{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T11:33:04Z","timestamp":1781350384737,"version":"3.54.1"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100016692","name":"Key Research and Development Program of Ningxia","doi-asserted-by":"publisher","award":["2021BEG02040"],"award-info":[{"award-number":["2021BEG02040"]}],"id":[{"id":"10.13039\/100016692","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.intimp.2024.111749","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T01:04:07Z","timestamp":1709255047000},"page":"111749","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Saikosaponin F ameliorates depression-associated dry eye disease by inhibiting TRIM8-induced TAK1 ubiquitination"],"prefix":"10.1016","volume":"130","author":[{"given":"Mingxia","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8891-5851","authenticated-orcid":false,"given":"Hongping","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sainan","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengqing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongwei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1010-6098","authenticated-orcid":false,"given":"Hanqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10161","key":"10.1016\/j.intimp.2024.111749_b0005","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1016\/S0140-6736(18)31948-2","article-title":"Depression","volume":"392","author":"Malhi","year":"2018","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.intimp.2024.111749_b0010","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1186\/s12888-019-2302-5","article-title":"Systematic review and meta-analysis of the relationship between sleep disorders and suicidal behaviour in patients with depression","volume":"19","author":"Wang","year":"2019","journal-title":"BMC Psychiatry"},{"issue":"6","key":"10.1016\/j.intimp.2024.111749_b0015","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1167\/tvst.7.6.35","article-title":"The Relationship of Dry Eye Disease with Depression and Anxiety: A Naturalistic Observational Study","volume":"7","author":"Kitazawa","year":"2018","journal-title":"Transl. Vis. Sci. Technol."},{"issue":"11","key":"10.1016\/j.intimp.2024.111749_b0020","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1136\/bjophthalmol-2013-303838","article-title":"Dry eye disease, dry eye symptoms and depression: the Beijing Eye Study","volume":"97","author":"Labb\u00e9","year":"2013","journal-title":"Br. J. Ophthalmol."},{"issue":"7800","key":"10.1016\/j.intimp.2024.111749_b0025","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/d41586-020-00837-4","article-title":"Map clusters of diseases to tackle multimorbidity","volume":"579","author":"Whitty","year":"2020","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.intimp.2024.111749_b0030","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.ajo.2014.11.028","article-title":"The association between dry eye disease and depression and anxiety in a large population-based study","volume":"159","author":"van der Vaart","year":"2015","journal-title":"Am. J. Ophthalmol."},{"issue":"5","key":"10.1016\/j.intimp.2024.111749_b0035","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1167\/iovs.13-11635","article-title":"Dry eye syndrome, posttraumatic stress disorder, and depression in an older male veteran population","volume":"54","author":"Fernandez","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"2","key":"10.1016\/j.intimp.2024.111749_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajo.2012.02.009","article-title":"Depression, post-traumatic stress disorder, and dry eye syndrome: a study utilizing the national United States Veterans Affairs administrative database","volume":"154","author":"Galor","year":"2012","journal-title":"Am. J. Ophthalmol."},{"issue":"3","key":"10.1016\/j.intimp.2024.111749_b0045","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jtos.2017.05.008","article-title":"TFOS DEWS II Definition and Classification Report","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul. Surf."},{"issue":"7","key":"10.1016\/j.intimp.2024.111749_b0050","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1167\/iovs.17-23397","article-title":"MyD88 Deficiency Protects Against Dry Eye-Induced Damage","volume":"59","author":"Reins","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"7","key":"10.1016\/j.intimp.2024.111749_b0055","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/s41419-022-05046-7","article-title":"FAK mediates LPS-induced inflammatory lung injury through interacting TAK1 and activating TAK1-NF\u03baB pathway","volume":"13","author":"Chen","year":"2022","journal-title":"Cell Death Dis."