{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:08:51Z","timestamp":1791428931424,"version":"4.3.3"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100018693","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023181","name":"Medical Research Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023181","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.intimp.2024.111919","type":"journal-article","created":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T01:23:27Z","timestamp":1711761807000},"page":"111919","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["PD-1 Receptor (+) T cells are associated with the efficacy of the combined treatment with regulatory t cells and rituximab in type 1 diabetes children via regulatory t cells suppressive activity amelioration"],"prefix":"10.1016","volume":"132","author":[{"given":"Maciej","family":"Zieli\u0144ski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Sakowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota","family":"Iwaszkiewicz-Grze\u015b","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateusz","family":"Gliwi\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matylda","family":"Hennig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"\u017bali\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Wo\u0142oszyn-Durkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Ja\u017awi\u0144ska-Cury\u0142\u0142o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halla","family":"Kami\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rados\u0142aw","family":"Owczuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"M\u0142ynarski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Przemys\u0142awa","family":"Jarosz-Chobot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur","family":"Bossowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8281-4408","authenticated-orcid":false,"given":"Agnieszka","family":"Szadkowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Fendler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwona","family":"Be\u0144-Skowronek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Chobot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"My\u015bliwiec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janusz","family":"Siebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Marek-Trzonkowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5287-5210","authenticated-orcid":false,"given":"Piotr","family":"Trzonkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.intimp.2024.111919_b0005","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1007\/s00125-021-05565-6","article-title":"Interactions between islets and regulatory immune cells in health and type 1 diabetes","volume":"64","author":"Budd","year":"2021","journal-title":"Diabetologia."},{"key":"10.1016\/j.intimp.2024.111919_b0010","doi-asserted-by":"crossref","first-page":"4199","DOI":"10.3389\/fimmu.2022.911151","article-title":"Nature vs. nurture: FOXP3, genetics, and tissue environment shape Treg function","volume":"13","author":"Raugh","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2024.111919_b0015","first-page":"14","article-title":"The need and benefit of immune monitoring to define patient and disease heterogeneity, mechanisms of therapeutic action and efficacy of intervention therapy for precision medicine in type 1 diabetes","author":"Roep","year":"2023","journal-title":"Front. Immunol."},{"issue":"9","key":"10.1016\/j.intimp.2024.111919_b0020","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S2213-8587(21)00181-9","article-title":"Defining a cure for type 1 diabetes: a call to action","volume":"9","author":"Roep","year":"2021","journal-title":"lancet. Diabetes. Endocrinol."},{"issue":"7","key":"10.1016\/j.intimp.2024.111919_b0025","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1056\/NEJMoa1902226","article-title":"An anti-CD3 antibody, teplizumab, in relatives at risk for type 1 diabetes","volume":"381","author":"Herold","year":"2019","journal-title":"N. Engl. J. Med."},{"issue":"18","key":"10.1016\/j.intimp.2024.111919_b0030","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.147474","article-title":"The effect of low-dose IL-2 and Treg adoptive cell therapy in patients with type 1 diabetes","volume":"6","author":"Dong","year":"2021","journal-title":"JCI. insight."},{"issue":"8","key":"10.1016\/j.intimp.2024.111919_b0035","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1111\/dom.14723","article-title":"Combined therapy with CD4+CD25highCD127\u2212 T regulatory cells and anti-CD20 antibody in recent-onset type 1 diabetes is superior to monotherapy: Randomized phase I\/II trial","volume":"24","author":"Zieli\u0144ski","year":"2022","journal-title":"Diabetes, Obes. Metab."},{"issue":"315","key":"10.1016\/j.intimp.2024.111919_b0040","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aad4134","article-title":"Type 1 diabetes immunotherapy using polyclonal regulatory T cells","volume":"7","author":"Bluestone","year":"2015","journal-title":"Sci. Transl. Med."},{"issue":"1","key":"10.1016\/j.intimp.2024.111919_b0045","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.clim.2014.03.016","article-title":"Therapy of type 1 diabetes with CD4(+)CD25(high)CD127-regulatory T cells prolongs survival of pancreatic islets - results of one -year-long follow-up","volume":"153","author":"Marek-Trzonkowska","year":"2014","journal-title":"Clin. Immunol."