{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:04:07Z","timestamp":1793318647350,"version":"4.5.0"},"reference-count":235,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T00:00:00Z","timestamp":1711324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.intimp.2024.111932","type":"journal-article","created":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T23:18:48Z","timestamp":1711927128000},"page":"111932","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"special_numbering":"C","title":["Signaling pathways in uric acid homeostasis and gout: From pathogenesis to therapeutic interventions"],"prefix":"10.1016","volume":"132","author":[{"given":"Shuangling","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haimei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-Ming","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuman","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2024.111932_b0005","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/s41584-019-0222-x","article-title":"Mouse models for human hyperuricaemia: a critical review","volume":"15","author":"Lu","year":"2019","journal-title":"Nat. Rev. Rheumatol."},{"issue":"Suppl 1","key":"10.1016\/j.intimp.2024.111932_b0010","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1186\/ar1906","article-title":"A concise history of gout and hyperuricemia and their treatment","volume":"8","author":"Nuki","year":"2006","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.intimp.2024.111932_b0015","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/s41584-020-0441-1","article-title":"Global epidemiology of gout: prevalence, incidence, treatment patterns and risk factors","volume":"16","author":"Dehlin","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.intimp.2024.111932_b0020","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1756-185X.2009.01381.x","article-title":"A brief history of gout","volume":"12","author":"Bhattacharjee","year":"2009","journal-title":"Int. J. Rheum. Dis."},{"key":"10.1016\/j.intimp.2024.111932_b0025","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/s41584-022-00844-x","article-title":"Beyond joint pain, could each gout flare lead to heart attack?","volume":"18","author":"Choi","year":"2022","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.intimp.2024.111932_b0030","doi-asserted-by":"crossref","first-page":"F1327","DOI":"10.1152\/ajprenal.00272.2019","article-title":"Uric acid and inflammation in kidney disease","volume":"318","author":"Jung","year":"2020","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.intimp.2024.111932_b0035","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev-physiol-021113-170343","article-title":"The molecular physiology of uric acid homeostasis","volume":"77","author":"Mandal","year":"2015","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.intimp.2024.111932_b0040","doi-asserted-by":"crossref","first-page":"E827","DOI":"10.1152\/ajpendo.00378.2020","article-title":"New insights into purine metabolism in metabolic diseases: role of xanthine oxidoreductase activity","volume":"319","author":"Furuhashi","year":"2020","journal-title":"Am. J. Phys. Endocrinol. Metab."},{"key":"10.1016\/j.intimp.2024.111932_b0045","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1093\/cvr\/cvaa127","article-title":"Inhibition of xanthine oxidase in the acute phase of myocardial infarction prevents skeletal muscle abnormalities and exercise intolerance","volume":"117","author":"Nambu","year":"2021","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.intimp.2024.111932_b0050","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1681\/ASN.2008060576","article-title":"Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells","volume":"20","author":"Cirillo","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.intimp.2024.111932_b0055","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1139\/y67-013","article-title":"Kinetics of uric acid transport and its production in rat small intestine","volume":"45","author":"Oh","year":"1967","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.intimp.2024.111932_b0060","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.semnephrol.2020.12.006","article-title":"Molecular pathophysiology of uric acid homeostasis","volume":"40","author":"Estiverne","year":"2020","journal-title":"Semin. Nephrol."},{"key":"10.1016\/j.intimp.2024.111932_b0065","doi-asserted-by":"crossref","first-page":"e0190194","DOI":"10.1371\/journal.pone.0190194","article-title":"Intestinal tract is an important organ for lowering serum uric acid in rats","volume":"12","author":"Yun","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2024.111932_b0070","doi-asserted-by":"crossref","first-page":"11838","DOI":"10.1039\/D1FO02539B","article-title":"Hypouricemic, hepatoprotective and nephroprotective roles of oligopeptides derived from Auxis thazard protein in hyperuricemic mice","volume":"12","author":"Wei","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.intimp.2024.111932_b0075","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.3899\/jrheum.130531","article-title":"Umami: the taste that drives purine intake","volume":"40","author":"Johnson","year":"2013","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.intimp.2024.111932_b0080","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1056\/NEJMoa035700","article-title":"Purine-rich foods, dairy and protein intake, and the risk of gout in men","volume":"350","author":"Choi","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.intimp.2024.111932_b0085","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1093\/ajh\/hpaa044","article-title":"Uric acid and hypertension: an update with recommendations","volume":"33","author":"Sanchez-Lozada","year":"2020","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.intimp.2024.111932_b0090","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41572-019-0115-y","article-title":"Gout","volume":"5","author":"Dalbeth","year":"2019","journal-title":"Nat. Rev. Disease Primers"},{"key":"10.1016\/j.intimp.2024.111932_b0095","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/S0140-6736(67)90494-1","article-title":"Fructose-induced hyperuricaemia","volume":"2","author":"Perheentupa","year":"1967","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.intimp.2024.111932_b0100","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1038\/ncomms3434","article-title":"Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome","volume":"4","author":"Lanaspa","year":"2013","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.intimp.2024.111932_b0105","doi-asserted-by":"crossref","first-page":"3138","DOI":"10.1073\/pnas.1713837115","article-title":"High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism","volume":"115","author":"Lanaspa","year":"2018","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.intimp.2024.111932_b0110","doi-asserted-by":"crossref","first-page":"14181","DOI":"10.1038\/ncomms14181","article-title":"Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice","volume":"8","author":"Andres-Hernando","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2024.111932_b0115","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/ki.2013.492","article-title":"Fructokinase activity mediates dehydration-induced renal injury","volume":"86","author":"Roncal Jimenez","year":"2014","journal-title":"Kidney Int."},{"key":"10.1016\/j.intimp.2024.111932_b0120","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1053\/j.ajkd.2015.08.021","article-title":"Heat stress nephropathy from exercise-induced uric acid crystalluria: A perspective on Mesoamerican nephropathy","volume":"67","author":"Roncal-Jimenez","year":"2016","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.intimp.2024.111932_b0125","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41584-019-0334-3","article-title":"Asymptomatic hyperuricaemia: a silent activator of the innate immune system","volume":"16","author":"Joosten","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.intimp.2024.111932_b0130","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1093\/rheumatology\/keq204","article-title":"Uric acid and evolution","volume":"49","author":"\u00c1lvarez-Lario","year":"2010","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.intimp.2024.111932_b0135","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1016\/j.febslet.2006.03.007","article-title":"Recapture of [S]-allantoin, the product of the two-step degradation of uric acid, by urate oxidase","volume":"580","author":"Gabison","year":"2006","journal-title":"FEBS Lett."},{"key":"10.1016\/j.intimp.2024.111932_b0140","doi-asserted-by":"crossref","first-page":"e8971","DOI":"10.7717\/peerj.8971","article-title":"Uricase-deficient rat is generated with CRISPR\/Cas9 technique","volume":"8","author":"Yu","year":"2020","journal-title":"PeerJ"},{"key":"10.1016\/j.intimp.2024.111932_b0145","doi-asserted-by":"crossref","first-page":"e0179195","DOI":"10.1371\/journal.pone.0179195","article-title":"Oral uricase eliminates blood uric acid in the hyperuricemic pig model","volume":"12","author":"Szczurek","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2024.111932_b0150","doi-asserted-by":"crossref","first-page":"3763","DOI":"10.1073\/pnas.1320393111","article-title":"Evolutionary history and metabolic insights of ancient mammalian uricases","volume":"111","author":"Kratzer","year":"2014","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.intimp.2024.111932_b0155","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1016\/j.biochi.2012.03.016","article-title":"Structure-based characterization of canine-human chimeric uricases and its evolutionary implications","volume":"94","author":"Zhang","year":"2012","journal-title":"Biochimie"},{"key":"10.1016\/j.intimp.2024.111932_b0160","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1053\/j.ackd.2012.07.009","article-title":"Renal transport of uric acid: evolving concepts and uncertainties","volume":"19","author":"Bobulescu","year":"2012","journal-title":"Adv. Chronic Kidney Dis."