{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T23:25:22Z","timestamp":1793489122366,"version":"4.5.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Jiangsu Province Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018556","name":"Science and Technology Program of Suzhou","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018556","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.intimp.2024.111904","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T13:44:40Z","timestamp":1711115080000},"page":"111904","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Inhibition of MAGL attenuates Intervertebral Disc Degeneration by Delaying nucleus pulposus senescence through STING"],"prefix":"10.1016","volume":"131","author":[{"given":"Chunyang","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiacheng","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiale","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingye","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongwei","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongkang","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dechun","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6372-512X","authenticated-orcid":false,"given":"Xiexing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiqing","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2024.111904_b0005","unstructured":"Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016, Lancet (London, England) 390(10100) (2017) 1211-1259."},{"issue":"1","key":"10.1016\/j.intimp.2024.111904_b0010","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41584-021-00713-z","article-title":"A new immunometabolic perspective of intervertebral disc degeneration","volume":"18","author":"Francisco","year":"2022","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.intimp.2024.111904_b0015","first-page":"1","article-title":"The NLRX1-SLC39A7 complex orchestrates mitochondrial dynamics and mitophagy to rejuvenate intervertebral disc by modulating mitochondrial Zn(2+) trafficking","author":"Song","year":"2023","journal-title":"Autophagy"},{"issue":"4","key":"10.1016\/j.intimp.2024.111904_b0020","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/s12276-022-00753-9","article-title":"Grem1 accelerates nucleus pulposus cell apoptosis and intervertebral disc degeneration by inhibiting TGF-\u03b2-mediated Smad2\/3 phosphorylation","volume":"54","author":"Chen","year":"2022","journal-title":"Exp. Mol. Med."},{"issue":"22","key":"10.1016\/j.intimp.2024.111904_b0025","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1101\/gad.1971610","article-title":"The essence of senescence","volume":"24","author":"Kuilman","year":"2010","journal-title":"Genes Dev."},{"issue":"9","key":"10.1016\/j.intimp.2024.111904_b0030","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/nrm2233","article-title":"Cellular senescence: when bad things happen to good cells","volume":"8","author":"Campisi","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.intimp.2024.111904_b0035","doi-asserted-by":"crossref","first-page":"770","DOI":"10.3389\/fphar.2019.00770","article-title":"Cellular senescence and the kidney: potential therapeutic Targets and tools","volume":"10","author":"Knoppert","year":"2019","journal-title":"Front Pharmacol"},{"issue":"3","key":"10.1016\/j.intimp.2024.111904_b0040","doi-asserted-by":"crossref","first-page":"e12927","DOI":"10.1111\/acel.12927","article-title":"Systemic clearance of p16(INK4a) -positive senescent cells mitigates age-associated intervertebral disc degeneration","volume":"18","author":"Patil","year":"2019","journal-title":"Aging Cell"},{"issue":"3","key":"10.1016\/j.intimp.2024.111904_b0045","doi-asserted-by":"crossref","first-page":"R45","DOI":"10.1186\/ar2198","article-title":"Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration","volume":"9","author":"Le Maitre","year":"2007","journal-title":"Arthritis Res. Ther."},{"issue":"3","key":"10.1016\/j.intimp.2024.111904_b0050","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031715","article-title":"The proteolysis of ECM in intervertebral disc degeneration","volume":"23","author":"Liang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.intimp.2024.111904_b0055","doi-asserted-by":"crossref","first-page":"e765","DOI":"10.1002\/ctm2.765","article-title":"m6A hypomethylation of DNMT3B regulated by ALKBH5 promotes intervertebral disc degeneration via E4F1 deficiency","volume":"12","author":"Li","year":"2022","journal-title":"Clin Transl Med"},{"issue":"2","key":"10.1016\/j.intimp.2024.111904_b0060","doi-asserted-by":"crossref","first-page":"552","DOI":"10.14336\/AD.2021.1025","article-title":"CB2R attenuates intervertebral disc degeneration by delaying nucleus pulposus cell senescence through AMPK\/GSK3\u03b2 pathway","volume":"13","author":"Du","year":"2022","journal-title":"Aging Dis."