{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:03:12Z","timestamp":1787670192637,"version":"build-2736575974"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007620","name":"Department of Education of Liaoning Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007620","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019033","name":"Key Research and Development Program of Liaoning Province","doi-asserted-by":"publisher","award":["LJKZZ20220094"],"award-info":[{"award-number":["LJKZZ20220094"]}],"id":[{"id":"10.13039\/501100019033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.intimp.2024.111885","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T22:21:08Z","timestamp":1710800468000},"page":"111885","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Immunoenhancement effect of cinobufagin on macrophages and the cyclophosphamide-induced immunosuppression mouse model"],"prefix":"10.1016","volume":"131","author":[{"given":"Yue-Zhu","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8133-3840","authenticated-orcid":false,"given":"Yi-Lun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.intimp.2024.111885_b0005","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1177\/10600280211046298","article-title":"A review of selumetinib in the treatment of neurofibromatosis type 1-related plexiform neurofibromas","volume":"56","author":"Anderson","year":"2022","journal-title":"Ann. Pharmacother."},{"issue":"3","key":"10.1016\/j.intimp.2024.111885_b0010","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.cmet.2022.01.007","article-title":"The hallmarks of cancer metabolism: Still emerging","volume":"34","author":"Pavlova","year":"2022","journal-title":"Cell Metab."},{"issue":"3","key":"10.1016\/j.intimp.2024.111885_b0015","doi-asserted-by":"crossref","first-page":"808","DOI":"10.3390\/nu12030818","article-title":"Nutrition and the immune system: A complicated tango","volume":"12","author":"Venter","year":"2020","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.intimp.2024.111885_b0020","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s12602-019-09567-0","article-title":"Effects of Bacillus cereus PAS38 on immune-related differentially expressed genes of spleen in broilers","volume":"12","author":"Gu","year":"2020","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"10.1016\/j.intimp.2024.111885_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.174999","article-title":"Vitexin-2-O-rhamnoside improves immunosuppression, oxidative stress, and phosphorylation of PI3K\/Akt signal pathway in cyclophosphamide treated mice","volume":"925","author":"Wang","year":"2022","journal-title":"Eur. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.intimp.2024.111885_b0030","first-page":"147","article-title":"Immunomodulatory effects of sinensetin on macrophage and cyclophosphamide-induced immunosuppression in mice","volume":"77","author":"Wang","year":"2022","journal-title":"Pharmazie"},{"issue":"12","key":"10.1016\/j.intimp.2024.111885_b0035","article-title":"Innate and daptive cellular immune responses to Mycobacterium tuberculosis infection","volume":"5","author":"Mayer-Barber","year":"2015","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"10","key":"10.1016\/j.intimp.2024.111885_b0040","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1002\/eji.201546178","article-title":"Aging of the immune system: Focus on inflammation and vaccination","volume":"46","author":"Pinti","year":"2016","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.intimp.2024.111885_b0045","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1146\/annurev-immunol-101320-031555","article-title":"Functional hallmarks of healthy macrophage responses: Their regulatory basis and disease relevance","volume":"40","author":"Sheu","year":"2022","journal-title":"Annu. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2024.111885_b0050","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1002\/JLB.4MR0220-446R","article-title":"Innate immune memory of tissue-resident macrophages and trained innate immunity: Re-vamping vaccine concept and strategies","volume":"108","author":"Xing","year":"2020","journal-title":"J. Leukoc. Biol."},{"issue":"9","key":"10.1016\/j.intimp.2024.111885_b0055","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1093\/jpp\/rgad059","article-title":"Cinobufagin: a promising therapeutic agent for cancer","volume":"75","author":"Dai","year":"2023","journal-title":"J. Pharm. Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2024.111885_b0060","first-page":"200","article-title":"Cinobufagin suppresses colorectal cancer growth via STAT3 pathway inhibition","volume":"11","author":"Bai","year":"2021","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.intimp.2024.111885_b0065","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.canlet.2022.01.025","article-title":"Chemically synthesized cinobufagin suppresses nasopharyngeal carcinoma metastasis by inducing ENKUR to stabilize p53 expression","volume":"531","author":"Hou","year":"2022","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.intimp.2024.111885_b0070","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s13046-022-02327-z","article-title":"CAR race to cancer immunotherapy: from CAR T, CAR NK to CAR macrophage therapy","volume":"41","author":"Pan","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.intimp.2024.111885_b0075","doi-asserted-by":"crossref","first-page":"13344","DOI":"10.1038\/s41598-022-17692-0","article-title":"Extracellular vesicles derived from GMSCs stimulated with TNF-\u03b1 and IFN-\u03b1 promote M2 macrophage polarization via enhanced CD73 and CD5L expression","volume":"12","author":"Watanabe","year":"2022","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.intimp.2024.111885_b0080","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1038\/s41596-020-0330-8","article-title":"Macrophage phagocytosis assay with reconstituted target particles","volume":"15","author":"Joffe","year":"2020","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.intimp.2024.111885_b0085","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.ijbiomac.2017.12.025","article-title":"Macrophage immunomodulatory activity of the polysaccharide isolated from Collybia radicata mushroom","volume":"108","author":"Wang","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"issue":"4","key":"10.1016\/j.intimp.2024.111885_b0090","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.molcel.2019.02.038","article-title":"Interleukin-1\u03b2 