},{"key":"10.1016\/j.intimp.2024.111932_b0165","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1172\/JCI42344","article-title":"Uric acid transport and disease","volume":"120","author":"So","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.intimp.2024.111932_b0170","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/ncomms1756","article-title":"Decreased extra-renal urate excretion is a common cause of hyperuricemia","volume":"3","author":"Ichida","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2024.111932_b0175","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1161\/01.HYP.0000028589.66335.AA","article-title":"Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity","volume":"40","author":"Watanabe","year":"2002","journal-title":"Hypertension"},{"key":"10.1016\/j.intimp.2024.111932_b0180","doi-asserted-by":"crossref","first-page":"6858","DOI":"10.1073\/pnas.78.11.6858","article-title":"Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis","volume":"78","author":"Ames","year":"1981","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.intimp.2024.111932_b0185","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1073\/pnas.1217296110","article-title":"Disrupted and transgenic urate oxidase alter urate and dopaminergic neurodegeneration","volume":"110","author":"Chen","year":"2013","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.intimp.2024.111932_b0190","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/nrrheum.2012.144","article-title":"The genetics of hyperuricaemia and gout","volume":"8","author":"Reginato","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.intimp.2024.111932_b0195","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41584-018-0004-x","article-title":"An update on the genetics of hyperuricaemia and gout","volume":"14","author":"Major","year":"2018","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.intimp.2024.111932_b0200","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1248\/bpb.33.498","article-title":"Renal secretion of uric acid by organic anion transporter 2 (OAT2\/SLC22A7) in human","volume":"33","author":"Sato","year":"2010","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.intimp.2024.111932_b0205","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1080\/15257770.2013.854902","article-title":"ABCG2 dysfunction increases serum uric acid by decreased intestinal urate excretion","volume":"33","author":"Takada","year":"2014","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"10.1016\/j.intimp.2024.111932_b0210","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1080\/15257770.2011.633953","article-title":"ABCG2 is a high-capacity urate transporter and its genetic impairment increases serum uric acid levels in humans","volume":"30","author":"Nakayama","year":"2011","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"10.1016\/j.intimp.2024.111932_b0215","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/nature742","article-title":"Molecular identification of a renal urate anion exchanger that regulates blood urate levels","volume":"417","author":"Enomoto","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2024.111932_b0220","doi-asserted-by":"crossref","first-page":"16332","DOI":"10.1074\/jbc.M800737200","article-title":"Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13)","volume":"283","author":"Bahn","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2024.111932_b0225","doi-asserted-by":"crossref","first-page":"C1215","DOI":"10.1152\/ajpcell.2001.280.5.C1215","article-title":"Cloning and functional characterization of a high-affinity Na(+)\/dicarboxylate cotransporter from mouse brain","volume":"280","author":"Pajor","year":"2001","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.intimp.2024.111932_b0230","doi-asserted-by":"crossref","first-page":"16998","DOI":"10.1074\/jbc.M114.554790","article-title":"Determinants of substrate and cation transport in the human Na+\/dicarboxylate cotransporter NaDC3","volume":"289","author":"Schlessinger","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2024.111932_b0235","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.dmpk.2020.06.006","article-title":"Mathematical modeling analysis of hepatic uric acid disposition using human sandwich-cultured hepatocytes","volume":"35","author":"Wada","year":"2020","journal-title":"Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.intimp.2024.111932_b0240","doi-asserted-by":"crossref","first-page":"15501","DOI":"10.1073\/pnas.0904411106","article-title":"Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy","volume":"106","author":"Preitner","year":"2009","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.intimp.2024.111932_b0245","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1517\/17460441.2.9.1251","article-title":"Drug discovery for hyperuricemia","volume":"2","author":"Anzai","year":"2007","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1016\/j.intimp.2024.111932_b0250","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s10157-011-0532-z","article-title":"Recent advances in renal urate transport: characterization of candidate transporters indicated by genome-wide association studies","volume":"16","author":"Anzai","year":"2012","journal-title":"Clin. Exp. Nephrol."},{"key":"10.1016\/j.intimp.2024.111932_b0255","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s11095-007-9359-4","article-title":"Comparison of the interaction of human organic anion transporter hOAT4 with PDZ proteins between kidney cells and placental cells","volume":"25","author":"Zhou","year":"2008","journal-title":"Pharm Res."},{"key":"10.1016\/j.intimp.2024.111932_b0260","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s12576-018-00658-1","article-title":"Identification of the multivalent PDZ protein PDZK1 as a binding partner of sodium-coupled monocarboxylate transporter SMCT1 (SLC5A8) and SMCT2 (SLC5A12)","volume":"69","author":"Srivastava","year":"2019","journal-title":"J. Physiol. Sci."},{"key":"10.1016\/j.intimp.2024.111932_b0265","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.1681\/ASN.2005030306","article-title":"Modulation of renal apical organic anion transporter 4 function by two PDZ domain-containing proteins","volume":"16","author":"Miyazaki","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.intimp.2024.111932_b0270","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1046\/j.1523-1755.2003.00266.x","article-title":"PDZK1: I. A major scaffolder in brush borders of proximal tubular cells","volume":"64","author":"Gisler","year":"2003","journal-title":"Kidney Int."},{"key":"10.1016\/j.intimp.2024.111932_b0275","doi-asserted-by":"crossref","first-page":"45942","DOI":"10.1074\/jbc.M406724200","article-title":"The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate-anion exchanger URAT1 via its C terminus","volume":"279","author":"Anzai","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2024.111932_b0280","doi-asserted-by":"crossref","first-page":"6678","DOI":"10.3390\/ijms22136678","article-title":"The Role of ABCG2 in the Pathogenesis of Primary Hyperuricemia and Gout-An Update","volume":"22","author":"Eckenstaler","year":"2021","journal-title":"International journal of molecular sciences"},{"key":"10.1016\/j.intimp.2024.111932_b0285","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1056\/NEJM197909063011011","article-title":"Hypouricemia","volume":"301","author":"Steele","year":"1979","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.intimp.2024.111932_b0290","doi-asserted-by":"crossref","first-page":"652","DOI":"10.3390\/biomedicines10030652","article-title":"Hypouricemia and urate transporters","volume":"10","author":"Otani","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.intimp.2024.111932_b0295","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1016\/S0140-6736(16)00346-9","article-title":"Gout","volume":"388","author":"Dalbeth","year":"2016","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.intimp.2024.111932_b0300","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/art.20761","article-title":"Intake of purine-rich foods, protein, and dairy products and relationship to serum levels of uric acid: the third National Health and nutrition examination survey","volume":"52","author":"Choi","year":"2005","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.intimp.2024.111932_b0305","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/S0140-6736(70)92269-5","article-title":"Fructose-induced hyperuricaemia","volume":"2","author":"Stirpe","year":"1970","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.intimp.2024.111932_b0310","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1055\/s-0028-1096782","article-title":"Fructose induced depletion of liver adenine nucleotides in man","volume":"3","author":"Bode","year":"1971","journal-title":"Hormone and metabolic research = Hormon-, und Stoffwechselforschung = Hormones et