},{"issue":"9","key":"10.1016\/j.intimp.2024.111919_b0050","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.2337\/dc12-0038","article-title":"Administration of CD4+CD25highCD127- regulatory T cells preserves \u03b2-cell function in type 1 diabetes in children","volume":"35","author":"Marek-Trzonkowska","year":"2012","journal-title":"Diabetes. Care."},{"issue":"304","key":"10.1016\/j.intimp.2024.111919_b0055","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaa7721","article-title":"Hurdles in therapy with regulatory T cells","volume":"7","author":"Trzonkowski","year":"2015","journal-title":"Sci. Transl. Med."},{"issue":"11\u201312","key":"10.1016\/j.intimp.2024.111919_b0060","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.3727\/096368911X566217","article-title":"The time is crucial for ex vivo expansion of T regulatory cells for therapy","volume":"20","author":"Marek","year":"2011","journal-title":"Cell. Transpl."},{"issue":"1","key":"10.1016\/j.intimp.2024.111919_b0065","doi-asserted-by":"crossref","first-page":"11915","DOI":"10.1038\/s41598-017-10151-1","article-title":"Mild hypothermia provides Treg stability","volume":"7","author":"Marek-Trzonkowska","year":"2017","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.intimp.2024.111919_b0070","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-13055-y","article-title":"Automated optimized parameters for T-distributed stochastic neighbor embedding improve visualization and analysis of large datasets","volume":"10","author":"Belkina","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2024.111919_b0075","unstructured":"E. Amid, M.K. Warmuth, TriMap: Large-scale Dimensionality Reduction Using Triplets, December 2019."},{"issue":"1","key":"10.1016\/j.intimp.2024.111919_b0080","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.cell.2015.05.047","article-title":"Data-driven phenotypic dissection of AML reveals progenitor-like cells that correlate with prognosis","volume":"162","author":"Levine","year":"2015","journal-title":"Cell."},{"issue":"W1","key":"10.1016\/j.intimp.2024.111919_b0085","doi-asserted-by":"crossref","first-page":"W147","DOI":"10.1093\/nar\/gkw419","article-title":"Heatmapper: web-enabled heat mapping for all","volume":"44","author":"Babicki","year":"2016","journal-title":"Nucleic. Acids. Res."},{"key":"10.1016\/j.intimp.2024.111919_b0090","unstructured":"Primary Immunodeficiency Diseases - Immunoglobulin Disorders | Choose the Right Test. https:\/\/arupconsult.com\/content\/immunoglobulin-disorders?_ga=2.163356788.958945285.1684150934-1231057015.1684150933&_gl=1*tlimzr*_ga*MTIzMTA1NzAxNS4xNjg0MTUwOTMz*_ga_Z8H49DQE4D*MTY4NDE1MDkzMy4xLjEuMTY4NDE1MTI0My4wLjAuMA.. Accessed May 15, 2023."},{"key":"10.1016\/j.intimp.2024.111919_b0095","first-page":"211","article-title":"Reduced PD-1 expression on circulating follicular and conventional FOXP3+ Treg cells in children with new onset type 1 diabetes and autoantibody-positive at-risk children","author":"Vecchione","year":"2020","journal-title":"Clin. Immunol."},{"issue":"6","key":"10.1016\/j.intimp.2024.111919_b0100","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s11892-021-01384-6","article-title":"The role of programmed death-1 in type 1 diabetes","volume":"21","author":"Tucker","year":"2021","journal-title":"Curr. Diab. Rep."},{"issue":"8","key":"10.1016\/j.intimp.2024.111919_b0105","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.2337\/dbi18-0002","article-title":"Collateral damage: insulin-dependent diabetes induced with checkpoint inhibitors","volume":"67","author":"Bluestone","year":"2018","journal-title":"Diabetes."},{"issue":"2","key":"10.1016\/j.intimp.2024.111919_b0110","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1056\/NEJMra1703481","article-title":"Immune-related adverse events associated with immune checkpoint blockade","volume":"378","author":"Postow","year":"2018","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.intimp.2024.111919_b0115","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1084\/jem.20051776","article-title":"Tissue expression of PD-L1 mediates peripheral T cell tolerance","volume":"203","author":"Keir","year":"2006","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.intimp.2024.111919_b0120","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.clim.2007.05.013","article-title":"Mechanisms of PDL1-mediated regulation of autoimmune diabetes","volume":"125","author":"Guleria","year":"2007","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.intimp.2024.111919_b0125","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.3389\/fimmu.2022.826152","article-title":"Rituximab in systemic lupus erythematosus: transient effects on autoimmunity associated lymphocyte phenotypes and implications for immunogenicity","volume":"13","author":"Faustini","year":"2022","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.intimp.2024.111919_b0130","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1182\/blood-2007-02-068999","article-title":"Response to B-cell\u2013depleting therapy with rituximab reverts the abnormalities of T-cell subsets in patients with idiopathic thrombocytopenic purpura","volume":"110","author":"Stasi","year":"2007","journal-title":"Blood."