{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T01:29:32Z","timestamp":1788485372180,"version":"build-2803163510"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.intimp.2024.111809","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T05:52:38Z","timestamp":1710309158000},"page":"111809","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Integrative analysis and validation of necroptosis-related molecular signature for evaluating diagnosis and immune features in Rheumatoid arthritis"],"prefix":"10.1016","volume":"131","author":[{"given":"Wei","family":"Wan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bole","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiewen","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7090-1674","authenticated-orcid":false,"given":"Dongbao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2024.111809_b0005","doi-asserted-by":"crossref","first-page":"1144250","DOI":"10.3389\/fendo.2023.1144250","article-title":"Significance of pyroptosis-related gene in the diagnosis and classification of rheumatoid arthritis","volume":"14","author":"Li","year":"2023","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.intimp.2024.111809_b0010","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1001\/jama.2018.13103","article-title":"Diagnosis and management of rheumatoid arthritis: a review","volume":"320","author":"Aletaha","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.intimp.2024.111809_b0015","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.724934","article-title":"Identification of diagnostic signatures and immune cell infiltration characteristics in rheumatoid arthritis by integrating bioinformatic analysis and machine-learning strategies","volume":"12","author":"Yu","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2024.111809_b0020","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid arthritis","volume":"388","author":"Smolen","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.intimp.2024.111809_b0025","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.809806","article-title":"Apoptosis, autophagy, NETosis, necroptosis, and pyroptosis mediated programmed cell death as targets for innovative therapy in rheumatoid arthritis","volume":"12","author":"Zhao","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2024.111809_b0030","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/s13075-017-1436-4","article-title":"The caspase-8\/RIPK3 signaling axis in antigen presenting cells controls the inflammatory arthritic response","volume":"19","author":"Dominguez","year":"2017","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.intimp.2024.111809_b0035","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1159\/000478746","article-title":"Inhibition of necroptosis attenuates kidney inflammation and interstitial fibrosis induced by unilateral ureteral obstruction","volume":"46","author":"Xiao","year":"2017","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.intimp.2024.111809_b0040","doi-asserted-by":"crossref","first-page":"1135014","DOI":"10.3389\/fimmu.2023.1135014","article-title":"KW2449 ameliorates collagen-induced arthritis by inhibiting RIPK1-dependent necroptosis","volume":"14","author":"Wang","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2024.111809_b0045","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.bbrc.2018.09.031","article-title":"Necrostatin-1 ameliorates adjuvant arthritis rat articular chondrocyte injury via inhibiting ASIC1a-mediated necroptosis","volume":"504","author":"Chen","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2024.111809_b0050","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.4049\/jimmunol.2000113","article-title":"RIPK3-MLKL-mediated neutrophil death requires concurrent activation of fibroblast activation protein-\u03b1","volume":"205","author":"Wang","year":"2020","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2024.111809_b0055","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1093\/bioinformatics\/bts034","article-title":"The sva package for removing batch effects and other unwanted variation in high-throughput experiments","volume":"28","author":"Leek","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.intimp.2024.111809_b0060","article-title":"Comprehensive analysis of necroptosis in pancreatic cancer for appealing its implications in prognosis, immunotherapy, and chemotherapy responses","volume":"13","author":"Fang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2024.111809_b0065","article-title":"Three differential expression analysis methods for RNA sequencing: limma, EdgeR, DESeq2","author":"Liu","year":"2021","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.intimp.2024.111809_b0070","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.intimp.2024.111809_b0075","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"key":"10.1016\/j.intimp.2024.111809_b0080","doi-asserted-by":"crossref","DOI":"10.3390\/nu12092652","article-title":"Logistic LASSO regression for dietary intakes and breast cancer","volume":"12","author":"McEligot","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.intimp.2024.111809_b0085","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1186\/s12859-018-2451-4","article-title":"SVM-RFE: selection and visualization of the most relevant features through non-linear kernels","volume":"19","author":"Sanz","year":"2018","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.intimp.2024.111809_b0090","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.neunet.2022.07.029","article-title":"Attention-based random forest and contamination model","volume":"154","author":"Utkin","year":"2022","journal-title":"Neural Netw."