},{"key":"10.1016\/j.intimp.2024.111904_b0065","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12866-016-0625-7","article-title":"Gut microbiota lipopolysaccharide accelerates inflamm-aging in mice","volume":"16","author":"Kim","year":"2016","journal-title":"BMC Microbiol."},{"issue":"Suppl 2","key":"10.1016\/j.intimp.2024.111904_b0070","first-page":"10","article-title":"Histology and pathology of the human intervertebral disc, the journal of bone and joint surgery","volume":"88","author":"Roberts","year":"2006","journal-title":"American"},{"issue":"4","key":"10.1016\/j.intimp.2024.111904_b0075","doi-asserted-by":"crossref","first-page":"R77","DOI":"10.1186\/ar2275","article-title":"Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1beta and TNFalpha expression profile","volume":"9","author":"Le Maitre","year":"2007","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.intimp.2024.111904_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2020.111417","article-title":"The miR-623\/CXCL12 axis inhibits LPS-induced nucleus pulposus cell apoptosis and senescence","volume":"194","author":"Zhong","year":"2021","journal-title":"Mech. Ageing Dev."},{"issue":"12","key":"10.1016\/j.intimp.2024.111904_b0085","doi-asserted-by":"crossref","DOI":"10.3390\/cells10123454","article-title":"The novel Monoacylglycerol lipase inhibitor MJN110 suppresses neuroinflammation, normalizes synaptic composition and improves behavioral performance in the repetitive traumatic brain injury mouse model","volume":"10","author":"Selvaraj","year":"2021","journal-title":"Cells"},{"issue":"4","key":"10.1016\/j.intimp.2024.111904_b0090","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.apsb.2019.10.006","article-title":"Monoacylglycerol lipase inhibitors: modulators for lipid metabolism in cancer malignancy, neurological and metabolic disorders","volume":"10","author":"Deng","year":"2020","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.intimp.2024.111904_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.freeradbiomed.2023.07.019","article-title":"MAGL inhibition relieves synovial inflammation and pain via regulating NOX4-Nrf2 redox balance in osteoarthritis","author":"Li","year":"2023","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"10.1016\/j.intimp.2024.111904_b0100","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13075-020-2096-3","article-title":"Combatting joint pain and inflammation by dual inhibition of monoacylglycerol lipase and cyclooxygenase-2 in a rat model of osteoarthritis","volume":"22","author":"Philpott","year":"2020","journal-title":"Arthritis Res. Ther."},{"issue":"6","key":"10.1016\/j.intimp.2024.111904_b0105","doi-asserted-by":"crossref","first-page":"e447","DOI":"10.1002\/ctm2.447","article-title":"Inhibition of MAGL activates the Keap1\/Nrf2 pathway to attenuate glucocorticoid-induced osteonecrosis of the femoral head","volume":"11","author":"Yang","year":"2021","journal-title":"Clin Transl Med"},{"issue":"7454","key":"10.1016\/j.intimp.2024.111904_b0110","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nature12306","article-title":"cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING","volume":"498","author":"Ablasser","year":"2013","journal-title":"Nature"},{"issue":"47","key":"10.1016\/j.intimp.2024.111904_b0115","doi-asserted-by":"crossref","first-page":"19386","DOI":"10.1073\/pnas.1215006109","article-title":"STING manifests self DNA-dependent inflammatory disease","volume":"109","author":"Ahn","year":"2012","journal-title":"PNAS"},{"key":"10.1016\/j.intimp.2024.111904_b0120","doi-asserted-by":"crossref","first-page":"5166","DOI":"10.1038\/ncomms6166","article-title":"Inflammation-driven carcinogenesis is mediated through STING","volume":"5","author":"Ahn","year":"2014","journal-title":"Nat Commun"},{"issue":"15","key":"10.1016\/j.intimp.2024.111904_b0125","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.259738","article-title":"Metformin inactivates the cGAS-STING pathway through autophagy and suppresses senescence in nucleus pulposus cells","volume":"135","author":"Ren","year":"2022","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.intimp.2024.111904_b0130","article-title":"Dehydrocostus lactone attenuates the senescence of nucleus pulposus cells and ameliorates intervertebral disc degeneration via inhibition of STING-TBK1\/NF-\u03baB and MAPK signaling","volume":"12","author":"Chen","year":"2021","journal-title":"Front Pharmacol"},{"issue":"4","key":"10.1016\/j.intimp.2024.111904_b0135","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/s41569-021-00624-2","article-title":"The role of cellular senescence in cardiac disease: basic biology and clinical relevance","volume":"19","author":"Mehdizadeh","year":"2022","journal-title":"Nat. Rev. Cardiol."},{"issue":"13","key":"10.1016\/j.intimp.2024.111904_b0140","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1080\/15384101.2016.1152433","article-title":"Disc cell senescence in intervertebral disc degeneration: causes and molecular pathways","volume":"15","author":"Feng","year":"2016","journal-title":"Cell Cycle (georgetown, Tex.)"