metabolisme"},{"key":"10.1016\/j.intimp.2024.111932_b0315","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/art.23245","article-title":"Sugar-sweetened soft drinks, diet soft drinks, and serum uric acid level: the third National Health and nutrition examination survey","volume":"59","author":"Choi","year":"2008","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.intimp.2024.111932_b0320","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1056\/NEJM198212233072602","article-title":"Ethanol-induced hyperuricemia: Evidence for increased urate production by activation of adenine nucleotide turnover","volume":"307","author":"Faller","year":"1982","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.intimp.2024.111932_b0325","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1172\/JCI111512","article-title":"Ethanol-induced activation of adenine nucleotide turnover. Evidence for a role of acetate","volume":"74","author":"Puig","year":"1984","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.intimp.2024.111932_b0330","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1002\/art.22762","article-title":"Coffee, tea, and caffeine consumption and serum uric acid level: the third national health and nutrition examination survey","volume":"57","author":"Choi","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.intimp.2024.111932_b0335","first-page":"1853","article-title":"Vitamin C intake and serum uric acid concentration in men","volume":"35","author":"Gao","year":"2008","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.intimp.2024.111932_b0340","doi-asserted-by":"crossref","first-page":"5227","DOI":"10.1038\/srep05227","article-title":"Common dysfunctional variants of ABCG2 have stronger impact on hyperuricemia progression than typical environmental risk factors","volume":"4","author":"Nakayama","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2024.111932_b0345","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1080\/15257770.2013.866679","article-title":"ABCG2 dysfunction increases the risk of renal overload hyperuricemia","volume":"33","author":"Matsuo","year":"2014","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"10.1016\/j.intimp.2024.111932_b0350","doi-asserted-by":"crossref","first-page":"5ra11","DOI":"10.1126\/scitranslmed.3000237","article-title":"Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a japanese population","volume":"1","author":"Matsuo","year":"2009","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.intimp.2024.111932_b0355","doi-asserted-by":"crossref","first-page":"43614","DOI":"10.1038\/srep43614","article-title":"Effects of multiple genetic loci on the pathogenesis from serum urate to gout","volume":"7","author":"Dong","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2024.111932_b0360","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1136\/ard.2009.113357","article-title":"Associations of a non-synonymous variant in SLC2A9 with gouty arthritis and uric acid levels in Han Chinese subjects and Solomon Islanders","volume":"69","author":"Tu","year":"2010","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.intimp.2024.111932_b0365","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s41065-018-0078-0","article-title":"Common variants in the SLC28A2 gene are associated with serum uric acid level and hyperuricemia and gout in Han Chinese","volume":"156","author":"Zhou","year":"2019","journal-title":"Hereditas"},{"key":"10.1016\/j.intimp.2024.111932_b0370","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s41065-019-0103-y","article-title":"ABCG2 gene polymorphism rs2231142 is associated with gout comorbidities but not allopurinol response in primary gout patients of a Chinese Han male population","volume":"156","author":"Zhang","year":"2019","journal-title":"Hereditas"},{"key":"10.1016\/j.intimp.2024.111932_b0375","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/imr.12833","article-title":"Urate-induced immune programming: Consequences for gouty arthritis and hyperuricemia","volume":"294","author":"Cab\u0103u","year":"2020","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.intimp.2024.111932_b0380","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nrrheum.2017.155","article-title":"Inflammation in gout: mechanisms and therapeutic targets","volume":"13","author":"So","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.intimp.2024.111932_b0385","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1016\/S0140-6736(21)00569-9","article-title":"Gout","volume":"397","author":"Dalbeth","year":"2021","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.intimp.2024.111932_b0390","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1172\/JCI28075","article-title":"MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals","volume":"116","author":"Chen","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.intimp.2024.111932_b0395","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/ni.2550","article-title":"Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome","volume":"14","author":"Misawa","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.intimp.2024.111932_b0400","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature04516","article-title":"Gout-associated uric acid crystals activate the NALP3 inflammasome","volume":"440","author":"Martinon","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2024.111932_b0405","doi-asserted-by":"crossref","first-page":"3237","DOI":"10.1002\/art.27667","article-title":"Engagement of fatty acids with toll-like receptor 2 drives interleukin-1\u03b2 production via the ASC\/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis","volume":"62","author":"Joosten","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.intimp.2024.111932_b0410","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1136\/annrheumdis-2014-206564","article-title":"Soluble uric acid primes TLR-induced proinflammatory cytokine production by human primary cells via inhibition of IL-1Ra","volume":"75","author":"Cri\u0219an","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.intimp.2024.111932_b0415","doi-asserted-by":"crossref","first-page":"5485","DOI":"10.1073\/pnas.1620910114","article-title":"Uric acid priming in human monocytes is driven by the AKT-PRAS40 autophagy pathway","volume":"114","author":"Cri\u015fan","year":"2017","journal-title":"PNAS"},{"key":"10.1016\/j.intimp.2024.111932_b0420","doi-asserted-by":"crossref","first-page":"39884","DOI":"10.1038\/srep39884","article-title":"Soluble uric acid activates the NLRP3 inflammasome","volume":"7","author":"Braga","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2024.111932_b0425","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1146\/annurev-pathmechdis-012418-013003","article-title":"Innate immune signaling in nonalcoholic fatty liver disease and cardiovascular diseases","volume":"14","author":"Cai","year":"2019","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.intimp.2024.111932_b0430","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1093\/cvr\/cvx130","article-title":"Insights into innate immune signalling in controlling cardiac remodelling","volume":"113","author":"Zhang","year":"2017","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.intimp.2024.111932_b0435","first-page":"210","article-title":"Reprogramming interferon regulatory factor signaling in cardiometabolic diseases","volume":"32","author":"Zhang","year":"2017","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.intimp.2024.111932_b0440","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.2174\/1389450116666150804110412","article-title":"Targeting interferon regulatory factor for cardiometabolic diseases: Opportunities and challenges","volume":"18","author":"Zhang","year":"2017","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.intimp.2024.111932_b0445","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1161\/HYPERTENSIONAHA.116.08192","article-title":"Reprogramming Innate Immune Signaling in Cardiometabolic Disease","volume":"69","author":"Zhang","year":"2017","journal-title":"Hypertension"},{"key":"10.1016\/j.intimp.2024.111932_b0450","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/s13075-016-1167-y","article-title":"Interleukin 37 limits monosodium urate crystal-induced innate immune responses in human and murine models of gout","volume":"18","author":"Liu","year":"2016","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.intimp.2024.111932_b0455","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1136\/annrheumdis-2019-216233","article-title":"Rare genetic variants in interleukin-37 link this anti-inflammatory cytokine to the pathogenesis and treatment of gout","volume":"79","author":"Kl\u00fcck","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.intimp.2024.111932_b0460","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/nrrheum.2014.124","article-title":"Improving cardiovascular and renal outcomes in gout: what should we target?","volume":"10","author":"Richette","year":"2014","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.intimp.2024.111932_b0465","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nrrheum.2009.236","article-title":"Update on gout: new therapeutic strategies and options","volume":"6","author":"Terkeltaub","year":"2010","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.intimp.2024.111932_b0470","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1056\/NEJMcp2203385","article-title":"Gout","volume":"387","author":"Mikuls","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.intimp.2024.111932_b0475","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.1002\/art.27600","article-title":"Canakinumab