{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:04:48Z","timestamp":1791770688801,"version":"4.3.4"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T00:00:00Z","timestamp":1740873600000},"content-version":"am","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81373167"],"award-info":[{"award-number":["81373167"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000516"],"award-info":[{"award-number":["82000516"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001696"],"award-info":[{"award-number":["82001696"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91542110"],"award-info":[{"award-number":["91542110"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2021RC020"],"award-info":[{"award-number":["2021RC020"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2023C03054"],"award-info":[{"award-number":["2023C03054"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2024C03048"],"award-info":[{"award-number":["2024C03048"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.intimp.2024.111768","type":"journal-article","created":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T15:35:39Z","timestamp":1709393739000},"page":"111768","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Toll-like receptor 2 deficiency promotes the generation of alloreactive \u03b3\u03b4T17 cells after cardiac transplantation in mice"],"prefix":"10.1016","volume":"130","author":[{"given":"Lingyun","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyu","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongchen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2024.111768_b0005","article-title":"Cardiac allograft rejection: Strategies for success in the face of immune challenges","author":"Patail","year":"2023","journal-title":"Cardiol. Rev."},{"key":"10.1016\/j.intimp.2024.111768_b0010","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/nrneph.2016.41","article-title":"Role of TLRs and DAMPs in allograft inflammation and transplant outcomes","volume":"12","author":"Braza","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.intimp.2024.111768_b0015","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.intimp.2018.03.002","article-title":"Toll-like receptors in immunity and inflammatory diseases: Past, present, and future","volume":"59","author":"Vijay","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2024.111768_b0020","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri1391","article-title":"Toll-like receptor signalling","volume":"4","author":"Akira","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.intimp.2024.111768_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121917","article-title":"Theranostic chimeric antigen receptor (CAR)-T cells: Insight into recent trends and challenges in solid tumors","volume":"328","author":"Kheyrolahzadeh","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2024.111768_b0030","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.3389\/fimmu.2019.02673","article-title":"TLR-2 and MyD88-dependent activation of MAPK and STAT proteins regulates proinflammatory cytokine response and immunity to experimental trypanosoma congolense infection","volume":"10","author":"Kuriakose","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2024.111768_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110547","article-title":"Toll-like receptor 2 deficiency alleviates acute pancreatitis by inactivating the NF-kappaB\/NLRP3 pathway","volume":"121","author":"Li","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2024.111768_b0040","doi-asserted-by":"crossref","first-page":"1052466","DOI":"10.3389\/fcimb.2022.1052466","article-title":"Identification of novel immune-related targets mediating disease progression in acute pancreatitis","volume":"12","author":"Liu","year":"2022","journal-title":"Front. Cell Infect. Microbiol."},{"key":"10.1016\/j.intimp.2024.111768_b0045","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.lfs.2017.04.006","article-title":"Toll-like receptor 2: An important immunomodulatory molecule during Helicobacter pylori infection","volume":"178","author":"Nemati","year":"2017","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2024.111768_b0050","doi-asserted-by":"crossref","first-page":"7119","DOI":"10.4049\/jimmunol.0802656","article-title":"TLR2 deficiency leads to increased Th17 infiltrates in experimental brain abscesses","volume":"182","author":"Nichols","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2024.111768_b0055","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.4049\/jimmunol.0801599","article-title":"TLR2 is a negative regulator of Th17 cells and tissue pathology in a pulmonary model of fungal infection","volume":"183","author":"Loures","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2024.111768_b0060","doi-asserted-by":"crossref","first-page":"H984","DOI":"10.1152\/ajpheart.01109.2009","article-title":"TLR2 ligands attenuate cardiac dysfunction in polymicrobial sepsis via a phosphoinositide 3-kinase-dependent mechanism","volume":"298","author":"Ha","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.intimp.2024.111768_b0065","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cellimm.2019.02.005","article-title":"Toll-like receptor 2 deficiency promotes the generation of alloreactive Th17 cells after cardiac transplantation in mice","volume":"338","author":"Li","year":"2019","journal-title":"Cell Immunol."