},{"issue":"12","key":"10.1016\/j.intimp.2024.111904_b0145","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1038\/nm.4000","article-title":"Cellular senescence in aging and age-related disease: from mechanisms to therapy","volume":"21","author":"Childs","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.intimp.2024.111904_b0150","doi-asserted-by":"crossref","unstructured":"H. Che, J. Li, Y. Li, C. Ma, H. Liu, J. Qin, J. Dong, Z. Zhang, C.J. Xian, D. Miao, L. Wang, Y. Ren, p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle, eLife 9 (2020).","DOI":"10.7554\/eLife.52570"},{"issue":"1","key":"10.1016\/j.intimp.2024.111904_b0155","doi-asserted-by":"crossref","first-page":"5213","DOI":"10.1038\/s41467-021-25453-2","article-title":"Long-term treatment with senolytic drugs dasatinib and quercetin ameliorates age-dependent intervertebral disc degeneration in mice","volume":"12","author":"Novais","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.intimp.2024.111904_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101902","article-title":"Epigenetic modifications of inflammation in intervertebral disc degeneration","volume":"87","author":"Kang","year":"2023","journal-title":"Ageing Res Rev"},{"issue":"5","key":"10.1016\/j.intimp.2024.111904_b0165","doi-asserted-by":"crossref","first-page":"R121","DOI":"10.1186\/ar4301","article-title":"An organ culture system to model early degenerative changes of the intervertebral disc II: profiling global gene expression changes","volume":"15","author":"Markova","year":"2013","journal-title":"Arthritis Res. Ther."},{"issue":"1","key":"10.1016\/j.intimp.2024.111904_b0170","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.bbrc.2013.02.034","article-title":"A role for TNF\u03b1 in intervertebral disc degeneration: a non-recoverable catabolic shift","volume":"433","author":"Purmessur","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.intimp.2024.111904_b0175","first-page":"1357","article-title":"Knockdown of miR-222 inhibits inflammation and the apoptosis of LPS-stimulated human intervertebral disc nucleus pulposus cells","volume":"44","author":"Zhang","year":"2019","journal-title":"Int. J. Mol. Med."},{"issue":"6","key":"10.1016\/j.intimp.2024.111904_b0180","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/cpt.108","article-title":"Cannabis in cancer care","volume":"97","author":"Abrams","year":"2015","journal-title":"Clin. Pharmacol. Ther."},{"issue":"3","key":"10.1016\/j.intimp.2024.111904_b0185","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/j.1476-5381.2010.00777.x","article-title":"Cannabinoid CB1 receptor-interacting proteins: novel targets for central nervous system drug discovery?","volume":"160","author":"Smith","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.intimp.2024.111904_b0190","doi-asserted-by":"crossref","unstructured":"X. Li, T. Hua, K. Vemuri, J.H. Ho, Y. Wu, L. Wu, P. Popov, O. Benchama, N. Zvonok, K. Locke, L. Qu, G.W. Han, M.R. Iyer, R. Cinar, N.J. Coffey, J. Wang, M. Wu, V. Katritch, S. Zhao, G. Kunos, L.M. Bohn, A. Makriyannis, R.C. Stevens, Z.J. Liu, Crystal Structure of the Human Cannabinoid Receptor CB2, Cell 176(3) (2019) 459-467 e13.","DOI":"10.1016\/j.cell.2018.12.011"},{"key":"10.1016\/j.intimp.2024.111904_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105978","article-title":"The ameliorating effect of cannabinoid type 2 receptor activation on brain, lung, liver and heart damage in cecal ligation and puncture-induced sepsis model in rats","volume":"78","author":"\u00c7ak\u0131r","year":"2020","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2024.111904_b0200","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s10020-021-00351-x","article-title":"CB2-mediated attenuation of nucleus pulposus degeneration via the amelioration of inflammation and oxidative stress in vivo and in vitro","volume":"27","author":"Cheng","year":"2021","journal-title":"Mol Med"},{"key":"10.1016\/j.intimp.2024.111904_b0205","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.bcp.2018.07.036","article-title":"Monoacylglycerol lipase (MAGL) as a promising therapeutic target","volume":"157","author":"Gil-Ord\u00f3\u00f1ez","year":"2018","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2024.111904_b0210","article-title":"Discovery of Monoacylglycerol lipase (MAGL) inhibitors based on a Pharmacophore-guided virtual screening study, molecules (Basel","volume":"26","author":"Jha","year":"2020","journal-title":"Switzerland)"},{"issue":"7","key":"10.1016\/j.intimp.2024.111904_b0215","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.chembiol.2009.05.009","article-title":"Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism","volume":"16","author":"Long","year":"2009","journal-title":"Chem. Biol."