for the treatment of acute flares in difficult-to-treat gouty arthritis: Results of a multicenter, phase II, dose-ranging study","volume":"62","author":"So","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.intimp.2024.111932_b0480","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s10787-020-00753-z","article-title":"Effect of canakinumab on clinical and biochemical parameters in acute gouty arthritis: A meta-analysis","volume":"29","author":"Jena","year":"2021","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.intimp.2024.111932_b0485","doi-asserted-by":"crossref","first-page":"R28","DOI":"10.1186\/ar2143","article-title":"A pilot study of IL-1 inhibition by anakinra in acute gout","volume":"9","author":"So","year":"2007","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.intimp.2024.111932_b0490","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1093\/rheumatology\/key402","article-title":"Anakinra for the treatment of acute gout flares: a randomized, double-blind, placebo-controlled, active-comparator, non-inferiority trial","volume":"58","author":"Janssen","year":"2019","journal-title":"Rheumatology (Oxford, England)"},{"key":"10.1016\/j.intimp.2024.111932_b0495","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1002\/art.41699","article-title":"A randomized, phase II study evaluating the efficacy and safety of anakinra in the treatment of gout flares","volume":"73","author":"Saag","year":"2021","journal-title":"Arthritis Rheumatol. (Hoboken, NJ)."},{"key":"10.1016\/j.intimp.2024.111932_b0500","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.3899\/jrheum.131226","article-title":"Rilonacept for gout flare prevention in patients receiving uric acid-lowering therapy: results of RESURGE, a phase III, international safety study","volume":"41","author":"Sundy","year":"2014","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.intimp.2024.111932_b0505","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1093\/rheumatology\/ket114","article-title":"Rilonacept for gout flare prevention during initiation of uric acid-lowering therapy: results from the PRESURGE-2 international, phase 3, randomized, placebo-controlled trial","volume":"52","author":"Mitha","year":"2013","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.intimp.2024.111932_b0510","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1002\/acr.21690","article-title":"Rilonacept (interleukin-1 trap) for prevention of gout flares during initiation of uric acid-lowering therapy: results from a phase III randomized, double-blind, placebo-controlled, confirmatory efficacy study","volume":"64","author":"Schumacher","year":"2012","journal-title":"Arthritis Care Res. (Hoboken)"},{"key":"10.1016\/j.intimp.2024.111932_b0515","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1093\/rheumatology\/kez203","article-title":"Difficult-to-treat gout flares: Eligibility for interleukin-1 inhibition in private practice is uncommon according to current EMA approval","volume":"58","author":"Pascart","year":"2019","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.intimp.2024.111932_b0520","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13020-020-0297-y","article-title":"Chinese herbal medicine for gout: a review of the clinical evidence and pharmacological mechanisms","volume":"15","author":"Chi","year":"2020","journal-title":"Chin. Med."},{"key":"10.1016\/j.intimp.2024.111932_b0525","first-page":"1521","article-title":"Discussion on TCM Name of Gout (\u6d4a\u7600\u75f9\u2014\u2014\u75db\u98ce\u4e2d\u533b\u75c5\u540d\u63a2\u8ba8)","volume":"52","author":"Zhu","year":"2011","journal-title":"Journal of Traditional Chinese Medicine"},{"key":"10.1016\/j.intimp.2024.111932_b0530","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s11655-007-9001-7","article-title":"Randomized and controlled clinical study of modified prescriptions of Simiao Pill in the treatment of acute gouty arthritis","volume":"14","author":"Shi","year":"2008","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.intimp.2024.111932_b0535","first-page":"65","article-title":"Overview of the Thinking of Treating Gout from Classic Prescriptions (\u4ece\u7ecf\u65b9\u8bba\u6cbb\u75db\u98ce\u7684\u601d\u8def\u6982\u8ff0)","volume":"13","author":"Zhang","year":"2010","journal-title":"Journal of Guangxi University of Chinese Medicine"},{"key":"10.1016\/j.intimp.2024.111932_b0540","first-page":"7","article-title":"Classical prescriptions and clinical treatments of gouty arthritis by famous TCM doctors","volume":"12","author":"Li","year":"2014","journal-title":"Chin. Med. Mod. Distance Educ. China"},{"key":"10.1016\/j.intimp.2024.111932_b0545","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1007\/s10067-013-2274-7","article-title":"Chinese herbal medicine for gout: a systematic review of randomized clinical trials","volume":"32","author":"Li","year":"2013","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.intimp.2024.111932_b0550","doi-asserted-by":"crossref","first-page":"8698232","DOI":"10.1155\/2021\/8698232","article-title":"Advances in experimental and clinical Research of the gouty arthritis treatment with traditional chinese medicine","volume":"2021","author":"Liang","year":"2021","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.intimp.2024.111932_b0555","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s11655-019-3058-y","article-title":"Progress in treatment of Gout using Chinese and Western medicine","volume":"26","author":"Wang","year":"2020","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.intimp.2024.111932_b0560","doi-asserted-by":"crossref","first-page":"e85008","DOI":"10.1371\/journal.pone.0085008","article-title":"Systematic review and meta-analysis of the clinical efficacy and adverse effects of Chinese herbal decoction for the treatment of gout","volume":"9","author":"Zhou","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2024.111932_b0565","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1142\/S0192415X19500629","article-title":"Application of Chinese medicine in acute and critical medical conditions","volume":"47","author":"Luo","year":"2019","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.intimp.2024.111932_b0570","first-page":"6655335","article-title":"Hepatocardiac or cardiohepatic interaction: From traditional Chinese medicine to Western medicine","volume":"2021","author":"Zhang","year":"2021","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.intimp.2024.111932_b0575","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.jep.2004.04.008","article-title":"A Chinese herbal medicine ermiao wan reduces serum uric acid level and inhibits liver xanthine dehydrogenase and xanthine oxidase in mice","volume":"93","author":"Kong","year":"2004","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2024.111932_b0580","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jchromb.2019.04.032","article-title":"Study on chemical constituents of herbal formula Er Miao Wan and GC-MS based metabolomics approach to evaluate its therapeutic effects on hyperuricemic rats","volume":"1118\u20131119","author":"Huang","year":"2019","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.intimp.2024.111932_b0585","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jep.2015.03.035","article-title":"A network pharmacology approach to determine active ingredients and rationality of herb combinations of modified-Simiaowan for treatment of gout","volume":"168","author":"Zhao","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2024.111932_b0590","doi-asserted-by":"crossref","first-page":"7672152","DOI":"10.1155\/2020\/7672152","article-title":"Modified Si-Miao pill for rheumatoid arthritis: A systematic review and meta-analysis","volume":"2020","author":"Wang","year":"2020","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.intimp.2024.111932_b0595","first-page":"278","article-title":"Comparative Study of Anti-Gouty Arthritis Effects of Sam-Myo-Whan according to Extraction Solvents","volume":"10","author":"Lee","year":"2021","journal-title":"Plants (Basel, Switzerland)"},{"key":"10.1016\/j.intimp.2024.111932_b0600","doi-asserted-by":"crossref","first-page":"e3792","DOI":"10.1002\/bmc.3792","article-title":"Metabolomic profiles delineate the effect of Sanmiao wan on hyperuricemia in rats","volume":"31","author":"Jiang","year":"2017","journal-title":"Biomedical chromatography: BMC"},{"key":"10.1016\/j.intimp.2024.111932_b0605","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jep.2018.04.025","article-title":"Achyranthis bidentatae radix enhanced articular distribution and anti-inflammatory effect of berberine in Sanmiao Wan using an acute gouty arthritis rat model","volume":"221","author":"Wu","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2024.111932_b0610","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114545","article-title":"Untargeted metabolomics reveal the therapeutic effects of Ermiao wan categorized formulas on rats with hyperuricemia","volume":"281","author":"Shan","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2024.111932_b0615","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jep.2009.12.035","article-title":"The dual actions of Sanmiao wan as a hypouricemic agent: down-regulation of hepatic XOD and renal mURAT1 in hyperuricemic