},{"key":"10.1016\/j.intimp.2024.111768_b0070","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/ni.3726","article-title":"IL-17(+) gammadelta T cells as kick-starters of inflammation","volume":"18","author":"Papotto","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.intimp.2024.111768_b0075","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/tri.12264","article-title":"High-mobility group box 1 accelerates early acute allograft rejection via enhancing IL-17+ gammadelta T-cell response","volume":"27","author":"Xia","year":"2014","journal-title":"Transpl. Int."},{"key":"10.1016\/j.intimp.2024.111768_b0080","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/labinvest.2010.141","article-title":"High-mobility group box 1 promotes early acute allograft rejection by enhancing IL-6-dependent Th17 alloreactive response","volume":"91","author":"Duan","year":"2011","journal-title":"Lab. Invest."},{"key":"10.1016\/j.intimp.2024.111768_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.imbio.2021.152107","article-title":"TLR2 and TLR4 mRNA expression levels in liver transplant patients with acute rejection","volume":"226","author":"Keshavarz","year":"2021","journal-title":"Immunobiology"},{"key":"10.1016\/j.intimp.2024.111768_b0090","doi-asserted-by":"crossref","first-page":"757","DOI":"10.6002\/ect.2019.0242","article-title":"Gene expression of toll-like receptors 2 and 4 in renal transplant rejection","volume":"18","author":"Heidari","year":"2020","journal-title":"Exp. Clin. Transplant."},{"key":"10.1016\/j.intimp.2024.111768_b0095","doi-asserted-by":"crossref","first-page":"4235","DOI":"10.1016\/j.transproceed.2010.09.091","article-title":"Cardiac allograft rejection correlates with increased expressions of Toll-like receptors 2 and 4 and allograft inflammatory factor 1","volume":"42","author":"McDaniel","year":"2010","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.intimp.2024.111768_b0100","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1016\/j.transproceed.2010.05.157","article-title":"Acute rejection of small intestine allografts is associated with increased expression of toll-like receptors","volume":"42","author":"Castillo","year":"2010","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.intimp.2024.111768_b0105","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1242\/dmm.003533","article-title":"Recipient Toll-like receptors contribute to chronic graft dysfunction by both MyD88- and TRIF-dependent signaling","volume":"3","author":"Wang","year":"2010","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.intimp.2024.111768_b0110","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.intimp.2015.10.007","article-title":"Effect of upregulated TLR2 expression from G-CSF-mobilized donor grafts on acute graft-versus-host disease","volume":"29","author":"Lee","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2024.111768_b0115","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/imm.12569","article-title":"A peptide tetramer Tk-tPN induces tolerance of cardiac allografting by conversion of type 1 to type 2 immune responses via the Toll-like receptor 2 signal-promoted activation of the MCP1 gene","volume":"147","author":"Li","year":"2016","journal-title":"Immunology"},{"key":"10.1016\/j.intimp.2024.111768_b0120","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1097\/SHK.0000000000000172","article-title":"TLR2 deficiency aggravates lung injury caused by mechanical ventilation","volume":"42","author":"Kuipers","year":"2014","journal-title":"Shock"},{"key":"10.1016\/j.intimp.2024.111768_b0125","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1007\/s11307-022-01795-1","article-title":"Recent trends in diagnostic biomarkers of tumor microenvironment","volume":"25","author":"Siminzar","year":"2023","journal-title":"Mol. Imaging Biol."},{"key":"10.1016\/j.intimp.2024.111768_b0130","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1111\/ajt.13350","article-title":"Hyperlipidemia promotes anti-donor Th17 responses that accelerate allograft rejection","volume":"15","author":"Yuan","year":"2015","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.intimp.2024.111768_b0135","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/ni.3742","article-title":"Interleukin 17 is a chief orchestrator of immunity","volume":"18","author":"Veldhoen","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.intimp.2024.111768_b0140","doi-asserted-by":"crossref","first-page":"363","DOI":"10.4049\/jimmunol.1601024","article-title":"IL-17-producing innate and pathogen-specific tissue resident memory gammadelta T cells expand in the lungs of bordetella pertussis-infected mice","volume":"198","author":"Misiak","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2024.111768_b0145","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.immuni.2009.08.001","article-title":"Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity","volume":"31","author":"Sutton","year":"2009","journal-title":"Immunity"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924002868?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924002868?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:52:37Z","timestamp":1778820757000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924002868"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":29,"alternative-id":["S1567576924002868"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.111768","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Toll-like receptor 2 deficiency promotes the generation of alloreactive \u03b3\u03b4T17 cells after cardiac transplantation in mice","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.111768","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111768"}}