{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:58:07Z","timestamp":1792807087618,"version":"4.5.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100015337","name":"Guangdong Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015337","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.intimp.2024.112098","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T20:46:54Z","timestamp":1713214014000},"page":"112098","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Honokiol suppress the PD-L1 expression to improve anti-tumor immunity in lung cancer"],"prefix":"10.1016","volume":"133","author":[{"given":"Lianxiang","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaorong","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youwen","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinglin","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.intimp.2024.112098_b0005","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a028480","article-title":"Interferon \u03b3 and its important roles in promoting and inhibiting spontaneous and therapeutic cancer immunity","volume":"11","author":"Alspach","year":"2019","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.intimp.2024.112098_b0010","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.molonc.2014.01.004","article-title":"Honokiol inhibits epithelial-mesenchymal transition in breast cancer cells by targeting signal transducer and activator of transcription 3\/Zeb1\/E-cadherin axis","volume":"8","author":"Avtanski","year":"2014","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.intimp.2024.112098_b0015","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.phrs.2019.04.004","article-title":"Honokiol for cancer therapeutics: A traditional medicine that can modulate multiple oncogenic targets","volume":"144","author":"Banik","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.intimp.2024.112098_b0020","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/s41586-018-0392-8","article-title":"Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response","volume":"560","author":"Chen","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2024.112098_b0025","doi-asserted-by":"crossref","DOI":"10.1093\/ibd\/izad099","article-title":"SIRT3 activator Honokiol inhibits Th17 cell differentiation and alleviates colitis","author":"Chen","year":"2023","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.intimp.2024.112098_b0030","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.ccell.2020.09.001","article-title":"The PD-1\/PD-L1-checkpoint restrains T cell immunity in tumor-draining lymph nodes","volume":"38","author":"Dammeijer","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.intimp.2024.112098_b0035","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1016\/j.mayocp.2019.01.013","article-title":"Non-small cell lung cancer: Epidemiology, screening, diagnosis, and treatment","volume":"94","author":"Duma","year":"2019","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.intimp.2024.112098_b0040","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.apsb.2021.09.010","article-title":"The generation of PD-L1 and PD-L2 in cancer cells: From nuclear chromatin reorganization to extracellular presentation","volume":"12","author":"Fan","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.intimp.2024.112098_b0045","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1002\/ijc.31357","article-title":"IFN-\u03b3-mediated inhibition of lung cancer correlates with PD-L1 expression and is regulated by PI3K-AKT signaling","volume":"143","author":"Gao","year":"2018","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.intimp.2024.112098_b0050","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.addr.2018.07.007","article-title":"Tumor targeting via EPR: Strategies to enhance patient responses","volume":"130","author":"Golombek","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.intimp.2024.112098_b0055","first-page":"3039","article-title":"Honokiol induces ferroptosis in colon cancer cells by regulating GPX4 activity","volume":"11","author":"Guo","year":"2021","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.intimp.2024.112098_b0060","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1186\/1471-2407-8-242","article-title":"Improved therapeutic effectiveness by combining liposomal honokiol with cisplatin in lung cancer model","volume":"8","author":"Jiang","year":"2008","journal-title":"BMC Cancer"},{"key":"10.1016\/j.intimp.2024.112098_b0065","article-title":"Prognostic value of PD-1, PD-L1 and PD-L2 deserves attention in head and neck cancer","volume":"13","author":"Jiang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2024.112098_b0070","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12943-018-0928-4","article-title":"Role of the tumor microenvironment in PD-L1\/PD-1-mediated tumor immune escape","volume":"18","author":"Jiang","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.intimp.2024.112098_b0075","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1186\/s13046-020-01741-5","article-title":"Evodiamine suppresses non-small cell lung cancer by elevating CD8(+) T cells and downregulating the MUC1-C\/PD-L1 axis","volume":"39","author":"Jiang","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.intimp.2024.112098_b0080","first-page":"11","article-title":"Honokiol microemulsion causes stage-dependent toxicity via dual roles in oxidation-reduction and apoptosis through FoxO Signaling pathway","author":"Li","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.intimp.2024.112098_b0085","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41392-021-00869-w","article-title":"Liposomal Honokiol induces ROS-mediated apoptosis via regulation of ERK\/p38-MAPK signaling and autophagic inhibition in human medulloblastoma","volume":"7","author":"Li","year":"2022","journal-title":"Signal. Transduct. Target Ther."