},{"key":"10.1016\/j.intimp.2024.111904_b0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2015.04.018","article-title":"The monoacylglycerol lipase inhibitor JZL184 decreases inflammatory response in skeletal muscle contusion in rats","volume":"761","author":"Jiang","year":"2015","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.intimp.2024.111904_b0225","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1089\/can.2020.0177","article-title":"Monoacylglycerol lipase inhibition using JZL184 attenuates paw inflammation and functional deficits in a mouse model of inflammatory arthritis","volume":"6","author":"Nass","year":"2021","journal-title":"Cannabis Cannabinoid Res."},{"issue":"10","key":"10.1016\/j.intimp.2024.111904_b0230","doi-asserted-by":"crossref","first-page":"e77706","DOI":"10.1371\/journal.pone.0077706","article-title":"Monoacylglycerol lipase (MAGL) inhibition attenuates acute lung injury in mice","volume":"8","author":"Costola-de-Souza","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.intimp.2024.111904_b0235","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/s41419-017-0151-z","article-title":"Prolactin inhibits the progression of intervertebral disc degeneration through inactivation of the NF-\u03baB pathway in rats","volume":"9","author":"Wu","year":"2018","journal-title":"Cell Death Dis"},{"issue":"4","key":"10.1016\/j.intimp.2024.111904_b0240","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1007\/s12035-015-9213-3","article-title":"Neuroprotective effect of JZL184 in MPP(+)-treated SH-SY5Y cells through CB2 receptors","volume":"53","author":"Aymerich","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.intimp.2024.111904_b0245","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.pharmthera.2017.02.033","article-title":"Monoglyceride lipase as a drug target: at the crossroads of arachidonic acid metabolism and endocannabinoid signaling","volume":"175","author":"Grabner","year":"2017","journal-title":"Pharmacol. Ther."},{"issue":"2","key":"10.1016\/j.intimp.2024.111904_b0250","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1748-1716.2011.02280.x","article-title":"The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors","volume":"204","author":"Savinainen","year":"2012","journal-title":"Acta Physiol (Oxf.)"},{"issue":"5","key":"10.1016\/j.intimp.2024.111904_b0255","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.4103\/1673-5374.355755","article-title":"Endocannabinoid control of neuroinflammation in traumatic brain injury by monoacylglycerol lipase in astrocytes","volume":"18","author":"Chen","year":"2023","journal-title":"Neural Regen. Res."},{"issue":"8","key":"10.1016\/j.intimp.2024.111904_b0260","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1096\/fj.10-176602","article-title":"Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation","volume":"25","author":"Alhouayek","year":"2011","journal-title":"FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology"},{"issue":"1","key":"10.1016\/j.intimp.2024.111904_b0265","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12974-023-02701-4","article-title":"Inhibition of 2-arachidonoylglycerol degradation enhances glial immunity by single-cell transcriptomic analysis","volume":"20","author":"Zhu","year":"2023","journal-title":"J. Neuroinflammation"},{"issue":"8","key":"10.1016\/j.intimp.2024.111904_b0270","doi-asserted-by":"crossref","first-page":"e13186","DOI":"10.1111\/acel.13186","article-title":"Aging aggravated liver ischemia and reperfusion injury by promoting STING-mediated NLRP3 activation in macrophages","volume":"19","author":"Zhong","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/j.intimp.2024.111904_b0275","series-title":"Proceedings of the National Academy of Sciences of the United States of America 118(37)","article-title":"NAD(+) supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING","author":"Hou","year":"2021"},{"issue":"8","key":"10.1016\/j.intimp.2024.111904_b0280","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.joca.2021.04.017","article-title":"Targeting STING attenuates ROS induced intervertebral disc degeneration","volume":"29","author":"Guo","year":"2021","journal-title":"Osteoarthr. Cartil."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924004223?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924004223?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T06:45:57Z","timestamp":1731739557000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924004223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":56,"alternative-id":["S1567576924004223"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.111904","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of MAGL attenuates Intervertebral Disc Degeneration by Delaying nucleus pulposus senescence through STING","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.111904","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111904"}}