},{"issue":"4","key":"10.1016\/j.intimp.2024.111919_b0135","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1182\/blood-2007-12-129262","article-title":"Analysis of regulatory T-cell changes in patients with idiopathic thrombocytopenic purpura receiving B cell\u2013depleting therapy with rituximab","volume":"112","author":"Stasi","year":"2008","journal-title":"Blood."},{"issue":"1","key":"10.1016\/j.intimp.2024.111919_b0140","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-2141.2010.08076.x","article-title":"The effect of rituximab on humoral and cell mediated immunity and infection in the treatment of autoimmune diseases","volume":"149","author":"Cooper","year":"2010","journal-title":"Br. J. Haematol."},{"issue":"2","key":"10.1016\/j.intimp.2024.111919_b0145","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/j.1365-2141.2004.04889.x","article-title":"The efficacy and safety of B-cell depletion with anti-CD20 monoclonal antibody in adults with chronic immune thrombocytopenic purpura","volume":"125","author":"Cooper","year":"2004","journal-title":"Br. J. Haematol."},{"issue":"25","key":"10.1016\/j.intimp.2024.111919_b0150","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1056\/NEJMoa032534","article-title":"Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis","volume":"350","author":"Edwards","year":"2004","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.intimp.2024.111919_b0155","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/cei.13256","article-title":"Dendritic cells, T cells and their interaction in rheumatoid arthritis","volume":"196","author":"Wehr","year":"2019","journal-title":"Clin. Exp. Immunol."},{"issue":"52","key":"10.1016\/j.intimp.2024.111919_b0160","doi-asserted-by":"crossref","first-page":"20878","DOI":"10.1073\/pnas.0709205105","article-title":"Therapeutic B cell depletion impairs adaptive and autoreactive CD4+ T cell activation in mice","volume":"104","author":"Bouaziz","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"22","key":"10.1016\/j.intimp.2024.111919_b0165","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1056\/NEJMoa0904452","article-title":"Rituximab, B-lymphocyte depletion, and preservation of beta-cell function","volume":"361","author":"Pescovitz","year":"2009","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.intimp.2024.111919_b0170","doi-asserted-by":"crossref","first-page":"453","DOI":"10.2337\/dc13-0626","article-title":"B-Lymphocyte depletion with rituximab and \u03b2-cell function: two-year results","volume":"37","author":"Pescovitz","year":"2014","journal-title":"Diabetes. Care."},{"issue":"6","key":"10.1016\/j.intimp.2024.111919_b0175","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1183\/09031936.00197710","article-title":"An open-label trial of rituximab therapy in pulmonary alveolar proteinosis","volume":"38","author":"Kavuru","year":"2011","journal-title":"Eur. Respir. J."},{"issue":"1","key":"10.1016\/j.intimp.2024.111919_b0180","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/MD.0b013e3182431ef6","article-title":"Rituximab for the treatment of IgG4-related disease: lessons from 10 consecutive patients","volume":"91","author":"Khosroshahi","year":"2012","journal-title":"Medicine (Baltimore)."},{"issue":"3","key":"10.1016\/j.intimp.2024.111919_b0185","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.4049\/jimmunol.181.3.1767","article-title":"IL-21-induced isotype switching to IgG and IgA by human naive B cells is differentially regulated by IL-4","volume":"181","author":"Avery","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2024.111919_b0190","article-title":"The Human IgG Subclasses","author":"Hamilton","year":"2001","journal-title":"Hum. IgG. Subclasses."},{"issue":"1","key":"10.1016\/j.intimp.2024.111919_b0195","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-32108-8","article-title":"Serum IgG2 levels are specifically associated with whole-body insulin-mediated glucose disposal in non-diabetic offspring of type 2 diabetic individuals: a cross-sectional study","volume":"8","author":"Fiorentino","year":"2018","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.intimp.2024.111919_b0200","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/cei.12390","article-title":"Rituximab impairs immunoglobulin (Ig)M and IgG (subclass) responses after influenza vaccination in rheumatoid arthritis patients","volume":"178","author":"Westra","year":"2014","journal-title":"Clin. Exp. Immunol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924004375?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924004375?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T23:59:57Z","timestamp":1719964797000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924004375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":40,"alternative-id":["S1567576924004375"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.111919","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PD-1 Receptor (+) T cells are associated with the efficacy of the combined treatment with regulatory t cells and rituximab in type 1 diabetes children via regulatory t cells suppressive activity amelioration","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.111919","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111919"}}