},{"issue":"32","key":"10.1016\/j.intimp.2024.111749_b0060","doi-asserted-by":"crossref","first-page":"19900","DOI":"10.1074\/jbc.M115.636795","article-title":"TGF\u03b2-activated Kinase 1 (TAK1) Inhibition by 5Z-7-Oxozeaenol Attenuates Early Brain Injury after Experimental Subarachnoid Hemorrhage","volume":"290","author":"Zhang","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.intimp.2024.111749_b0065","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.4049\/jimmunol.2200322","article-title":"TAK1 Limits Death Receptor Fas-Induced Proinflammatory Cell Death in Macrophages","volume":"209","author":"Maeda","year":"2022","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2024.111749_b0070","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1002\/hep.28971","article-title":"The E3 ligase tripartite motif 8 targets TAK1 to promote insulin resistance and steatohepatitis","volume":"65","author":"Yan","year":"2017","journal-title":"Hepatology"},{"issue":"8","key":"10.1016\/j.intimp.2024.111749_b0075","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.7150\/ijbs.33323","article-title":"Tripartite Motif 8 Deficiency Relieves Hepatic Ischaemia\/reperfusion Injury via TAK1-dependent Signalling Pathways","volume":"15","author":"Tao","year":"2019","journal-title":"Int. J. Biol. Sci."},{"issue":"2","key":"10.1016\/j.intimp.2024.111749_b0080","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1007\/s10753-016-0491-3","article-title":"Tripartite Motif 8 (TRIM8) Positively Regulates Pro-inflammatory Responses in Pseudomonas aeruginosa-Induced Keratitis Through Promoting K63-Linked Polyubiquitination of TAK1 Protein","volume":"40","author":"Guo","year":"2017","journal-title":"Inflammation"},{"issue":"10","key":"10.1016\/j.intimp.2024.111749_b0085","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27103255","article-title":"Production of Prosaikogenin F, Prosaikogenin G, Saikogenin F and Saikogenin G by the Recombinant Enzymatic Hydrolysis of Saikosaponin and their Anti-Cancer Effect","volume":"27","author":"Lee","year":"2022","journal-title":"Molecules"},{"issue":"4","key":"10.1016\/j.intimp.2024.111749_b0090","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1007\/s10753-016-0377-4","article-title":"Anti-Inflammation Effects and Potential Mechanism of Saikosaponins by Regulating Nicotinate and Nicotinamide Metabolism and Arachidonic Acid Metabolism","volume":"39","author":"Ma","year":"2016","journal-title":"Inflammation"},{"issue":"4","key":"10.1016\/j.intimp.2024.111749_b0095","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1742-7843.2008.00280.x","article-title":"Effect of Bupleuri Radix extracts on the toxicity of 5-fluorouracil in HepG2 hepatoma cells and normal human lymphocytes","volume":"103","author":"Kang","year":"2008","journal-title":"Basic Clin. Paharmacol. Toxicol."},{"key":"10.1016\/j.intimp.2024.111749_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110043","article-title":"Inhibition of IL-6 methylation by Saikosaponin C regulates neuroinflammation to alleviate depression","volume":"118","author":"Bai","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"3","key":"10.1016\/j.intimp.2024.111749_b0105","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.jep.2009.05.013","article-title":"Beneficial effect of Bupleurum polysaccharides on autoimmune disease induced by Campylobacter jejuni in BALB\/c mice","volume":"124","author":"Wang","year":"2009","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2024.111749_b0110","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1080\/13880209.2016.1262433","article-title":"A systematic review of the active saikosaponins and extracts isolated from Radix Bupleuri and their applications","volume":"55","author":"Yuan","year":"2017","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.intimp.2024.111749_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116729","article-title":"Saikosaponin B2 ameliorates depression-induced microglia activation by inhibiting ferroptosis-mediated neuroinflammation and ER stress","volume":"316","author":"Wang","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2024.111749_b0120","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.neuropharm.2019.05.027","article-title":"Modulation of LPA1 receptor-mediated neuronal apoptosis by Saikosaponin-d: A target involved in depression","volume":"155","author":"Xu","year":"2019","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.intimp.2024.111749_b0125","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s12974-019-1474-8","article-title":"Baicalin ameliorates neuroinflammation-induced depressive-like behavior through inhibition of toll-like receptor 4 expression via the PI3K\/AKT\/FoxO1 pathway","volume":"16","author":"Guo","year":"2019","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.intimp.2024.111749_b0130","first-page":"809","article-title":"Effects of Lycium barbarum (goji berry) on dry eye disease in rats","volume":"17","author":"Chien","year":"2018","journal-title":"Mol. Med. Rep."