","year":"2016","journal-title":"Endocrinol. Metab. (Seoul)"},{"key":"10.1016\/j.intimp.2024.111671_b0115","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.944323","article-title":"Linagliptin in combination with metformin ameliorates diabetic osteoporosis through modulating BMP-2 and sclerostin in the high-fat diet fed C57BL\/6 mice","volume":"13","author":"Nirwan","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"5","key":"10.1016\/j.intimp.2024.111671_b0120","doi-asserted-by":"crossref","first-page":"218","DOI":"10.5582\/ddt.2020.03073","article-title":"Effects of the linagliptin, dipeptidyl peptidase-4 inhibitor, on bone fragility induced by type 2 diabetes mellitus in obese mice","volume":"14","author":"Kanda","year":"2020","journal-title":"Drug Discov. Ther."},{"issue":"4","key":"10.1016\/j.intimp.2024.111671_b0125","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23042388","article-title":"Neuroprotective effects of the DPP4 inhibitor vildagliptin in in vivo and in vitro models of Parkinson's disease","volume":"23","author":"Pariyar","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.intimp.2024.111671_b0130","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1536\/ihj.19-117","article-title":"Vildagliptin, a DPP-4 inhibitor, attenuates endothelial dysfunction and atherogenesis in nondiabetic apolipoprotein E-deficient mice","volume":"60","author":"Aini","year":"2019","journal-title":"Int. Heart J."},{"key":"10.1016\/j.intimp.2024.111671_b0135","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ejphar.2014.10.008","article-title":"Gemigliptin, a novel dipeptidyl peptidase-4 inhibitor, exhibits potent anti-glycation properties in vitro and in vivo","volume":"744","author":"Jung","year":"2014","journal-title":"Eur. J. Pharmacol."},{"issue":"11","key":"10.1016\/j.intimp.2024.111671_b0140","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1002\/jbmr.2277","article-title":"Blockade of CD26 signaling inhibits human osteoclast development","volume":"29","author":"Nishida","year":"2014","journal-title":"J. Bone Miner. Res."},{"issue":"21","key":"10.1016\/j.intimp.2024.111671_b0145","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1182\/blood.V120.21.1348.1348","article-title":"Targeting CD26 with humanized monoclonal antibody, as a novel approach to inhibit human osteoclast differentiation and subsequent bone resorption","volume":"120","author":"Nishida","year":"2012","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.intimp.2024.111671_b0150","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.jcjd.2018.01.006","article-title":"Dipeptidyl peptidase-4 inhibitor, vildagliptin, improves trabecular bone mineral density and microstructure in obese, insulin-resistant, pre-diabetic rats","volume":"42","author":"Charoenphandhu","year":"2018","journal-title":"Can. J. Diabetes"},{"issue":"1","key":"10.1016\/j.intimp.2024.111671_b0155","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s12015-021-10285-w","article-title":"Influence of dipeptidyl peptidase-4 (DPP4) on mesenchymal stem-cell (MSC) biology: implications for regenerative medicine - review","volume":"18","author":"Torrecillas-Baena","year":"2022","journal-title":"Stem Cell Rev. Rep."},{"key":"10.1016\/j.intimp.2024.111671_b0160","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ejphar.2014.01.028","article-title":"Saxagliptin affects long-bone microarchitecture and decreases the osteogenic potential of bone marrow stromal cells","volume":"727","author":"Sbaraglini","year":"2014","journal-title":"Eur. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.intimp.2024.111671_b0165","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1002\/jbmr.3364","article-title":"Estrogen deficiency-mediated M2 macrophage osteoclastogenesis contributes to M1\/M2 ratio alteration in ovariectomized osteoporotic mice","volume":"33","author":"Dou","year":"2018","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.intimp.2024.111671_b0170","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.687037","article-title":"Immunoporosis: role of innate immune cells in osteoporosis","volume":"12","author":"Saxena","year":"2021","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2024.111671_b0175","doi-asserted-by":"crossref","first-page":"E50","DOI":"10.1210\/jc.2014-2751","article-title":"Alternative activation of human macrophages is rescued by estrogen treatment in vitro and impaired by menopausal status","volume":"100","author":"Toniolo","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.intimp.2024.111671_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.109745","article-title":"Toosendanin inhibits osteoclast formation and alleviate postmenopausal osteoporosis by regulating the p38 signaling pathway","volume":"116","author":"Tan","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"11","key":"10.1016\/j.intimp.2024.111671_b0185","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1002\/jbmr.4413","article-title":"Osteal macrophages support osteoclast-mediated resorption and contribute to bone pathology in a postmenopausal osteoporosis mouse model","volume":"36","author":"Batoon","year":"2021","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.intimp.2024.111671_b0190","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.biomaterials.2017.10.033","article-title":"CD169(+) macrophages are critical for osteoblast maintenance and promote intramembranous and endochondral ossification during bone repair","volume":"196","author":"Batoon","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.intimp.2024.111671_b0195","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1028932","article-title":"Mangiferin promotes osteogenic differentiation and alleviates osteoporosis in the ovariectomized mouse via the AXL\/ERK5 pathway","volume":"13","author":"He","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.intimp.2024.111671_b0200","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1080\/03008207.2019.1670650","article-title":"ERK5 negatively regulates Kruppel-like factor 4 and promotes osteogenic lineage cell proliferation in response to MEK5 overexpression or fluid shear stress","volume":"62","author":"Zhang","year":"2021","journal-title":"Connect. Tissue Res."},{"issue":"18","key":"10.1016\/j.intimp.2024.111671_b0205","doi-asserted-by":"crossref","first-page":"8734","DOI":"10.1111\/jcmm.16829","article-title":"Fluid shear stress regulates osteoblast proliferation and apoptosis via the lncRNA TUG1\/miR-34a\/FGFR1 axis","volume":"25","author":"Wang","year":"2021","journal-title":"J. Cell Mol. Med."},{"issue":"2","key":"10.1016\/j.intimp.2024.111671_b0210","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.yexcr.2016.03.014","article-title":"Fluid shear stress suppresses TNF-\u03b1-induced apoptosis in MC3T3-E1 cells: Involvement of ERK5-AKT-FoxO3a-Bim\/FasL signaling pathways","volume":"343","author":"Bin","year":"2016","journal-title":"Exp. Cell Res."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924001899?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924001899?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:56:28Z","timestamp":1778619388000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924001899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":42,"alternative-id":["S1567576924001899"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.111671","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel mechanism of Vildagliptin in regulating bone metabolism and mitigating osteoporosis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.111671","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111671"}}