{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:00:50Z","timestamp":1790251250603,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["202300410461"],"award-info":[{"award-number":["202300410461"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017700","name":"Henan Provincial Science and Technology Research Project","doi-asserted-by":"publisher","award":["202210472011"],"award-info":[{"award-number":["202210472011"]}],"id":[{"id":"10.13039\/501100017700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017700","name":"Henan Provincial Science and Technology Research Project","doi-asserted-by":"publisher","award":["222102310016"],"award-info":[{"award-number":["222102310016"]}],"id":[{"id":"10.13039\/501100017700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.intimp.2024.111728","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T18:01:29Z","timestamp":1709316089000},"page":"111728","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["SiRNA-HIF-1\u03b1 delivered by attenuated Salmonella enhances the efficacy of Lenvatinib against hepatocellular carcinoma"],"prefix":"10.1016","volume":"130","author":[{"given":"Pengfei","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingshu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinwei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenning","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqing","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongguo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuhua","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiesuo","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijie","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhuang","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2022","key":"10.1016\/j.intimp.2024.111728_b0005","first-page":"7","article-title":"Cancer statistics","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.intimp.2024.111728_b0010","first-page":"1411","article-title":"Hepatocellular carcinoma","volume":"146","author":"Schultheiss","year":"2021","journal-title":"Dtsch. Med. Wochenschr."},{"key":"10.1016\/j.intimp.2024.111728_b0015","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/01.sla.0000075047.47175.35","article-title":"Clinical significance of angiogenesis in gastrointestinal cancers: a target for novel prognostic and therapeutic approaches","volume":"238","author":"Poon","year":"2003","journal-title":"Ann. Surg."},{"key":"10.1016\/j.intimp.2024.111728_b0020","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1002\/hep.21353","article-title":"Significance of circulating endothelial progenitor cells in hepatocellular carcinoma","volume":"44","author":"Ho","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2024.111728_b0025","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1634\/theoncologist.2012-0388","article-title":"Antiangiogenic therapies for advanced hepatocellular carcinoma","volume":"18","author":"Sampat","year":"2013","journal-title":"Oncologist"},{"key":"10.1016\/j.intimp.2024.111728_b0030","doi-asserted-by":"crossref","first-page":"4368","DOI":"10.1200\/JCO.2002.10.088","article-title":"Vascular permeability factor\/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy","volume":"20","author":"Dvorak","year":"2002","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.intimp.2024.111728_b0035","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.gendis.2020.03.010","article-title":"Targeting angiogenesis for liver cancer: Past, present, and future","volume":"7","author":"Zhu","year":"2020","journal-title":"Genes Dis."},{"key":"10.1016\/j.intimp.2024.111728_b0040","doi-asserted-by":"crossref","DOI":"10.1177\/1533033820971677","article-title":"The prognostic value of circulating VEGF-A level in patients with hepatocellular cancer","volume":"19","author":"Lacin","year":"2020","journal-title":"Technol. Cancer Res. Treat."},{"key":"10.1016\/j.intimp.2024.111728_b0045","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.ccell.2019.08.007","article-title":"Tumor cell biodiversity drives microenvironmental reprogramming in liver cancer","volume":"36","author":"Ma","year":"2019","journal-title":"Cancer Cell"},{"key":"10.1016\/j.intimp.2024.111728_b0050","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/2045-824X-6-18","article-title":"Lenvatinib, an angiogenesis inhibitor targeting VEGFR\/FGFR, shows broad antitumor activity in human tumor xenograft models associated with microvessel density and pericyte coverage","volume":"6","author":"Yamamoto","year":"2014","journal-title":"Vasc. Cell"},{"key":"10.1016\/j.intimp.2024.111728_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2020.188391","article-title":"Lenvatinib for hepatocellular carcinoma: From preclinical mechanisms to anti-cancer therapy","volume":"1874","author":"Zhao","year":"2020","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"10.1016\/j.intimp.2024.111728_b0060","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1055\/s-0038-1673621","article-title":"Immunomodulatory effects of current targeted therapies on hepatocellular carcinoma: Implication for the future of immunotherapy","volume":"38","author":"Lin","year":"2018","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.intimp.2024.111728_b0065","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1667\/RR14016.1","article-title":"HIF-1 alpha regulates the response of primary sarcomas to radiation therapy through a cell autonomous mechanism","volume":"183","author":"Zhang","year":"2015","journal-title":"Radiat. Res."