induces mtDNA release to activate innate immune signaling via cGAS-STING","volume":"74","author":"Aarreberg","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.intimp.2024.111885_b0095","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3389\/fimmu.2019.00276","article-title":"NLRP3 inflammasome and inflammatory bowel disease","volume":"10","author":"Zhen","year":"2019","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2024.111885_b0100","doi-asserted-by":"crossref","first-page":"700","DOI":"10.3390\/biom11050700","article-title":"Immunology of acute and chronic wound healing","volume":"11","author":"Raziyeva","year":"2021","journal-title":"Biomolecules"},{"issue":"9","key":"10.1016\/j.intimp.2024.111885_b0105","doi-asserted-by":"crossref","first-page":"e14251","DOI":"10.1111\/jfbc.14251","article-title":"Shrimp peptide hydrolysate modulates the immune response in cyclophosphamide immunosuppressed mice model","volume":"46","author":"Khan","year":"2022","journal-title":"J. Food Biochem."},{"issue":"7","key":"10.1016\/j.intimp.2024.111885_b0110","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1021\/acs.jafc.1c06502","article-title":"Effects of exopolysaccharides from Lactiplantibacillus plantarum JLAU103 on intestinal immune response, oxidative stress, and microbial communities in cyclophosphamide-induced immunosuppressed mice","volume":"70","author":"Wang","year":"2022","journal-title":"J. Agric. Food Chem."},{"issue":"1","key":"10.1016\/j.intimp.2024.111885_b0115","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12885-020-07742-z","article-title":"Neutral polysaccharide from Panax notoginseng enhanced cyclophosphamide antitumor efficacy in hepatoma H22-bearing mice","volume":"21","author":"Liu","year":"2021","journal-title":"BMC Cancer"},{"key":"10.1016\/j.intimp.2024.111885_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.115957","article-title":"Cultured Cordyceps sinensis polysaccharides modulate intestinal mucosal immunity and gut microbiota in cyclophosphamide-treated mice","volume":"235","author":"Ying","year":"2020","journal-title":"Carbohydr. Polym."},{"issue":"3","key":"10.1016\/j.intimp.2024.111885_b0125","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1039\/C9FO02780G","article-title":"Longan pulp polysaccharide protects against cyclophosphamide-induced immunosuppression in mice by promoting intestinal secretory IgA synthesis","volume":"11","author":"Bai","year":"2020","journal-title":"Food Funct."},{"issue":"2","key":"10.1016\/j.intimp.2024.111885_b0130","doi-asserted-by":"crossref","first-page":"206","DOI":"10.4162\/nrp.2023.17.2.206","article-title":"Immune-enhancing effect of hydrolyzed and fermented Platycodon grandiflorum extract in cyclophosphamide-induced immunosuppressed BALB\/c mice","volume":"17","author":"Lee","year":"2023","journal-title":"Nutr. Res. Pract."},{"issue":"3","key":"10.1016\/j.intimp.2024.111885_b0135","doi-asserted-by":"crossref","first-page":"414","DOI":"10.4014\/jmb.1210.10010","article-title":"Lactobacillus plantarum HY7712 ameliorates cyclophosphamide-induced immunosuppression in mice","volume":"23","author":"Jang","year":"2013","journal-title":"J. Microbiol. Biotechnol."},{"key":"10.1016\/j.intimp.2024.111885_b0140","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.fsi.2019.10.041","article-title":"Teleost cytotoxic T cells","volume":"95","author":"Yamaguchi","year":"2019","journal-title":"Fish Shellfish Immunol."},{"issue":"6","key":"10.1016\/j.intimp.2024.111885_b0145","doi-asserted-by":"crossref","first-page":"8509","DOI":"10.1002\/jcp.27782","article-title":"CD8(+) cytotoxic T lymphocytes in cancer immunotherapy: A review","volume":"234","author":"Farhood","year":"2019","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.intimp.2024.111885_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2021.104159","article-title":"Immune adjuvant effects of interferon-gamma (IFN-\u03b3) of flounder (Paralichthys olivaceus) against Edwardsiella tarda","volume":"123","author":"Wang","year":"2021","journal-title":"Dev. Comp. Immunol."},{"issue":"12","key":"10.1016\/j.intimp.2024.111885_b0155","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1002\/eji.202249892","article-title":"IL-4\/IL-13-producing ILC2s are required for timely control of intestinal helminth infection in mice","volume":"52","author":"Varela","year":"2022","journal-title":"Eur. J. Immunol."},{"issue":"11","key":"10.1016\/j.intimp.2024.111885_b0160","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1161\/CIRCRESAHA.121.319077","article-title":"Interleukin-6 signaling and anti-interleukin-6 therapeutics in cardiovascular disease","volume":"128","author":"Ridker","year":"2021","journal-title":"Circ. Res."},{"key":"10.1016\/j.intimp.2024.111885_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2022.108189","article-title":"Novel strategies exploiting interleukin-12 in cancer immunotherapy","volume":"239","author":"Cirella","year":"2022","journal-title":"Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.intimp.2024.111885_b0170","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13054-022-03893-6","article-title":"Immune effects of PI3K\/Akt\/HIF-1\u03b1-regulated glycolysis in polymorphonuclear neutrophils during sepsis","volume":"26","author":"Pan","year":"2022","journal-title":"Crit. Care"},{"issue":"28","key":"10.1016\/j.intimp.2024.111885_b0175","doi-asserted-by":"crossref","first-page":"5759","DOI":"10.1021\/acs.jafc.6b01854","article-title":"Preventive effects of a novel polysaccharide from Sepia esculenta ink on ovarian failure and its action mechanisms in cyclophosphamide-treated mice","volume":"64","author":"Liu","year":"2016","journal-title":"J. Agric. Food Chem."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692400403X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692400403X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T06:45:27Z","timestamp":1731739527000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156757692400403X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":35,"alternative-id":["S156757692400403X"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.111885","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunoenhancement effect of cinobufagin on macrophages and the cyclophosphamide-induced immunosuppression mouse model","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.111885","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111885"}}