},{"key":"10.1016\/j.intimp.2024.112098_b0090","doi-asserted-by":"crossref","first-page":"2181746","DOI":"10.1080\/10717544.2023.2181746","article-title":"Polysialic acid-functionalized liposomes for efficient honokiol delivery to inhibit breast cancer growth and metastasis","volume":"30","author":"Li","year":"2023","journal-title":"Drug Deliv."},{"key":"10.1016\/j.intimp.2024.112098_b0095","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s13402-020-00557-x","article-title":"Synergistic killing effect of paclitaxel and honokiol in non-small cell lung cancer cells through paraptosis induction","volume":"44","author":"Li","year":"2021","journal-title":"Cell Oncol. (Dordr.)"},{"key":"10.1016\/j.intimp.2024.112098_b0100","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s13020-021-00541-z","article-title":"Honokiol alleviates LPS-induced acute lung injury by inhibiting NLRP3 inflammasome-mediated pyroptosis via Nrf2 activation in vitro and in vivo","volume":"16","author":"Liu","year":"2021","journal-title":"Chin. Med."},{"key":"10.1016\/j.intimp.2024.112098_b0105","doi-asserted-by":"crossref","first-page":"4678","DOI":"10.7150\/thno.36276","article-title":"Distinct PD-L1\/PD1 profiles and clinical implications in intrahepatic cholangiocarcinoma patients with different risk factors","volume":"9","author":"Lu","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.intimp.2024.112098_b0110","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232213774","article-title":"Fascaplysin induces apoptosis and ferroptosis, and enhances anti-PD-1 immunotherapy in non-small cell lung cancer (NSCLC) by promoting PD-L1 expression","volume":"23","author":"Luo","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2024.112098_b0115","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3389\/fphar.2017.00199","article-title":"Honokiol induces apoptosis, G1 arrest, and autophagy in KRAS mutant lung cancer cells","volume":"8","author":"Luo","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2024.112098_b0120","doi-asserted-by":"crossref","DOI":"10.1172\/JCI137750","article-title":"CHI3L1 regulates PD-L1 and anti-CHI3L1-PD-1 antibody elicits synergistic antitumor responses","volume":"131","author":"Ma","year":"2021","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.intimp.2024.112098_b0125","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.827921","article-title":"Biological characteristics and clinical significance of soluble PD-1\/PD-L1 and exosomal PD-L1 in cancer","volume":"13","author":"Niu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2024.112098_b0130","doi-asserted-by":"crossref","first-page":"4014","DOI":"10.1158\/1078-0432.CCR-15-0016","article-title":"Induction of PD-L1 expression by the EML4-ALK oncoprotein and downstream signaling pathways in non-small cell lung cancer","volume":"21","author":"Ota","year":"2015","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.intimp.2024.112098_b0135","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1002\/mnfr.201501007","article-title":"Honokiol targets mitochondria to halt cancer progression and metastasis","volume":"60","author":"Pan","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.intimp.2024.112098_b0140","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1186\/s12974-018-1330-2","article-title":"The IFN-\u03b3\/PD-L1 axis between T cells and tumor microenvironment: hints for glioma anti-PD-1\/PD-L1 therapy","volume":"15","author":"Qian","year":"2018","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.intimp.2024.112098_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153647","article-title":"Honokiol: A review of its pharmacological potential and therapeutic insights","volume":"90","author":"Rauf","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2024.112098_b0150","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.biopha.2018.08.054","article-title":"Honokiol: An anticancer lignan","volume":"107","author":"Rauf","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2024.112098_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102945","article-title":"A novel combination therapy with Cabozantinib and Honokiol effectively inhibits c-Met-Nrf2-induced renal tumor growth through increased oxidative stress","volume":"68","author":"Rawat","year":"2023","journal-title":"Redox. Biol."},{"key":"10.1016\/j.intimp.2024.112098_b0160","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.596825","article-title":"PD-L1 and PD-L2 expression in cervical cancer: Regulation and biomarker potential","volume":"11","author":"Rotman","year":"2020","journal-title":"Front. Immunol."},{"issue":"7","key":"10.1016\/j.intimp.2024.112098_b0165","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.3390\/cancers12071782","article-title":"A novel combination treatment with Honokiol and Rapamycin effectively restricts c-Met-induced growth of renal cancer cells, and also inhibits the expression of tumor Cell PD-L1 involved in immune escape","volume":"12","author":"Sabarwal","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.intimp.2024.112098_b0170","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.addr.2020.07.002","article-title":"Liposomes: Advancements and innovation in the manufacturing process","volume":"154\u2013155","author":"Shah","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.intimp.2024.112098_b0175","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s13046-019-1161-8","article-title":"Inhibition of ATM reverses EMT and decreases metastatic potential of cisplatin-resistant lung cancer cells through JAK\/STAT3\/PD-L1 pathway","volume":"38","author":"Shen","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.intimp.2024.112098_b0180","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.964442","article-title":"The role of PD-1\/PD-L1 and application of immune-checkpoint inhibitors in human