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Li, Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity, Cell 176(6) (2019) 1447-1460 e14.","DOI":"10.1016\/j.cell.2019.01.016"},{"issue":"1","key":"10.1016\/j.intimp.2024.111971_b0295","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1021\/acsmedchemlett.8b00466","article-title":"Discovery of a novel cGAMP competitive ligand of the inactive form of STING","volume":"10","author":"Siu","year":"2019","journal-title":"ACS Med Chem Lett"},{"issue":"7713","key":"10.1016\/j.intimp.2024.111971_b0300","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41586-018-0287-8","article-title":"Targeting STING with covalent small-molecule inhibitors","volume":"559","author":"Haag","year":"2018","journal-title":"Nature"},{"issue":"24","key":"10.1016\/j.intimp.2024.111971_b0305","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2105465118","article-title":"STING inhibitors target the cyclic dinucleotide binding pocket","volume":"118","author":"Hong","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.intimp.2024.111971_b0310","doi-asserted-by":"crossref","unstructured":"S. Li, Z. Hong, Z. Wang, F. Li, J. Mei, L. Huang, X. Lou, S. Zhao, L. Song, W. Chen, Q. Wang, H. Liu, Y. Cai, H. Yu, H. Xu, G. Zeng, Q. Wang, J. Zhu, X. Liu, N. Tan, C. Wang, The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING, Cell reports 25(12) (2018) 3405-3421 e7.","DOI":"10.1016\/j.celrep.2018.11.097"},{"issue":"5","key":"10.1016\/j.intimp.2024.111971_b0315","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1021\/acsmedchemlett.9b00027","article-title":"Discovery of GSK8612, a highly selective and potent TBK1 inhibitor","volume":"10","author":"Thomson","year":"2019","journal-title":"ACS Med Chem Lett"},{"issue":"4","key":"10.1016\/j.intimp.2024.111971_b0320","first-page":"630","article-title":"Effects of salvianolic acids on endothelial cells against damage induced by cholestane-3beta-5alpha-6beta-triol","volume":"116","author":"Ren","year":"2003","journal-title":"Chin Med J (engl)"},{"issue":"8","key":"10.1016\/j.intimp.2024.111971_b0325","first-page":"721","article-title":"Effects of salvianolic acid-a on rat hepatic stellate cell proliferation and collagen production in culture","volume":"21","author":"Liu","year":"2000","journal-title":"Acta Pharmacol Sin"},{"issue":"7","key":"10.1016\/j.intimp.2024.111971_b0330","first-page":"629","article-title":"Salvianolate inhibits proliferation and endothelin release in cultured rat mesangial cells","volume":"22","author":"Xu","year":"2001","journal-title":"Acta Pharmacol Sin"},{"issue":"3","key":"10.1016\/j.intimp.2024.111971_b0335","doi-asserted-by":"crossref","first-page":"279","DOI":"10.5021\/ad.2019.31.3.279","article-title":"Inhibition of Poly(I:C)-induced inflammation by salvianolic acid a in skin keratinocytes","volume":"31","author":"Zhang","year":"2019","journal-title":"Ann Dermatol"},{"issue":"5","key":"10.1016\/j.intimp.2024.111971_b0340","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/cpr.12056","article-title":"In silico analysis and experimental validation of molecular mechanisms of salvianolic acid A-inhibited LPS-stimulated inflammation, in RAW264.7 macrophages","volume":"46","author":"Huang","year":"2013","journal-title":"Cell Prolif"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924004892?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924004892?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:56:46Z","timestamp":1778619406000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924004892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":68,"alternative-id":["S1567576924004892"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.111971","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Salvianolic acid A prevents UV-induced skin damage by inhibiting the cGAS-STING pathway","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.111971","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. 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