},{"key":"10.1016\/j.intimp.2024.111809_b0095","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1471-2105-12-77","article-title":"pROC: an open-source package for R and S+ to analyze and compare ROC curves","volume":"12","author":"Robin","year":"2011","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.intimp.2024.111809_b0100","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/cac2.12067","article-title":"A nomogram for predicting overall survival in patients with low-grade endometrial stromal sarcoma: a population-based analysis","volume":"40","author":"Wu","year":"2020","journal-title":"Cancer Commun. (Lond.)"},{"key":"10.1016\/j.intimp.2024.111809_b0105","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.607622","article-title":"Identification and verification of immune-related gene prognostic signature based on ssGSEA for osteosarcoma","volume":"10","author":"Xiao","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.intimp.2024.111809_b0110","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1093\/bioinformatics\/btq170","article-title":"ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking","volume":"26","author":"Wilkerson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.intimp.2024.111809_b0115","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: gene set variation analysis for microarray and RNA-seq data","volume":"14","author":"H\u00e4nzelmann","year":"2013","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.intimp.2024.111809_b0120","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/978-1-4939-7493-1_12","article-title":"Profiling tumor infiltrating immune cells with CIBERSORT","volume":"1711","author":"Chen","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.intimp.2024.111809_b0125","doi-asserted-by":"crossref","first-page":"2506843","DOI":"10.1155\/2019\/2506843","article-title":"Deciphering immune-associated genes to predict survival in clear cell renal cell cancer","volume":"2019","author":"Hu","year":"2019","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.intimp.2024.111809_b0130","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/s41596-018-0103-9","article-title":"Pathway enrichment analysis and visualization of omics data using g:Profiler, GSEA, Cytoscape and EnrichmentMap","volume":"14","author":"Reimand","year":"2019","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.intimp.2024.111809_b0135","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","article-title":"The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis","volume":"31","author":"Arnett","year":"1988","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.intimp.2024.111809_b0140","doi-asserted-by":"crossref","first-page":"9810","DOI":"10.1038\/s41598-022-13750-9","article-title":"Improved diagnosis of rheumatoid arthritis using an artificial neural network","volume":"12","author":"Bai","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2024.111809_b0145","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.2147\/IJN.S155475","article-title":"Synovitis in mice with inflammatory arthritis monitored with quantitative analysis of dynamic contrast-enhanced NIR fluorescence imaging using iRGD-targeted liposomes as fluorescence probes","volume":"13","author":"Wu","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.intimp.2024.111809_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2020.108629","article-title":"The possible roles of necroptosis during cerebral ischemia and ischemia \/ reperfusion injury","volume":"695","author":"Liao","year":"2020","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.intimp.2024.111809_b0155","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.cell.2009.05.037","article-title":"Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation","volume":"137","author":"Cho","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2024.111809_b0160","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.cell.2009.05.021","article-title":"Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha","volume":"137","author":"He","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2024.111809_b0165","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/82732","article-title":"Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule","volume":"1","author":"Holler","year":"2000","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.intimp.2024.111809_b0170","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1126\/science.1172308","article-title":"RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis","volume":"325","author":"Zhang","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.intimp.2024.111809_b0175","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1126\/science.7533326","article-title":"The Fas death factor","volume":"267","author":"Nagata","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.intimp.2024.111809_b0180","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1126\/science.281.5381.1305","article-title":"Death receptors: signaling and modulation","volume":"281","author":"Ashkenazi","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.intimp.2024.111809_b0185","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0955-0674(99)80034-9","article-title":"Apoptosis control by death and decoy receptors","volume":"11","author":"Ashkenazi","year":"1999","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.intimp.2024.111809_b0190","doi-asserted-by":"crossref","first-page":"20049","DOI":"10.1074\/jbc.274.29.20049","article-title":"Suicidal