},{"key":"10.1016\/j.intimp.2024.111728_b0070","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/15384047.2017.1294285","article-title":"Hypoxia promotes chemotherapy resistance by down-regulating SKA1 gene expression in human osteosarcoma","volume":"18","author":"Ma","year":"2017","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.intimp.2024.111728_b0075","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.semcdb.2005.03.001","article-title":"The HIF pathway in cancer","volume":"16","author":"Maxwell","year":"2005","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.intimp.2024.111728_b0080","doi-asserted-by":"crossref","first-page":"7658","DOI":"10.1158\/1078-0432.CCR-05-0460","article-title":"The androgen receptor is significantly associated with vascular endothelial growth factor and hypoxia sensing via hypoxia-inducible factors HIF-1a, HIF-2a, and the prolyl hydroxylases in human prostate cancer","volume":"11","author":"Boddy","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.intimp.2024.111728_b0085","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.ccell.2017.10.003","article-title":"An HIF-1alpha\/VEGF-A axis in cytotoxic T cells regulates tumor progression","volume":"32","author":"Palazon","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.intimp.2024.111728_b0090","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/35888","article-title":"Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans","volume":"391","author":"Fire","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2024.111728_b0095","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3008362","article-title":"RNAi therapies: drugging the undruggable","volume":"6","author":"Wu","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.intimp.2024.111728_b0100","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25112692","article-title":"Lipid and polymer-based nanoparticle siRNA delivery systems for cancer therapy","volume":"25","author":"Mainini","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.intimp.2024.111728_b0105","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.addr.2019.05.004","article-title":"Strategies, design, and chemistry in siRNA delivery systems","volume":"144","author":"Dong","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.intimp.2024.111728_b0110","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/s41419-019-1418-3","article-title":"PD-1-siRNA delivered by attenuated Salmonella enhances the antimelanoma effect of pimozide","volume":"10","author":"Zhao","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2024.111728_b0115","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/cgt.2012.12","article-title":"Targeted therapy via oral administration of attenuated Salmonella expression plasmid-vectored Stat3-shRNA cures orthotopically transplanted mouse HCC","volume":"19","author":"Tian","year":"2012","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.intimp.2024.111728_b0120","first-page":"4537","article-title":"Tumor-targeted Salmonella as a novel anticancer vector","volume":"57","author":"Pawelek","year":"1997","journal-title":"Cancer Res."},{"key":"10.1016\/j.intimp.2024.111728_b0125","doi-asserted-by":"crossref","first-page":"5859","DOI":"10.1158\/0008-5472.CAN-07-0098","article-title":"Intratumoral delivery and suppression of prostate tumor growth by attenuated Salmonella enterica serovar typhimurium carrying plasmid-based small interfering RNAs","volume":"67","author":"Zhang","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.intimp.2024.111728_b0130","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/aja.2011.179","article-title":"Plasmid-based Survivin shRNA and GRIM-19 carried by attenuated Salmonella suppresses tumor cell growth","volume":"14","author":"Liu","year":"2012","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.intimp.2024.111728_b0135","first-page":"323","article-title":"Expression and purification of functional human vascular endothelial growth factor-a121; the most important angiogenesis factor","volume":"4","author":"Kazemi-Lomedasht","year":"2014","journal-title":"Adv. Pharm. Bull."