},{"issue":"10","key":"10.1016\/j.intimp.2024.111749_b0135","doi-asserted-by":"crossref","first-page":"6829","DOI":"10.1167\/iovs.14-14744","article-title":"Dry eye-induced CCR7+CD11b+ cell lymph node homing is induced by COX-2 activities","volume":"55","author":"Ji","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"7","key":"10.1016\/j.intimp.2024.111749_b0140","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1097\/00003226-200310000-00008","article-title":"Grading of corneal and conjunctival staining in the context of other dry eye tests","volume":"22","author":"Bron","year":"2003","journal-title":"Cornea"},{"issue":"1","key":"10.1016\/j.intimp.2024.111749_b0145","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12974-021-02091-5","article-title":"Fluoxetine regulates eEF2 activity (phosphorylation) via HDAC1 inhibitory mechanism in an LPS-induced mouse model of depression","volume":"18","author":"Li","year":"2021","journal-title":"J. Neuroinflammation"},{"issue":"7","key":"10.1016\/j.intimp.2024.111749_b0150","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1111\/cns.13645","article-title":"Galectin-1 ameliorates perioperative neurocognitive disorders in aged mice","volume":"27","author":"Shen","year":"2021","journal-title":"CNS Neurosci. Ther."},{"issue":"1","key":"10.1016\/j.intimp.2024.111749_b0155","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/s12974-019-1656-4","article-title":"R\u00e9aux-Le Goazigo, Chronic dry eye induced corneal hypersensitivity, neuroinflammatory responses, and synaptic plasticity in the mouse trigeminal brainstem","volume":"16","author":"Fakih","year":"2019","journal-title":"J. Neuroinflammation"},{"issue":"11","key":"10.1016\/j.intimp.2024.111749_b0160","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22116133","article-title":"Aged Mice Devoid of the M3 Muscarinic Acetylcholine Receptor Develop Mild Dry Eye Disease","volume":"22","author":"Musayeva","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"30","key":"10.1016\/j.intimp.2024.111749_b0165","doi-asserted-by":"crossref","first-page":"4243","DOI":"10.1038\/onc.2017.8","article-title":"GATA3 interacts with and stabilizes HIF-1\u03b1 to enhance cancer cell invasiveness","volume":"36","author":"Lin","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.intimp.2024.111749_b0170","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.798335","article-title":"Lipocalin-2 Regulates Hippocampal Microglial Activation in Poststroke Depression","volume":"13","author":"Wei","year":"2021","journal-title":"Front. Aging Neurosci."},{"issue":"11","key":"10.1016\/j.intimp.2024.111749_b0175","doi-asserted-by":"crossref","first-page":"7376","DOI":"10.1167\/iovs.14-15257","article-title":"Intrastromal delivery of bevacizumab using microneedles to treat corneal neovascularization","volume":"55","author":"Kim","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"4","key":"10.1016\/j.intimp.2024.111749_b0180","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/s41401-020-0484-5","article-title":"The artemisinin analog SM934 alleviates dry eye disease in rodent models by regulating TLR4\/NF-\u03baB\/NLRP3 signaling","volume":"42","author":"Yang","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"issue":"7","key":"10.1016\/j.intimp.2024.111749_b0185","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.it.2013.03.007","article-title":"Cell type-specific function of TAK1 in innate immune signaling","volume":"34","author":"Ajibade","year":"2013","journal-title":"Trends Immunol."},{"issue":"6844","key":"10.1016\/j.intimp.2024.111749_b0190","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/35085597","article-title":"TAK1 is a ubiquitin-dependent kinase of MKK and IKK","volume":"412","author":"Wang","year":"2001","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.intimp.2024.111749_b0195","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/JCP.0000000000001382","article-title":"Dry Those Crying Eyes: The Role of Depression and Antidepressants in Dry Eye Disease","volume":"41","author":"Rakofsky","year":"2021","journal-title":"J. Clin. Psychopharmacol."},{"issue":"Suppl 3","key":"10.1016\/j.intimp.2024.111749_b0200","first-page":"619","article-title":"Depression and dry eye disease: a need for an interdisciplinary approach?","volume":"31","author":"Weatherby","year":"2019","journal-title":"Psychiatr. Danub."},{"issue":"6","key":"10.1016\/j.intimp.2024.111749_b0205","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1097\/ICO.0b013e3182261590","article-title":"Dry eye disease in patients with depressive and anxiety disorders in Shanghai","volume":"31","author":"Wen","year":"2012","journal-title":"Cornea"},{"issue":"1","key":"10.1016\/j.intimp.2024.111749_b0210","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1167\/iovs.18-25572","article-title":"Selective Serotonin Reuptake Inhibitors Aggravate Depression-Associated Dry Eye Via Activating the NF-\u03baB Pathway","volume":"60","author":"Zhang","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"4","key":"10.1016\/j.intimp.2024.111749_b0215","first-page":"311","article-title":"Role of serotonin in gastrointestinal physiology and pathology","volume":"36","author":"Cirillo","year":"2011","journal-title":"Minerva Endocrinol."