cancers","volume":"13","author":"Tang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2024.112098_b0185","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0140-6736(21)00312-3","article-title":"Lung cancer","volume":"398","author":"Thai","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.intimp.2024.112098_b0190","doi-asserted-by":"crossref","first-page":"5943","DOI":"10.7150\/thno.41498","article-title":"ACT001 reduces the expression of PD-L1 by inhibiting the phosphorylation of STAT3 in glioblastoma","volume":"10","author":"Tong","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.intimp.2024.112098_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.129381","article-title":"Mitigation of honokiol on fluoride-induced mitochondrial oxidative stress, mitochondrial dysfunction, and cognitive deficits through activating AMPK\/PGC-1\u03b1\/Sirt3","volume":"437","author":"Wang","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.intimp.2024.112098_b0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2021.108899","article-title":"Formononetin represses cervical tumorigenesis by interfering with the activation of PD-L1 through MYC and STAT3 downregulation","volume":"100","author":"Wang","year":"2022","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.intimp.2024.112098_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109058","article-title":"Honokiol alleviates ulcerative colitis by targeting PPAR-\u03b3-TLR4-NF-\u03baB signaling and suppressing gasdermin-D-mediated pyroptosis in vivo and in vitro","volume":"111","author":"Wang","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2024.112098_b0210","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1002\/ijc.24244","article-title":"Liposomal honokiol inhibits VEGF-D-induced lymphangiogenesis and metastasis in xenograft tumor model","volume":"124","author":"Wen","year":"2009","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.intimp.2024.112098_b0215","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13045-022-01242-2","article-title":"Improvement of the anticancer efficacy of PD-1\/PD-L1 blockade via combination therapy and PD-L1 regulation","volume":"15","author":"Wu","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.intimp.2024.112098_b0220","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1038\/s41467-022-29401-6","article-title":"USP8 inhibition reshapes an inflamed tumor microenvironment that potentiates the immunotherapy","volume":"13","author":"Xiong","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2024.112098_b0225","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.biomaterials.2017.07.002","article-title":"Liposomal honokiol induced lysosomal degradation of Hsp90 client proteins and protective autophagy in both gefitinib-sensitive and gefitinib-resistant NSCLC cells","volume":"141","author":"Yang","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.intimp.2024.112098_b0230","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12943-021-01489-2","article-title":"Combination strategies with PD-1\/PD-L1 blockade: current advances and future directions","volume":"21","author":"Yi","year":"2022","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.intimp.2024.112098_b0235","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.jtho.2016.04.014","article-title":"PD-L1 expression in lung cancer","volume":"11","author":"Yu","year":"2016","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.intimp.2024.112098_b0240","article-title":"Immune checkpoint inhibitor-associated pneumonitis in non-small cell lung cancer: Current understanding in characteristics, diagnosis, and management","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2024.112098_b0245","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1007\/s10147-017-1161-7","article-title":"PD-L1 induced by IFN-\u03b3 from tumor-associated macrophages via the JAK\/STAT3 and PI3K\/AKT signaling pathways promoted progression of lung cancer","volume":"22","author":"Zhang","year":"2017","journal-title":"Int. J. Clin. Oncol."},{"key":"10.1016\/j.intimp.2024.112098_b0250","doi-asserted-by":"crossref","first-page":"824","DOI":"10.7150\/thno.49600","article-title":"A novel STAT3 inhibitor W2014-S regresses human non-small cell lung cancer xenografts and sensitizes EGFR-TKI acquired resistance","volume":"11","author":"Zheng","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.intimp.2024.112098_b0255","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/s41423-020-00577-5","article-title":"The cutting-edge progress of immune-checkpoint blockade in lung cancer","volume":"18","author":"Zhou","year":"2021","journal-title":"Cell Mol. Immunol."},{"key":"10.1016\/j.intimp.2024.112098_b0260","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.apsb.2022.07.019","article-title":"Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis","volume":"13","author":"Zhou","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.intimp.2024.112098_b0265","doi-asserted-by":"crossref","first-page":"328rv324","DOI":"10.1126\/scitranslmed.aad7118","article-title":"PD-L1 (B7\u2013H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations","volume":"8","author":"Zou","year":"2016","journal-title":"Sci. Transl. Med."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924006167?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924006167?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T20:08:21Z","timestamp":1715630901000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924006167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":53,"alternative-id":["S1567576924006167"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.112098","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Honokiol suppress the PD-L1 expression to improve anti-tumor immunity in lung cancer","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.112098","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112098"}}