mice","volume":"128","author":"Wang","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2024.111932_b0620","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.jep.2010.02.012","article-title":"Simiao pill ameliorates urate underexcretion and renal dysfunction in hyperuricemic mice","volume":"128","author":"Hu","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2024.111932_b0625","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.intimp.2015.11.010","article-title":"Suppressive effect of Sanmiao formula on experimental gouty arthritis by inhibiting cartilage matrix degradation: An in vivo and in vitro study","volume":"30","author":"Zhu","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2024.111932_b0630","doi-asserted-by":"crossref","first-page":"955","DOI":"10.3389\/fphar.2020.00955","article-title":"Simiao decoction alleviates gouty arthritis by modulating proinflammatory cytokines and the gut ecosystem","volume":"11","author":"Lin","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2024.111932_b0635","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.113825","article-title":"Modified simiaowan prevents articular cartilage injury in experimental gouty arthritis by negative regulation of STAT3 pathway","volume":"270","author":"Shi","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2024.111932_b0640","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jep.2015.06.015","article-title":"Simiao pill ameliorates renal glomerular injury via increasing Sirt1 expression and suppressing NF-\u03baB\/NLRP3 inflammasome activation in high fructose-fed rats","volume":"172","author":"Ma","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2024.111932_b0645","first-page":"63","article-title":"Jia-Wei-Si-Miao-Wan alleviates acute gouty arthritis by targeting NLRP3 inflammasome","volume":"33","author":"Yuan","year":"2019","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"10.1016\/j.intimp.2024.111932_b0650","article-title":"The anti-inflammatory and uric acid lowering effects of Si-Miao-San on gout","volume":"12","author":"Cao","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2024.111932_b0655","first-page":"5477","article-title":"Research progress on traditional Chinese medicine on the treatment of rheumatoid arthritis","volume":"32","author":"Wei","year":"2017","journal-title":"China J. Trad. Chin. Med. Pharma."},{"key":"10.1016\/j.intimp.2024.111932_b0660","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jep.2015.10.024","article-title":"Characteristics of traditional Chinese medicine use in patients with rheumatoid arthritis in Taiwan: A nationwide population-based study","volume":"176","author":"Huang","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2024.111932_b0665","doi-asserted-by":"crossref","first-page":"3399","DOI":"10.2147\/JMDH.S334134","article-title":"A comparison of the risk of fracture in rheumatoid arthritis patients with and without receiving Chinese herbal medicine","volume":"14","author":"Liao","year":"2021","journal-title":"J. Multidiscip. Healthc."},{"key":"10.1016\/j.intimp.2024.111932_b0670","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ctim.2019.05.029","article-title":"Use of Chinese herbal medicines by rheumatoid arthritis patients was associated with lower risk of stroke: A retrospective cohort study","volume":"45","author":"Lai","year":"2019","journal-title":"Complement. Ther. Med."},{"key":"10.1016\/j.intimp.2024.111932_b0675","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3389\/fphar.2020.00169","article-title":"Adjunctive Chinese herbal products therapy reduces the risk of ischemic stroke among patients with rheumatoid arthritis","volume":"11","author":"Shen","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2024.111932_b0680","first-page":"326","article-title":"Observation for 30 cases of gouty arthritis treated with modified Jiawei Guizhi Shaoyao Zhimu decoction","volume":"19","author":"He","year":"2013","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"10.1016\/j.intimp.2024.111932_b0685","first-page":"167","article-title":"Clinical research on therapeutic effect of modified Guizhi Shaoyao Zhimu decoction in treatment of wind-cold-dampness bi syndrome in acute gouty arthritis","volume":"32","author":"Shen","year":"2014","journal-title":"Chin. Arch. Tradit. Chin. Med."},{"key":"10.1016\/j.intimp.2024.111932_b0690","doi-asserted-by":"crossref","first-page":"5186210","DOI":"10.1155\/2022\/5186210","article-title":"Clinical effect of the Guizhi Shaoyao Zhimu decoction in the treatment of hyperuricemia","volume":"2022","author":"Yang","year":"2022","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.intimp.2024.111932_b0695","first-page":"286","article-title":"Effect of Guizhi Shaoyao Zhimu Tang on Plasma Inflammatory Factors in Patients with Acute Gouty Arthritis (\u6842\u679d\u828d\u836f\u77e5\u6bcd\u6c64\u5bf9\u6025\u6027\u75db\u98ce\u6027\u5173\u8282\u708e\u60a3\u8005\u8840\u6d46\u708e\u75c7\u56e0\u5b50\u7684\u5f71\u54cd)","volume":"22","author":"Hu","year":"2013","journal-title":"Journal of Emergency in Traditional Chinese Medicine"},{"key":"10.1016\/j.intimp.2024.111932_b0700","first-page":"37","article-title":"Cassia twig peony rhizoma anemarrhenae decoction on acute gouty arthritis rats anti-inflammatory mechanisms discussed","volume":"30","author":"Wu","year":"2015","journal-title":"Guangming J. Chin. Med."},{"key":"10.1016\/j.intimp.2024.111932_b0705","first-page":"16","article-title":"Guizhishaoyaozhimu tang on acute gouty arthritis cytokines IL-1, IL-4 effect","volume":"17","author":"Xiao","year":"2011","journal-title":"Guiding J. Trad. Chin. Med. Pharma."},{"key":"10.1016\/j.intimp.2024.111932_b0710","first-page":"131","article-title":"Influences of Guizhi Shaoyao Zhimu Tang on the expression of IL-6 and TNF-\u03b1 in rats with acute gouty arthritis (\u6842\u679d\u828d\u836f\u77e5\u6bcd\u6c64\u5bf9\u6025\u6027\u75db\u98ce\u6027\u5173\u8282\u708e\u5927\u9f20IL- 6, TNF-\u03b1 \u8868\u8fbe\u7684\u5f71\u54cd)","volume":"45","author":"Li","year":"2013","journal-title":"New Chinese Medicine"},{"key":"10.1016\/j.intimp.2024.111932_b0715","first-page":"784","article-title":"Effect of Guizhi Shaoyao Zhimu decoction on expression of inflammatory signals of toll-MyD88 signaling pathway in rat macrophages induced by sodium uric acid","volume":"32","author":"Wang","year":"2017","journal-title":"Acta Chin. Med."},{"key":"10.1016\/j.intimp.2024.111932_b0720","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1038\/nature04656","article-title":"Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice","volume":"440","author":"Saleh","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2024.111932_b0725","first-page":"170","article-title":"Effect of Guizhishaoyaozhimu decoction on expression of neutrophil inflammatory signal in monosodium urate-induced rats based on NLRP3 inflammasome signaling pathway","volume":"16","author":"Fang","year":"2016","journal-title":"Chin. Remed. Clin."},{"key":"10.1016\/j.intimp.2024.111932_b0730","first-page":"472","article-title":"Research on the effect of guizhishaoyaozhimu decoction on the expression of inflammatory signal in macrophage induced with monosodium urate crystals based on NLRP3 inflammasomes signaling pathway","volume":"22","author":"Fang","year":"2016","journal-title":"J. Basic Chin. Med."},{"key":"10.1016\/j.intimp.2024.111932_b0735","first-page":"104","article-title":"Research progress in the treatment of gout with traditional Chinese medicine classic prescriptions (\u4e2d\u533b\u7ecf\u5178\u65b9\u5242\u6cbb\u7597\u75db\u98ce\u7684\u7814\u7a76\u8fdb\u5c55)","volume":"39","author":"Lang","year":"2023","journal-title":"Pharmacology and Clinics of Chinese Materia Medica"},{"key":"10.1016\/j.intimp.2024.111932_b0740","first-page":"1705","article-title":"Efficacy and safety of Baihu Jia Guizhi Tang in the treatment of acute gouty arthritis: a Meta-analysis (\u767d\u864e\u52a0\u6842\u679d\u6c64\u6cbb\u7597\u6025\u6027\u75db\u98ce\u6027\u5173\u8282\u708e\u7684\u7597\u6548\u4e0e\u5b89\u5168\u6027Meta\u5206\u6790)","volume":"30","author":"Li","year":"2021","journal-title":"Journal of Emergency in Traditional Chinese Medicine"},{"key":"10.1016\/j.intimp.2024.111932_b0745","first-page":"54","article-title":"The efficacy of Baihu Jia Guizhi Tang in the treatment of acute attack of gout: a Meta-analysis (\u767d\u864e\u52a0\u6842\u679d\u6c64\u6cbb\u7597\u75db\u98ce\u6025\u6027\u53d1\u4f5c\u671f\u7597\u6548Meta\u5206\u6790)","volume":"44","author":"Peng","year":"2022","journal-title":"Journal of Guizhou University of Traditional Chinese Medicine"},{"key":"10.1016\/j.intimp.2024.111932_b0750","first-page":"1647","article-title":"A meta analysis of clinical efficacy of white tiger decoction combined with cinnamon twig decoction","volume":"41","author":"Shao","year":"2021","journal-title":"Henan Trad. Chin. Med."},{"key":"10.1016\/j.intimp.2024.111932_b0755","first-page":"23","article-title":"Efficacy of modified Baihu Jia Guizhi tang in the treatment of acute gouty arthritis","volume":"10","author":"Yang","year":"2021","journal-title":"Rheumatism and Arthritis"},{"key":"10.1016\/j.intimp.2024.111932_b0760","first-page":"123","article-title":"Clinical study of Baihu Guizhi Tang in the treatment of acute gouty arthritis (\u767d\u864e\u6842\u679d\u6c64\u6cbb\u7597\u6025\u6027\u75db\u98ce\u6027\u5173\u8282\u708e\u4e34\u5e8a\u7814\u7a76)","volume":"11","author":"Li","year":"2015","journal-title":"Asia-Pacific Traditional Medicine"},{"key":"10.1016\/j.intimp.2024.111932_b0765","first-page":"230","article-title":"40 cases of gouty arthritis were treated with modified Baihu Guizhi Tang (\u514d\u714e\u4e2d\u836f\u767d\u864e\u6842\u679d\u6c64\u52a0\u5473\u6cbb\u7597\u75db\u98ce\u6027\u5173\u8282\u708e40\u4f8b)","volume":"26","author":"Zhang","year":"2010","journal-title":"Journal of Nanjing University of Traditional Chinese Medicine"},{"key":"10.1016\/j.intimp.2024.111932_b0770","first-page":"495","article-title":"Clinical observation of Baihu plus Guizhi decoction in treating acute gouty arthritis","volume":"36","author":"Huang","year":"2019","journal-title":"J. Guangzhou Univ. Trad. Chin. Med."