tendencies: apoptotic cell death by caspase family proteinases","volume":"274","author":"Wolf","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2024.111809_b0195","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0092-8674(00)81874-7","article-title":"Apoptosis by death factor","volume":"88","author":"Nagata","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2024.111809_b0200","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/JLB.4A0220-114RR","article-title":"Selective killing of human M1 macrophages by Smac mimetics alone and M2 macrophages by Smac mimetics and caspase inhibition","volume":"110","author":"Ali","year":"2021","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.intimp.2024.111809_b0205","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cyto.2013.04.011","article-title":"The two directions of TNF-related apoptosis-inducing ligand in rheumatoid arthritis","volume":"63","author":"Audo","year":"2013","journal-title":"Cytokine"},{"key":"10.1016\/j.intimp.2024.111809_b0210","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s12016-020-08800-x","article-title":"Chronic granulomatous disease: a comprehensive review","volume":"61","author":"Yu","year":"2021","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.intimp.2024.111809_b0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107593","article-title":"Induction of programmed necrosis: a novel anti-cancer strategy for natural compounds","volume":"214","author":"Yu","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.intimp.2024.111809_b0220","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.tcb.2015.12.002","article-title":"TNF and ROS crosstalk in inflammation","volume":"26","author":"Blaser","year":"2016","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.intimp.2024.111809_b0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101273","article-title":"A novel NOX2 inhibitor attenuates human neutrophil oxidative stress and ameliorates inflammatory arthritis in mice","volume":"26","author":"Liu","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.intimp.2024.111809_b0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102898","article-title":"TNF\u03b1 counteracts interleukin-10 anti-inflammatory pathway through the NOX2-Lyn-SHP-1 axis in human monocytes","volume":"67","author":"Ben-Khemis","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.intimp.2024.111809_b0235","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1089\/jir.1993.13.241","article-title":"PKR: proposed nomenclature for the RNA-dependent protein kinase induced by interferon","volume":"13","author":"Clemens","year":"1993","journal-title":"J. Interferon Res."},{"key":"10.1016\/j.intimp.2024.111809_b0240","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S1074-7613(00)00014-5","article-title":"Essential role for the dsRNA-dependent protein kinase PKR in innate immunity to viral infection","volume":"13","author":"Balachandran","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2024.111809_b0245","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.chom.2021.04.016","article-title":"Toxoplasma gondii secreted effectors co-opt host repressor complexes to inhibit necroptosis","volume":"29","author":"Rosenberg","year":"2021","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.intimp.2024.111809_b0250","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.redox.2017.08.011","article-title":"PKR activation causes inflammation and MMP-13 secretion in human degenerated articular chondrocytes","volume":"14","author":"Ma","year":"2018","journal-title":"Redox. Biol."},{"key":"10.1016\/j.intimp.2024.111809_b0255","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.bj.2020.06.010","article-title":"Innate immunity drives pathogenesis of rheumatoid arthritis","volume":"44","author":"Edilova","year":"2021","journal-title":"Biomed. J."},{"key":"10.1016\/j.intimp.2024.111809_b0260","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.3389\/fphar.2019.01255","article-title":"Targeting macrophages: friends or foes in disease?","volume":"10","author":"Ardura","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2024.111809_b0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2019.102397","article-title":"Macrophage M1\/M2 polarization and rheumatoid arthritis: a systematic review","volume":"18","author":"Tardito","year":"2019","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.intimp.2024.111809_b0270","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.3389\/fimmu.2017.01958","article-title":"M1 and M2 monocytes in rheumatoid arthritis: a contribution of imbalance of M1\/M2 monocytes to osteoclastogenesis","volume":"8","author":"Fukui","year":"2017","journal-title":"Front. Immunol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924003278?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924003278?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T06:43:09Z","timestamp":1731739389000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924003278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":54,"alternative-id":["S1567576924003278"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.111809","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrative analysis and validation of necroptosis-related molecular signature for evaluating diagnosis and immune features in Rheumatoid arthritis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.111809","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111809"}}