},{"issue":"3","key":"10.1016\/j.intimp.2024.111749_b0220","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.neuroscience.2006.06.036","article-title":"Serotonin-induced in vitro long-term facilitation exhibits differential pattern sensitivity in cervical and thoracic inspiratory motor output","volume":"142","author":"Lovett-Barr","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.intimp.2024.111749_b0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2021.113138","article-title":"Saikosaponin A improved depression-like behavior and inhibited hippocampal neuronal apoptosis after cerebral ischemia through p-CREB\/BDNF pathway","volume":"403","author":"Wang","year":"2021","journal-title":"Behav. Brain Res."},{"issue":"11","key":"10.1016\/j.intimp.2024.111749_b0230","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1176\/appi.ajp.2015.15020152","article-title":"Inflammation: depression fans the flames and feasts on the heat","volume":"172","author":"Kiecolt-Glaser","year":"2015","journal-title":"Am. J. Psychiatry"},{"issue":"4","key":"10.1016\/j.intimp.2024.111749_b0235","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1097\/ICO.0000000000000756","article-title":"Comparison of Topical Application of TSG-6, Cyclosporine, and Prednisolone for Treating Dry Eye","volume":"35","author":"Kim","year":"2016","journal-title":"Cornea"},{"key":"10.1016\/j.intimp.2024.111749_b0240","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.actbio.2022.01.044","article-title":"Alleviation of dry eye syndrome with one dose of antioxidant, anti-inflammatory, and mucoadhesive lysine-carbonized nanogels","volume":"141","author":"Lin","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.intimp.2024.111749_b0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.107268","article-title":"Syringin exerts neuroprotective effects in a rat model of cerebral ischemia through the FOXO3a\/NF-\u03baB pathway","volume":"90","author":"Tan","year":"2021","journal-title":"Int. Immunopharmacol."},{"issue":"12","key":"10.1016\/j.intimp.2024.111749_b0250","doi-asserted-by":"crossref","first-page":"e2300180","DOI":"10.1002\/advs.202300180","article-title":"Biomimetic Remodeling of Microglial Riboflavin Metabolism Ameliorates Cognitive Impairment by Modulating Neuroinflammation","volume":"10","author":"Zhang","year":"2023","journal-title":"Adv. Sci. (Weinh)"},{"issue":"15","key":"10.1016\/j.intimp.2024.111749_b0255","doi-asserted-by":"crossref","first-page":"10641","DOI":"10.1074\/jbc.274.15.10641","article-title":"Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation","volume":"274","author":"Sakurai","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2024.111749_b0260","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.expneurol.2012.09.010","article-title":"TAK1 inhibition for treatment of cerebral ischemia","volume":"239","author":"Ridder","year":"2013","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.intimp.2024.111749_b0265","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jpsychires.2022.06.026","article-title":"Gonadal hormone trigger the dynamic microglial alterations through Traf6\/TAK1 axis that correlate with depressive behaviors","volume":"152","author":"Peng","year":"2022","journal-title":"J. Psychiatr. Res."},{"issue":"8","key":"10.1016\/j.intimp.2024.111749_b0270","doi-asserted-by":"crossref","first-page":"5347","DOI":"10.1074\/jbc.M109.076976","article-title":"Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK\/NF-kappaB and JNK\/AP-1 activation","volume":"285","author":"Fan","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"48","key":"10.1016\/j.intimp.2024.111749_b0275","doi-asserted-by":"crossref","first-page":"19341","DOI":"10.1073\/pnas.1110946108","article-title":"Tripartite motif 8 (TRIM8) modulates TNF\u03b1- and IL-1\u03b2-triggered NF-\u03baB activation by targeting TAK1 for K63-linked polyubiquitination","volume":"108","author":"Li","year":"2011","journal-title":"PNAS"},{"issue":"7","key":"10.1016\/j.intimp.2024.111749_b0280","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1161\/STROKEAHA.118.023376","article-title":"Silencing of Long Noncoding RNA Nespas Aggravates Microglial Cell Death and Neuroinflammation in Ischemic Stroke","volume":"50","author":"Deng","year":"2019","journal-title":"Stroke"},{"issue":"2","key":"10.1016\/j.intimp.2024.111749_b0285","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1161\/HYPERTENSIONAHA.116.07741","article-title":"Tripartite Motif 8 Contributes to Pathological Cardiac Hypertrophy Through Enhancing Transforming Growth Factor \u03b2-Activated Kinase 1-Dependent Signaling Pathways","volume":"69","author":"Chen","year":"2017","journal-title":"Hypertension"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924002674?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924002674?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T18:19:39Z","timestamp":1761589179000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924002674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":57,"alternative-id":["S1567576924002674"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.111749","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Saikosaponin F ameliorates depression-associated dry eye disease by inhibiting TRIM8-induced TAK1 ubiquitination","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.111749","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111749"}}