},{"key":"10.1016\/j.intimp.2024.111932_b0775","first-page":"18","article-title":"Baihu Jia Guizhi tang has effect on degree of joint swelling and inflammatory factors in rats with acute gouty arthritis","volume":"52","author":"Zhou","year":"2020","journal-title":"New Chin. Med."},{"key":"10.1016\/j.intimp.2024.111932_b0780","first-page":"1283","article-title":"Mechanism of Baihu Jiaguizhi Tang improving renal tubular injury in rats with uric acid nephropathy (\u767d\u864e\u52a0\u6842\u679d\u6c64\u52a0\u51cf\u6539\u5584\u5c3f\u9178\u6027\u80be\u75c5\u5927\u9f20\u80be\u5c0f\u7ba1\u635f\u4f24\u7684\u673a\u5236)","volume":"17","author":"Wang","year":"2022","journal-title":"World Chinese Medicine"},{"key":"10.1016\/j.intimp.2024.111932_b0785","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1186\/s13063-022-06194-z","article-title":"Effect of Baihu and Guizhi decoction in acute gouty arthritis: study protocol for a randomized controlled trial","volume":"23","author":"He","year":"2022","journal-title":"Trials"},{"key":"10.1016\/j.intimp.2024.111932_b0790","first-page":"41","article-title":"Clinical observation and nursing of Bi-Xie-Shen-Shi-Tang in the treatment of acute gouty arthritis (\u8406\u85a2\u6e17\u6e7f\u6c64\u6cbb\u7597\u6025\u6027\u75db\u98ce\u6027\u5173\u8282\u708e\u7597\u6548\u89c2\u5bdf\u53ca\u62a4\u7406)","volume":"23","author":"Zhou","year":"2015","journal-title":"China\u2019s Naturopathy"},{"key":"10.1016\/j.intimp.2024.111932_b0795","first-page":"3353","article-title":"Sixty-eight cases of gout patients were treated with modified Bi-Xie-Shen-Shi-Tang (\u8406\u85a2\u6e17\u6e7f\u6c64\u52a0\u51cf\u6cbb\u7597\u75db\u98ce68\u4f8b)","volume":"17","author":"Zhang","year":"2013","journal-title":"The Medical Forum"},{"key":"10.1016\/j.intimp.2024.111932_b0800","first-page":"252","article-title":"Meta-analysis of effects of bixie shenshi decoction as main prescription in gouty arthritis","volume":"31","author":"Li","year":"2022","journal-title":"Proc. Clin. Med."},{"key":"10.1016\/j.intimp.2024.111932_b0805","first-page":"34","article-title":"Clinical observation of \u201cBixie Shenshi decoction\u201d in treating 30 cases of acute gouty arthritis","volume":"43","author":"Qu","year":"2009","journal-title":"Shanghai J. Trad. Chin. Med."},{"key":"10.1016\/j.intimp.2024.111932_b0810","first-page":"301","article-title":"Study on the Mechanism of Bi Xie Shen Shi Tang in Reducing Uric Acid Based on the Expression of OCT1 in Hyperuricemic Mice (\u57fa\u4e8e\u9ad8\u5c3f\u9178\u8840\u75c7\u5c0f\u9f20OCT1\u8868\u8fbe\u7684\u8406\u85a2\u6e17\u6e7f\u6c64\u964d\u5c3f\u9178\u673a\u5236\u7814\u7a76), Lingnan","volume":"20","author":"He","year":"2015","journal-title":"Journal of Emergency Medicine"},{"key":"10.1016\/j.intimp.2024.111932_b0815","first-page":"67","article-title":"Analysis of the acute gouty arthritis with Bixie Shenshi decoction and febuxostat","volume":"16","author":"Wang","year":"2019","journal-title":"Med. Innov. China"},{"key":"10.1016\/j.intimp.2024.111932_b0820","first-page":"129","article-title":"The integrative medicine and nursing on 60 cases of acute gouty arthritis","volume":"10","author":"Lu","year":"2018","journal-title":"Clin. J. Chin. Med."},{"key":"10.1016\/j.intimp.2024.111932_b0825","first-page":"158","article-title":"Influence of Si miao Bixie Decoction on IL-1\u03b2, PGE2 of Acute Gouty Arthritis","volume":"34","author":"Ye","year":"2010","journal-title":"Journal of Zhejiang Chinese Medical University"},{"key":"10.1016\/j.intimp.2024.111932_b0830","first-page":"84","article-title":"Clinical observation of clearing heat, reducing dampness, promoting blood circulation and removing blood stasis in the treatment of gouty arthritis in high altitude area (\u6e05\u70ed\u5229\u6e7f\u6d3b\u8840\u5316\u7600\u6cd5\u6cbb\u7597\u9ad8\u6d77\u62d4\u5730\u533a\u75db\u98ce\u6027\u5173\u8282\u708e\u4e34\u5e8a\u89c2\u5bdf)","volume":"46","author":"Li","year":"2014","journal-title":"New Chinese Medicine"},{"key":"10.1016\/j.intimp.2024.111932_b0835","first-page":"28","article-title":"Observation on therapeutic effect of integrated traditional Chinese and western medicine on acute gouty arthritis (\u4e2d\u897f\u533b\u7ed3\u5408\u6cbb\u7597\u6025\u6027\u75db\u98ce\u6027\u5173\u8282\u708e\u7597\u6548\u89c2\u5bdf)","volume":"7","author":"Luo","year":"2010","journal-title":"China Medical Herald"},{"key":"10.1016\/j.intimp.2024.111932_b0840","first-page":"1515","article-title":"Clinical research on the treatment for gouty arthritis with the combination of traditional Chinese and Western medicine","volume":"25","author":"Liu","year":"2007","journal-title":"Chin. Arch. Tradit. Chin. Med."},{"key":"10.1016\/j.intimp.2024.111932_b0845","article-title":"Effect of chinese herbal medicines on Hearing loss risk in rheumatoid arthritis patients: Retrospective claims analysis","volume":"8","author":"Li","year":"2021","journal-title":"Front. Med."},{"key":"10.1016\/j.intimp.2024.111932_b0850","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1111\/1756-185X.13571","article-title":"Association between use of Chinese herbal medicine and depression risk in patients with rheumatoid arthritis: A nationwide retrospective cohort study","volume":"22","author":"Li","year":"2019","journal-title":"Int. J. Rheum. Dis."},{"key":"10.1016\/j.intimp.2024.111932_b0855","first-page":"86","article-title":"Influence of Chinese Angelica pain-assuaging decoction and disassembled decoction on serum uric acid in rats","volume":"19","author":"Rong","year":"2013","journal-title":"Guiding J. Trad. Chin. Med. Pharma."},{"key":"10.1016\/j.intimp.2024.111932_b0860","first-page":"61","article-title":"The effects of Dang Gui Nian Tong decoction and its decomposed recipeson blood uric acid of mice with experimental uricemia","volume":"30","author":"Wang","year":"2010","journal-title":"Mod. Chin. Med."},{"key":"10.1016\/j.intimp.2024.111932_b0865","first-page":"44","article-title":"Effects of Danggui Niantong Decoction and its separate components on the expression of uric acid, IL-1\u03b2, TNF-\u03b1, COX-2 in acute gouty arthritis rats","volume":"33","author":"Xu","year":"2013","journal-title":"J. Hunan Univ. Chin. Med."},{"key":"10.1016\/j.intimp.2024.111932_b0870","first-page":"398","article-title":"Influnce of Dangguiniantong decoction on IL\u20131\u03b2 and TNF\u2013\u03b1 of rats with acute gouty arthritis","volume":"30","author":"Shen","year":"2012","journal-title":"Chin. Arch. Tradit. Chin. Med."},{"key":"10.1016\/j.intimp.2024.111932_b0875","first-page":"69","article-title":"Effects of Danggui Niantong Pills on blood uric acid and xanthine oxidase in experimental hyperuricemia rats (\u5f53\u5f52\u62c8\u75db\u4e38\u5bf9\u5b9e\u9a8c\u6027\u9ad8\u5c3f\u9178\u8840\u75c7\u5927\u9f20\u8840\u5c3f\u9178\u53ca\u9ec4\u560c\u5464\u6c27\u5316\u9176\u7684\u5f71\u54cd)","volume":"28","author":"Wang","year":"2008","journal-title":"Modern Chinese Medicine"},{"key":"10.1016\/j.intimp.2024.111932_b0880","first-page":"3116","article-title":"Efficacy and Mechanism of Action of Danggui Niantong Decoction against Acute Gouty Arthritis in a Mouse Model:an Experimental Study","volume":"24","author":"Chen","year":"2021","journal-title":"Chinese General Practice"},{"key":"10.1016\/j.intimp.2024.111932_b0885","first-page":"60","article-title":"A Summary of 40 Cases of Gout Treated with Dang-Gui-Nian-Tong-Tang (\u5f53\u5f52\u62c8\u75db\u6c64\u52a0\u51cf\u6cbb\u7597\u75db\u98ce40\u4f8b\u7597\u6548\u5c0f\u7ed3)","author":"Xia","year":"1987","journal-title":"Journal of Traditional Chinese Medicine"},{"key":"10.1016\/j.intimp.2024.111932_b0890","first-page":"25","article-title":"20 Cases of Gouty Arthritis Treated with Dang-Gui-Nian-Tong-Tang (\u5f53\u5f52\u62c8\u75db\u6c64\u6cbb\u7597\u75db\u98ce\u6027\u5173\u8282\u708e20\u4f8b)","volume":"16","author":"Guo","year":"2000","journal-title":"Journal of Practical Traditional Chinese Medicine"},{"key":"10.1016\/j.intimp.2024.111932_b0895","first-page":"1072","article-title":"Clinical observation of Dang-Gui-Nian-Tong-Tang in the treatment of acute gouty arthritis (\u5f53\u5f52\u62c8\u75db\u6c64\u6cbb\u7597\u6025\u6027\u75db\u98ce\u6027\u5173\u8282\u708e\u4e34\u5e8a\u89c2\u5bdf)","volume":"18","author":"Shen","year":"2009","journal-title":"Journal of Emergency in Traditional Chinese Medicine"},{"key":"10.1016\/j.intimp.2024.111932_b0900","first-page":"42","article-title":"Effect of Dang-Gui-Nian-Tong-Tang on Serum MMP-3 in Patients with Acute Gouty Arthritis (\u5f53\u5f52\u62c8\u75db\u6c64\u5bf9\u6025\u6027\u75db\u98ce\u6027\u5173\u8282\u708e\u60a3\u8005\u8840\u6e05MMP-3\u7684\u5f71\u54cd)","volume":"3","author":"Lei","year":"2011","journal-title":"Clinical Journal of Chinese Medicine"},{"key":"10.1016\/j.intimp.2024.111932_b0905","first-page":"353","article-title":"Influence of Dangguiniantong Decoction on the IL-1, IL-8 and TNF-\u03b1 of Acute Gouty