},{"key":"10.1016\/j.intimp.2024.111728_b0140","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.bbapap.2007.09.008","article-title":"PI3K\/PTEN signaling in tumorigenesis and angiogenesis","volume":"1784","author":"Jiang","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.intimp.2024.111728_b0145","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1042\/BST0350172","article-title":"Role of PTEN\/PI3K pathway in endothelial cells","volume":"35","author":"Suzuki","year":"2007","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.intimp.2024.111728_b0150","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/cvr\/cvm102","article-title":"Endothelial sprouting and angiogenesis: matrix metalloproteinases in the lead","volume":"78","author":"van Hinsbergh","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.intimp.2024.111728_b0155","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.3892\/mmr.2015.3866","article-title":"Apelin\/APJ signaling promotes hypoxia-induced proliferation of endothelial progenitor cells via phosphoinositide-3 kinase\/Akt signaling","volume":"12","author":"Zhang","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.intimp.2024.111728_b0160","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1038\/s41598-017-01960-5","article-title":"Nimbolide upregulates RECK by targeting miR-21 and HIF-1alpha in cell lines and in a hamster oral carcinogenesis model","volume":"7","author":"Kowshik","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2024.111728_b0165","doi-asserted-by":"crossref","first-page":"240","DOI":"10.2174\/1568009620666200115162814","article-title":"Targeting Proliferating Cell Nuclear Antigen (PCNA) as an effective strategy to inhibit tumor cell proliferation","volume":"20","author":"Cardano","year":"2020","journal-title":"Curr. Cancer Drug Targets"},{"key":"10.1016\/j.intimp.2024.111728_b0170","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.cca.2019.01.011","article-title":"Ki-67 protein as a tumour proliferation marker","volume":"491","author":"Menon","year":"2019","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.intimp.2024.111728_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2021.145796","article-title":"Up-down regulation of HIF-1alpha in cancer progression","volume":"798","author":"Rashid","year":"2021","journal-title":"Gene"},{"key":"10.1016\/j.intimp.2024.111728_b0180","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1002\/med.21771","article-title":"The role of hypoxia-inducible factor 1 in tumor immune evasion","volume":"41","author":"You","year":"2021","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.intimp.2024.111728_b0185","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.addr.2017.04.010","article-title":"Progress in tumor-associated macrophage (TAM)-targeted therapeutics","volume":"114","author":"Ngambenjawong","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.intimp.2024.111728_b0190","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/978-3-030-34461-0_18","article-title":"Hypoxia compromises anti-cancer immune responses","volume":"1232","author":"Multhoff","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.intimp.2024.111728_b0195","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3389\/fimmu.2018.00040","article-title":"Hypoxia pathway proteins as central mediators of metabolism in the tumor cells and their microenvironment","volume":"9","author":"Sormendi","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2024.111728_b0200","doi-asserted-by":"crossref","unstructured":"M. Kudo, Immune Checkpoint Blockade in Hepatocellular Carcinoma: 2017 Update, Liver Cancer 6 (2016) 1-12.","DOI":"10.1159\/000449342"},{"key":"10.1016\/j.intimp.2024.111728_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2022.216038","article-title":"Immune checkpoint inhibitor resistance in hepatocellular carcinoma","volume":"555","author":"Wang","year":"2023","journal-title":"Cancer Lett."},{"key":"10.1016\/j.intimp.2024.111728_b0210","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/S2468-1253(23)00147-4","article-title":"Immune checkpoint inhibitors in hepatocellular carcinoma: emerging challenges in clinical practice","volume":"8","author":"Pinter","year":"2023","journal-title":"Lancet Gastroenterol. Hepatol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924002467?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924002467?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T18:12:52Z","timestamp":1761588772000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924002467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":42,"alternative-id":["S1567576924002467"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.111728","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SiRNA-HIF-1\u03b1 delivered by attenuated Salmonella enhances the efficacy of Lenvatinib against hepatocellular carcinoma","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.111728","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111728"}}