Arthritis","volume":"20","author":"Shen","year":"2011","journal-title":"Journal of Emergency in Traditional Chinese Medicine"},{"key":"10.1016\/j.intimp.2024.111932_b0910","first-page":"71","article-title":"Application of Angelica Pain-Relieving Decoction in the Treatment of Gout","volume":"23","author":"Ma","year":"2021","journal-title":"Popular Science & Technology"},{"key":"10.1016\/j.intimp.2024.111932_b0915","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1142\/S0192415X95000316","article-title":"The anti-inflammatory and anti-hyperuricemic effects of Chinese herbal formula danggui-nian-tong-tang on acute gouty arthritis: a comparative study with indomethacin and allopurinol","volume":"23","author":"Chou","year":"1995","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.intimp.2024.111932_b0920","first-page":"274","article-title":"Treating 75 cases of acute gouty arthritis with damp-heat accumulation syndrome by Danggui Niantong Tang combined with Xuanbi Tang (\u5f53\u5f52\u62c8\u75db\u6c64\u5408\u5ba3\u75f9\u6c64\u6cbb\u7597\u6025\u6027\u75db\u98ce\u6027\u5173\u8282\u708e\u6e7f\u70ed\u8574\u7ed3\u8bc175\u4f8b), Zhejiang","volume":"56","author":"Wang","year":"2021","journal-title":"Journal of Traditional Chinese Medicine"},{"key":"10.1016\/j.intimp.2024.111932_b0925","first-page":"25","article-title":"The clinical observation of treating 44 cases of acute gouty arthritis in angelica niantong decoction plus simiao san","volume":"3","author":"Chen","year":"2011","journal-title":"Clin. J. Chin. Med."},{"key":"10.1016\/j.intimp.2024.111932_b0930","first-page":"169","article-title":"Efficacy of danggui zhantong tang combined with Sanmiao Wan in treatment of damp-heat accumulation type gouty arthritis","volume":"21","author":"Jiang","year":"2015","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"10.1016\/j.intimp.2024.111932_b0935","first-page":"101","article-title":"Meta Analysis of Modified Danggui Niantong Decoction in Treating Damp-heat Blocking Collateral Gouty Nephropathy","volume":"34","author":"Zhou","year":"2021","journal-title":"Journal of Medical Information"},{"key":"10.1016\/j.intimp.2024.111932_b0940","first-page":"73","article-title":"Efficacy analysis of Angelica niantong decoction on grade I hypertension complicated with hyperuricemia","volume":"38","author":"Zheng","year":"2022","journal-title":"Chin. Community Doctors"},{"key":"10.1016\/j.intimp.2024.111932_b0945","first-page":"55","article-title":"Observation on the Effect of Danggui Niantong Tang on Hypertension with Hyperuricemia (\u5f53\u5f52\u62c8\u75db\u6c64\u52a0\u51cf\u6cbb\u7597\u9ad8\u8840\u538b\u5408\u5e76\u9ad8\u5c3f\u9178\u8840\u75c7\u7684\u7597\u6548\u89c2\u5bdf)","volume":"16","author":"Zhou","year":"2016","journal-title":"Cardio-cerebrovascular Disease Prevention and Treatment"},{"key":"10.1016\/j.intimp.2024.111932_b0950","first-page":"1155","article-title":"Study on the mechanism of Danggui Niantong decoction for hyperuricemic nephropathy mice, Shaanxi","volume":"40","author":"Li","year":"2019","journal-title":"Journal of Traditional Chinese Medicine"},{"key":"10.1016\/j.intimp.2024.111932_b0955","first-page":"21+39","article-title":"Summary of 14 Cases of Gout Treated with Xuanbi Tang (\u5ba3\u75f9\u6c64\u6cbb\u7597\u75db\u98ce14\u4f8b\u5c0f\u7ed3), Hubei","volume":"17","author":"Cui","year":"1995","journal-title":"Journal of Traditional Chinese Medicine"},{"key":"10.1016\/j.intimp.2024.111932_b0960","first-page":"27","article-title":"Treatment of 32, Cases of Primary Gout with Xuanbi Tang (\u5ba3\u75f9\u6c64\u52a0\u51cf\u6cbb\u7597\u539f\u53d1\u6027\u75db\u98ce32\u4f8b)","volume":"4","author":"Lv","year":"1992","journal-title":"Clinical Journal of Traditional Chinese Medicine"},{"key":"10.1016\/j.intimp.2024.111932_b0965","first-page":"35","article-title":"60 Cases of Gouty Arthritis Treated with Ermiao San and Xuanbi Tang (\u4e8c\u5999\u6563\u5408\u5ba3\u75f9\u6c64\u52a0\u51cf\u6cbb\u7597\u75db\u98ce\u6027\u5173\u8282\u708e60\u4f8b)","volume":"34","author":"Liu","year":"2006","journal-title":"Acta Chinese Medicine and Pharmacology"},{"key":"10.1016\/j.intimp.2024.111932_b0970","first-page":"28","article-title":"Treatment of Gouty Arthritis with Xuanbi Decoction and Sanmiao Pill (\u5ba3\u75f9\u6c64\u5408\u4e09\u5999\u4e38\u6cbb\u7597\u75db\u98ce\u6027\u5173\u8282\u708e)","volume":"2","author":"Cai","year":"1990","journal-title":"The Journal of Traditional Chinese Orthopedics and Traumatology"},{"key":"10.1016\/j.intimp.2024.111932_b0975","first-page":"35","article-title":"Clinical Observation on 80 Cases of Gout Treated with Simiao Pill and Xuanbi Decoction (\u56db\u5999\u4e38\u5408\u5ba3\u75f9\u6c64\u52a0\u51cf\u6cbb\u7597\u75db\u98ce80\u4f8b\u4e34\u5e8a\u89c2\u5bdf), Jiangxi","volume":"48","author":"Xia","year":"2017","journal-title":"Journal of Traditional Chinese Medicine"},{"key":"10.1016\/j.intimp.2024.111932_b0980","first-page":"36","article-title":"Kuang Huitao\u2019s Experience in Treating Gout with Shuanghe Simiao Xuanbi Tang (\u65f7\u60e0\u6843\u8fd0\u7528\u53cc\u5408\u56db\u5999\u5ba3\u75f9\u6c64\u6cbb\u7597\u75db\u98ce\u7ecf\u9a8c), Hunan","volume":"32","author":"Liao","year":"2016","journal-title":"Journal of Traditional Chinese Medicine"},{"key":"10.1016\/j.intimp.2024.111932_b0985","first-page":"9","article-title":"Modified Wuling San in the Treatment of Gout (\u4e94\u82d3\u6563\u52a0\u5473\u6cbb\u7597\u75db\u98ce), Yunnan","volume":"12","author":"Shen","year":"1991","journal-title":"Journal of Traditional Chinese Medicine and Materia Medica"},{"key":"10.1016\/j.intimp.2024.111932_b0990","first-page":"19","article-title":"Clinical Observation on the Treatment of Hyperuricemia with Modified Wuling San (\u4e94\u82d3\u6563\u52a0\u5473\u6cbb\u7597\u9ad8\u5c3f\u9178\u8840\u75c7\u4e34\u5e8a\u89c2\u5bdf), Beijing","volume":"22","author":"Wang","year":"2003","journal-title":"Journal of Traditional Chinese Medicine"},{"key":"10.1016\/j.intimp.2024.111932_b0995","first-page":"124","article-title":"Clinical Observation on Wuling San in Treating Acute Attack of Gouty Arthritis of Foot and Ankle (\u4e94\u82d3\u6563\u6cbb\u7597\u8db3\u8e1d\u90e8\u75db\u98ce\u6027\u5173\u8282\u708e\u6025\u6027\u53d1\u4f5c\u671f\u4e34\u5e8a\u89c2\u5bdf)","volume":"48","author":"Li","year":"2016","journal-title":"New Chinese Medicine"},{"key":"10.1016\/j.intimp.2024.111932_b1000","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1142\/S0192415X19500757","article-title":"Professor CHEN Jifan's clinical experience in treating gouty arthritis","volume":"39","author":"Huang","year":"2019","journal-title":"J. Hunan Univ. Chin. Med."},{"key":"10.1016\/j.intimp.2024.111932_b1005","first-page":"2111","article-title":"Efficacy of yinchen wuling powder combined with rattan drugs on acute gouty arthritis and its effect on the balance of Th17\/Treg cells","volume":"29","author":"Cao","year":"2020","journal-title":"J. Emerg. Trad. Chin. Med."},{"key":"10.1016\/j.intimp.2024.111932_b1010","first-page":"94","article-title":"60 Cases of Gouty Arthritis Treated with Yinchen Wuling San (\u8335\u9648\u4e94\u82d3\u6563\u6cbb\u7597\u75db\u98ce\u6027\u5173\u8282\u708e60\u4f8b)","volume":"11","author":"Wang","year":"2013","journal-title":"Chinese Medicine Modern Distance Education of China"},{"key":"10.1016\/j.intimp.2024.111932_b1015","first-page":"1348","article-title":"Therapeutic effect of auricular acupoint pressing combined with Yinchen Wuling powder on acute gouty arthritis","volume":"36","author":"Shi","year":"2019","journal-title":"J. Guangzhou Univ. Trad. Chin. Med."},{"key":"10.1016\/j.intimp.2024.111932_b1020","first-page":"27","article-title":"Observation on the Effect of Yinchen Wuling San Plus Fire Needle Peri needling on Acute Gouty Arthritis of Lower Extremities (\u8335\u9648\u4e94\u82d3\u6563\u52a0\u51cf\u914d\u5408\u706b\u9488\u56f4\u523a\u6cbb\u7597\u4e0b\u80a2\u6025\u6027\u75db\u98ce\u6027\u5173\u8282\u708e\u6548\u679c\u89c2\u5bdf)","volume":"28","author":"Lv","year":"2021","journal-title":"Chinese Journal of Rural Medicine and Pharmacy"},{"key":"10.1016\/j.intimp.2024.111932_b1025","first-page":"33","article-title":"Treatment of 20 Cases of Gout with Yinchen Wuling San and Fangji Fuling Tang (\u8335\u9648\u4e94\u82d3\u6563\u5408\u9632\u5df1\u832f\u82d3\u6c64\u6cbb\u7597\u75db\u98ce20\u4f8b)","volume":"9","author":"Pi","year":"2011","journal-title":"Chinese Medicine Modern Distance Education of China"},{"key":"10.1016\/j.intimp.2024.111932_b1030","first-page":"81","article-title":"Clinical observation on modified simiao wuling powder decoction in treatment of acute gouty arthritis","volume":"18","author":"Wang","year":"2016","journal-title":"J. Hubei Univ. Chin. Med."},{"key":"10.1016\/j.intimp.2024.111932_b1035","first-page":"1381","article-title":"86 Cases of Acute Gouty Arthritis Treated with Modified Wuling San and Liuyi San (\u4e94\u82d3\u6563\u5408\u516d\u4e00\u6563\u52a0\u5473\u6cbb\u7597\u6025\u6027\u75db\u98ce\u6027\u5173\u8282\u708e86\u4f8b), Guangming","volume":"26","author":"Wei","year":"2011","journal-title":"Journal of Chinese Medicine"},{"key":"10.1016\/j.intimp.2024.111932_b1040","first-page":"64","article-title":"Clinical Observation on the Treatment of Gout in the Intermittent Period of Damp and heat with Zhizi Baipi Tang and Wuling San (\u6800\u5b50\u67cf\u76ae\u6c64\u5408\u4e94\u82d3\u6563\u52a0\u5473\u6cbb\u7597\u6e7f\u70ed\u8d28\u95f4\u6b47\u671f\u75db\u98ce\u4e34\u5e8a\u89c2\u5bdf), Yunnan","volume":"42","author":"Lin","year":"2021","journal-title":"Journal of Traditional Chinese Medicine and Materia Medica"},{"key":"10.1016\/j.intimp.2024.111932_b1045","first-page":"53","article-title":"Clinical effect observation on classical prescriptions \u201cWuling San\u201d for gouty arthritis of phlegm turbid stasis syndrome","volume":"11","author":"Yang","year":"2020","journal-title":"Chin. Manipulation Rehab. Med."},{"key":"10.1016\/j.intimp.2024.111932_b1050","first-page":"52","article-title":"Therapeutic effect of modified wuling powder on GA and its influence to XO","volume":"38","author":"Huang","year":"2021","journal-title":"Inform. Trad. Chin. Med."},{"key":"10.1016\/j.intimp.2024.111932_b1055","first-page":"86","article-title":"Observation on treating gouty arthritis with Wuling San plus the Jinhuang ointment","volume":"12","author":"Liu","year":"2020","journal-title":"Clin. J. Chin. Med."},{"key":"10.1016\/j.intimp.2024.111932_b1060","first-page":"1712","article-title":"Thirty-five cases of gout interval with spleen-Yang deficiency treated with five substances powder with poria for acupoint sticking","volume":"37","author":"Chen","year":"2017","journal-title":"Henan Trad. Chin. Med."},{"key":"10.1016\/j.intimp.2024.111932_b1065","doi-asserted-by":"crossref","first-page":"214","DOI":"10.3724\/SP.J.1009.2013.00214","article-title":"Wuling san ameliorates urate under-excretion and renal dysfunction in hyperuricemic mice","volume":"11","author":"Ding","year":"2013","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.intimp.2024.111932_b1070","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jep.2015.04.011","article-title":"Wuling San protects kidney dysfunction by inhibiting renal TLR4\/MyD88 signaling and NLRP3 inflammasome activation in high fructose-induced hyperuricemic mice","volume":"169","author":"Yang","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2024.111932_b1075","first-page":"1209","article-title":"Exploration on origin of simiao yong'an decoction","volume":"45","author":"Zhao","year":"2020","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.intimp.2024.111932_b1080","first-page":"136","article-title":"Textual Research on the Origin of Simiao Yong\u2019an Tang (\u56db\u5999\u52c7\u5b89\u6c64\u6e90\u51fa\u4eca\u8003), Shaanxi","author":"Yu","year":"1992","journal-title":"Journal of Traditional Chinese Medicine"},{"key":"10.1016\/j.intimp.2024.111932_b1085","first-page":"409","article-title":"Effect of Traditional Chinese Medicine on Arterial Embolism Gangrene (\u4e2d\u533b\u6cbb\u7597\u52a8\u8108\u6813\u585e\u6027\u574f\u75bd\u75c7\u7684\u6210\u6548)","author":"Lv","year":"1956","journal-title":"Journal of Traditional Chinese Medicine"},{"key":"10.1016\/j.intimp.2024.111932_b1090","unstructured":"Department of, Traditional Chinese Medicine of the First Hospital of Tianjin Special District H, China. Report on the treatment of thromboangiitis obliterans (\u6cbb\u7597\u8840\u6813\u95ed\u585e\u6027\u8109\u7ba1\u708e\u7684\u62a5\u544a), Journal of Traditional Chinese Medicine (1958) 752\u2013753."},{"key":"10.1016\/j.intimp.2024.111932_b1095","first-page":"36","article-title":"Cases of Gout Treated with Modified Simiao Yong\u2019an Tang (\u56db\u5999\u52c7\u5b89\u6c64\u52a0\u5473\u6cbb\u7597\u75db\u98ce43\u4f8b), Hunan","volume":"19","author":"Zhang","year":"2003","journal-title":"Journal of Traditional Chinese Medicine"},{"key":"10.1016\/j.intimp.2024.111932_b1100","first-page":"840","article-title":"Treatment of 27 Cases of Obstinate Gout with Modified Simiao Yong\u2019an Decoction (\u52a0\u5473\u56db\u5999\u52c7\u5b89\u6c64\u6cbb\u7597\u987d\u56fa\u6027\u75db\u98ce27\u4f8b), Hebei","volume":"23","author":"Zhu","year":"2001","journal-title":"Journal of Traditional Chinese Medicine"},{"key":"10.1016\/j.intimp.2024.111932_b1105","first-page":"223","article-title":"Observation on therapeutic effect of Simiao Yong\u2019an decoction on 42 cases of gout of rheumatic heat and arthralgia type (\u56db\u5999\u52c7\u5b89\u6c64\u6cbb\u7597\u98ce\u6e7f\u70ed\u75db\u75f9\u578b\u75db\u98ce42\u4f8b\u7597\u6548\u89c2\u5bdf), Jilin","volume":"29","author":"Zhao","year":"2009","journal-title":"Journal of Chinese Medicine"},{"key":"10.1016\/j.intimp.2024.111932_b1110","first-page":"31","article-title":"Treatment of 32 Cases of, Acute Gouty Arthritis with Simiao Yong\u2019an Decoction and Wuling San (\u56db\u5999\u52c7\u5b89\u6c64\u5408\u4e94\u82d3\u6563\u6cbb\u7597\u6025\u6027\u75db\u98ce\u6027\u5173\u8282\u708e32\u4f8b)","volume":"19","author":"Tao","year":"2011","journal-title":"China\u2019s Naturopathy"},{"key":"10.1016\/j.intimp.2024.111932_b1115","first-page":"18","article-title":"16 Cases of Gouty Arthritis Treated with Simiao Yong\u2019an Decoction and Simiao Powder (\u56db\u5999\u52c7\u5b89\u6c64\u5408\u56db\u5999\u6563\u52a0\u5473\u6cbb\u7597\u75db\u98ce\u6027\u5173\u8282\u708e16\u4f8b)","volume":"16","author":"Zhou","year":"1996","journal-title":"Journal of Hunan University of Chinese Medicine"},{"key":"10.1016\/j.intimp.2024.111932_b1120","first-page":"539","article-title":"Treatment of 65 Cases of Acute Gouty Arthritis with Simiao Yong\u2019an Decoction (\u56db\u5999\u52c7\u5b89\u6c64\u6cbb\u7597\u6025\u6027\u75db\u98ce\u6027\u5173\u8282\u708e65\u4f8b), Shaanxi","volume":"28","author":"Wang","year":"2007","journal-title":"Journal of Traditional Chinese Medicine"},{"key":"10.1016\/j.intimp.2024.111932_b1125","first-page":"113","article-title":"Effect of Simiao Yong'an decoction on acute attack of type 2 diabetes mellitus and gout","volume":"35","author":"Xiong","year":"2017","journal-title":"J. Sichuan Trad. Chin. Med."},{"key":"10.1016\/j.intimp.2024.111932_b1130","first-page":"148","article-title":"Observation on the efficacy of modified Simiao Yong'an decoction (four valiant decoction for well-being with additional integrants) in the treatment of acute gouty arthritis of damp-heat accumulation type","volume":"60","author":"Tang","year":"2022","journal-title":"China Modern Doctor"},{"key":"10.1016\/j.intimp.2024.111932_b1135","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.semnephrol.2011.08.003","article-title":"Urate transporters: An evolving field","volume":"31","author":"Anzai","year":"2011","journal-title":"Semin. Nephrol."},{"key":"10.1016\/j.intimp.2024.111932_b1140","doi-asserted-by":"crossref","first-page":"e0264696","DOI":"10.1371\/journal.pone.0264696","article-title":"Uricase-deficient rats with similarly stable serum uric acid to human's are sensitive model animals for studying hyperuricemia","volume":"17","author":"Gao","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2024.111932_b1145","doi-asserted-by":"crossref","first-page":"401","DOI":"10.4103\/cjop.CJOP-D-22-00131","article-title":"The pan-liver network theory: From traditional chinese medicine to western medicine","volume":"66","author":"Zhang","year":"2023","journal-title":"Chin. J. Physiol."},{"key":"10.1016\/j.intimp.2024.111932_b1150","doi-asserted-by":"crossref","first-page":"e23527","DOI":"10.1097\/MD.0000000000023527","article-title":"Acupuncture for gouty arthritis: A PRISMA-compliant protocol for a systematic review and meta-analysis of randomized controlled trials","volume":"99","author":"Lee","year":"2020","journal-title":"Medicine"},{"key":"10.1016\/j.intimp.2024.111932_b1155","doi-asserted-by":"crossref","first-page":"e24719","DOI":"10.1097\/MD.0000000000024719","article-title":"Acupuncture to treat asymptomatic hyperuricemia: A protocol for systematic review and meta-analysis of randomized controlled trials","volume":"100","author":"Hwang","year":"2021","journal-title":"Medicine"},{"key":"10.1016\/j.intimp.2024.111932_b1160","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.chom.2024.02.001","article-title":"Alistipes indistinctus-derived hippuric acid promotes intestinal urate excretion to alleviate hyperuricemia","volume":"32","author":"Xu","year":"2024","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.intimp.2024.111932_b1165","doi-asserted-by":"crossref","first-page":"1194026","DOI":"10.3389\/fphar.2023.1194026","article-title":"Yao-Shan of traditional Chinese medicine: An old story for metabolic health","volume":"14","author":"Yang","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2024.111932_b1170","doi-asserted-by":"crossref","first-page":"1234307","DOI":"10.3389\/fimmu.2023.1234307","article-title":"TCM \u201cmedicine and food homology\u201d in the management of post-COVID disorders","volume":"14","author":"Ng","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2024.111932_b1175","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1016\/j.crfs.2022.10.028","article-title":"Effects of polysaccharides-riched Prunus mume fruit juice concentrate on uric acid excretion and gut microbiota in mice with adenine-induced chronic kidney disease","volume":"5","author":"Huang","year":"2022","journal-title":"Curr. Res. Food Sci."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924004508?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924004508?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T06:05:19Z","timestamp":1731650719000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924004508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":235,"alternative-id":["S1567576924004508"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.111932","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Signaling pathways in uric acid homeostasis and gout: From pathogenesis to therapeutic interventions","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.111932","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"111932"}}